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Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Fei Guo, Celia Sigua, Purva Bali, Michael Pranpat, Warren Fiskus, Nicholas Lawrence, Kapil Bhalla

Cancer Res (2005) 65 (9_Supplement): 771.

Published: 01 May 2005

View articletitled, Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Journal Articles

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Purva Bali, Fei Guo, Warren Fiskus, Michael Pranpat, Celia Sigua, Kapil Bhalla

Cancer Res (2005) 65 (9_Supplement): 769–770.

Published: 01 May 2005

View articletitled, Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Journal Articles

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Prince George, Purva Bali, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Warren Fiskus, Anna Scuto, Srinivas Annavarapu, Lynn Moscinski, Kapil Bhalla

Cancer Res (2004) 64 (10): 3645–3652.

https://doi.org/10.1158/0008-5472.CAN-04-0006

Published: 17 May 2004

View articletitled, Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Journal Articles

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Ravi Gutti, Prince George, Purva Bali, Jianguo Tao, Fei Guo, Celia Sigua, Yunqing Li, Lynn Moscinski, Peter Atadja, Kapil N. Bhalla

Cancer Res (2004) 64 (7_Supplement): 699.

Published: 01 April 2004

View articletitled, A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Journal Articles

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-x_L and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Fei Guo, Celia Sigua, Purva Bali, Prince George, Ravi Gutti, Yunqing Li, Kapil N. Bhalla

Cancer Res (2004) 64 (7_Supplement): 135–136.

Published: 01 April 2004

View articletitled, Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Journal Articles

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Fei Guo, Celia Sigua, Jianguo Tao, Purva Bali, Prince George, Yunqing Li, Sylvie Wittmann, Lynn Moscinski, Peter Atadja, Kapil Bhalla

Cancer Res (2004) 64 (7): 2580–2589.

https://doi.org/10.1158/0008-5472.CAN-03-2629

Published: 01 April 2004

View articletitled, Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

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Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-x_L and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

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AACR Journals

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Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Email alerts

AACR Journals

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Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-x_L and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells