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Journal Articles

Abstract 4839: Harnessing the cGAS-STING signaling and immune checkpoint pathways to enhance the tumor microenvironment for breast cancer immunotherapy

Free
Shu-Ping Wang, Marvin Angelo Aberin, Saurabh Singh, Soumya Chatterjee, Guang-Zhi Sui, Joy Khag, Weng-Lang Yang, Chen-Yang Shen, Yao-Ming Chang, Shih-Yu Chen, Chandan Guha
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4839.
https://doi.org/10.1158/1538-7445.AM2025-4839
Published: 21 April 2025
View articletitled, Abstract 4839: Harnessing the cGAS-STING signaling and immune checkpoint pathways to enhance the tumor microenvironment for breast cancer immunotherapy
Journal Articles

Abstract 709: Enhancing prostate cancer treatment: Synergistic effects of mechano-thermal focused ultrasound and radiation therapy

Free
Soumya Chatterjee, Saurabh Singh, Stephen Barry, Chandan Guha
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 709.
https://doi.org/10.1158/1538-7445.AM2024-709
Published: 22 March 2024
View articletitled, Abstract 709: Enhancing prostate cancer treatment: Synergistic effects of mechano-thermal focused ultrasound and radiation therapy
Journal Articles

Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression

Free
Marvin A. Aberin, Yu-Ling (Pony) Lee, Xin-Guo Hsu, Chen-Yang Shen, Yao-Ming Chang, Kun-Yuan Lin, Chandan Guha, Shu-Ping Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3646.
https://doi.org/10.1158/1538-7445.AM2023-3646
Published: 04 April 2023
View articletitled, Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression
Journal Articles

Abstract 5986: The CDK4/6 inhibitor palbociclib sensitizes oral cavity squamous cell carcinoma to navitoclax-induced apoptosis-An in vitro and in vivo study

Free
Nitisha Shrivastava, Nicole Kawachi, Michael B. Prystowsky, Evripidis Gavathiotis, Chandan Guha, Thomas J. Ow
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5986.
https://doi.org/10.1158/1538-7445.AM2023-5986
Published: 04 April 2023
View articletitled, Abstract 5986: The CDK4/6 inhibitor palbociclib sensitizes oral cavity squamous cell carcinoma to navitoclax-induced apoptosis-An in vitro and in vivo study
Journal Articles

Abstract 1851: Mechanisms underlying focused ultrasound-induced immunogenicity in melanoma

Free
Sandra Pelka, Sanmay Bandyopadhyay, Sanjay Pandey, Chandan Guha, Fernando Macian
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1851.
https://doi.org/10.1158/1538-7445.AM2023-1851
Published: 04 April 2023
View articletitled, Abstract 1851: Mechanisms underlying focused ultrasound-induced immunogenicity in melanoma
Journal Articles

Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation

Available to Purchase
Brett I. Bell, Justin Vercellino, N. Patrik Brodin, Christian Velten, Lalitha S.Y. Nanduri, Prashanth K.B. Nagesh, Kathryn E. Tanaka, Yanan Fang, Yanhua Wang, Rodney Macedo, Jeb English, Michelle M. Schumacher, Phaneendra K. Duddempudi, Patrik Asp, Wade Koba, Shahin Shajahan, Laibin Liu, Wolfgang A. Tomé, Weng-Lang Yang, Richard Kolesnick, Chandan Guha
Journal: Cancer Research
Cancer Res (2022) 82 (15): 2678–2691.
https://doi.org/10.1158/0008-5472.CAN-22-0656
Published: 03 August 2022
View articletitled, Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Open the PDF for Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation in another window
Includes: Supplementary data
Journal Articles

Abstract 938: Characterization of a murine pancreatic ductal adenocarcinoma (PDAC) model with tamoxifen inducible pancreas-specific blockade of transforming growth factor-β (TGF-β) signaling with KrasG12D expression

Free
Sanjay Pandey, Brett Bell, Claudia G. Chavez, Wade Koba, Talicia Savage, Patrik Asp, Indranil Basu, Chandan Guha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 938.
https://doi.org/10.1158/1538-7445.AM2022-938
Published: 15 June 2022
View articletitled, Abstract 938: Characterization of a murine pancreatic ductal adenocarcinoma (PDAC) model with tamoxifen inducible pancreas-specific blockade of transforming growth factor-β (TGF-β) signaling with KrasG12D expression
Journal Articles

Abstract 1319: Complement activation in pancreatic ductal adenocarcinoma

Free
Brett I. Bell, Sanjay Pandey, Patrik Asp, Chandan Guha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1319.
https://doi.org/10.1158/1538-7445.AM2022-1319
Published: 15 June 2022
View articletitled, Abstract 1319: Complement activation in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4201: Immune priming with low intensity focused ultrasound and radiation therapy in murine breast cancer

Free
Michelle M. Schumacher, Claudia Gutierrez Chavez, Saurabh Singh, Chandra Karunakaran, Sanjay Pandey, Mayank Kumar, Rodney Macedo Gonzales, Chandan Guha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4201.
https://doi.org/10.1158/1538-7445.AM2022-4201
Published: 15 June 2022
View articletitled, Abstract 4201: Immune priming with low intensity focused ultrasound and radiation therapy in murine breast cancer
Journal Articles

Abstract 3444: Administration of anti-CD40 enhances local and systemic antitumor efficacy of radiotherapy in allograft tumor model of a check-point blockade resistant melanoma

Free
Sanjay Pandey, Claudia G. Chavez, Indranil Basu, Andy Minn, Chandan Guha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3444.
https://doi.org/10.1158/1538-7445.AM2022-3444
Published: 15 June 2022
View articletitled, Abstract 3444: Administration of anti-CD40 enhances local and systemic antitumor efficacy of radiotherapy in allograft tumor model of a check-point blockade resistant melanoma
Journal Articles

Abstract 203: The role of FOXM1 in senescence suppression and radiation resistance in oral cavity squamous cell carcinoma

Free
Nitisha Shrivastava, Yisrael Wallach, Daniel Li, Carlos Thomas, Michael B. Prystowsky, Indranil Basu, Chandan Guha, Thomas J. Ow
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 203.
https://doi.org/10.1158/1538-7445.AM2022-203
Published: 15 June 2022
View articletitled, Abstract 203: The role of FOXM1 in senescence suppression and radiation resistance in oral cavity squamous cell carcinoma
Journal Articles

Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis

Free
Krishanu Bhowmick, Richard Amdur, Xiyan Xiang, Herbert Yu, Linda L. Wong, Shuyun Rao, Aiwu R. He, Karan Amin, Daewa Zaheer, Raj K. Narayan, Sanjaya K. Satapathy, Chandan Guha, Patricia S. Latham, Kirti Shetty, Nancy R. Gough, Lopa Mishra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3379.
https://doi.org/10.1158/1538-7445.AM2022-3379
Published: 15 June 2022
View articletitled, Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis
Journal Articles

Abstract 1958: Inhibition of CDK4/6 in head and neck squamous cell carcinoma dismantles key DNA repair pathways in response to radiation treatment

Free
Nitisha Shrivastava, Carlos Thomas, Daniel Li, Cory D. Fulcher, Michael B. Prystowsky, Indranil Basu, Chandan Guha, Thomas J. Ow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1958.
https://doi.org/10.1158/1538-7445.AM2021-1958
Published: 01 July 2021
View articletitled, Abstract 1958: Inhibition of CDK4/6 in head and neck squamous cell carcinoma dismantles key DNA repair pathways in response to radiation treatment
Journal Articles

Abstract 2986: Conditional reprogramming of primary head and neck tumor cells to establish consistent and diverse cell line models

Free
Daniel Li, Carlos Thomas, Nitisha Shrivastava, Nicholas Gadsden, Nicole Kawachi, Bradley A. Schiff, Richard V. Smith, Nicolas F. Schlecht, Michael B. Prystowsky, Gregory Rosenblatt, Stelby Augustine, Chandan Guha, Evripidis Gavathiotis, Robert D. Burk, Vikas Mehta, Thomas J. Ow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2986.
https://doi.org/10.1158/1538-7445.AM2021-2986
Published: 01 July 2021
View articletitled, Abstract 2986: Conditional reprogramming of primary head and neck tumor cells to establish consistent and diverse cell line models
Journal Articles

Abstract 6640: Stabilized recombinant trefoil factor 2 (TFF2-CTP) enhances anti-tumor activity of PD-1 blockade in mouse models of colorectal cancer

Free
Woosook Kim, Na Fu, Phaneendra Duddempudi, Zinaida Dubeykovskaya, Steven Almo, Chandan Guha, Seth Lederman, Timothy Wang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6640.
https://doi.org/10.1158/1538-7445.AM2020-6640
Published: 15 August 2020
View articletitled, Abstract 6640: Stabilized recombinant trefoil factor 2 (TFF2-CTP) enhances anti-tumor activity of PD-1 blockade in mouse models of colorectal cancer
Journal Articles

Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

Free
Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura Dawson, Thomas Karasic, Joseph Llovet, Richard Finn, John Groopman, Hashem El-Serag, Satdarshan Monga, Xin Wei Wang, Michael Karin, Robert Schwartz, Kenneth Tanabe, Lewis Roberts, Preethi Gunaratne, Allan Tsung, Kimberly Brown, Theodore Lawrence, Riad Salem, Amit Singal, Amy Kim, Atoosa Rabiee, Linda Resar, Jeffrey Meyer, Yujin Hoshida, Aiwu Ruth He, Kalpana Ghoshal, Patrick Ryan, Elizabeth Jaffee, Chandan Guha, Lopa Mishra, Norman Coleman, Mansoor Ahmed
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5897.
https://doi.org/10.1158/0008-5472.CAN-19-2958
Published: 15 November 2019
View articletitled, Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Open the PDF for Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma in another window
Journal Articles

Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

Free
Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura A. Dawson, Thomas Karasic, Josep M. Llovet, Richard S. Finn, John D. Groopman, Hashem B. El-Serag, Satdarshan P. Monga, Xin Wei Wang, Michael Karin, Robert E. Schwartz, Kenneth K. Tanabe, Lewis R. Roberts, Preethi H. Gunaratne, Allan Tsung, Kimberly A. Brown, Theodore S. Lawrence, Riad Salem, Amit G. Singal, Amy K. Kim, Atoosa Rabiee, Linda Resar, Jeffrey Meyer, Yujin Hoshida, Aiwu Ruth He, Kalpana Ghoshal, Patrick B. Ryan, Elizabeth M. Jaffee, Chandan Guha, Lopa Mishra, C. Norman Coleman, Mansoor M. Ahmed
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (17): 4326–4330.
https://doi.org/10.1158/0008-5472.CAN-19-0803
Published: 03 September 2019
View articletitled, Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Open the PDF for Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma in another window
Journal Articles

Abstract 3938: Acoustic immune priming of radiation therapy eradicates primary tumor and reduces distant metastases in triple-negative murine breast cancer

Free
Saurabh Singh, Claudia Gutierrez-Chavez, Karin Skalina, Wade Koba, Indranil Basu, Stephen Barry, Chandan Guha
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3938.
https://doi.org/10.1158/1538-7445.AM2019-3938
Published: 01 July 2019
View articletitled, Abstract 3938: Acoustic immune priming of radiation therapy eradicates primary tumor and reduces distant metastases in triple-negative murine breast cancer
Journal Articles

Abstract CT005: FLT3 ligand (CDX-301) and stereotactic radiotherapy for advanced non-small cell lung cancer

Free
Nitin Ohri, Balazs Halmos, Haiying Cheng, Tony Abraham, Tahir Yahya, Madhur Garg, William Bodner, Rafi Kabarriti, Shalom Kalnicki, Michael J. Yellin, Tibor Keler, Chandan Guha
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT005.
https://doi.org/10.1158/1538-7445.AM2018-CT005
Published: 01 July 2018
View articletitled, Abstract CT005: FLT3 ligand (CDX-301) and stereotactic radiotherapy for advanced non-small cell lung cancer
Journal Articles

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Free
Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, Nandini Ramachandra, Orsi Giricz, Vineeth Sukrithan, George Nwankwo, Samira Shahnaz, Tushar D. Bhagat, Sanchari Bhattacharyya, Amer Assal, Aditi Shastri, Shanisha Gordon-Mitchell, Andrea Pellagatti, Jacqueline Boultwood, Carolina Schinke, Yiting Yu, Chandan Guha, James Rizzi, Jennifer Garrus, Suzy Brown, Lance Wollenberg, Grant Hogeland, Dale Wright, Mark Munson, Mareli Rodriguez, Stefan Gross, David Chantry, Yiyu Zou, Leonidas C. Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4841–4849.
https://doi.org/10.1158/0008-5472.CAN-15-3062
Published: 14 August 2016
View articletitled, Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Open the PDF for Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia in another window
Includes: Supplementary data