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Carl-Henrik Heldin
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Journal Articles

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

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Yanyu Zhang, Jessica Cedervall, Anahita Hamidi, Melanie Herre, Kati Viitaniemi, Gabriela D'Amico, Zuoxiu Miao, Ragaseema Valsala Madhavan Unnithan, Alessandra Vaccaro, Luuk van Hooren, Maria Georganaki, Åsa Thulin, Qi Qiao, Johanna Andrae, Agneta Siegbahn, Carl-Henrik Heldin, Kari Alitalo, Christer Betsholtz, Anna Dimberg, Anna-Karin Olsson
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3345–3358.
https://doi.org/10.1158/0008-5472.CAN-19-3533
Published: 14 August 2020
View articletitled, Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
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Includes: Supplementary data
Journal Articles

Abstract 1982: TGF-beta induced SIK cooperates with Smurf2 to negatively regulate type I receptor kinase signaling

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Michael Vanlandewijck, Peter Lönn, Marcin Kowanetz, Katarzyna Kowanetz, Christer Bush, Carl-Henrik Heldin, Aristidis Moustakas
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1982.
https://doi.org/10.1158/1538-7445.AM2011-1982
Published: 15 April 2011
View articletitled, Abstract 1982: TGF-beta induced SIK cooperates with Smurf2 to negatively regulate type I receptor kinase signaling
Journal Articles

Mechanisms for induction of hyaluronan synthesis and CD44 expression in human skin fibroblasts by PDGF-BB

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Lingli Li, Yuejuan Li, Trias Asteriou, Carl Henrik Heldin, Paraskevi Heldin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1064.
Published: 01 May 2005
View articletitled, Mechanisms for induction of hyaluronan synthesis and CD44 expression in human skin fibroblasts by PDGF-BB
Journal Articles

Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate

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Masao Furuhashi, Tobias Sjöblom, Alexandra Abramsson, Jens Ellingsen, Patrick Micke, Hong Li, Erika Bergsten-Folestad, Ulf Eriksson, Rainer Heuchel, Christer Betsholtz, Carl-Henrik Heldin, Arne Östman
Journal: Cancer Research
Cancer Res (2004) 64 (8): 2725–2733.
https://doi.org/10.1158/0008-5472.CAN-03-1489
Published: 15 April 2004
View articletitled, Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate
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Journal Articles

Inhibition of PDGF Receptor Signaling in Tumor Stroma Enhances Antitumor Effect of Chemotherapy

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Kristian Pietras, Kristofer Rubin, Tobias Sjöblom, Elisabeth Buchdunger, Mats Sjöquist, Carl-Henrik Heldin, Arne Östman
Journal: Cancer Research
Cancer Res (2002) 62 (19): 5476–5484.
Published: 01 October 2002
View articletitled, Inhibition of PDGF Receptor Signaling in Tumor Stroma Enhances Antitumor Effect of Chemotherapy
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Journal Articles

Growth Inhibition of Dermatofibrosarcoma Protuberans Tumors by the Platelet-derived Growth Factor Receptor Antagonist STI571 through Induction of Apoptosis

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Tobias Sjöblom, Akira Shimizu, Kevin P. O’Brien, Kristian Pietras, Paola Dal Cin, Elisabeth Buchdunger, Jan P. Dumanski, Arne Östman, Carl-Henrik Heldin
Journal: Cancer Research
Cancer Res (2001) 61 (15): 5778–5783.
Published: 01 August 2001
View articletitled, Growth Inhibition of Dermatofibrosarcoma Protuberans Tumors by the Platelet-derived Growth Factor Receptor Antagonist STI571 through Induction of Apoptosis
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Journal Articles

Inhibition of Platelet-derived Growth Factor Receptors Reduces Interstitial Hypertension and Increases Transcapillary Transport in Tumors

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Kristian Pietras, Arne Östman, Mats Sjöquist, Elisabeth Buchdunger, Rolf K. Reed, Carl-Henrik Heldin, Kristofer Rubin
Journal: Cancer Research
Cancer Res (2001) 61 (7): 2929–2934.
Published: 01 April 2001
View articletitled, Inhibition of Platelet-derived Growth Factor Receptors Reduces Interstitial Hypertension and Increases Transcapillary Transport in Tumors
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Journal Articles

The Dermatofibrosarcoma Protuberans-associated Collagen Type Iα1/Platelet-derived Growth Factor (PDGF) B-Chain Fusion Gene Generates a Transforming Protein That Is Processed to Functional PDGF-BB

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Akira Shimizu, Kevin P. O’Brien, Tobias Sjöblom, Kristian Pietras, Elisabeth Buchdunger, V. Peter Collins, Carl-Henrik Heldin, Jan P. Dumanski, Arne Östman
Journal: Cancer Research
Cancer Res (1999) 59 (15): 3719–3723.
Published: 01 August 1999
View articletitled, The Dermatofibrosarcoma Protuberans-associated Collagen Type Iα1/Platelet-derived Growth Factor (PDGF) B-Chain Fusion Gene Generates a Transforming Protein That Is Processed to Functional PDGF-BB
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Journal Articles

Increased Smad Expression and Activation Are Associated with Apoptosis in Normal and Malignant Prostate after Castration

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Greger Brodin, Peter ten Dijke, Keiko Funa, Carl-Henrik Heldin, Maréne Landström
Journal: Cancer Research
Cancer Res (1999) 59 (11): 2731–2738.
Published: 01 June 1999
View articletitled, Increased Smad Expression and Activation Are Associated with Apoptosis in Normal and Malignant Prostate after Castration
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Journal Articles

Association of Loss of Heterozygosity on Chromosome 17p with High Platelet-derived Growth Factor α Receptor Expression in Human Malignant Gliomas

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Monica Hermanson, Keiko Funa, Jens Koopmann, David Maintz, Andreas Waha, Bengt Westermark, Carl-Henrik Heldin, Otmar D. Wiestler, David N. Louis, Andreas von Deimling, Monica Nistér
Journal: Cancer Research
Cancer Res (1996) 56 (1): 164–171.
Published: 01 January 1996
View articletitled, Association of Loss of Heterozygosity on Chromosome 17p with High Platelet-derived Growth Factor α Receptor Expression in Human Malignant Gliomas
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Journal Articles

Selective Platelet-derived Growth Factor Receptor Kinase Blockers Reverse sis-Transformation

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Marina Kovalenko, Aviv Gazit, Annette Böhmer, Charlotte Rorsman, Lars Rönnstrand, Carl-Henrik Heldin, Johannes Waltenberger, Frank-D. Böhmer, Alexander Levitzki
Journal: Cancer Research
Cancer Res (1994) 54 (23): 6106–6114.
Published: 01 December 1994
View articletitled, Selective Platelet-derived Growth Factor Receptor Kinase Blockers Reverse sis-Transformation
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Journal Articles

Platelet-derived Growth Factor and Its Receptors in Human Glioma Tissue: Expression of Messenger RNA and Protein Suggests the Presence of Autocrine and Paracrine Loops

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Monica Hermanson, Keiko Funa, Magdalena Hartman, Lena Claesson-Welsh, Carl-Henrik Heldin, Bengt Westermark, Monica Nistér
Journal: Cancer Research
Cancer Res (1992) 52 (11): 3213–3219.
Published: 01 June 1992
View articletitled, Platelet-derived Growth Factor and Its Receptors in Human Glioma Tissue: Expression of Messenger RNA and Protein Suggests the Presence of Autocrine and Paracrine Loops
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Journal Articles

Expression of Platelet-derived Growth Factor and Its Receptors in Neuroendocrine Tumors of the Digestive System

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Arvind Chaudhry, Vasilis Papanicolaou, Kjell Öberg, Carl-Henrik Heldin, Keiko Funa
Journal: Cancer Research
Cancer Res (1992) 52 (4): 1006–1012.
Published: 01 February 1992
View articletitled, Expression of Platelet-derived Growth Factor and Its Receptors in Neuroendocrine Tumors of the Digestive System
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Journal Articles

Platelet-derived Growth Factor in Autocrine Transformation

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Bengt Westermark, Carl-Henrik Heldin
Journal: Cancer Research
Cancer Res (1991) 51 (19): 5087–5092.
Published: 01 October 1991
View articletitled, Platelet-derived Growth Factor in Autocrine Transformation
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Journal Articles

Expression of Platelet-derived Growth Factor β-Receptors on Stromal Tissue Cells in Human Carcinoid Tumors

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Keiko Funa, Vasilis Papanicolaou, Claes Juhlin, Jonas Rastad, Göran Åkerström, Carl-Henrik Heldin, Kjell Öberg
Journal: Cancer Research
Cancer Res (1990) 50 (3): 748–753.
Published: 01 February 1990
View articletitled, Expression of Platelet-derived Growth Factor β-Receptors on Stromal Tissue Cells in Human Carcinoid Tumors
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Journal Articles

Frequent Expression of Growth Factors for Mesenchymal Cells in Human Mammary Carcinoma Cell Lines

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Rolando Peres, Christer Betsholtz, Bengt Westermark, Carl-Henrik Heldin
Journal: Cancer Research
Cancer Res (1987) 47 (13): 3425–3429.
Published: 01 July 1987
View articletitled, Frequent Expression of Growth Factors for Mesenchymal Cells in Human Mammary Carcinoma Cell Lines
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Journal Articles

Clonal Variation in the Production of a Platelet-derived Growth Factor-like Protein and Expression of Corresponding Receptors in a Human Malignant Glioma

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Monica Nistér, Carl-Henrik Heldin, Bengt Westermark
Journal: Cancer Research
Cancer Res (1986) 46 (1): 332–340.
Published: 01 January 1986
View articletitled, Clonal Variation in the Production of a Platelet-derived Growth Factor-like Protein and Expression of Corresponding Receptors in a Human Malignant Glioma
Open the PDF for Clonal Variation in the Production of a Platelet-derived Growth Factor-like Protein and Expression of Corresponding Receptors in a Human Malignant Glioma in another window