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Carlotta Costa
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Journal Articles

Abstract LT018: The perivascular niche protects ALK+ lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis

Cristina Mastini, Marco Campisi, Carlotta Costa, Chiara Ambrogio, Giulia Germena, Silvia Peola, Cinzia Martinengo, Enrico Patrucco, Ines Mota, Maddalena Arrigoni, Martina Olivero, Raffaele Calogero, Valeria Chiono, Roger D. Kamm, Emilio Hirsch, Jon C. Aster, Claudia Voena, Roberto Chiarle
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): LT018.
https://doi.org/10.1158/1538-7445.TME21-LT018
Published: 01 March 2021
View article titled, Abstract LT018: The perivascular niche protects ALK+ lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis
Journal Articles

Abstract 1903: PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ká inhibitors in breast cancer

Carlotta Costa, Ye Wang, Amy Ly, Yasuyuki Hosono, Ellen Murchie, Charlotte S. Walmsley, Tiffany Huynh, Christopher Healy, Rachel Peterson, Shogo Yanase, Charles T. Jakubik, Laura E. Henderson, Leah J. Damon, Daria Timonina, Ioannis Sanidas, Christopher J. Pinto, Mari Mino-Kenudson, James Stone, Nicholas J. Dyson, Leif W. Ellisen, Aditya Bardia, Hiromichi Ebi, Cyril H. Benes, Jeffrey A. Engelman, Dejan Juric
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1903.
https://doi.org/10.1158/1538-7445.AM2020-1903
Published: 15 August 2020
View article titled, Abstract 1903: PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ká inhibitors in breast cancer
Journal Articles

Abstract P1-19-28: Genomic screening reveals UBA1 as a potent and druggable target in diverse models of triple negative breast cancer

Sheeba Jacob, Tia H. Turner, Ann K. Yu, Colin M. Coon, Mohammad A. Alzubi, Charles T. Jakubik, Ynes Bouck, Mikhail G. Dozmorov, Sosipatros A. Boikos, Jennifer Koblinski, Joshua C. Harrell, Cyril H. Benes, Carlotta Costa, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-19-28.
https://doi.org/10.1158/1538-7445.SABCS19-P1-19-28
Published: 15 February 2020
View article titled, Abstract P1-19-28: Genomic screening reveals UBA1 as a potent and druggable target in diverse models of triple negative breast cancer
Journal Articles

Abstract 5502: Characterization of a hotspot PTEN mutation in endometrial cancer

Ye Wang, Charles Jakubik, Rachel Peterson, Cyril Benes, Wilhelm Haas, Jeffrey Engelman, Carlotta Costa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5502.
https://doi.org/10.1158/1538-7445.AM2018-5502
Published: 01 July 2018
View article titled, Abstract 5502: Characterization of a hotspot <em>PTEN</em> mutation in endometrial cancer
Journal Articles

Abstract 3026: Targeting GPX4 in tumor-associated stromal cells increases inflammatory-cell infiltration

Shrikanta Chattopadhyay, Cherrie Huang, Ninib Baryawno, Nicolas Severe, Vasanthi Viswanathan, Carlotta Costa, David Scadden, Stuart Schreiber
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3026.
https://doi.org/10.1158/1538-7445.AM2017-3026
Published: 01 July 2017
View article titled, Abstract 3026: Targeting GPX4 in tumor-associated stromal cells increases inflammatory-cell infiltration
Journal Articles

Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Gino B. Ferraro, David P. Kodack, Vasileios Askoxylakis, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Alexander Z. Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Youngchul Song, Carlotta Costa, Kamila Naxerova, Christina Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, Ryan C. Miller, Marni B. Siegel, Carey K. Anders, Melinda Sanders, Valeria M. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5008.
https://doi.org/10.1158/1538-7445.AM2017-5008
Published: 01 July 2017
View article titled, Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Journal Articles

Abstract 4648: Uncover novel drug combinations for triple negative breast cancer

Carlotta Costa, Anahita Dastur, Rachel Peterson, Damon Leah, Regina Egan, Ryan March, Cyril Benes, Jeffrey Engelman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4648.
https://doi.org/10.1158/1538-7445.AM2016-4648
Published: 15 July 2016
View article titled, Abstract 4648: Uncover novel drug combinations for triple negative breast cancer
Journal Articles

Abstract 3846: Sensitivity of NOTCH1 mutant T-ALL to ABT-263

Anahita Dastur, Carlotta Costa, Anthony Faber, Cyril Benes
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3846.
https://doi.org/10.1158/1538-7445.AM2016-3846
Published: 15 July 2016
View article titled, Abstract 3846: Sensitivity of NOTCH1 mutant T-ALL to ABT-263
Journal Articles

EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Yong Jia, Jose Juarez, Jie Li, Mari Manuia, Matthew J. Niederst, Celin Tompkins, Noelito Timple, Mei-Ting Vaillancourt, AnneMarie Culazzo Pferdekamper, Elizabeth L. Lockerman, Chun Li, Jennifer Anderson, Carlotta Costa, Debbie Liao, Eric Murphy, Michael DiDonato, Badry Bursulaya, Gerald Lelais, Jordi Barretina, Matthew McNeill, Robert Epple, Thomas H. Marsilje, Nuzhat Pathan, Jeffrey A. Engelman, Pierre-Yves Michellys, Peter McNamara, Jennifer Harris, Steven Bender, Shailaja Kasibhatla
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1591–1602.
https://doi.org/10.1158/0008-5472.CAN-15-2581
Published: 14 March 2016
View article titled, EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Open the PDF for EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor in another window
Includes: Supplementary data
Journal Articles

Abstract 2933: Assessment of ABT-263 activity across a comprehensive cancer cell line collection leads to a novel, potent combination therapy for small cell lung cancer

Anthony C. Faber, Carlotta Costa, Anahita Dastur, Cyril Benes, Jeffrey Engelman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2933.
https://doi.org/10.1158/1538-7445.AM2014-2933
Published: 01 October 2014
View article titled, Abstract 2933: Assessment of ABT-263 activity across a comprehensive cancer cell line collection leads to a novel, potent combination therapy for small cell lung cancer
Journal Articles

Abstract 2619: Meausuring PIP3 reveals the unexpected role of p110B in luminal breast cancers

Carlotta Costa, Hiromichi Ebi, Anthony C. Faber, Madhuri Nishtala, Youngchul Song, Cyril H. Benes, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2619.
https://doi.org/10.1158/1538-7445.AM2014-2619
Published: 01 October 2014
View article titled, Abstract 2619: Meausuring PIP3 reveals the unexpected role of p110B in luminal breast cancers
Journal Articles

Abstract 955: Transformation from NSCLC to SCLC in EGFR mutant lung cancers with acquired resistance to EGFR inhibitors

Matthew J. Niederst, Lecia V. Sequist, Elizabeth L. Lockerman, Angel R. Garcia, Carlotta Costa, Farhiya Mohamoud, Darrell R. Borger, Toshi Shioda, Gad Getz, Anthony J. Iafrate, Mari Mino-Kenudson, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 955.
https://doi.org/10.1158/1538-7445.AM2014-955
Published: 01 October 2014
View article titled, Abstract 955: Transformation from NSCLC to SCLC in EGFR mutant lung cancers with acquired resistance to EGFR inhibitors
Journal Articles

MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

Alexa B. Turke, Youngchul Song, Carlotta Costa, Rebecca Cook, Carlos L. Arteaga, John M. Asara, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3228–3237.
https://doi.org/10.1158/0008-5472.CAN-11-3747
Published: 01 July 2012
View article titled, MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors
Open the PDF for MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors in another window
Includes: Supplementary data
Journal Articles

The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc42 Activation

Chiara Ambrogio, Claudia Voena, Andrea D. Manazza, Cinzia Martinengo, Carlotta Costa, Tomas Kirchhausen, Emilio Hirsch, Giorgio Inghirami, Roberto Chiarle
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8899–8907.
https://doi.org/10.1158/0008-5472.CAN-08-2568
Published: 30 October 2008
View article titled, The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc42 Activation
Open the PDF for The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc42 Activation in another window
Includes: Multimedia, Supplementary data