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Bruce C Baguley
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Journal Articles

Abstract 29: MEK and PI3K signaling cooperate through mTORC1/2 to promote PIK3CA mutant melanoma cell proliferation

Jillian M. Silva, Marian M. Deuker, Bruce C. Baguley, Martin McMahon
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 29.
https://doi.org/10.1158/1538-7445.AM2016-29
Published: 15 July 2016
View article titled, Abstract 29: MEK and PI3K signaling cooperate through mTORC1/2 to promote PIK3CA mutant melanoma cell proliferation
Journal Articles

Abstract 1644: Design and discovery of PWT33597 (VDC-597), a dual inhibitor of PI3-kinase alpha and mTOR

Gordon W. Rewcastle, Jack U. Flanagan, Anna C. Giddens, Swarna A. Gamage, Sophia KY Tsang, Jackie D. Kendall, Bruce C. Baguley, Christina M. Buchanan, David J. Matthews, Marie O'Farrell, Stephen MF Jamieson, William A. Denny, Peter R. Shepherd
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1644.
https://doi.org/10.1158/1538-7445.AM2014-1644
Published: 01 October 2014
View article titled, Abstract 1644: Design and discovery of PWT33597 (VDC-597), a dual inhibitor of PI3-kinase alpha and mTOR
Journal Articles

Abstract 4443: Molecular mechanistic study of ASA404 (vadimezan)-induced endothelial cell death

Alan Huang, Yan Chen, Xiaoyan Li, Helen He, Margaret McLaughlin, Rebecca Mosher, Colleen Conway, Brant Firestone, Frank Cook, Bailin Zhang, Bruce C. Baguley, Dean B. Evans, Robert Schlegel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4443.
https://doi.org/10.1158/1538-7445.AM10-4443
Published: 15 April 2010
View article titled, Abstract 4443: Molecular mechanistic study of ASA404 (vadimezan)-induced endothelial cell death
Journal Articles

Abstract 1660: The antitumor action of ASA404 (vadimezan; DMXAA); potential involvement of vascular endothelial growth factor (VEGF)

Bruce C. Baguley, Xiaobin Zhan, Graeme J. Finlay, William R. Wilson, Jacqueline Ross, Dean B. Evans, Stephen B. Fox, Sarah P. Gunningham, Margaret J. Currie
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1660.
https://doi.org/10.1158/1538-7445.AM10-1660
Published: 15 April 2010
View article titled, Abstract 1660: The antitumor action of ASA404 (vadimezan; DMXAA); potential involvement of vascular endothelial growth factor (VEGF)
Journal Articles

Association of Mutant TP53 with Alternative Lengthening of Telomeres and Favorable Prognosis in Glioma

Yu-Jen Chen, Vicky Hakin-Smith, Mario Teo, George E. Xinarianos, David A. Jellinek, Thomas Carroll, David McDowell, Martin R. MacFarlane, Ronald Boet, Bruce C. Baguley, Antony W. Braithwaite, Roger R. Reddel, Janice A. Royds
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6473–6476.
https://doi.org/10.1158/0008-5472.CAN-06-0910
Published: 03 July 2006
View article titled, Association of Mutant <em>TP53</em> with Alternative Lengthening of Telomeres and Favorable Prognosis in Glioma
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Journal Articles

In vitro studies of bidentate pyridyl phosphine gold(I) and silver(I) complexes as potential antitumour agents in ovarian tumor cell lines and isolated hepatocytes

Johnson J. Liu, Peter Galettis, Li Ding, Alistair Farr, Lenushka Maharaj, Gabi Haddad, Hasitha Samarasinha, Adam C. McGechan, Bruce C. Baguley, Susan J. Berners-Price, Mark J. McKeage
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 148.
Published: 01 May 2005
View article titled, <em>In vitro</em> studies of bidentate pyridyl phosphine gold(I) and silver(I) complexes as potential antitumour agents in ovarian tumor cell lines and isolated hepatocytes
Journal Articles

Comparative Biodistribution and Metabolism of Carbon-11-labeled N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating Analogues

Safiye Osman, Gail Rowlinson-Busza, Sajinder K. Luthra, Eric O. Aboagye, Gavin D. Brown, Frank Brady, Ralph Myers, Swarna A. Gamage, William A. Denny, Bruce C. Baguley, Pat M. Price
Journal: Cancer Research
Cancer Res (2001) 61 (7): 2935–2944.
Published: 01 April 2001
View article titled, Comparative Biodistribution and Metabolism of Carbon-11-labeled <em>N-</em>[2-(Dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating Analogues
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Journal Articles

Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis in Vivo by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA)

Zhihui Cao, Bruce C Baguley, Lai-Ming Ching
Journal: Cancer Research
Cancer Res (2001) 61 (4): 1517–1521.
Published: 02 February 2001
View article titled, Interferon-inducible Protein 10 Induction and Inhibition of Angiogenesis <em>in Vivo</em> by the Antitumor Agent 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA)
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Journal Articles

Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice

Lai-Ming Ching, David Goldsmith, Wayne R. Joseph, Heinrich Körner, Jonathon D. Sedgwick, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1999) 59 (14): 3304–3307.
Published: 15 July 1999
View article titled, Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice
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Journal Articles

Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: A Novel Approach to Cancer Therapy

Wayne R. Joseph, Zhihui Cao, Kathleen G. Mountjoy, Elaine S. Marshall, Bruce C. Baguley, Lai-Ming Ching
Journal: Cancer Research
Cancer Res (1999) 59 (3): 633–638.
Published: 01 February 1999
View article titled, Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α <em>in Situ</em> Using 5,6-Dimethylxanthenone-4-acetic Acid: <subtitle>A Novel Approach to Cancer Therapy</subtitle>
Open the PDF for Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α <em>in Situ</em> Using 5,6-Dimethylxanthenone-4-acetic Acid: <subtitle>A Novel Approach to Cancer Therapy</subtitle> in another window
Journal Articles

Studies on the Metabolism of the Novel Antitumor Agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in Rats and Humans prior to Phase I Clinical Trials

Safiye Osman, Sajinder K. Luthra, Frank Brady, Susan P. Hume, Gavin Brown, Robert J. A. Harte, Julian C. Matthews, William A. Denny, Bruce C. Baguley, Terry Jones, Pat M. Price
Journal: Cancer Research
Cancer Res (1997) 57 (11): 2172–2180.
Published: 01 June 1997
View article titled, Studies on the Metabolism of the Novel Antitumor Agent [<em>N-methyl</em>-<sup>11</sup>C]<em>N</em>-[2-(dimethylamino)ethyl]acridine-4-carboxamide in Rats and Humans prior to Phase I Clinical Trials
Open the PDF for Studies on the Metabolism of the Novel Antitumor Agent [<em>N-methyl</em>-<sup>11</sup>C]<em>N</em>-[2-(dimethylamino)ethyl]acridine-4-carboxamide in Rats and Humans prior to Phase I Clinical Trials in another window
Journal Articles

Preclinical Prediction of Factors Influencing the Elimination of 5,6-Dimethylxanthenone-4-acetic Acid, a New Anticancer Drug

John O. Miners, Leanne Valente, Karen J. Lillywhite, Peter I. Mackenzie, Brian Burchell, Bruce C. Baguley, Philip Kestell
Journal: Cancer Research
Cancer Res (1997) 57 (2): 284–289.
Published: 01 January 1997
View article titled, Preclinical Prediction of Factors Influencing the Elimination of 5,6-Dimethylxanthenone-4-acetic Acid, a New Anticancer Drug
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Journal Articles

Induction of Tumor Necrosis Factor-β Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488)

Lai-Ming Ching, Wayne R. Joseph, Kathryn E. Crosier, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1994) 54 (4): 870–872.
Published: 01 February 1994
View article titled, Induction of Tumor Necrosis Factor-<em>β</em> Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488)
Open the PDF for Induction of Tumor Necrosis Factor-<em>β</em> Messenger RNA in Human and Murine Cells by the Flavone Acetic Acid Analogue 5,6-Dimethylxanthenone-4-acetic Acid (NSC 640488) in another window
Journal Articles

Relative Activity of Structural Analogues of Amsacrine against Human Leukemia Cell Lines Containing Amsacrine-sensitive or -resistant Forms of Topoisomerase II: Use of Computer Simulations in New Drug Development

Leonard A. Zwelling, Michael J. Mitchell, Patricia Satitpunwaycha, Janice Mayes, Elizabeth Altschuler, Michael Hinds, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1992) 52 (1): 209–217.
Published: 01 January 1992
View article titled, Relative Activity of Structural Analogues of Amsacrine against Human Leukemia Cell Lines Containing Amsacrine-sensitive or -resistant Forms of Topoisomerase II: Use of Computer Simulations in New Drug Development
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Journal Articles

Tumor-dependent Increased Plasma Nitrate Concentrations as an Indication of the Antitumor Effect of Flavone-8-acetic Acid and Analogues in Mice

Lindy L. Thomsen, Lai-Ming Ching, Li Zhuang, John B. Gavin, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1991) 51 (1): 77–81.
Published: 01 January 1991
View article titled, Tumor-dependent Increased Plasma Nitrate Concentrations as an Indication of the Antitumor Effect of Flavone-8-acetic Acid and Analogues in Mice
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Journal Articles

Evidence for the Production of Nitric Oxide by Activated Macrophages Treated with the Antitumor Agents Flavone-8-acetic Acid and Xanthenone-4-acetic Acid

Lindy L. Thomsen, Lai-Ming Ching, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1990) 50 (21): 6966–6970.
Published: 01 November 1990
View article titled, Evidence for the Production of Nitric Oxide by Activated Macrophages Treated with the Antitumor Agents Flavone-8-acetic Acid and Xanthenone-4-acetic Acid
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Journal Articles

Disposition of Amsacrine and Its Analogue 9-({;2-Methoxy-4-[(methylsulfonyl)-amino]phenyl}amino)-N,5-dimethyl-4-acridinecarboxamide (CI-921) in Plasma, Liver, and Lewis Lung Tumors in Mice

Philip Kestell, James W. Paxton, Pandora C. Evans, Deborah Young, Jeffrey L. Jurlina, Iain G. C. Robertson, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1990) 50 (3): 503–508.
Published: 01 February 1990
View article titled, Disposition of Amsacrine and Its Analogue 9-({;2-Methoxy-4-[(methylsulfonyl)-amino]phenyl}amino)-<em>N</em>,5-dimethyl-4-acridinecarboxamide (CI-921) in Plasma, Liver, and Lewis Lung Tumors in Mice
Open the PDF for Disposition of Amsacrine and Its Analogue 9-({;2-Methoxy-4-[(methylsulfonyl)-amino]phenyl}amino)-<em>N</em>,5-dimethyl-4-acridinecarboxamide (CI-921) in Plasma, Liver, and Lewis Lung Tumors in Mice in another window
Journal Articles

Phase I Trial of the Amsacrine Analogue 9-({2-Methoxy-4-[(methylsulfonyl)amino]-phenyl}]amino)-N,5-dimethyl-4-acridinecarboxamide (CI-921)

Janet R. Hardy, Vernon J. Harvey, James W. Paxton, Pandora Evans, Shelba Smith, William Grove, Antonio J. Grillo-Lopez, Bruce C. Baguley
Journal: Cancer Research
Cancer Res (1988) 48 (22): 6593–6596.
Published: 01 November 1988
View article titled, Phase I Trial of the Amsacrine Analogue 9-({2-Methoxy-4-[(methylsulfonyl)amino]-phenyl}]amino)-<em>N</em>,5-dimethyl-4-acridinecarboxamide (CI-921)
Open the PDF for Phase I Trial of the Amsacrine Analogue 9-({2-Methoxy-4-[(methylsulfonyl)amino]-phenyl}]amino)-<em>N</em>,5-dimethyl-4-acridinecarboxamide (CI-921) in another window
Journal Articles

Mechanism of Resistance of Noncycling Mammalian Cells to 4′-(9-Acridinylamino)methanesulfon-m-anisidide: Comparison of Uptake, Metabolism, and DNA Breakage in Log- and Plateau-Phase Chinese Hamster Fibroblast Cell Cultures

Maxine A. Robbie, Bruce C. Baguley, William A. Denny, John B. Gavin, William R. Wilson
Journal: Cancer Research
Cancer Res (1988) 48 (2): 310–319.
Published: 01 January 1988
View article titled, Mechanism of Resistance of Noncycling Mammalian Cells to 4′-(9-Acridinylamino)methanesulfon-<em>m</em>-anisidide: Comparison of Uptake, Metabolism, and DNA Breakage in Log- and Plateau-Phase Chinese Hamster Fibroblast Cell Cultures
Open the PDF for Mechanism of Resistance of Noncycling Mammalian Cells to 4′-(9-Acridinylamino)methanesulfon-<em>m</em>-anisidide: Comparison of Uptake, Metabolism, and DNA Breakage in Log- and Plateau-Phase Chinese Hamster Fibroblast Cell Cultures in another window
Journal Articles

Synthesis, Antitumor Activity, and DNA Binding Properties of a New Derivative of Amsacrine, N-5-Dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-4-acridinecarboxamide

Bruce C. Baguley, William A. Denny, Graham J. Atwell, Graeme J. Finlay, Gordon W. Rewcastle, Simon J. Twigden, William R. Wilson
Journal: Cancer Research
Cancer Res (1984) 44 (8): 3245–3251.
Published: 01 August 1984
View article titled, Synthesis, Antitumor Activity, and DNA Binding Properties of a New Derivative of Amsacrine, <em>N</em>-5-Dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-4-acridinecarboxamide
Open the PDF for Synthesis, Antitumor Activity, and DNA Binding Properties of a New Derivative of Amsacrine, <em>N</em>-5-Dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenylamino]-4-acridinecarboxamide in another window