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Carlos Caldas
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Journal Articles

Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer

Open Access
Abigail Shea, Yaniv Eyal-Lubling, Daniel Guerrero-Romero, Raquel Manzano Garcia, Wendy Greenwood, Martin O’Reilly, Dimitra Georgopoulou, Maurizio Callari, Giulia Lerda, Sophia Wix, Agnese Giovannetti, Riccardo Masina, Elham Esmaeilishirazifard, Wei Cope, Alistair G. Martin, Ai Nagano, Lisa Young, Steven Kupczak, Yi Cheng, Helen Bardwell, Elena Provenzano, Justine Kane, Jonny Lay, Louise Grybowicz, Karen McAdam, Carlos Caldas, Jean Abraham, Oscar M. Rueda, Alejandra Bruna
Journal: Cancer Research
Cancer Res (2025) 85 (3): 567–584.
https://doi.org/10.1158/0008-5472.CAN-24-1703
Published: 01 February 2025
View articletitled, Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer
Open the PDF for Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB242: Prediction of patient response to neoadjuvant chemotherapy in breast cancer from their deconvolved tumor microenvironment transcriptome

Free
Saugato Rahman Dhruba, Sahil Sahni, Binbin Wang, Di Wu, Yael Schmidt, Eldad Shulman, Sanju Sinha, Stephen-John Sammut, Carlos Caldas, Kun Wang, Eytan Ruppin
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB242.
https://doi.org/10.1158/1538-7445.AM2024-LB242
Published: 05 April 2024
View articletitled, Abstract LB242: Prediction of patient response to neoadjuvant chemotherapy in breast cancer from their deconvolved tumor microenvironment transcriptome
Journal Articles

Abstract 476: Predicting response to treatment in early breast cancer using dynamic integrative multi-omic profiling

Free
Stephen-John Sammut, Mireia Crispin-Ortuzar, Suet-Feung Chin, Elena Provenzano, Wei Cope, Ali Dariush, Sarah-Jane Dawson, Paul D. Pharoah, Florian Markowetz, Oscar M. Rueda, Helena M. Earl, Carlos Caldas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 476.
https://doi.org/10.1158/1538-7445.AM2022-476
Published: 15 June 2022
View articletitled, Abstract 476: Predicting response to treatment in early breast cancer using dynamic integrative multi-omic profiling
Journal Articles

Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification

Available to Purchase
Benedetta Pellegrino, Andrea Herencia-Ropero, Alba Llop-Guevara, Flaminia Pedretti, Alejandro Moles-Fernández, Cristina Viaplana, Guillermo Villacampa, Marta Guzmán, Olga Rodríguez, Judit Grueso, Jose Jiménez, Enrique J. Arenas, Andrea Degasperi, João M.L. Dias, Josep V. Forment, Mark J. O'Connor, Olivier Déas, Stefano Cairo, Yinghui Zhou, Antonino Musolino, Carlos Caldas, Serena Nik-Zainal, Robert B. Clarke, Paolo Nuciforo, Orland Díez, Xavier Serres-Créixams, Vicente Peg, Martín Espinosa-Bravo, Teresa Macarulla, Ana Oaknin, Joaquin Mateo, Joaquín Arribas, Rodrigo Dienstmann, Meritxell Bellet, Mafalda Oliveira, Cristina Saura, Sara Gutiérrez-Enríquez, Judith Balmaña, Violeta Serra
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1646–1657.
https://doi.org/10.1158/0008-5472.CAN-21-2409
Published: 15 April 2022
View articletitled, Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification
Open the PDF for Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification in another window
Includes: Supplementary data
Journal Articles

Abstract P3-09-18: The association between genomic alterations and body mass index in patients with early breast cancer

Free
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Karen Van Baelen, Maxim De Schepper, Sophia Leduc, Edoardo Isnaldi, Sam Aparicio, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Andrew Green, Hazem Khout, Eyfjörð Jórunn, Stian Knappskog, Savitri Krishnamurthy, Sunil Lakhani, Anita Langerod, John WM Martens, Leigh Murphy, Serena Nik-Zainal, Colin Purdie, Emad Rakha, Andrea Richardson, Anne Salomon, Peter Simpson, Christos Sotiriou, Paul Span, Benita Kiat-Tee Tan, Alastair Thompson, Stefania Tommasi, Marc Van de Vijver, Steven Van Laere, Alain Viari, Giuseppe Floris, Elia Biganzoli, François Richard, Christine Desmedt
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-18.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-18
Published: 15 February 2022
View articletitled, Abstract P3-09-18: The association between genomic alterations and body mass index in patients with early breast cancer
Journal Articles

Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients

Open Access
Ramona Woitek, Mary A. McLean, Stephan Ursprung, Oscar M. Rueda, Raquel Manzano Garcia, Matthew J. Locke, Lucian Beer, Gabrielle Baxter, Leonardo Rundo, Elena Provenzano, Joshua Kaggie, Andrew Patterson, Amy Frary, Johanna Field-Rayner, Vasiliki Papalouka, Justine Kane, Arnold J.V. Benjamin, Andrew B. Gill, Andrew N. Priest, David Y. Lewis, Roslin Russell, Ashley Grimmer, Brian White, Beth Latimer-Bowman, Ilse Patterson, Amy Schiller, Bruno Carmo, Rhys Slough, Titus Lanz, James Wason, Rolf F. Schulte, Suet-Feung Chin, Martin J. Graves, Fiona J. Gilbert, Jean E. Abraham, Carlos Caldas, Kevin M. Brindle, Evis Sala, Ferdia A. Gallagher
Journal: Cancer Research
Cancer Res (2021) 81 (23): 6004–6017.
https://doi.org/10.1158/0008-5472.CAN-21-1499
Published: 01 December 2021
View articletitled, Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients
Open the PDF for Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Abstract LB009: Dynamic changes in the compositions of cancer associated-fibroblasts correlate with clinical outcome in breast cancer

Free
Gil Friedman, Oshrat Levi-Galibov, Eyal David, Chamutal Bornstein, Amir Giladi, Maya Dadiani, Avi Mayo, Coral Halperin, Meirav Pevsner-Fischer, Hagar Lavon, Shimrit Mayer, Reinat Nevo, Yaniv Stein, Nora Balint-Lahat, Iris Barshack, H. Raza Ali, Carlos Caldas, Einav Nili Gal-Yam, Uri Alon, Ido Amit, Ruth Scherz-Shouval
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB009.
https://doi.org/10.1158/1538-7445.AM2021-LB009
Published: 01 July 2021
View articletitled, Abstract LB009: Dynamic changes in the compositions of cancer associated-fibroblasts correlate with clinical outcome in breast cancer
Journal Articles

Abstract 2817: Metabolic heterogeneity in breast cancer integrative clusters to screen metabolic vulnerabilities for diagnosis and treatment response

Free
Susana Ros, Alan J. Wright, Flaviu Bulat, Wendy Greenwood, De-en Hu, Maurizio Callari, Ming Li Chia, Violeta Serra, Oscar Rueda, Alejandra Bruna, Carlos Caldas, Kevin M. Brindle
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2817.
https://doi.org/10.1158/1538-7445.AM2021-2817
Published: 01 July 2021
View articletitled, Abstract 2817: Metabolic heterogeneity in breast cancer integrative clusters to screen metabolic vulnerabilities for diagnosis and treatment response
Journal Articles

Abstract 2174: The genomic and anti-tumor immune evolution of breast cancer

Free
Juan Blanco-Heredia, Carla Anjos Souza, Samuel Gonçalves-Ribeiro, Maria Gonzalez-Cao, Maurizio Callari, Francesc Tresserra, Rafael Rossell, Carlos Caldas, Leticia De Mattos-Arruda
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2174.
https://doi.org/10.1158/1538-7445.AM2021-2174
Published: 01 July 2021
View articletitled, Abstract 2174: The genomic and anti-tumor immune evolution of breast cancer
Journal Articles

Abstract GS4-07: Assessing prognosis after neoadjuvant therapy: A comparison between anatomic ypAJCC staging, residual cancer burden class and neo-bioscore

Free
Marieke EM van der Noordaa, Christina Yau, Sonal Shad, Marie Osdoit, Tessa G Steenbruggen, Diane de Croze, Anne-Sophie Hamy, Marick Lae, Fabien Reyal, Maria Del Monte-Millán, Miguel Martin, Sara Lopez Tarruella, I-SPY 2 TRIAL Consortium, Judy C Boughey, Matthew Goetz, Tanya Hoskin, Rebecca Gould, Vincent Valero, Gabe Sonke, Maartje van Seijen, Jelle Wesseling, John Bartlett, Stephan Edge, Mi-Ok Kim, Jean Abraham, Carlos Caldas, Helena Earl, Elena Provenzano, Stephen-John Sammut, David Cameron, Ashley Graham, Peter Hall, Lorna MacKintosh, Fang Fan, Andrew K Godwin, Kelsey Schwensen, Priyanka Sharma, Angela DeMichele, Janet Dunn, Louise Hiller, Larry Hayward, Jeremy Thomas, Kimberley Cole, Lajos Pusztai, Laura van 't Veer, Fraser Symmans, Laura Esserman
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS4-07.
https://doi.org/10.1158/1538-7445.SABCS20-GS4-07
Published: 15 February 2021
View articletitled, Abstract GS4-07: Assessing prognosis after neoadjuvant therapy: A comparison between anatomic ypAJCC staging, residual cancer burden class and neo-bioscore
Journal Articles

Abstract PD13-02: Site of recurrence after neoadjuvant therapy: A multi-center pooled analysis

Free
Sonal Shad, Marieke van der Noordaa, Marie Osdoit, Diane de Croze, Anne-Sophie Hamy, Marick Lae, Fabien Reyal, Miguel Martin, María Del Monte-Millán, Sara López-Tarruella, I-SPY 2 TRIAL Consortium, Judy C Boughey, Matthew P Goetz, Tanya Hoskin, Rebekah Gould, Vicente Valero, Gabe Sonke, Tessa G Steenbruggen, Maartje van Seijen, Jelle Wesseling, John Bartlett, Stephen Edge, Mi-Ok Kim, Jean Abraham, Carlos Caldas, Helena Earl, Elena Provenzano, Stephen-John Sammut, David Cameron, Ashley Graham, Peter Hall, Lorna Mackintosh, Fan Fang, Andrew K Godwin, Kelsey Schwensen, Priyanka Sharma, Angela DeMichele, Janet Dunn, Louise Hiller, Larry Hayward, Jeremy Thomas, Kimberly Cole, Lajos Pusztai, Laura Van't Veer, Fraser Symmans, Laura Esserman, Christina Yau
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD13-02.
https://doi.org/10.1158/1538-7445.SABCS20-PD13-02
Published: 15 February 2021
View articletitled, Abstract PD13-02: Site of recurrence after neoadjuvant therapy: A multi-center pooled analysis
Journal Articles

Abstract GS4-08: Clinical utility of repeated circulating tumor cell (CTC) enumeration as early treatment monitoring tool in metastatic breast cancer (MBC) - a global pooled analysis with individual patient data

Free
Wolfgang J Janni, Tracy C. Yab, Daniel F. Hayes, Massimo Cristofanilli, Francois-Clement Bidard, Michail Ignatiadis, Meredith M. Regan, Catherine Alix-Panabières, William E. Barlow, Carlos Caldas, Lisa A. Carey, Luc Dirix, Tanja Fehm, Jose A. Garcia-Saenz, Paola Gazzaniga, Daniele Generali, Lorenzo Gerratana, Rafael Gisbert-Criado, William Jacot, Zefei Jiang, Evi Lianidou, Mark J.M. Magbanua, Luis Manso, Dimitrios Mavroudis, Volkmar Müller, Elisabetta Munzone, Klaus Pantel, Jean-Yves Pierga, Brigitte Rack, Sabine Riethdorf, Hope S. Rugo, Kostandinos Sideras, Stefan Sleijfer, Jeffrey Smerage, Justin Stebbing, Leon W.M.M. Terstappen, José Vidal-Martínez, Rita Zamarchi, Karthik Giridhar, Thomas W.P. Friedl, Minetta C. Liu
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS4-08.
https://doi.org/10.1158/1538-7445.SABCS20-GS4-08
Published: 15 February 2021
View articletitled, Abstract GS4-08: Clinical utility of repeated circulating tumor cell (CTC) enumeration as early treatment monitoring tool in metastatic breast cancer (MBC) - a global pooled analysis with individual patient data
Journal Articles

Abstract 4077: Quantitative proteomics reveals novel immunomodulatory pathways of resistance to PARP therapy

Free
Jakob Vowinckel, Yuehan Feng, Dimitra Georgopoulou, Alejandra Bruna, Tobias Treiber, Abigail Shea, Giulia Lerda, Martin O'Reilly, Kristina Beeler, Carlos Caldas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4077.
https://doi.org/10.1158/1538-7445.AM2020-4077
Published: 15 August 2020
View articletitled, Abstract 4077: Quantitative proteomics reveals novel immunomodulatory pathways of resistance to PARP therapy
Journal Articles

Abstract P3-10-06: Combination of BET and FGFR inhibition as a rational therapeutic strategy for invasive lobular breast cancer

Free
Darran P O'Connor, Louise Walsh, Kathryn Haley, Bruce Moran, Brian Mooney, Stephen Madden, Sudipto Das, Oscar Rueda, Catriona Dowling, Damir Vareslija, Suet-Feung Chin, Sabine Linn, Leonie Young, Karin Jirstrom, John P Crown, Rene Bernards, Carlos Caldas, William M Gallagher, Triona Ni Chonghaile
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-10-06.
https://doi.org/10.1158/1538-7445.SABCS19-P3-10-06
Published: 15 February 2020
View articletitled, Abstract P3-10-06: Combination of BET and FGFR inhibition as a rational therapeutic strategy for invasive lobular breast cancer
Journal Articles

EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

Free
Guillermo Peluffo, Ashim Subedee, Nicholas W. Harper, Natalie Kingston, Bojana Jovanović, Felipe Flores, Laura E. Stevens, Francisco Beca, Anne Trinh, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Katherine Murphy, Ying Su, Andriy Marusyk, Clive S. D'Santos, Oscar M. Rueda, Andrew H. Beck, Carlos Caldas, Jason S. Carroll, Kornelia Polyak
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (16): 4173–4183.
https://doi.org/10.1158/0008-5472.CAN-18-3264
Published: 15 August 2019
View articletitled, EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis
Open the PDF for EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis in another window
Includes: Supplementary data
Journal Articles

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

Free
Jorge Gómez-Miragaya, Ander Díaz-Navarro, Raul Tonda, Sergi Beltran, Luis Palomero, Marta Palafox, Lacey E. Dobrolecki, Chen Huang, Suhas Vasaikar, Bing Zhang, Gerburg M. Wulf, Alejandro Collado-Sole, Eva M. Trinidad, Purificación Muñoz, Laia Paré, Aleix Prat, Alejandra Bruna, Carlos Caldas, Joaquín Arribas, María Teresa Soler-Monso, Anna Petit, Judith Balmaña, Cristina Cruz, Violeta Serra, Miguel Angel Pujana, Michael T. Lewis, Xose S. Puente, Eva González-Suárez
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4258–4270.
https://doi.org/10.1158/0008-5472.CAN-18-3835
Published: 15 August 2019
View articletitled, Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Open the PDF for Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

Free
Mark J. O'Connor, Cristina Cruz, Marta Castroviejo-Bermejo, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Zhongwu Lai, Josep Forment, Krishna Bulusu, Alba Llop-Guevara, Brian Dougherty, Cristina Saura, Rachel Brough, Chris J. Lord, Alejandra Bruna, Carlos Caldas, Stephen Fawell, J Carl Barrett, Susan E. Critchlow, Judith Balmaña, Elaine Cadogan, Violeta Serra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 932.
https://doi.org/10.1158/1538-7445.AM2019-932
Published: 01 July 2019
View articletitled, Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response
Journal Articles

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

Free
Violeta Serra, Cristina Cruz, Zhongwu Lai, Marta Castroviejo-Bermejo, Marta Palafox, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Filippos Michopoulos, Rachel Brough, Brian Dougherty, Elaine Cadogan, Susan Critchlow, Alejandra Bruna, J. Carl Barrett, Cristina Saura, Christopher J. Lord, Carlos Caldas, Joaquin Arribas, Judith Balmaña, Mark J. O’Connor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3503.
https://doi.org/10.1158/1538-7445.AM2019-3503
Published: 01 July 2019
View articletitled, Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer
Journal Articles

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer

Free
Orla T. Cox, Shelley J. Edmunds, Katja Simon-Keller, Bo Li, Bruce Moran, Niamh E. Buckley, Milan Bustamante-Garrido, Nollaig Healy, Ciara H. O'Flanagan, William M. Gallagher, Richard D. Kennedy, René Bernards, Carlos Caldas, Suet-Feung Chin, Alexander Marx, Rosemary O'Connor
Journal: Cancer Research
Cancer Res (2019) 79 (10): 2619–2633.
https://doi.org/10.1158/0008-5472.CAN-18-2787
Published: 15 May 2019
View articletitled, PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer
Open the PDF for PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis

Free
Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino, Letizia Lanzetti
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (13): 3432–3444.
https://doi.org/10.1158/0008-5472.CAN-17-3018
Published: 01 July 2018
View articletitled, High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Open the PDF for High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis in another window
Includes: Supplementary data