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Carol J. Thiele
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Journal Articles

Abstract 6921: NAMPT inhibition impacts energy metabolism, induces DNA damage, and mediates tumor regression in preclinical neuroblastoma models

Amy Yu, Sophia Varriano, Amy James, Kristine Isanogle, Nimit Patel, Caleb Kim, Unsun Lee, Victor J. Collins, Ariana E. Nelson, Ming Sun, Ye Yang, Bhushan L. Thakur, Arnulfo Mendoza, Sameer H. Issaq, John F. Shern, Mirit I. Aladjem, Daniel R. Crooks, Joseph D. Kalen, Simone Difilippantonio, Craig J. Thomas, Rosa Nguyen, Carol J. Thiele, Christine M. Heske
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6921.
https://doi.org/10.1158/1538-7445.AM2025-6921
Published: 21 April 2025
View articletitled, Abstract 6921: NAMPT inhibition impacts energy metabolism, induces DNA damage, and mediates tumor regression in preclinical neuroblastoma models
Journal Articles

HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype

Man Xu, Ming Sun, Xiyuan Zhang, Rosa Nguyen, Haiyan Lei, Jack F. Shern, Carol J. Thiele, Zhihui Liu
Journal: Cancer Research
Cancer Res (2023) 83 (5): 686–699.
https://doi.org/10.1158/0008-5472.CAN-22-2042
Published: 02 March 2023
View articletitled, HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype
Open the PDF for HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype in another window
Includes: Supplementary data
Journal Articles

Abstract 701: Loss of PRC2 enforces a mesenchymal neural crest stem cell phenotype in NF1-deficient cancer through activation of core transcription factors

Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 701.
https://doi.org/10.1158/1538-7445.AM2022-701
Published: 15 June 2022
View articletitled, Abstract 701: Loss of PRC2 enforces a mesenchymal neural crest stem cell phenotype in NF1-deficient cancer through activation of core transcription factors
Journal Articles

Abstract A46: Charting the synthetic lethality landscape in pediatric cancer to advance whole-exome precision-based treatments

Fiorella Schischlik, Joo Sang Lee, Nirali Shah, Rosandra N. Kaplan, Carol J. Thiele, Brigitte Widemann, Eytan Ruppin
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A46.
https://doi.org/10.1158/1538-7445.PEDCA19-A46
Published: 15 July 2020
View articletitled, Abstract A46: Charting the synthetic lethality landscape in pediatric cancer to advance whole-exome precision-based treatments
Journal Articles

Abstract B42: Mutant RAS represses CASZ1, a novel regulator of MYOD and MYOG, to inhibit embryonal rhabdomyosarcoma differentiation

Zhihui Liu, Xiyuan Zhang, Haiyan Lei, Norris Lam, Oliver Yockey, Max Xu, Arnulfo Mendoza, Jun S Wei, Javed Khan, Marielle E. Yohe, Jack F. Shern, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B42.
https://doi.org/10.1158/1538-7445.PEDCA19-B42
Published: 15 July 2020
View articletitled, Abstract B42: Mutant RAS represses CASZ1, a novel regulator of MYOD and MYOG, to inhibit embryonal rhabdomyosarcoma differentiation
Journal Articles

Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma

Ming Sun, Veronica Veschi, Sukriti Bagchi, Man Xu, Arnulfo Mendoza, Zhihui Liu, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4937–4950.
https://doi.org/10.1158/0008-5472.CAN-19-0695
Published: 01 October 2019
View articletitled, Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma
Open the PDF for Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2537: Targeting chromosomal passenger complex by disruption of INCENP function inhibits tumor progression in neuroblastoma

Ming Sun, Veronica Veschi, Norris Lam, Sukriti Bagchi, Man Xu, Arnulfo Mendoza, Zhihui Liu, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2537.
https://doi.org/10.1158/1538-7445.AM2019-2537
Published: 01 July 2019
View articletitled, Abstract 2537: Targeting chromosomal passenger complex by disruption of INCENP function inhibits tumor progression in neuroblastoma
Journal Articles

Abstract 3170: AKT/mTOR pharmacologic inhibition sensitizes RAS/MAPK-activated neuroblastoma cells to MEK1/2 inhibitors

Marielle Yohe, Norris Lam, Joshua Kowalczyk, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3170.
https://doi.org/10.1158/1538-7445.AM2018-3170
Published: 01 July 2018
View articletitled, Abstract 3170: AKT/mTOR pharmacologic inhibition sensitizes RAS/MAPK-activated neuroblastoma cells to MEK1/2 inhibitors
Journal Articles

Abstract 5522: Novel myogenic differentiation transcription factor CASZ1 suppresses rhabdomyosarcoma tumor growth

Zhihui Liu, Norris Lam, Arnulfo Mendoza, Jun S. Wei, John F. Shern, Marielle Yohe, Javed Khan, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5522.
https://doi.org/10.1158/1538-7445.AM2017-5522
Published: 01 July 2017
View articletitled, Abstract 5522: Novel myogenic differentiation transcription factor CASZ1 suppresses rhabdomyosarcoma tumor growth
Journal Articles

Abstract 2439: Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150 increases the chemosensitivity and decreases tumor-initiating potential of neuroblastoma cells

Seiichi Odate, Shuang Yan, Veronica Veschi, Norris Lam, Zhihui Liu, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2439.
https://doi.org/10.1158/1538-7445.AM2016-2439
Published: 15 July 2016
View articletitled, Abstract 2439: Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150 increases the chemosensitivity and decreases tumor-initiating potential of neuroblastoma cells
Journal Articles

Abstract 487: Whole genome screen to identify genes targeting MYCN-driven embryonal tumors

Carol J. Thiele, Zhihui Liu, Veronica Veschi, Eugene Buehler, Scott Martin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 487.
https://doi.org/10.1158/1538-7445.AM2015-487
Published: 01 August 2015
View articletitled, Abstract 487: Whole genome screen to identify genes targeting MYCN-driven embryonal tumors
Journal Articles

Abstract 2630: Tumor suppressor CASZ1 inhibits normal myoblast and rhabdomyosarcoma (RMS) migration.

Zhihui Liu, Wilson Chan, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2630.
https://doi.org/10.1158/1538-7445.AM2013-2630
Published: 15 April 2013
View articletitled, Abstract 2630: Tumor suppressor CASZ1 inhibits normal myoblast and rhabdomyosarcoma (RMS) migration.
Journal Articles

Abstract 5040: CASZ1 haploinsufficiency in murine embryonic stem cells causes increased MYC expression, aberrant lineage commitment, and prevents neurogenesis.

Stanley He, Ryan Virden, Zhihui LIu, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5040.
https://doi.org/10.1158/1538-7445.AM2013-5040
Published: 15 April 2013
View articletitled, Abstract 5040: CASZ1 haploinsufficiency in murine embryonic stem cells causes increased MYC expression, aberrant lineage commitment, and prevents neurogenesis.
Journal Articles

Abstract 5447: Phosphorylation status of Ascl1 regulates neuroblastoma self-renewal and differentiation.

Luke A. Wylie, Carol J. Thiele, Anna Philpott
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5447.
https://doi.org/10.1158/1538-7445.AM2013-5447
Published: 15 April 2013
View articletitled, Abstract 5447: Phosphorylation status of Ascl1 regulates neuroblastoma self-renewal and differentiation.
Journal Articles

Abstract 1440: Validation of potential therapeutic targeting of IL-6/JAK/STAT3 pathway by AZD1480 in neuroblastoma and other pediatric tumors

Shuang Yan, Carol J Thiele
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1440.
https://doi.org/10.1158/1538-7445.AM2012-1440
Published: 15 April 2012
View articletitled, Abstract 1440: Validation of potential therapeutic targeting of IL-6/JAK/STAT3 pathway by AZD1480 in neuroblastoma and other pediatric tumors
Journal Articles

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

Chunxi Wang, Zhihui Liu, Chan-Wook Woo, Zhijie Li, Lifeng Wang, Jun S. Wei, Victor E. Marquez, Susan E. Bates, Qihuang Jin, Javed Khan, Kai Ge, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2012) 72 (1): 315–324.
https://doi.org/10.1158/0008-5472.CAN-11-0961
Published: 02 January 2012
View articletitled, EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR
Open the PDF for EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR in another window
Includes: Supplementary data
Journal Articles

Abstract 4342: The allosteric Akt inhibitor MK-2206 inhibits neuroblastoma tumor cell growth in vitro and in vivo

Zhijie Li, Sridevi Ramalingam, Shuang Yan, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4342.
https://doi.org/10.1158/1538-7445.AM2011-4342
Published: 15 April 2011
View articletitled, Abstract 4342: The allosteric Akt inhibitor MK-2206 inhibits neuroblastoma tumor cell growth in vitro and in vivo
Journal Articles

Abstract 4880: CASZ1, a neuroblastoma tumor suppressor gene, is epigenetically silenced by EZH2

Chunxi Wang, Chanwook Woo, Zhihui Liu, Jun Wei, Young Song, Lifeng Wang, Javed Khan, Kai Ge, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4880.
https://doi.org/10.1158/1538-7445.AM10-4880
Published: 15 April 2010
View articletitled, Abstract 4880: CASZ1, a neuroblastoma tumor suppressor gene, is epigenetically silenced by EZH2
Journal Articles

Abstract 5014: Identification and analysis of critical domains within the neuroblastoma tumor suppressor gene CASZ1

Ryan A. Virden, Zhihui Liu, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5014.
https://doi.org/10.1158/1538-7445.AM10-5014
Published: 15 April 2010
View articletitled, Abstract 5014: Identification and analysis of critical domains within the neuroblastoma tumor suppressor gene CASZ1
Journal Articles

Abstract 5015: Hcasz5, CASZ1 gene transcript variant 2 with 5 zinc fingers functions as a tumor suppressor in Neuroblastoma

Zhihui Liu, Wendy B. London, John Maris, Carol J. Thiele
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5015.
https://doi.org/10.1158/1538-7445.AM10-5015
Published: 15 April 2010
View articletitled, Abstract 5015: Hcasz5, CASZ1 gene transcript variant 2 with 5 zinc fingers functions as a tumor suppressor in Neuroblastoma