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Carmen J. Allegra
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Journal Articles

Abstract 7223: A triplet therapeutic strategy targeting MEK, BCL-XL, and EGFR, for KRAS-mutant pancreatic ductal adenocarcinoma

Gerik W. Tushoski-Alemán, Alexandra J. Crespin, Chibeze J. Oguejiofor, Jordan A. McKean, Kelly M. Herremans, Thomas J. George, Carmen J. Allegra, Steven J. Hughes, Song Han
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7223.
https://doi.org/10.1158/1538-7445.AM2024-7223
Published: 22 March 2024
View articletitled, Abstract 7223: A triplet therapeutic strategy targeting MEK, BCL-XL, and EGFR, for KRAS-mutant pancreatic ductal adenocarcinoma
Journal Articles

Abstract 5313: A BCL-XL PROTAC degrader DT2216 synergizes with KRASG12C inhibitors for effectively treating KRASG12C-mutated cancers

Sajid Khan, Janet Wiegand, Peiyi Zhang, Wanyi Hu, Dinesh Thummuri, Vivekananda Budamagunta, Nan Hua, Lingtao Jin, Carmen J. Allegra, Edmund S. Kopetz, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5313.
https://doi.org/10.1158/1538-7445.AM2022-5313
Published: 15 June 2022
View articletitled, Abstract 5313: A BCL-XL PROTAC degrader DT2216 synergizes with KRASG12C inhibitors for effectively treating KRASG12C-mutated cancers
Journal Articles

Abstract 3407: Development of a chemokine signature identifying dMMR patients (pts) with poor prognosis

Ying Wang, Rim S. Kim, Corey Lipchik, Ashok Srinivasan, Huichen Feng, Nan Song, Carmen J. Allegra, Patrick G. Gavin, Samuel A. Jacobs, Norman Wolmark, Peter C. Lucas, Katherine L. Pogue-Geile
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3407.
https://doi.org/10.1158/1538-7445.AM2019-3407
Published: 01 July 2019
View articletitled, Abstract 3407: Development of a chemokine signature identifying dMMR patients (pts) with poor prognosis
Journal Articles

Abstract 2257: Phase II study of dual immune checkpoint blockade (ICB) with durvalumab (Durva) plus tremelimumab (T) following palliative hypofractionated radiotherapy (SBRT) in patients (pts) with microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) progressing on chemotherapy: NSABP FC-9

James J. Lee, Greg Yothers, Thomas J. George, Marwan G. Fakih, Atrayee Basu Mallick, Edith P. Mitchell, James L. Wade, John C. Krauss, Omar R. Kayaleh, Dwight E. Heron, Carmen J. Allegra, Corey Lipchik, Huichen Feng, Marion Joy, Ashok Srinivasan, Katherine L. Pogue-Geile, Peter C. Lucas, Sarah E. Warren, Alessandra Cesano, Samuel A. Jacobs
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2257.
https://doi.org/10.1158/1538-7445.AM2019-2257
Published: 01 July 2019
View articletitled, Abstract 2257: Phase II study of dual immune checkpoint blockade (ICB) with durvalumab (Durva) plus tremelimumab (T) following palliative hypofractionated radiotherapy (SBRT) in patients (pts) with microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) progressing on chemotherapy: NSABP FC-9
Journal Articles

Abstract 1923: KRAS-mutant (mt) colorectal cancer (CRC) organoid models generated from patient-derived xenografts (PDX) show response to combination of trametinib (Tm), neratinib (N), and trastuzumab (Tz)

Rekha Pal, Ashok Srinivasan, Peter C. Lucas, Carmen J. Allegra, Angela M. Davies, Alshad S. Lalani, Samuel A. Jacobs, Katherine L. Pogue-Geile
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1923.
https://doi.org/10.1158/1538-7445.AM2019-1923
Published: 01 July 2019
View articletitled, Abstract 1923: KRAS-mutant (mt) colorectal cancer (CRC) organoid models generated from patient-derived xenografts (PDX) show response to combination of trametinib (Tm), neratinib (N), and trastuzumab (Tz)
Journal Articles

Abstract LB-087: Inflammatory and stem-like colorectal cancer (CRC) subtypes identified in patient-derived xenograft (PDX) models show tumor growth inhibition (TGI) by the combination of trametinib (T) and neratinib (N) irrespective of KRAS mutation (MT) status

Rekha Pal, Nan Song, Ying Wang, Ashok Srinivasan, Peter C. Lucas, Carmen J. Allegra, Angela M. Davies, Alshad S. Lalani, Samuel A. Jacobs, Katherine L. Pogue-Geile
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-087.
https://doi.org/10.1158/1538-7445.AM2018-LB-087
Published: 01 July 2018
View articletitled, Abstract LB-087: Inflammatory and stem-like colorectal cancer (CRC) subtypes identified in patient-derived xenograft (PDX) models show tumor growth inhibition (TGI) by the combination of trametinib (T) and neratinib (N) irrespective of KRAS mutation (MT) status
Journal Articles

Abstract 5684: NSABP FC-7 correlative study: HER2 amplification (amp) in circulating cell-free DNA (cfDNA) in metastatic colorectal cancer (mCRC) resistant to anti-EGFR therapy (tx)

S. Rim Kim, Ashok Srinivasan, Carmen J. Allegra, Samuel Jacobs, Rebecca J. Nagy, Richard B. Lanman, AmirAli Talasaz, Patrick Gavin, Rekha Pal, Peter C. Lucas, Kay Pogue-Geile
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5684.
https://doi.org/10.1158/1538-7445.AM2017-5684
Published: 01 July 2017
View articletitled, Abstract 5684: NSABP FC-7 correlative study: HER2 amplification (amp) in circulating cell-free DNA (cfDNA) in metastatic colorectal cancer (mCRC) resistant to anti-EGFR therapy (tx)
Journal Articles

Identification of 5-fluorouracil-inducible Target Genes Using cDNA Microarray Profiling

Pamela J. Maxwell, Daniel B. Longley, Tariq Latif, John Boyer, Wendy Allen, Maria Lynch, Ultan McDermott, D. Paul Harkin, Carmen J. Allegra, Patrick G. Johnston
Journal: Cancer Research
Cancer Res (2003) 63 (15): 4602–4606.
Published: 07 August 2003
View articletitled, Identification of 5-fluorouracil-inducible Target Genes Using cDNA Microarray Profiling
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Journal Articles

Epitope Mapping of a Series of Human Thymidylate Synthase Monoclonal Antibodies

Katherine A. Behan, Patrick G. Johnston, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1998) 58 (12): 2606–2611.
Published: 01 June 1998
View articletitled, Epitope Mapping of a Series of Human Thymidylate Synthase Monoclonal Antibodies
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Journal Articles

Thymidylate Synthase Gene and Protein Expression Correlate and Are Associated with Response to 5-Fluorouracil in Human Colorectal and Gastric Tumors

Patrick G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman, Kathleen D. Danenberg, Carmen J. Allegra, Peter V. Danenberg, Lawrence Leichman
Journal: Cancer Research
Cancer Res (1995) 55 (7): 1407–1412.
Published: 01 April 1995
View articletitled, Thymidylate Synthase Gene and Protein Expression Correlate and Are Associated with Response to 5-Fluorouracil in Human Colorectal and Gastric Tumors
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Journal Articles

Identification of a Protein Factor Secreted by 3T3-L1 Preadipocytes Inhibitory for the Human MCF-7 Breast Cancer Cell Line

Patrick G. Johnston, Christina M. Rondinone, Donna Voeller, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1992) 52 (24): 6860–6865.
Published: 01 December 1992
View articletitled, Identification of a Protein Factor Secreted by 3T3-L1 Preadipocytes Inhibitory for the Human MCF-7 Breast Cancer Cell Line
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Journal Articles

Immunological Quantitation of Thymidylate Synthase Using the Monoclonal Antibody TS 106 in 5-Fluorouracil-sensitive and -resistant Human Cancer Cell Lines

Patrick G. Johnston, James C. Drake, Jane Trepel, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1992) 52 (16): 4306–4312.
Published: 01 August 1992
View articletitled, Immunological Quantitation of Thymidylate Synthase Using the Monoclonal Antibody TS 106 in 5-Fluorouracil-sensitive and -resistant Human Cancer Cell Lines
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Journal Articles

Intracellular Metabolism of 5-Formyl Tetrahydrofolate in Human Breast and Colon Cell Lines

Donna M. Boarman, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1992) 52 (1): 36–44.
Published: 01 January 1992
View articletitled, Intracellular Metabolism of 5-Formyl Tetrahydrofolate in Human Breast and Colon Cell Lines
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Journal Articles

Production and Characterization of Monoclonal Antibodies That Localize Human Thymidylate Synthase in the Cytoplasm of Human Cells and Tissue

Patrick G. Johnston, Chi-Ming Liang, Sally Henry, Bruce A. Chabner, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1991) 51 (24): 6668–6676.
Published: 01 December 1991
View articletitled, Production and Characterization of Monoclonal Antibodies That Localize Human Thymidylate Synthase in the Cytoplasm of Human Cells and Tissue
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Journal Articles

Enhancement of the Toxicity and DNA Incorporation of Arabinosyl-5-azacytosine and 1-β-d-Arabinofuranosylcytosine by Cyclopentenyl Cytosine

Jean L. Grem, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1990) 50 (22): 7279–7284.
Published: 01 November 1990
View articletitled, Enhancement of the Toxicity and DNA Incorporation of Arabinosyl-5-azacytosine and 1-β-d-Arabinofuranosylcytosine by Cyclopentenyl Cytosine
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Journal Articles

Interaction of γ Interferon and 5-Fluorouracil in the H630 Human Colon Carcinoma Cell Line

Edward Chu, Sydelle Zinn, Donna Boarman, Carmen J. Allegra
Journal: Cancer Research
Cancer Res (1990) 50 (18): 5834–5840.
Published: 01 September 1990
View articletitled, Interaction of γ Interferon and 5-Fluorouracil in the H630 Human Colon Carcinoma Cell Line
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Journal Articles

Interaction of Methotrexate Polyglutamates and Dihydrofolate during Leucovorin Rescue in a Human Breast Cancer Cell Line (MCF-7)

Carmen J. Allegra, Donna Boarman
Journal: Cancer Research
Cancer Res (1990) 50 (12): 3574–3578.
Published: 01 June 1990
View articletitled, Interaction of Methotrexate Polyglutamates and Dihydrofolate during Leucovorin Rescue in a Human Breast Cancer Cell Line (MCF-7)
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