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Chad J. Creighton
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Journal Articles

Abstract A019: UALCAN Mobile app, an update to the cancer multi-omic data analysis application

Sooryanarayana Varambally, David Rubey, Darshan Shimoga Chandrashekar, Ahmedur Rahman Shovon, Gopi Chand Puli, Santhosh Kumar Karthikeyan, Upender Manne, Chad J. Creighton, Sidarth Kumar
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): A019.
https://doi.org/10.1158/1538-7445.GENFUNC25-A019
Published: 11 March 2025
View article titled, Abstract A019: UALCAN Mobile app, an update to the cancer multi-omic data analysis application
Journal Articles

Abstract 2270: UALCAN Mobile, An app for cancer gene expression data analysis

Sooryanarayana Varambally, Darshan Shimoga Chandrashekar, Gopi Chand Puli, Santhosh Kumar Karthikeyan, Upender Manne, Chad J. Creighton, Sidarth Kumar
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2270.
https://doi.org/10.1158/1538-7445.AM2024-2270
Published: 22 March 2024
View article titled, Abstract 2270: UALCAN Mobile, An app for cancer gene expression data analysis
Journal Articles

Abstract PR02: Modeling breast cancer through somatic precision gene editing with high flexibility and efficiency

Wen Bu, Yi Li, Chad J Creighton, Kelsey S Heavener, Carolina Gutierrez, Yongchao Dou, Weiyu Jiang, Bing Zhang, Amy T Ku, Shixia Huang
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): PR02.
https://doi.org/10.1158/1538-7445.ADVBC23-PR02
Published: 01 February 2024
View article titled, Abstract PR02: Modeling breast cancer through somatic precision gene editing with high flexibility and efficiency
Journal Articles

Abstract 6007: p16 epimutation modulates the tumor microenvironment and promotes malignancy of Apc-mutant colon cancer

Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Wei Li, Lanlan Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6007.
https://doi.org/10.1158/1538-7445.AM2023-6007
Published: 04 April 2023
View article titled, Abstract 6007: <em>p16</em> epimutation modulates the tumor microenvironment and promotes malignancy of <em>Apc</em>-mutant colon cancer
Journal Articles

A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis

Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I.J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4441–4454.
https://doi.org/10.1158/0008-5472.CAN-21-1112
Published: 01 September 2021
View article titled, A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer

Fei Yue, Weiyu Jiang, Amy T Ku, Adelaide IJ Young, Weijie Zhang, Eric P Souto, Yankun Gao, Zhihan Yu, Yi Wang, Chad J Creighton, Chandandeep Nagi, Tao Wang, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD15-03.
https://doi.org/10.1158/1538-7445.SABCS20-PD15-03
Published: 15 February 2021
View article titled, Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer
Journal Articles

Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Yutaka Midorikawa, Shogo Yamamoto, Kenji Tatsuno, Claire Renard-Guillet, Shingo Tsuji, Akimasa Hayashi, Hiroki Ueda, Shiro Fukuda, Takanori Fujita, Hiroto Katoh, Shumpei Ishikawa, Kyle R. Covington, Chad J. Creighton, Masahiko Sugitani, David A. Wheeler, Tatsuhiro Shibata, Genta Nagae, Tadatoshi Takayama, Hiroyuki Aburatani
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3810–3819.
https://doi.org/10.1158/0008-5472.CAN-20-0225
Published: 15 September 2020
View article titled, Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
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Includes: Supplementary data
Journal Articles

Abstract 5213: Drug repurposing to treat triple negative breast cancer (TNBC) based on a novel ER beta-p53-p73 signaling axis

Chetan C. Oturkar, Christina Adams, Utpal K. Mukhopadhyay, Alexander Caradori, Manasori Oshi, Yoshihisa Tokumaru, Chad J. Creighton, Jun H. Park, Nishant Gandhi, Kazuaki Takabe, Kristopher M. Attwood, Benny A. Kaipparettu, Gokul M. Das
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5213.
https://doi.org/10.1158/1538-7445.AM2020-5213
Published: 15 August 2020
View article titled, Abstract 5213: Drug repurposing to treat triple negative breast cancer (TNBC) based on a novel ER beta-p53-p73 signaling axis
Journal Articles

Abstract P3-06-12: Autophagy-mediated survival mechanism to c-Src inhibitor therapy in triple negative breast cancer

Kwanghwa Jung, Junhyoung Park, Tirupataiah Sirupangi, Dongya Jia, Nishant Gandhi, Shivanand Pudakalakatti, Jessica Elswood, Weston Porter, Nagireddy Putluri, Xiang H.-F Zhang, Xi Chen, Pratip K. Bhattacharya, Chad J. Creighton, Michael T. Lewis, Jeffrey M. Rosen, Lee-Jun C. Wong, Gokul M. Das, C. Kent Osborne, Mothaffar F Rimawi, Benny Abraham Kaipparettu
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-06-12.
https://doi.org/10.1158/1538-7445.SABCS19-P3-06-12
Published: 15 February 2020
View article titled, Abstract P3-06-12: Autophagy-mediated survival mechanism to c-Src inhibitor therapy in triple negative breast cancer
Journal Articles

Abstract GS3-08: Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network

Tari A King, Minetta C Liu, Marni B McClure, Toshinori Hinoue, Benjamin J Kelly, Chad J Creighton, Jay Bowen, Kristen Leraas, Robyn T Burns, Sara Coppens, Salma Rezk, Amy L Garrett, Justin M Balko, Joel S Parker, Ben H Park, Ian Krop, Carey Anders, Katherine A Hoadley, Julie Gastier-Foster, Mothaffar F Rimawi, Rita Nanda, Nancy U Lin, Claudine Isaacs, P. Kelly Marcom, Anna Maria Storniolo, Fergus J Couch, Elaine R Mardis, Adrian V Lee, Uma Chandran, Peter W Laird, Susan G Hilsenbeck, Larry Norton, Andrea L Richardson, W. Fraser Symmans, Lisa A Carey, Antonio C Wolff, Nancy E Davidson, Charles M Perou, the AURORA US Network
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS3-08.
https://doi.org/10.1158/1538-7445.SABCS19-GS3-08
Published: 15 February 2020
View article titled, Abstract GS3-08: Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network
Journal Articles

Abstract 2481: Developing analysis platform for pan-cancer study of DNA methylation, mirna and lncrna expression based on tumor subtypes using TCGA data

Darshan Shimoga Chandrashekar, Chad J. Creighton, Israel Ponce-Rodriguez, Sooryanarayana Varambally
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2481.
https://doi.org/10.1158/1538-7445.AM2019-2481
Published: 01 July 2019
View article titled, Abstract 2481: Developing analysis platform for pan-cancer study of DNA methylation, mirna and lncrna expression based on tumor subtypes using TCGA data
Journal Articles

Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes

Wen Bu, Zhenyu Liu, Weiyu Jiang, Chandandeep Nagi, Shixia Huang, Dean P. Edwards, Eunji Jo, Qianxing Mo, Chad J. Creighton, Susan G. Hilsenbeck, Andrew D. Leavitt, Michael T. Lewis, Stephen T. C. Wong, Yi Li
Journal: Cancer Research
Cancer Res (2019) 79 (1): 61–71.
https://doi.org/10.1158/0008-5472.CAN-18-1087
Published: 02 January 2019
View article titled, Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes
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Includes: Supplementary data
Journal Articles

Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling

Carla Danussi, Promita Bose, Pedro Silberman, John S. Van Arnam, Mark Vitucci, Oliver Tang, Adriana Heguy, Timothy A. Chan, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4322.
https://doi.org/10.1158/1538-7445.AM2018-4322
Published: 01 July 2018
View article titled, Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling
Journal Articles

Abstract 5240: Functional and therapeutic significance of ESR1 gene fusions in breast cancer

Jonathan T. Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W. Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Romalho, Raquel M. Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, W V. Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan Parikh, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Vera Suman, Kelly K. Hunt, Mark A. Watson, Katherine A. Hoadley, E A. Thompson, Xi Chen, Shyam M. Kavuri, Chad J. Creighton, Christopher A. Maher, Charles M. Perou, Svasti Haricharan, Matthew J. Ellis
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5240.
https://doi.org/10.1158/1538-7445.AM2018-5240
Published: 01 July 2018
View article titled, Abstract 5240: Functional and therapeutic significance of <em>ESR1</em> gene fusions in breast cancer
Journal Articles

Abstract 1331: Inhibition of mitochondrial reprogramming regulated c-Src in triple-negative breast cancer activates autophagy-mediated survival mechanism

Kwang Hwa Jung, Jun Hyoung Park, Tirupataiah Sirupangi, Dongya Jia, Shivanand Pudakalakatti, Nishant Gandhi, Jessica Elswood, Vasanta Putluri, Chad J. Creighton, Weston Porter, Michael T. Lewis, Xi Chen, Nagireddy Putluri, Pratip K. Bhattacharya, Lee-Jun C. Wong, Gokul M. Das, Benny A. Kaipparettu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1331.
https://doi.org/10.1158/1538-7445.AM2018-1331
Published: 01 July 2018
View article titled, Abstract 1331: Inhibition of mitochondrial reprogramming regulated c-Src in triple-negative breast cancer activates autophagy-mediated survival mechanism
Journal Articles

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

Li-Yuan Yu-Lee, Guoyu Yu, Yu-Chen Lee, Song-Chang Lin, Jing Pan, Tianhong Pan, Kai-Jie Yu, Bin Liu, Chad J. Creighton, Jaime Rodriguez-Canales, Pamela A. Villalobos, Ignacio I. Wistuba, Eulalia de Nadal, Francesc Posas, Gary E. Gallick, Sue-Hwa Lin
Journal: Cancer Research
Cancer Res (2018) 78 (11): 2911–2924.
https://doi.org/10.1158/0008-5472.CAN-17-1051
Published: 31 May 2018
View article titled, Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway
Open the PDF for Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway in another window
Includes: Supplementary data
Journal Articles

Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer

Lamiaa El-Shennawy, Oleksii Dubrovskyi, Irida Kastrati, Jeanne M. Danes, Yiqun Zhang, Herbert E. Whiteley, Chad J. Creighton, Jonna Frasor
Journal: Cancer Research
Cancer Res (2018) 78 (4): 974–984.
https://doi.org/10.1158/0008-5472.CAN-17-1686
Published: 14 February 2018
View article titled, Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer
Open the PDF for Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer in another window
Includes: Supplementary data
Journal Articles

RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression

Yongquan Wang, Jianghua Wang, Li Zhang, Omer Faruk Karatas, Longjiang Shao, Yiqun Zhang, Patricia Castro, Chad J. Creighton, Michael Ittmann
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4247–4257.
https://doi.org/10.1158/0008-5472.CAN-17-0669
Published: 14 August 2017
View article titled, RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression
Open the PDF for RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression in another window
Includes: Supplementary data
Journal Articles

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression

Lucia Casadei, Federica Calore, Chad J. Creighton, Michele Guescini, Kara Batte, O. Hans Iwenofu, Abeba Zewdu, Danielle A. Braggio, Kate Lynn Bill, Paolo Fadda, Francesca Lovat, Gonzalo Lopez, Pierluigi Gasparini, James L. Chen, Raleigh D. Kladney, Gustavo Leone, Dina Lev, Carlo M. Croce, Raphael E. Pollock
Journal: Cancer Research
Cancer Res (2017) 77 (14): 3846–3856.
https://doi.org/10.1158/0008-5472.CAN-16-2984
Published: 13 July 2017
View article titled, Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression
Open the PDF for Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression in another window
Includes: Supplementary data
Journal Articles

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer

Hengyu Lu, Nicole Villafane, Turgut Dogruluk, Caitlin L. Grzeskowiak, Kathleen Kong, Yiu Huen Tsang, Oksana Zagorodna, Angeliki Pantazi, Lixing Yang, Nicholas J. Neill, Young Won Kim, Chad J. Creighton, Roel G. Verhaak, Gordon B. Mills, Peter J. Park, Raju Kucherlapati, Kenneth L. Scott
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3502–3512.
https://doi.org/10.1158/0008-5472.CAN-16-2745
Published: 02 July 2017
View article titled, Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer
Open the PDF for Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer in another window
Includes: Supplementary data