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Journal Articles

SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells

Min Zhou, Zihao Wu, Fen Wei, Chen Duan, Xiaoying Lin, Waiyi Zou, Chang Liu, Jingxuan Pan, Yanli Jin
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2117
Published: 13 March 2025
View article titled, SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells
Open the PDF for SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells in another window
Includes: Supplementary data
Journal Articles

PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma

Guannan Shu, Minyu Chen, Wuyuan Liao, Liangmin Fu, Mingjie Lin, Chengpeng Gui, Junjie Cen, Jun Lu, Zhenhua Chen, Jinhuan Wei, Wei Chen, Yinghan Wang, Jiangquan Zhu, Tianxin Zhao, Xiaonan Liu, Jiajia Jing, Guo-chang Liu, Yihui Pan, Junhang Luo, Jiaxing Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1659–1679.
https://doi.org/10.1158/0008-5472.CAN-23-2521
Published: 15 May 2024
View article titled, PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma
Open the PDF for PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PO2-27-11: Antitumor efficacy and safety of sacibertinib (Hemay022) in combination with endocrine therapy in patients with ER+ and HER2+ metastatic breast cancer: A phase Ib study

Hui-Ping Li, Qingyuan Zhang, Ruyan Zhang, Yaxin Liu, Chang Liu, Xianjun Hu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-27-11.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-27-11
Published: 02 May 2024
View article titled, Abstract PO2-27-11: Antitumor efficacy and safety of sacibertinib (Hemay022) in combination with endocrine therapy in patients with ER+ and HER2+ metastatic breast cancer: A phase Ib study
Journal Articles

Abstract SY22-01: A strategy to intervene mitotic kinases to induce mitotic catastrophe in cancer cells

Motoko Takahashi, Minji Jo, Nana Kamakura, Chang Liu, Utako Kato, Toru Hirota
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): SY22-01.
https://doi.org/10.1158/1538-7445.AM2024-SY22-01
Published: 05 April 2024
View article titled, Abstract SY22-01: A strategy to intervene mitotic kinases to induce mitotic catastrophe in cancer cells
Journal Articles

Abstract CT089: A phase 1 multi-center, open label, dose escalation study to evaluate the safety, pharmacokinetics (PK) and anti-tumor activity of T-1301, a novel small molecular multi-target kinase inhibitor, in patients with advanced solid tumors

Jen-Shi Chen, Ming-Huang Chen, Yi-Chang Liu, Wen-Chi Chou, Nai-Jung Chiang, Hui-Ching Wang, Ta-Sen Yeh, Shih-Feng Cho, Cheng-Hsu Wang, I-Fang Lee, Li-Tzong Chen
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT089.
https://doi.org/10.1158/1538-7445.AM2024-CT089
Published: 05 April 2024
View article titled, Abstract CT089: A phase 1 multi-center, open label, dose escalation study to evaluate the safety, pharmacokinetics (PK) and anti-tumor activity of T-1301, a novel small molecular multi-target kinase inhibitor, in patients with advanced solid tumors
Journal Articles

Abstract LB061: Aurora kinases inhibition enhances neoadjuvant chemotherapy response in triple negative breast cancer

Jia Xu, Chang Liu, Bohan Ning, Ali Cem Kucukdagli, Yunjia Chen
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB061.
https://doi.org/10.1158/1538-7445.AM2024-LB061
Published: 05 April 2024
View article titled, Abstract LB061: Aurora kinases inhibition enhances neoadjuvant chemotherapy response in triple negative breast cancer
Journal Articles

Abstract 6316: Exploring the resistant mechanism of CAR T cell therapy targeting CLDN18.2 by single-cell sequencing

Mingyang Ma, Changsong Qi, Chang Liu, Lei Jiang, Min Tao, Dan Liu, Panpan Zhang, Zhi Peng, Xiaotian Zhang, Jifang Gong, Yang Chen, Chunhong Zheng, Mi Deng, Lin Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6316.
https://doi.org/10.1158/1538-7445.AM2024-6316
Published: 22 March 2024
View article titled, Abstract 6316: Exploring the resistant mechanism of CAR T cell therapy targeting CLDN18.2 by single-cell sequencing
Journal Articles

Abstract 3617: Expansion and persistence of anti-BCMA CAR T cells correlates with durability of responses in multiple myeloma patients

Kai Wu, Karen Law, Guy Ledergor, Chang Liu, Zenghua Fan, Vibha Gurunathan, Averey Lea, Matthew Clark, Serena Kwek, Alexander Cheung, Jeffrey Wolf, Ajai Chari, Anupuma Kumar, Justin Eyquem, Thomas Martin, Lawrence Fong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3617.
https://doi.org/10.1158/1538-7445.AM2024-3617
Published: 22 March 2024
View article titled, Abstract 3617: Expansion and persistence of anti-BCMA CAR T cells correlates with durability of responses in multiple myeloma patients
Journal Articles

Abstract 6916: InnoPanelTMand InnoPediaTM: resources of engineered cell lines and xenografts for drug discovery

Siyu Li, Chang Liu, Na Wang, Yuqing Hu, Jinying Ning, Feng Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6916.
https://doi.org/10.1158/1538-7445.AM2024-6916
Published: 22 March 2024
View article titled, Abstract 6916: InnoPanel<sup>TM</sup>and InnoPedia<sup>TM</sup>: resources of engineered cell lines and xenografts for drug discovery
Journal Articles

Abstract 28: In vivoscreening platform based on BaF3 kinase engineered cell lines for discovery of next-generation kinase inhibitors

Tongtong Liu, Feng He, Xuyang Duan, shuliang Li, Chang Liu, Jinying Ning, Feng Hao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 28.
https://doi.org/10.1158/1538-7445.AM2023-28
Published: 04 April 2023
View article titled, Abstract 28: <em>In vivo</em>screening platform based on Ba&lt;/&gt;F3 kinase engineered cell lines for discovery of next-generation kinase inhibitors
Journal Articles

Abstract 5196: Novel humanized CD36 mouse model for therapeutic studies

Linlin Wang, Chang Liu, Rebecca Soto, Chengzhang Shang, Qingcong Lin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5196.
https://doi.org/10.1158/1538-7445.AM2023-5196
Published: 04 April 2023
View article titled, Abstract 5196: Novel humanized CD36 mouse model for therapeutic studies
Journal Articles

Abstract 26: BaF3 RAS cell panel, a powerful cell model for Ras inhibitor discovery and development

PENG YAO, Yu Wang, Chang Liu, Na Wang, Wei Meng, Jinying Ning, Feng Hao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 26.
https://doi.org/10.1158/1538-7445.AM2023-26
Published: 04 April 2023
View article titled, Abstract 26: BaF3 RAS cell panel, a powerful cell model for Ras inhibitor discovery and development
Journal Articles

Abstract 6158: BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel

Jie Li, Nan Hu, Yilu Zhang, Xiaolong Yang, Minjuan Deng, Wenfeng Gong, Longbo Yin, Yong Liu, Yajuan Gao, Wei Wei, Xing Wang, Xinyi Liang, Yanwen Ma, Xuxing Sang, Chang Liu, Jingyuan Wang, Qianqian Lu, Fengtao Song, Xi Yuan, Yibing Wang, Jing Li, Wei Jin, Xuesong Liu, Xiaomin Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6158.
https://doi.org/10.1158/1538-7445.AM2023-6158
Published: 04 April 2023
View article titled, Abstract 6158: BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel
Journal Articles

Abstract 3260: Potentiation of Type I interferon signaling leads to in vivo efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397

Kaiko Kunii, Jeff J. Song, Danielle Zimmerman, Chang Liu, Kristy G. Kuplast-Barr, Jonathan J. Novak, Sunaina P. Nayak, Joseph M. Gozgit, Melissa M. Vasbinder, Kristen McEachern, Kevin W. Kuntz, Heike Keilhack, Jennifer R. Molina
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3260.
https://doi.org/10.1158/1538-7445.AM2023-3260
Published: 04 April 2023
View article titled, Abstract 3260: Potentiation of Type I interferon signaling leads to <em>in vivo</em> efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397
Journal Articles

Abstract 1643: B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A novel animal model for generation of IL12 therapies

Linlin Wang, Chang Liu, Veronika Chromikova, Ruili Lyu, Tianquan Jin, Mari Kuraguchi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1643.
https://doi.org/10.1158/1538-7445.AM2022-1643
Published: 15 June 2022
View article titled, Abstract 1643: B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A novel animal model for generation of IL12 therapies
Journal Articles

Abstract 1836: RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in patient tumors

Kristy Kuplast-Barr, Melissa L. Johnson, Manish R. Patel, Timothy A. Yap, Gerald S. Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika L. Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1836.
https://doi.org/10.1158/1538-7445.AM2022-1836
Published: 15 June 2022
View article titled, Abstract 1836: RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in patient tumors
Journal Articles

Abstract 856: Coiled-coil domain containing 3 suppresses breast cancer growth by protecting p53 from proteasome-mediated degradation

Hyemin Lee, Caiyue Li, Ji Hoon Jung, Yiwei Zhang, Jieqiong Wang, Chang Liu, Allyson M. Segall, Roger L. Sheffmaker, Shelya X. Zeng, Hua Lu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 856.
https://doi.org/10.1158/1538-7445.AM2022-856
Published: 15 June 2022
View article titled, Abstract 856: Coiled-coil domain containing 3 suppresses breast cancer growth by protecting p53 from proteasome-mediated degradation
Journal Articles

Abstract 377: Evaluating delivery of TFR1-targeting therapies to the CNS in a novel humanized TFR1 mouse model

Chang Liu, Chengzhang Shang, Limei Ma, Xiaofei Zhou, Chaoshe Guo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 377.
https://doi.org/10.1158/1538-7445.AM2022-377
Published: 15 June 2022
View article titled, Abstract 377: Evaluating delivery of TFR1-targeting therapies to the CNS in a novel humanized TFR1 mouse model
Journal Articles

Abstract 6212: Multiomics analyses reveal multimodal Fusobacterium DNA damage perturbations in colorectal cancer

Radhika Kataria, Jelmar Quist, Sunjae Lee, Anargyros Megalios, Elinor Sawyer, Thomas Hardiman, Chang Liu, Katherine Kelly, Theo Portlock, Saeed Shoaie, Anita Grigoriadis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6212.
https://doi.org/10.1158/1538-7445.AM2022-6212
Published: 15 June 2022
View article titled, Abstract 6212: Multiomics analyses reveal multimodal <em>Fusobacterium</em> DNA damage perturbations in colorectal cancer
Journal Articles

Abstract 6182: A comprehensive panel of reporter cell lines to accelerate immune-checkpoint antibody discovery

Guoqian Wang, Zhengcheng Guo, Hongling Chen, Chang Liu, Jinying Ning, Feng Hao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6182.
https://doi.org/10.1158/1538-7445.AM2022-6182
Published: 15 June 2022
View article titled, Abstract 6182: A comprehensive panel of reporter cell lines to accelerate immune-checkpoint antibody discovery