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Journal Articles

Integrating Plasma Cell-Free DNA Fragment End Motif and Size with Genomic Features Enables Lung Cancer Detection

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Tae-Rim Lee, Jin Mo Ahn, Junnam Lee, Dasom Kim, Juntae Park, Byeong-Ho Jeong, Dongryul Oh, Sang Man Kim, Gyou-Chul Jung, Beom Hee Choi, Min-Jung Kwon, Mengchi Wang, Michael Salmans, Andrew Carson, Bryan Leatham, Kristin Fathe, Byung In Lee, Byoungsok Jung, Chang-Seok Ki, Young Sik Park, Eun-Hae Cho
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1696–1707.
https://doi.org/10.1158/0008-5472.CAN-24-1517
Published: 02 May 2025
View articletitled, Integrating Plasma Cell-Free DNA Fragment End Motif and Size with Genomic Features Enables Lung Cancer Detection
Open the PDF for Integrating Plasma Cell-Free DNA Fragment End Motif and Size with Genomic Features Enables Lung Cancer Detection in another window
Includes: Supplementary data
Journal Articles

Abstract LB107: Association of circulating free DNA (cfDNA) maximum variant allele frequency (mVAF) levels with clinical outcomes in patients (pts) with metastatic nonsquamous non-small cell lung cancer (NSCLC) treated with pembrolizumab (pembro) + chemotherapy (chemo) in the phase 2 KEYNOTE-782 trial

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Jair Bar, Emilio Esteban, Delvys Rodríguez-Abreu, Santiago Ponce-Aix, Zsuzsanna Szalai, Enriqueta Felip, Maya Gottfried, Mariano Provencio Pulla, Andrew Robinson, Andrea Fülöp, Suman Bannur Rao, D. Ross Camidge, Giovanna Speranza, Nathan Hunkapiller, Robert McDaniel, Byoungsok Jung, David Burkhardt, Ruth Mauntz, Cai Chen, Carol Pena, Razvan Cristescu, Elisha J. Dettman, Steven M. Townson, Julie Kobie, Tibor Csőszi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB107.
https://doi.org/10.1158/1538-7445.AM2024-LB107
Published: 05 April 2024
View articletitled, Abstract LB107: Association of circulating free DNA (cfDNA) maximum variant allele frequency (mVAF) levels with clinical outcomes in patients (pts) with metastatic nonsquamous non-small cell lung cancer (NSCLC) treated with pembrolizumab (pembro) + chemotherapy (chemo) in the phase 2 KEYNOTE-782 trial
Journal Articles

Abstract LB297: Analytical validation of a tissue-free, multi-cancer, post-diagnosis cancer research test that uses cell-free DNA methylation profiling

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Mohini Desai, Svetlana Rakhmanova Shchegrov, Shoujie Chai, Yifan Zhou, Tracy Nguyen, Yirang Cho, Collin Melton, Eric Scott, Manami Roychowdhury-Saha, Pei-Yun Chang, Rita Shaknovich, Byoungsok Jung
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB297.
https://doi.org/10.1158/1538-7445.AM2023-LB297
Published: 14 April 2023
View articletitled, Abstract LB297: Analytical validation of a tissue-free, multi-cancer, post-diagnosis cancer research test that uses cell-free DNA methylation profiling
Journal Articles

Abstract CT216: Response to first-line (1L) pembrolizumab (pembro) + chemotherapy (chemo) in non-small cell lung cancer (NSCLC) by blood tumor mutational burden (bTMB): the phase 2 KEYNOTE-782 trial

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Jair Bar, Emilio Esteban, Delvys Rodríguez-Abreu, Santiago Ponce Aix, Zsuzsanna Szalai, Enriqueta Felip, Maya Gottfried, Mariano Provencio Pulla, Andrew Robinson, Andrea Fülöp, Suman B. Rao, D. Ross Camidge, Giovanna Speranza, Steven M. Townson, Julie Kobie, Mark Ayers, Elisha J. Dettman, Robert McDaniel, Byoungsok Jung, David Burkhardt, Ruth Mauntz, Tibor Csőszi
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT216.
https://doi.org/10.1158/1538-7445.AM2023-CT216
Published: 14 April 2023
View articletitled, Abstract CT216: Response to first-line (1L) pembrolizumab (pembro) + chemotherapy (chemo) in non-small cell lung cancer (NSCLC) by blood tumor mutational burden (bTMB): the phase 2 KEYNOTE-782 trial
Journal Articles

Abstract 112: Analytical performance of a cfDNA-based targeted methylation multi-cancer early detection test for population-scale screening

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Gregory E. Alexander, Byoungsok Jung, Lijuan Ji, Ekaterina Revenkova, Payal Shah, Jacqueline Brooks, Jeremy Carter, Zhao Dong, Lane Eubank, Maryam Hosseini, Xinyi Hou, Hannah Kiarie, Neda Ronaghi, Fabian E. Ortega, Madhuvanthi Ramaiah, Kate Rhodes, Rita Shaknovich, Seyedmehdi Shojaee, Sonya Parpart-Li, Nathan Hunkapiller
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 112.
https://doi.org/10.1158/1538-7445.AM2021-112
Published: 01 July 2021
View articletitled, Abstract 112: Analytical performance of a cfDNA-based targeted methylation multi-cancer early detection test for population-scale screening
Journal Articles

Abstract 721: Analytical validation of a multi-cancer early detection test with tissue localization using a cell-free DNA-based targeted methylation assay

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Gregory Alexander, Wendy Lin, Madhuvanthi Ramaiah, Byoungsok Jung, Lijuan Ji, Ekaterina Revenkova, Payal Shah, Christian Croisetiere, Jennifer Berman, Lane Eubank, Gunjan Naik, Jacqueline Brooks, Andrea Mich, Seyedmehdi Shojaee, Neda Ronaghi, Hemanshi Chawla, Xinyi Hou, Qinwen Liu, Christopher Yakym, Patriss Wais Moradi, Meredith Halks-Miller, Nathan Hunkapiller, Sonya Parpart-Li, Alexander Aravanis
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 721.
https://doi.org/10.1158/1538-7445.AM2020-721
Published: 15 August 2020
View articletitled, Abstract 721: Analytical validation of a multi-cancer early detection test with tissue localization using a cell-free DNA-based targeted methylation assay
Journal Articles

Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA)

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Alexander A. Aravanis, Geoffrey R. Oxnard, Tara Maddala, Earl Hubbell, Oliver Venn, Arash Jamshidi, Ling Shen, Hamed Amini, John A. Beausang, Craig Betts, Daniel Civello, Konstantin Davydov, Saniya Fazullina, Darya Filippova, Sante Gnerre, Samuel Gross, Chenlu Hou, Roger Jiang, Byoungsok Jung, Kathryn Kurtzman, Collin Melton, Shivani Nautiyal, Jonathan Newman, Joshua Newman, Cosmos Nicolaou, Richard Rava, Onur Sakarya, Ravi Vijaya Satya, Seyedmehdi Shojaee, Kristan Steffen, Anton Valouev, Hui Xu, Jeanne Yue, Nan Zhang, Jose Baselga, Rosanna Lapham, Daron G. Davis, David Smith, Donald Richards, Michael V. Seiden, Charles Swanton, Timothy J. Yeatman, Robert Tibshirani, Christina Curtis, Sylvia K. Plevritis, Richard Williams, Eric Klein, Anne-Renee Hartman, Minetta C. Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-343.
https://doi.org/10.1158/1538-7445.AM2018-LB-343
Published: 01 July 2018
View articletitled, Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA)
Journal Articles

Abstract 4342: Ultra-deep next generation sequencing (NGS) of plasma cell-free DNA (cfDNA) from patients with advanced lung cancers: results from the Actionable Genome Consortium

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Bob T. Li, Filip Janku, Pasi A. Janne, Gordon B. Mills, Kiran Madwani, Ryan S. Alden, Cloud P. Paweletz, Marc Ladanyi, Alex Aravanis, Byoungsok Jung, Sante Gnerre, Amy J. Sehnert, David B. Solit, Gregory J. Riely, Geoffrey R. Oxnard
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4342.
https://doi.org/10.1158/1538-7445.AM2016-4342
Published: 15 July 2016
View articletitled, Abstract 4342: Ultra-deep next generation sequencing (NGS) of plasma cell-free DNA (cfDNA) from patients with advanced lung cancers: results from the Actionable Genome Consortium