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Journal Articles

Abstract LB-151: Positively selected enhancer elements endow tumor cells with metastatic competence

James J. Morrow, Tyler E. Miller, Alina Saiakhova, Michael M. Lizardo, Cynthia F. Bartels, Ian Bayles, Stevephen Hung, Arnulfo Mendoza, Jay T. Myers, Frederick Allen, Analisa DiFeo, Brian P. Rubin, Alex Y. Huang, Paul S. Meltzer, Lee J. Helman, Chand Khanna, Peter C. Scacheri
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-151.
https://doi.org/10.1158/1538-7445.AM2016-LB-151
Published: 15 July 2016
View article titled, Abstract LB-151: Positively selected enhancer elements endow tumor cells with metastatic competence
Journal Articles

CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ

Hangyi H. Yan, Jian Jiang, Yanli Pang, B.R. Achyut, Michael Lizardo, Xinhua Liang, Kent Hunter, Chand Khanna, Christine Hollander, Li Yang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (24): 5283–5298.
https://doi.org/10.1158/0008-5472.CAN-15-2282-T
Published: 14 December 2015
View article titled, CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ
Open the PDF for CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ in another window
Includes: Supplementary data
Journal Articles

Abstract 4517: Plasma and tumor pharmacokinetics of IV LMP744, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study

Julie L. Eiseman, Julianne Holleran, David L. McCormick, Miguel Muzzio, Joseph M. Covey, Chand Khanna, Christina Mazcko, Yves Pommier, Melissa Paolini, Amy Leblanc, Jenna H. Burton, James H. Doroshow, Joseph E. Tomaszewski, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4517.
https://doi.org/10.1158/1538-7445.AM2015-4517
Published: 01 August 2015
View article titled, Abstract 4517: Plasma and tumor pharmacokinetics of IV LMP744, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study
Journal Articles

Abstract 5574: High prevalence of germline TP53 mutations in young osteosarcoma cases

Lisa J. Mirabello, Meredith Yeager, Phuong L. Mai, Julie Gastier-Foster, Richard Gorlick, Chand Khanna, Ana Patiño-Garcia, Luis Sierrasesúmaga, Fernando Lecanda, Irene L. Andrulis, Jay S. Wunder, Nalan Gokgoz, Donald A. Barkauskas, Xijun Zhang, Aurelie Vogt, Kristine Jones, Joseph F. Boland, Stephen J. Chanock, Sharon A. Savage
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5574.
https://doi.org/10.1158/1538-7445.AM2015-5574
Published: 01 August 2015
View article titled, Abstract 5574: High prevalence of germline TP53 mutations in young osteosarcoma cases
Journal Articles

Abstract 3172: CCL9 induction in myeloid cells of the premetastatic niche enhances tumor cell survival and metastatic colonization

Hannah HY Yan, Yanli Pang, Kent Hunter, Chand Khanna, Li Yang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3172.
https://doi.org/10.1158/1538-7445.AM2015-3172
Published: 01 August 2015
View article titled, Abstract 3172: CCL9 induction in myeloid cells of the premetastatic niche enhances tumor cell survival and metastatic colonization
Journal Articles

Abstract 2468: A p53 and microRNA-mediated pathway regulates mesenchymal stem cell differentiation

Yunlong He, Shunlin Jiang, Wendy Dubois, Ling Ren, Chand Khanna, Jing Huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2468.
https://doi.org/10.1158/1538-7445.AM2014-2468
Published: 01 October 2014
View article titled, Abstract 2468: A p53 and microRNA-mediated pathway regulates mesenchymal stem cell differentiation
Journal Articles

Abstract 3417: The genomic landscape of canine melanoma reveals broad mutational heterogeneity and recurrent patterns of structural variation

William P. Hendricks, Victoria Zismann, Berry Button, Christophe Legendre, Waibhav Tembe, Holly Yin, Michael Bittner, Donald Berry, Matthew Huentelman, Chand Khanna, Patricia LoRusso, Matthew Breen, Aleksandar Sekulic, Jeffrey Trent
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3417.
https://doi.org/10.1158/1538-7445.AM2014-3417
Published: 01 October 2014
View article titled, Abstract 3417: The genomic landscape of canine melanoma reveals broad mutational heterogeneity and recurrent patterns of structural variation
Journal Articles

Abstract 4632: Plasma and tumor pharmacokinetics of IV LMP400, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study

Julie L. Eiseman, Julianne Holleran, David L. McCormick, Miguel Muzzio, Joseph M. Covey, Chand Khanna, Christina Mazcko, Yves Pommier, Melissa Paoloni, James D. Doroshow, Joseph E. Tomaszewski, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4632.
https://doi.org/10.1158/1538-7445.AM2014-4632
Published: 01 October 2014
View article titled, Abstract 4632: Plasma and tumor pharmacokinetics of IV LMP400, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study
Journal Articles

Abstract 4028: Identification of a novel combination therapy that prevents the metastatic outgrowth and reduces the viability of dormant breast cancer cells

Lara H. El Touny, Anthony Vieira, Arnulfo Mendoza, Chand Khanna, Mark J. Hoenerhoff, Jeffrey E. Green
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4028.
https://doi.org/10.1158/1538-7445.AM2014-4028
Published: 01 October 2014
View article titled, Abstract 4028: Identification of a novel combination therapy that prevents the metastatic outgrowth and reduces the viability of dormant breast cancer cells
Journal Articles

Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma.

Sharon A. Savage, Lisa Mirabello, Zhaoming Wang, Julie Gastier-Foster, Richard Gorlick, Chand Khanna, Adrienne M. Flanagan, Roberto Tirabosco, Irene L. Andrulis, Jay Wunder, Nalan Gokgoz, Ana Patino-Garcia, Luis Sierrasesumaga, Fernando Lecanda, Nilgun Kurucu, Inci Ergurhan Ilhan, Neriman Sari, Massimo Serra, Claudia Hattinger, Piero Picci, Logan Spector, Donald A. Barkauskas, Neyssa Marina, Siliva Caminada de Toledo, Sergio Petrilli, Maria Fernanda Amary, Dina Halai, David Thomas, Chester Douglass, Paul Meltzer, Kevin Jacobs, Charles C. Chung, Sonja I. Berndt, Mark P. Purdue, Neil E. Caporaso, Margaret Tucker, Nathaniel Rothman, Maria Teresa Landi, Debra T. Silverman, Peter Kraft, David J. Hunter, Nuria Malats, Manolis Kogevinas, Sholom Wacholder, Rebecca Troisi, Lee Helman, Joseph F. Fraumeni, Jr., Meredith Yeager, Robert Hoover, Stephen J. Chanock
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4593.
https://doi.org/10.1158/1538-7445.AM2013-4593
Published: 15 April 2013
View article titled, Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma.
Journal Articles

Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma

George W. Kosturko, Gulay Bulut, Sung-Hyeok Hong, Veronica Rodriguez, Milton Brown, Jeffrey Toretsky, Chand Khanna, Mikell Paige, Aykut Uren
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3906.
https://doi.org/10.1158/1538-7445.AM2012-3906
Published: 15 April 2012
View article titled, Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma
Journal Articles

Abstract 3421: Nm23, a metastasis suppressor gene, binds the cytoskeletal linker Ezrin to regulate motility

Jean-Claude A. Marshall, Joshua Collins, Ming Zhou, Timothy Veenstra, Chand Khanna, Patricia Steeg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3421.
https://doi.org/10.1158/1538-7445.AM2012-3421
Published: 15 April 2012
View article titled, Abstract 3421: Nm23, a metastasis suppressor gene, binds the cytoskeletal linker Ezrin to regulate motility
Journal Articles

Abstract 4190: Ezrin plays a key role in the regulation of translation in metastatic osteosarcoma

James J. Morrow, Joseph Briggs, Ling Ren, Kristi Chakrabarti, Jessica Cassavaugh, Timothy D. Veenstra, Qingrong Chen, Javed Khan, Aykut Uren, Chand Khanna
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4190.
https://doi.org/10.1158/1538-7445.AM2012-4190
Published: 15 April 2012
View article titled, Abstract 4190: Ezrin plays a key role in the regulation of translation in metastatic osteosarcoma
Journal Articles

Abstract 1365: The PAMM (pulmonary assessment of metastatic morbidity) diagnostic: A novel non-invasive method for evaluating lung metastasis in murine models

Radhika V. Gharpure, Arnulfo Mendoza, John U. Dennis, Chand Khanna
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1365.
https://doi.org/10.1158/1538-7445.AM2012-1365
Published: 15 April 2012
View article titled, Abstract 1365: The PAMM (pulmonary assessment of metastatic morbidity) diagnostic: A novel non-invasive method for evaluating lung metastasis in murine models
Journal Articles

Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma

Ling Ren, Sung-Hyeok Hong, Qing-Rong Chen, Joseph Briggs, Jessica Cassavaugh, Satish Srinivasan, Michael M. Lizardo, Arnulfo Mendoza, Ashley Y. Xia, Narayan Avadhani, Javed Khan, Chand Khanna
Journal: Cancer Research
Cancer Res (2012) 72 (4): 1001–1012.
https://doi.org/10.1158/0008-5472.CAN-11-0210
Published: 14 February 2012
View article titled, Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma
Open the PDF for Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1447: An unbiased screen for Nm23-H1 interacting proteins identifies the cytoskeletal crosslinking protein Ezrin

Jean-Claude A. Marshall, Joshua Collins, Ming Zhou, Timothy Veenstra, Chand Khanna, Patricia Steeg
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1447.
https://doi.org/10.1158/1538-7445.AM2011-1447
Published: 15 April 2011
View article titled, Abstract 1447: An unbiased screen for Nm23-H1 interacting proteins identifies the cytoskeletal crosslinking protein Ezrin
Journal Articles

Abstract 5332: Evaluation of GD2 expression in patients with osteosarcoma

John Tarim, Rebecca S. Sowers, Sajida Piperdi, Chand Khanna, Richard G. Gorlick
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5332.
https://doi.org/10.1158/1538-7445.AM2011-5332
Published: 15 April 2011
View article titled, Abstract 5332: Evaluation of GD2 expression in patients with osteosarcoma
Journal Articles

Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents

Gülay Bulut, Sung-Hyeok Hong, Kevin Chen, Said Rahim, George W. Kosturko, Elspeth M. Beauchamp, Eric Glasgow, Jeffrey A. Toretsky, Chand Khanna, Aykut Uren
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4505.
https://doi.org/10.1158/1538-7445.AM2011-4505
Published: 15 April 2011
View article titled, Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents
Journal Articles

Abstract 1446: Dissecting the role of PTEN/Akts in metastatic melanoma

Yanlin Yu, Ziyang Liu, Yixin Yu, Arnulfo Mendoza, Chand Khanna, Glenn Merlino
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1446.
https://doi.org/10.1158/1538-7445.AM2011-1446
Published: 15 April 2011
View article titled, Abstract 1446: Dissecting the role of PTEN/Akts in metastatic melanoma
Journal Articles

Abstract 1550: Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma

Gulay Bulut, Kevin Chen, Eric Glasgow, Sung-Hyeok Hong, Hyun-Shik Lee, George Kosturko, Jeffrey A. Toretsky, Ira Daar, Chand Khanna, Aykut Uren
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1550.
https://doi.org/10.1158/1538-7445.AM10-1550
Published: 15 April 2010
View article titled, Abstract 1550: Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma