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Journal Articles

Abstract 2933: Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

Colin J. Henderson, Nico Scheer, Yury Kapelyukh, Aileen McLaren, Kenneth MacLeod, Anja Rode, De Lin, C Roland Wolf

Cancer Res (2019) 79 (13_Supplement): 2933.

https://doi.org/10.1158/1538-7445.AM2019-2933

Published: 01 July 2019

View article titled, Abstract 2933: Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

Journal Articles

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer

John P. Thomson, Raffaele Ottaviano, Elif B. Unterberger, Harri Lempiäinen, Arne Muller, Remi Terranova, Robert S. Illingworth, Shaun Webb, Alastair R.W. Kerr, Marcus J. Lyall, Amanda J. Drake, C. Roland Wolf, Jonathan G. Moggs, Michael Schwarz, Richard R. Meehan

Cancer Res (2016) 76 (10): 3097–3108.

https://doi.org/10.1158/0008-5472.CAN-15-1910

Published: 12 May 2016

View article titled, Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer

Includes: Supplementary data

Journal Articles

Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models

A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson, C. Roland Wolf

Cancer Res (2015) 75 (21): 4573–4581.

https://doi.org/10.1158/0008-5472.CAN-15-1454

Published: 01 November 2015

View article titled, Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models

Includes: Supplementary data

Journal Articles

In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

Colin J. Henderson, Aileen W. McLaren, C. Roland Wolf

Cancer Res (2014) 74 (16): 4378–4387.

https://doi.org/10.1158/0008-5472.CAN-14-0792

Published: 13 August 2014

View article titled, In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

Includes: Supplementary data

Journal Articles

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Colin J. Henderson, Kenneth J. Ritchie, Aileen McLaren, Probir Chakravarty, C. Roland Wolf

Cancer Res (2011) 71 (22): 7048–7060.

https://doi.org/10.1158/0008-5472.CAN-11-0882

Published: 13 November 2011

View article titled, Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Includes: Supplementary data

Journal Articles

Abstract 3566: Anti-tumor activity of CXR1002, a novel anti-cancer compound that induces ER stress: Human tumor xenograft efficacy and in vitro mode of action

Anna L. Barnett, Shaohong Ding, Carol Murray, Dongtao N. Lee, Simon Plummer, TR Jeffry Evans, Iain MacPherson, Donald Bissett, Clifford R. Elcombe, C Roland Wolf

Cancer Res (2010) 70 (8_Supplement): 3566.

https://doi.org/10.1158/1538-7445.AM10-3566

Published: 15 April 2010

View article titled, Abstract 3566: Anti-tumor activity of CXR1002, a novel anti-cancer compound that induces ER stress: Human tumor xenograft efficacy and in vitro mode of action

Journal Articles

Abstract #433: Novel mutations in the K-Ras oncogene: implications for personalised medicine in the treatment of colorectal cancer

Rebecca Bounds, Helga Wolf, Simone Weidlich, Norman Pratt, Francis Carey, Robert Steele, Gillian Smith, C. Roland Wolf

Cancer Res (2009) 69 (9_Supplement): 433.

Published: 01 May 2009

View article titled, Abstract #433: Novel mutations in the K-Ras oncogene: implications for personalised medicine in the treatment of colorectal cancer

Journal Articles

Glutathione Transferase π Plays a Critical Role in the Development of Lung Carcinogenesis following Exposure to Tobacco-Related Carcinogens and Urethane

Kenneth J. Ritchie, Colin J. Henderson, Xiu Jun Wang, Olga Vassieva, Dianne Carrie, Peter B. Farmer, Margaret Gaskell, Kevin Park, C. Roland Wolf

Cancer Res (2007) 67 (19): 9248–9257.

https://doi.org/10.1158/0008-5472.CAN-07-1764

Published: 01 October 2007

View article titled, Glutathione Transferase π Plays a Critical Role in the Development of Lung Carcinogenesis following Exposure to Tobacco-Related Carcinogens and Urethane

Journal Articles

Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

Xiu Jun Wang, John D. Hayes, C. Roland Wolf

Cancer Res (2006) 66 (22): 10983–10994.

https://doi.org/10.1158/0008-5472.CAN-06-2298

Published: 15 November 2006

View article titled, Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

Includes: Supplementary data

Journal Articles

Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

Georgia J. Pass, Dianne Carrie, Michael Boylan, Sally Lorimore, Eric Wright, Brian Houston, Colin J. Henderson, C. Roland Wolf

Cancer Res (2005) 65 (10): 4211–4217.

https://doi.org/10.1158/0008-5472.CAN-04-4103

Published: 16 May 2005

View article titled, Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

Journal Articles

Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Volker M. Arlt, Marie Stiborova, Colin J. Henderson, Martin R. Osborne, Christian A. Bieler, Eva Frei, Vaclav Martinek, Bruno Sopko, C. Roland Wolf, Heinz H. Schmeiser, David H. Phillips

Cancer Res (2005) 65 (7): 2644–2652.

https://doi.org/10.1158/0008-5472.CAN-04-3544

Published: 01 April 2005

View article titled, Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Includes: Supplementary data

Journal Articles

Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines

Ruth L. Stephen, Mattias C. U. Gustafsson, Morag Jarvis, Roger Tatoud, Barry R. Marshall, Deborah Knight, Ewa Ehrenborg, Adrian L. Harris, C. Roland Wolf, Colin N. A. Palmer

Cancer Res (2004) 64 (9): 3162–3170.

https://doi.org/10.1158/0008-5472.CAN-03-2760

Published: 03 May 2004

View article titled, Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines

Journal Articles

Mutations of APC, K-ras, and p53 Are Associated with Specific Chromosomal Aberrations in Colorectal Adenocarcinomas

Amy Leslie, Norman R. Pratt, Karen Gillespie, Mark Sales, Neil M. Kernohan, Gillian Smith, C. Roland Wolf, Francis A. Carey, Robert J. C. Steele

Cancer Res (2003) 63 (15): 4656–4661.

Published: 07 August 2003

View article titled, Mutations of APC, K-ras, and p53 Are Associated with Specific Chromosomal Aberrations in Colorectal Adenocarcinomas

Journal Articles

The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

Michael McMahon, Ken Itoh, Masayuki Yamamoto, Simon A. Chanas, Colin J. Henderson, Lesley I. McLellan, C. Roland Wolf, Christophe Cavin, John D. Hayes

Cancer Res (2001) 61 (8): 3299–3307.

Published: 15 April 2001

View article titled, The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

Journal Articles

Nitric Oxide Synthases Catalyze the Activation of Redox Cycling and Bioreductive Anticancer Agents

Andrew P. Garner, Mark J. I. Paine, Ignacio Rodriguez-Crespo, Edwin C. Chinje, Paul Ortiz De Montellano, Ian J. Stratford, David G. Tew, C. Roland Wolf

Cancer Res (1999) 59 (8): 1929–1934.

Published: 15 April 1999

View article titled, Nitric Oxide Synthases Catalyze the Activation of Redox Cycling and Bioreductive Anticancer Agents

Journal Articles

Role of Cytochrome P-450 from the Human CYP3A Gene Family in the Potentiation of Morpholino Doxorubicin by Human Liver Microsomes

Alexander D. Lewis, Derick H. M. Lau, George E. Durán, C. Roland Wolf, Branimir I. Sikic

Cancer Res (1992) 52 (16): 4379–4384.

Published: 01 August 1992

View article titled, Role of Cytochrome P-450 from the Human CYP3A Gene Family in the Potentiation of Morpholino Doxorubicin by Human Liver Microsomes

Journal Articles

Activation of Mitomycin C by NADPH:Cytochrome P-450 Reductase

H. Frances J. Bligh, Agnieszka Bartoszek, Craig N. Robson, Ian D. Hickson, Charles B. Kasper, Jean D. Beggs, C. Roland Wolf

Cancer Res (1990) 50 (24): 7789–7792.

Published: 01 December 1990

View article titled, Activation of Mitomycin C by NADPH:Cytochrome P-450 Reductase

Journal Articles

Reduced Levels of Drug-induced DNA Cross-Linking in Nitrogen Mustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity

Craig N. Robson, Alex D. Lewis, C. Roland Wolf, John D. Hayes, Andrew Hall, Stephen J. Proctor, Adrian L. Harris, Ian D. Hickson

Cancer Res (1987) 47 (22): 6022–6027.

Published: 01 November 1987

View article titled, Reduced Levels of Drug-induced DNA Cross-Linking in Nitrogen Mustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity

Journal Articles

Metabolic Basis for the Protective Effect of the Antioxidant Ethoxyquin on Aflatoxin B₁ Hepatocarcinogenesis in the Rat

H. George Mandel, Margaret M. Manson, David J. Judah, Janet L. Simpson, Jonathan A. Green, Lesley M. Forrester, C. Roland Wolf, Gordon E. Neal

Cancer Res (1987) 47 (19): 5218–5223.

Published: 01 October 1987

View article titled, Metabolic Basis for the Protective Effect of the Antioxidant Ethoxyquin on Aflatoxin B1 Hepatocarcinogenesis in the Rat

Journal Articles

Development of Cytochrome P-450-altered Preneoplastic and Neoplastic Lesions during Nitrosamine-induced Hepatocarcinogenesis in the Rat

Albrecht Buchmann, Michael Schwarz, Rolf Schmitt, C. Roland Wolf, Franz Oesch, Werner Kunz

Cancer Res (1987) 47 (11): 2911–2918.

Published: 01 June 1987

View article titled, Development of Cytochrome P-450-altered Preneoplastic and Neoplastic Lesions during Nitrosamine-induced Hepatocarcinogenesis in the Rat

NARROW

Abstract 2933: Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer

Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models

In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Abstract 3566: Anti-tumor activity of CXR1002, a novel anti-cancer compound that induces ER stress: Human tumor xenograft efficacy and in vitro mode of action

Abstract #433: Novel mutations in the K-Ras oncogene: implications for personalised medicine in the treatment of colorectal cancer

Glutathione Transferase π Plays a Critical Role in the Development of Lung Carcinogenesis following Exposure to Tobacco-Related Carcinogens and Urethane

Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines

Mutations of APC, K-ras, and p53 Are Associated with Specific Chromosomal Aberrations in Colorectal Adenocarcinomas

The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

Nitric Oxide Synthases Catalyze the Activation of Redox Cycling and Bioreductive Anticancer Agents

Role of Cytochrome P-450 from the Human CYP3A Gene Family in the Potentiation of Morpholino Doxorubicin by Human Liver Microsomes

Activation of Mitomycin C by NADPH:Cytochrome P-450 Reductase

Reduced Levels of Drug-induced DNA Cross-Linking in Nitrogen Mustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity

Metabolic Basis for the Protective Effect of the Antioxidant Ethoxyquin on Aflatoxin B₁ Hepatocarcinogenesis in the Rat

Development of Cytochrome P-450-altered Preneoplastic and Neoplastic Lesions during Nitrosamine-induced Hepatocarcinogenesis in the Rat

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