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Journal Articles

Abstract 2548: The central nervous system immune cell interactome is a function of cancer lineage, tumor microenvironment and STAT3 expression

Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel Verhaak, Anand Shakar, Santhoshi Krishnan, Frederick S. Varn, Victor A. Arietta, Pravesh Gupta, Sherise D. Ferguson, Jason Huse, Gregory N. Fuller, James Long, Dan Winskowski, Ben Freiberg, C. David James, Leonidas C. Platanias, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2548.
https://doi.org/10.1158/1538-7445.AM2022-2548
Published: 15 June 2022
View article titled, Abstract 2548: The central nervous system immune cell interactome is a function of cancer lineage, tumor microenvironment and STAT3 expression
Journal Articles

Abstract PR011: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM

Atique U. Ahmed, Jack M. Shireman, Fatemeh Atash, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol H. Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S. Lesniak, C. David James, Roger Stupp, Priya Kumthekar, Craig M. Horbinski, Issam Ben-Sahra
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): PR011.
https://doi.org/10.1158/1538-7445.EVODYN22-PR011
Published: 15 May 2022
View article titled, Abstract PR011: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM
Journal Articles

Abstract B034: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM

Atique U. Ahmed, Jack M. Shireman, Fatemeh Atash, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol H. Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S. Lesniak, C. David James, Roger Stupp, Priya Kumthekar, Craig M. Horbinski, Issam Ben-Sahra
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B034.
https://doi.org/10.1158/1538-7445.EVODYN22-B034
Published: 15 May 2022
View article titled, Abstract B034: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM
Journal Articles

SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes

Xiao Song, Xuechao Wan, Tianzhi Huang, Chang Zeng, Namratha Sastry, Bingli Wu, C. David James, Craig Horbinski, Ichiro Nakano, Wei Zhang, Bo Hu, Shi-Yuan Cheng
Journal: Cancer Research
Cancer Res (2019) 79 (20): 5288–5301.
https://doi.org/10.1158/0008-5472.CAN-19-1504
Published: 15 October 2019
View article titled, SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
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Includes: Supplementary data
Journal Articles

Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas

Robert F. Koncar, Brittany R. Dey, Ann-Catherine J. Stanton, Nishant Agrawal, Michelle L. Wassell, Lauren H. McCarl, Abigail. L. Locke, Lauren Sanders, Olena Morozova-Vaske, Max I. Myers, Ronald L. Hamilton, Angel M. Carcaboso, Gary Kohanbash, Baoli Hu, Nduka M. Amankulor, James Felker, Madhuri Kambhampati, Javad Nazarian, Oren J. Becher, C. David James, Rintaro Hashizume, Alberto Broniscer, Ian F. Pollack, Sameer Agnihotri
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4026–4041.
https://doi.org/10.1158/0008-5472.CAN-18-3521
Published: 15 August 2019
View article titled, Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas
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Journal Articles

Abstract 5443: Methylation-dependent suppression of Tissue Factor is a key contributor to the less aggressive phenotype in IDH1 mutant versus IDH1 wild-type gliomas

Dusten J. Unruh, Snezana Mirkov, Seamus Caragher, Jann Sarkaria, Atique Ahmed, C. David James, Craig Horbinski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5443.
https://doi.org/10.1158/1538-7445.AM2018-5443
Published: 01 July 2018
View article titled, Abstract 5443: Methylation-dependent suppression of Tissue Factor is a key contributor to the less aggressive phenotype in IDH1 mutant versus IDH1 wild-type gliomas
Journal Articles

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

Robin G. Lerner, Stefan Grossauer, Banafsheh Kadkhodaei, Ian Meyers, Maxim Sidorov, Katharina Koeck, Rintaro Hashizume, Tomoko Ozawa, Joanna J. Phillips, Mitchel S. Berger, Theodore Nicolaides, C. David James, Claudia K. Petritsch
Journal: Cancer Research
Cancer Res (2015) 75 (24): 5355–5366.
https://doi.org/10.1158/0008-5472.CAN-14-3689
Published: 14 December 2015
View article titled, Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells
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Includes: Supplementary data
Journal Articles

Abstract B44: Therapeutic response of primary glioblastoma cancer stem cells relative to patient-matched non-stem tumor cells

Shaun D. Fouse, Raman P. Nagarajan, Jean Nakamura, C. David James, Susan Chang, Joseph F. Costello
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): B44.
https://doi.org/10.1158/1538-7445.FBCR11-B44
Published: 28 October 2014
View article titled, Abstract B44: Therapeutic response of primary glioblastoma cancer stem cells relative to patient-matched non-stem tumor cells
Journal Articles

Abstract 3114: Mutational inactivation of STAG2 causes aneuploidy in human cancer

David Solomon, Taeyon Kim, Laura Diaz-Martinez, Joshlean Fair, Abdel Elkahloun, Brent Harris, Jeffrey Toretsky, Steven Rosenberg, Neerav Shukla, Marc Ladanyi, Yardena Samuels, C. David James, Hongtao Yu, Jung-Sik Kim, Todd Waldman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3114.
https://doi.org/10.1158/1538-7445.AM2012-3114
Published: 15 April 2012
View article titled, Abstract 3114: Mutational inactivation of STAG2 causes aneuploidy in human cancer
Journal Articles

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

Karine Michaud, David A. Solomon, Eric Oermann, Jung-Sik Kim, Wei-Zhu Zhong, Michael D. Prados, Tomoko Ozawa, C. David James, Todd Waldman
Journal: Cancer Research
Cancer Res (2010) 70 (8): 3228–3238.
https://doi.org/10.1158/0008-5472.CAN-09-4559
Published: 14 April 2010
View article titled, Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts
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Includes: Supplementary data
Journal Articles

Noninvasive Detection of Target Modulation following Phosphatidylinositol 3-Kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Christopher S. Ward, Humsa S. Venkatesh, Myriam M. Chaumeil, Alissa H. Brandes, Mark VanCriekinge, Hagit Dafni, Subramaniam Sukumar, Sarah J. Nelson, Daniel B. Vigneron, John Kurhanewicz, C. David James, Daphne A. Haas-Kogan, Sabrina M. Ronen
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1296–1305.
https://doi.org/10.1158/0008-5472.CAN-09-2251
Published: 14 February 2010
View article titled, Noninvasive Detection of Target Modulation following Phosphatidylinositol 3-Kinase Inhibition Using Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy
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Journal Articles

Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma

Bruno M. Costa, Justin S. Smith, Ying Chen, Justin Chen, Heidi S. Phillips, Kenneth D. Aldape, Giuseppe Zardo, Janice Nigro, C. David James, Jane Fridlyand, Rui M. Reis, Joseph F. Costello
Journal: Cancer Research
Cancer Res (2010) 70 (2): 453–462.
https://doi.org/10.1158/0008-5472.CAN-09-2189
Published: 13 January 2010
View article titled, Reversing <em>HOXA9</em> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
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Includes: Supplementary data
Journal Articles

Oncogenic BRAF Mutation with CDKN2A Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas

Joshua D. Schiffman, J. Graeme Hodgson, Scott R. VandenBerg, Patrick Flaherty, Mei-Yin C. Polley, Mamie Yu, Paul G. Fisher, David H. Rowitch, James M. Ford, Mitchel S. Berger, Hanlee Ji, David H. Gutmann, C. David James
Journal: Cancer Research
Cancer Res (2010) 70 (2): 512–519.
https://doi.org/10.1158/0008-5472.CAN-09-1851
Published: 13 January 2010
View article titled, Oncogenic <em>BRAF</em> Mutation with <em>CDKN2A</em> Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas
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Includes: Supplementary data
Journal Articles

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

Kan V. Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T. Huang, Shawn Sarkaria, David Ahkavan, Julie Dang, Eduard B. Dinca, Seema B. Plaisier, Isaac Oderberg, Yohan Lee, Zugen Chen, Jeremy S. Caldwell, Yongmin Xie, Joseph A. Loo, David Seligson, Arnab Chakravari, Francis Y. Lee, Roberto Weinmann, Timothy F. Cloughesy, Stanley F. Nelson, Gabriele Bergers, Thomas Graeber, Frank B. Furnari, C. David James, Webster K. Cavenee, Terrance G. Johns, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6889–6898.
https://doi.org/10.1158/0008-5472.CAN-09-0347
Published: 31 August 2009
View article titled, Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
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Includes: Supplementary data
Journal Articles

p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts

Eduard B. Dinca, Kan V. Lu, Jann N. Sarkaria, Russell O. Pieper, Michael D. Prados, Daphne A. Haas-Kogan, Scott R. VandenBerg, Mitchel S. Berger, C. David James
Journal: Cancer Research
Cancer Res (2008) 68 (24): 10034–10039.
https://doi.org/10.1158/0008-5472.CAN-08-1687
Published: 15 December 2008
View article titled, p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts
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Includes: Supplementary data
Journal Articles

Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors

Joo Mi Yi, Hsing-Chen Tsai, Sabine C. Glöckner, Steven Lin, Joyce E. Ohm, Hari Easwaran, C. David James, Joseph F. Costello, Gregory Riggins, Charles G. Eberhart, John Laterra, Angelo L. Vescovi, Nita Ahuja, James G. Herman, Kornel E. Schuebel, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2008) 68 (19): 8094–8103.
https://doi.org/10.1158/0008-5472.CAN-07-6208
Published: 30 September 2008
View article titled, Abnormal DNA Methylation of <em>CD133</em> in Colorectal and Glioblastoma Tumors
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Includes: Supplementary data
Journal Articles

Development and molecular characterization of an intracranial model of invasive cns lymphoma using bioluminescence imaging

Cigall Kadoch, Eduard Dinca, Juliana Karrim, Ramona Voicu, Lingjing Chen, C. David James, James Rubenstein
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 402.
Published: 01 May 2008
View article titled, Development and molecular characterization of an intracranial model of invasive cns lymphoma using bioluminescence imaging
Journal Articles

Chromosomal domains of transcriptional activation by PI3K/AKT pathway alterations in glioblastomas

Bruno Costa, Justin Smith, Ying Chen, Kenneth Aldape, Giuseppe Zardo, Janice Nigro, Heidi Phillips, C. David James, Jane Fridlyand, Joseph Costello
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 242.
Published: 01 May 2007
View article titled, Chromosomal domains of transcriptional activation by PI3K/AKT pathway alterations in glioblastomas
Journal Articles

Retargeted Oncolytic Measles Strains Entering via the EGFRvIII Receptor Maintain Significant Antitumor Activity against Gliomas with Increased Tumor Specificity

Cory Allen, Sompong Vongpunsawad, Takafumi Nakamura, C. David James, Mark Schroeder, Roberto Cattaneo, Caterina Giannini, James Krempski, Kah-Whye Peng, Jenny M. Goble, Joon H. Uhm, Stephen J. Russell, Evanthia Galanis
Journal: Cancer Research
Cancer Res (2006) 66 (24): 11840–11850.
https://doi.org/10.1158/0008-5472.CAN-06-1200
Published: 18 December 2006
View article titled, Retargeted Oncolytic Measles Strains Entering via the EGFRvIII Receptor Maintain Significant Antitumor Activity against Gliomas with Increased Tumor Specificity
Open the PDF for Retargeted Oncolytic Measles Strains Entering via the EGFRvIII Receptor Maintain Significant Antitumor Activity against Gliomas with Increased Tumor Specificity in another window
Includes: Supplementary data
Journal Articles

Use of an orthotopic xenograft model and corresponding xenograft cell cultures to evaluate MGMT promoter hypermethylation and temozolomide response in glioblastoma.

Gaspar Kitange, Brett L. Carlson, Jeff Lamont, Mark Schroeder, Jann N. Sarkaria, C. David James
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1334.
Published: 15 April 2006
View article titled, Use of an orthotopic xenograft model and corresponding xenograft cell cultures to evaluate MGMT promoter hypermethylation and temozolomide response in glioblastoma.