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Cameron J. Koch
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Journal Articles

Abstract 1037: Agents that target the PI3K/mTOR pathway decrease oxygen consumption, reduce tumor hypoxia and improve radiation response in solid tumors.

George J. Cerniglia, Natalie Daurio, Shannon M. Gallagher-Colombo, Theresa M. Busch, Stephen W. Tuttle, Cameron J. Koch, Alexander Lin, Constantinos Koumenis, Amit Maity
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1037.
https://doi.org/10.1158/1538-7445.AM2013-1037
Published: 15 April 2013
View article titled, Abstract 1037: Agents that target the PI3K/mTOR pathway decrease oxygen consumption, reduce tumor hypoxia and improve radiation response in solid tumors.
Journal Articles

Abstract SY34-04: Do we need to know what pO2 hypoxia is

Cameron J. Koch
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): SY34-04.
https://doi.org/10.1158/1538-7445.AM10-SY34-04
Published: 15 April 2010
View article titled, Abstract SY34-04: Do we need to know what pO<sub>2</sub> hypoxia is
Journal Articles

Abstract 2272: Comparison of bioreductive metabolism of tirapazamine, its second generation analogue SN 30000 and hypoxia imaging agent EF5 in human tumor cell lines

Jingli Wang, Rita Patel, Dianne Ferry, Michael P. Hay, Cameron J. Koch, William R. Wilson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2272.
https://doi.org/10.1158/1538-7445.AM10-2272
Published: 15 April 2010
View article titled, Abstract 2272: Comparison of bioreductive metabolism of tirapazamine, its second generation analogue SN 30000 and hypoxia imaging agent EF5 in human tumor cell lines
Journal Articles

Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling

Naseer Qayum, Ruth J. Muschel, Jae Hong Im, Lukxmi Balathasan, Cameron J. Koch, Sonal Patel, W. Gillies McKenna, Eric J. Bernhard
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6347–6354.
https://doi.org/10.1158/0008-5472.CAN-09-0657
Published: 29 July 2009
View article titled, Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling
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Includes: Supplementary data
Journal Articles

Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy

Nabendu Pore, Anjali K. Gupta, George J. Cerniglia, Zibin Jiang, Eric J. Bernhard, Sydney M. Evans, Cameron J. Koch, Stephen M. Hahn, Amit Maity
Journal: Cancer Research
Cancer Res (2006) 66 (18): 9252–9259.
https://doi.org/10.1158/0008-5472.CAN-06-1239
Published: 18 September 2006
View article titled, Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy
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Includes: Supplementary data
Journal Articles

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

Bennett Kaufman, Orit Scharf, Jeffrey Arbeit, Margaret Ashcroft, J. Martin Brown, Richard K. Bruick, J. Donald Chapman, Sydney M. Evans, Amato J. Giaccia, Adrian L. Harris, Eric Huang, Randall Johnson, William Kaelin, Jr., Cameron J. Koch, Patrick Maxwell, James Mitchell, Len Neckers, Garth Powis, Joseph Rajendran, Gregg L. Semenza, Jonathan Simons, Erik Storkebaum, Michael J. Welch, Murray Whitelaw, Giovanni Melillo, S. Percy Ivy
Journal: Cancer Research
Cancer Res (2004) 64 (9): 3350–3356.
https://doi.org/10.1158/0008-5472.CAN-03-2611
Published: 03 May 2004
View article titled, Proceedings of the Oxygen Homeostasis/Hypoxia Meeting
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Journal Articles

Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast cancer cells

Geza Acs, Mei Chen, Xiaowei Xu, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1145.
Published: 01 April 2004
View article titled, Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast cancer cells
Journal Articles

Microenvironmental factors affecting cell growth in human brain tumors.

Kevin W. Jenkins, W. Timothy Jenkins, Sydney M. Evans, Kevin D. Judy, Isolde Dunphy, Stephen M. Hahn, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 828.
Published: 01 April 2004
View article titled, Microenvironmental factors affecting cell growth in human brain tumors.
Journal Articles

Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding

Sydney M. Evans, Kevin D. Judy, Isolde Dunphy, W. Timothy Jenkins, Peter T. Nelson, Ruth Collins, E. Paul Wileyto, Kevin Jenkins, Stephen M. Hahn, Craig W. Stevens, Alexander R. Judkins, Peter Phillips, Birgit Geoerger, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2004) 64 (5): 1886–1892.
https://doi.org/10.1158/0008-5472.CAN-03-2424
Published: 02 March 2004
View article titled, Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding
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Journal Articles

Photodynamic Therapy Creates Fluence Rate-dependent Gradients in the Intratumoral Spatial Distribution of Oxygen

Theresa M. Busch, E. Paul Wileyto, Micheal J. Emanuele, Fabio Del Piero, Laura Marconato, Eli Glatstein, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2002) 62 (24): 7273–7279.
Published: 15 December 2002
View article titled, Photodynamic Therapy Creates Fluence Rate-dependent Gradients in the Intratumoral Spatial Distribution of Oxygen
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Journal Articles

Radiosensitization of Hypoxic Tumor Cells by Dodecafluoropentane: A Gas-Phase Perfluorochemical Emulsion

Cameron J. Koch, Patricia R. Oprysko, A. Lee Shuman, W. Timothy Jenkins, Gordon Brandt, Sydney M. Evans
Journal: Cancer Research
Cancer Res (2002) 62 (13): 3626–3629.
Published: 01 July 2002
View article titled, Radiosensitization of Hypoxic Tumor Cells by Dodecafluoropentane: <subtitle>A Gas-Phase Perfluorochemical Emulsion</subtitle>
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Journal Articles

The Farnesyltransferase Inhibitor L744,832 Reduces Hypoxia in Tumors Expressing Activated H-ras

Elizabeth Cohen-Jonathan, Sydney M. Evans, Cameron J. Koch, Ruth J. Muschel, W. Gillies McKenna, JunMin Wu, Eric J. Bernhard
Journal: Cancer Research
Cancer Res (2001) 61 (5): 2289–2293.
Published: 01 March 2001
View article titled, The Farnesyltransferase Inhibitor L744,832 Reduces Hypoxia in Tumors Expressing Activated H-<em>ras</em>
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Journal Articles

Depletion of Tumor Oxygenation during Photodynamic Therapy: Detection by the Hypoxia Marker EF3 [2-(2-Nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide]

Theresa M. Busch, Stephen M. Hahn, Sydney M. Evans, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2000) 60 (10): 2636–2642.
Published: 15 May 2000
View article titled, Depletion of Tumor Oxygenation during Photodynamic Therapy: Detection by the Hypoxia Marker EF3 [2-(2-Nitroimidazol-1[<em>H</em>]-yl)-<em>N</em>-(3,3,3-trifluoropropyl)acetamide]
Open the PDF for Depletion of Tumor Oxygenation during Photodynamic Therapy: Detection by the Hypoxia Marker EF3 [2-(2-Nitroimidazol-1[<em>H</em>]-yl)-<em>N</em>-(3,3,3-trifluoropropyl)acetamide] in another window
Journal Articles

Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding

Sydney M. Evans, Stephen Hahn, Deirdre R. Pook, W. Timothy Jenkins, Ara A. Chalian, Paul Zhang, Craig Stevens, Randall Weber, Gregory Weinstein, Ivor Benjamin, Natasha Mirza, Mark Morgan, Steven Rubin, W. Gillies McKenna, Edith M. Lord, Cameron J. Koch
Journal: Cancer Research
Cancer Res (2000) 60 (7): 2018–2024.
Published: 01 April 2000
View article titled, Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding
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Journal Articles

Hypoxia-mediated Apoptosis from Angiogenesis Inhibition Underlies Tumor Control by Recombinant Interleukin 12

Michael S. Gee, Cameron J. Koch, Sydney M. Evans, W. Timothy Jenkins, Charles H. Pletcher, Jr., Jonni S. Moore, Holly K. Koblish, Jungeun Lee, Edith M. Lord, Giorgio Trinchieri, William M. F. Lee
Journal: Cancer Research
Cancer Res (1999) 59 (19): 4882–4889.
Published: 01 October 1999
View article titled, Hypoxia-mediated Apoptosis from Angiogenesis Inhibition Underlies Tumor Control by Recombinant Interleukin 12
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Journal Articles

Interleukin 2 Expression by Tumor Cells Alters Both the Immune Response and the Tumor Microenvironment

Jungeun Lee, Bruce M. Fenton, Cameron J. Koch, John G. Frelinger, Edith M. Lord
Journal: Cancer Research
Cancer Res (1998) 58 (7): 1478–1485.
Published: 01 April 1998
View article titled, Interleukin 2 Expression by Tumor Cells Alters Both the Immune Response and the Tumor Microenvironment
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Journal Articles

Tamoxifen Induces Hypoxia in MCF-7 Xenografts

Sydney M. Evans, Cameron J. Koch, Kristine M. Laughlin, W. Timothy Jenkins, Thomas Van Winkle, David F. Wilson
Journal: Cancer Research
Cancer Res (1997) 57 (22): 5155–5161.
Published: 01 November 1997
View article titled, Tamoxifen Induces Hypoxia in MCF-7 Xenografts
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Journal Articles

2-Nitroimidazole (EF5) Binding Predicts Radiation Resistance in Individual 9L s.c. Tumors

Sydney M. Evans, W. Timothy Jenkins, Barbara Joiner, Edith M. Lord, Cameron J. Koch
Journal: Cancer Research
Cancer Res (1996) 56 (2): 405–411.
Published: 01 January 1996
View article titled, 2-Nitroimidazole (EF5) Binding Predicts Radiation Resistance in Individual 9L s.c. Tumors
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Journal Articles

Mapping of the Vascular Endothelial Growth Factor-producing Hypoxic Cells in Multicellular Tumor Spheroids Using a Hypoxia-specific Marker

Nahid S. Waleh, Michael D. Brody, Merrill A. Knapp, Holly L. Mendonca, Edith M. Lord, Cameron J. Koch, Keith R. Laderoute, Robert M. Sutherland
Journal: Cancer Research
Cancer Res (1995) 55 (24): 6222–6226.
Published: 01 December 1995
View article titled, Mapping of the Vascular Endothelial Growth Factor-producing Hypoxic Cells in Multicellular Tumor Spheroids Using a Hypoxia-specific Marker
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Journal Articles

Induction of Apoptosis at Different Oxygen Tensions: Evidence That Oxygen Radicals Do Not Mediate Apoptotic Signaling

Ruth J. Muschel, Eric J. Bernhard, Luis Garza, W. Gillies McKenna, Cameron J. Koch
Journal: Cancer Research
Cancer Res (1995) 55 (5): 995–998.
Published: 01 March 1995
View article titled, Induction of Apoptosis at Different Oxygen Tensions: Evidence That Oxygen Radicals Do Not Mediate Apoptotic Signaling
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