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Britta Weigelt
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Journal Articles

Abstract 2464: Inferring genomic properties from H&E whole-slide images of >60,000 solid tumors

Kevin M. Boehm, Arfath Pasha, Armaan Kohli, Raymond Lim, Tom Pollard, Darin Moore, JianJiong Gao, Nikolaos M. Dimitriou, Madison Darmofal, Meera Hameed, Ahmet Dogan, Natasha Rekhtman, Klaus J. Busam, Lora H. Ellenson, Jie-Fu Chen, Fresia Pareja, Daniel Gomez, Hikmat Al-Ahmadie, Nancy Lee, Eric Sherman, Jason Chang, Himanshu Nagar, Britta Weigelt, James Fagin, Susan Fu, Jonathan Alarcon, Neelraj Patil, Areej Alsaafin, Georgios Asimomitis, Anika Begum, Andrew Aukerman, Justin Jee, Christopher Fong, Michele Waters, Lior Z. Braunstein, Michael F. Berger, Luke R. Pike, Pedram Razavi, Paul Romesser, Walid K. Chatila, Aasiya Islam, Elana Sverdlik, Ino de Brujin, Karl Pichotta, Nikolaus Schultz, Sohrab P. Shah, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2464.
https://doi.org/10.1158/1538-7445.AM2025-2464
Published: 21 April 2025
View articletitled, Abstract 2464: Inferring genomic properties from H&E whole-slide images of >60,000 solid tumors
Journal Articles

Abstract 7145: The pan-cancer landscape of RIT1 genetic alterations

Matteo Repetto, Pier Selenica, Soo-Ryum Yang, Britta Weigelt, Alexander Drilon
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7145.
https://doi.org/10.1158/1538-7445.AM2025-7145
Published: 21 April 2025
View articletitled, Abstract 7145: The pan-cancer landscape of RIT1 genetic alterations
Journal Articles

A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms

Fresia Pareja, Higinio Dopeso, Yi Kan Wang, Andrea M. Gazzo, David N. Brown, Monami Banerjee, Pier Selenica, Jan H. Bernhard, Fatemeh Derakhshan, Edaise M. da Silva, Lorraine Colon-Cartagena, Thais Basili, Antonio Marra, Jillian Sue, Qiqi Ye, Arnaud Da Cruz Paula, Selma Yeni Yildirim, Xin Pei, Anton Safonov, Hunter Green, Kaitlyn Y. Gill, Yingjie Zhu, Matthew C.H. Lee, Ran A. Godrich, Adam Casson, Britta Weigelt, Nadeem Riaz, Hannah Y. Wen, Edi Brogi, Diana L. Mandelker, Matthew G. Hanna, Jeremy D. Kunz, Brandon Rothrock, Sarat Chandarlapaty, Christopher Kanan, Joe Oakley, David S. Klimstra, Thomas J. Fuchs, Jorge S. Reis-Filho
Journal: Cancer Research
Cancer Res (2024) 84 (20): 3478–3489.
https://doi.org/10.1158/0008-5472.CAN-24-1322
Published: 15 October 2024
View articletitled, A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms
Open the PDF for A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms in another window
Includes: Supplementary data
Journal Articles

Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets

Fresia Pareja, Andrea Gazzo, Higinio Dopeso, David Brown, Pier Selenica, Yingjie Zhu, Juan Blanco-Heredia, Laxmi Gusain, Xin Pei, Giacomo Montagna, Nour Abuhadra, Hanna Y Wen, Edi Brogi, Nadeem Riaz, Sarat Chandarlapaty, Maurizio Scaltriti, Larry Norton, Simon Powell, Jorge Reis-Filho, Britta Weigelt
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-14-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-14-08
Published: 02 May 2024
View articletitled, Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets
Journal Articles

Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics

Fresia Pareja, Higinio Dopeso, Yikan Wang, Andrea Gazzo, David Brown, Pier Selenica, Jan Bernhard, Fatemeh Derakhshan, Edaise M. da Silva, Lorraine Colon-Cartagena, Thais Basili, Antonio Marra, Jillian Sue, Qiqi Ye, Arnaud Da Cruz Paula, Selma Yeni, Xin Pei, Hunter Green, Kaitlyn Gill, Yingjie Zhu, Matthew Lee, Ran Godrich, Adam Casson, Britta Weigelt, Nadeem Riaz, Hanna Y Wen, Edi Brogi, Matthew Hanna, Diana Mandelker, Jeremy Kunz, Brandon Rothrock, Sarat Chandarlapaty, Christopher Kanan, Gerard Oakley III, David Klimstra, Thomas Fuchs, Jorge Reis-Filho
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): GS03-04.
https://doi.org/10.1158/1538-7445.SABCS23-GS03-04
Published: 02 May 2024
View articletitled, Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics
Journal Articles

Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2

Rei Kudo, Anton Safonov, Edaise M. da Silva, Qing Li, Hong Shao, Marie Will, Harikrishna Nakshatri, Jorge Reis-Filho, Shom Goel, Andrew Koff, Britta Weigelt, Qamar Khan, Pedram Razavi, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS12-03.
https://doi.org/10.1158/1538-7445.SABCS23-PS12-03
Published: 02 May 2024
View articletitled, Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2
Journal Articles

Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies

Higinio Dopeso, Yingjie Zhu, Laxmi Gusain, Thais Basili, David Brown, Fatemeh Derakhshan, Edaise M. da Silva, Richard Koche, Pierre-Jacques Hamard, Xinyu Guo, Eneda Toska, Elisa DeStanchina, Hong Zhang, Jorge Reis-Filho, Britta Weigelt, Fresia Pareja
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3936.
https://doi.org/10.1158/1538-7445.AM2024-3936
Published: 22 March 2024
View articletitled, Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies
Journal Articles

Abstract 4293: Chromosomal instability causes epigenetic aberrations in cancer

Albert S. Agustinus, Duaa Al-Rawi, Bhargavi Dameracharla, Ramya Raviram, Bailey S. Jones, Stephanie Stransky, Lorenzo Scipioni, Jens Luebeck, Melody Di Bona, Danguole Norkunaite, Robert M. Myers, Mercedes Duran, Seongmin Choi, Britta Weigelt, Shira Yomtoubian, Andrew McPherson, Eleonore Toufektchan, Kristina Keuper, Paul S. Mischel, Vivek Mittal, Sohrab P. Shah, John Maciejowski, Zuzana Storchova, Enrico Gratton, Peter Ly, Dan Landau, Mathieu F. Bakhoum, Richard P. Koche, Simone Sidoli, Vineet Bafna, Yael David, Samuel F. Bakhoum
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4293.
https://doi.org/10.1158/1538-7445.AM2024-4293
Published: 22 March 2024
View articletitled, Abstract 4293: Chromosomal instability causes epigenetic aberrations in cancer
Journal Articles

Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer

Zeda Zhang, Xin Fang, Yu-jui Ho, Sascha Haubner, Friederike Kogel, Clemens Hinterleitner, Stella Paffenholz, Kevin Chen, Wei Luan, Amanda Kulick, Gertrude Gunset, Andreina Garcia Angus, Jing Zhang, Zijian Xu, Adam Wang, Qingwen Jiang, Elisa de Stanchina, Britta Weigelt, Dmitriy Zamarin, Aveline Filliol, Judith Feucht, Jorge Mansilla-Soto, Corina Amor, Michel Sadelain, Scott Lowe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 115.
https://doi.org/10.1158/1538-7445.AM2024-115
Published: 22 March 2024
View articletitled, Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer
Journal Articles

Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer

Ignacio Vázquez-García, Matthew Myers, Marc J. Williams, Samuel S. Freeman, Jun Li, Hongyu Shi, Gryte Satas, Nicholas Ceglia, Florian Uhlitz, MSK SPECTRUM Consortium, Britta Weigelt, Dmitriy Zamarin, Andrew McPherson, Samuel F. Bakhoum, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_2): PR012.
https://doi.org/10.1158/1538-7445.CANEVOL23-PR012
Published: 01 February 2024
View articletitled, Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer
Journal Articles

Abstract B042: Clinical and molecular characterization of Lynch syndrome-associated pancreas adenocarcinoma (PDAC)

Emily Harrold, Catherine A. O'Connor, David Lin, Andrea Gazzo, Henry Walch, Megha Ranganathan, Amanda Catchings, Sarah Kane, Fergus Keane, Deborah M. Thurtle-Schmidt, Fiyinfolu Balogun, Anna Varghese, Kenneth Yu, David Kelsen, Alicia Latham, Britta Weigelt, Wungki Park, Zsofia Stadler, Eileen M. O'Reilly
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B042.
https://doi.org/10.1158/1538-7445.PANCA2023-B042
Published: 16 January 2024
View articletitled, Abstract B042: Clinical and molecular characterization of Lynch syndrome-associated pancreas adenocarcinoma (PDAC)
Journal Articles

Abstract 102: Transient chromosomal instability as a driver of ovarian cancer genome evolution

Ignacio Vazquez-Garcia, Florian Uhlitz, Marc J. Williams, Jun Li, Hongyu Shi, Samuel Freeman, Matthew Myers, MSK SPECTRUM Consortium, Britta Weigelt, Dmitriy Zamarin, Andrew McPherson, Samuel F. Bakhoum, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 102.
https://doi.org/10.1158/1538-7445.AM2023-102
Published: 29 May 2023
View articletitled, Abstract 102: Transient chromosomal instability as a driver of ovarian cancer genome evolution
Journal Articles

Abstract 1407: Refining endometrial carcinoma of no-specific molecular subtype by sources of estrogen signaling

Clarissa Lam, Carol Aghajanian, Nadeem Abu-Rustum, Britta Weigelt, Lora Ellenson, Amir Momeni Boroujeni
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1407.
https://doi.org/10.1158/1538-7445.AM2023-1407
Published: 04 April 2023
View articletitled, Abstract 1407: Refining endometrial carcinoma of no-specific molecular subtype by sources of estrogen signaling
Journal Articles

Abstract 130: Distinct mutational drivers and evolutionary pathways in stage IA non-myoinvasive endometrioid endometrial cancer

Sara Moufarrij, Carol Aghajanian, Nadeem Abu Rustum, Lora Ellenson, Britta Weigelt, Amir Momeni
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 130.
https://doi.org/10.1158/1538-7445.AM2023-130
Published: 04 April 2023
View articletitled, Abstract 130: Distinct mutational drivers and evolutionary pathways in stage IA non-myoinvasive endometrioid endometrial cancer
Journal Articles

Abstract P1-13-17: Hyperactivation of the EGFR pathway is associated with resistance to tucatinib in HER2-positive breast cancer models

Fu-Tien Liao, Tia Gordon, Chia Chia Liu, Pier Selenica, Yingjie Zhu, Juber Patel, Sarmistha Nanda, Lanfang Qin, Xiaoyong Fu, Andrea Gazzo, Antonio Marra, Juan Blanco-Heredia, Britta Weigelt, Jorge Reis-Filho, C. Kent Osborne, Mothaffar Rimawi, Rachel Schiff, Jamunarani Veeraraghavan
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-13-17.
https://doi.org/10.1158/1538-7445.SABCS22-P1-13-17
Published: 01 March 2023
View articletitled, Abstract P1-13-17: Hyperactivation of the EGFR pathway is associated with resistance to tucatinib in HER2-positive breast cancer models
Journal Articles

Abstract B007: Endogenous retrotransposable elements induction in SMARCA4-deficient ovarian cancer is associated with immunomodulatory changes in the tumor microenvironment

Melica N. Brodeur, Siyu Sun, Yingjie Zhu, Benjamin Greenbaum, Britta Weigelt, Dmitriy Zamarin
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B007.
https://doi.org/10.1158/1538-7445.CancEpi22-B007
Published: 01 December 2022
View articletitled, Abstract B007: Endogenous retrotransposable elements induction in SMARCA4-deficient ovarian cancer is associated with immunomodulatory changes in the tumor microenvironment
Journal Articles

Abstract 2553: Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L. Lim, Michelle Wu, Neeman Mohibullah, Arvin Eric B. Ruiz, Kevin M. Boehm, Viktoria Bojilova, Christopher J. Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M. Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, Rami Vanguri, Marc J. Williams, Allen W. Zhang, Vance Broach, Dennis S. Chi, Arnaud Da Cruz Paula, Ginger J. Gardner, Sarah H. Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnes Viale, Yonina Bykov, Fatemeh N. Derakhshan, Luke Geneslaw, Ana Maroldi, Andrea Schietinger, Travis J. Hollmann, Samuel F. Bakhoum, Robert A. Soslow, Lora H. Ellenson, Nadeem Abu-Rustum, Carol Aghajanian, Claire F. Friedman, Andrew McPherson, Britta Weigelt, MSK SPECTRUM Consortium, Dmitriy Zamarin, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2553.
https://doi.org/10.1158/1538-7445.AM2022-2553
Published: 15 June 2022
View articletitled, Abstract 2553: Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes
Journal Articles

Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor

Hilla Solomon, Radha Mukherjee, Xiaoping Chen, HuiYong Zhao, Elisa de Stanchina, Britta Weigelt, Alison M. Schram, Carol Aghajanian, Mallika Singh, Jan Smith, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB089.
https://doi.org/10.1158/1538-7445.AM2022-LB089
Published: 15 June 2022
View articletitled, Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor
Journal Articles

Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications

Jamunarani Veeraraghavan, Fu-Tien Liao, Tia Gordon, Pier Selenica, Sarmistha Nanda, Lanfang Qin, Yingjie Zhu, Juber A. Patel, Andrea Gazzo, Fabio Stossi, Michael A. Mancini, Carolina Gutierrez, Britta Weigelt, Jorge S. Reis-Filho, C. Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB517A.
https://doi.org/10.1158/1538-7445.AM2022-LB517A
Published: 15 June 2022
View articletitled, Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications
Journal Articles

Abstract 3768: Epigenetic dysregulation from chromosomal transit in micronuclei

Albert S. Agustinus, Ramya Raviram, Bhargavi Dameracharla, Jens Luebeck, Stephanie Stransky, Lorenzo Scipioni, Robert M. Myers, Melody Di Bona, Mercedes Duran, Britta Weigelt, Shira Yomtoubian, Eleonore Toufektchan, Paul S. Mischel, Vivek Mittal, Sohrab Shah, John Maciejowski, Enrico Gratton, Peter Ly, Mathieu F. Bakhoum, Dan Landau, Vineet Bafna, Simone Sidoli, Yael David, Samuel F. Bakhoum
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3768.
https://doi.org/10.1158/1538-7445.AM2022-3768
Published: 15 June 2022
View articletitled, Abstract 3768: Epigenetic dysregulation from chromosomal transit in micronuclei