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Brian Dougherty
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Journal Articles

Abstract 936: Targeted proteomics and next-generation sequencing (NGS) for biomarker discovery in metastatic colorectal cancer (mCRC)

William J. Kelly, Barrett Nuttall, Marlon Rebelatto, Marcus Schick, Armin Meier, Steve Sweet, Beom-Jun Kim, David Chain, Yeoun Jin Kim, Zhongwu Lai, Ying Wang, Todd H. Creasy, Ramya Gurrapu, Sakshi Gulati, Alice Barkell, Brian Dougherty, Danielle Carroll, Fabiola Cecchi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 936.
https://doi.org/10.1158/1538-7445.AM2024-936
Published: 22 March 2024
View article titled, Abstract 936: Targeted proteomics and next-generation sequencing (NGS) for biomarker discovery in metastatic colorectal cancer (mCRC)
Journal Articles

Abstract 5016: Building better contrived samples to properly evaluate Next-generation MRD and LBx assays

Paul Labrousse, Hugh Russell, David Shera, Daniel Stetson, Barrett Nuttall, Brian Dougherty, Darren Hodgson, James Hadfield
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5016.
https://doi.org/10.1158/1538-7445.AM2024-5016
Published: 22 March 2024
View article titled, Abstract 5016: Building better contrived samples to properly evaluate Next-generation MRD and LBx assays
Journal Articles

Abstract 4342: Breast cancer multi-omic single cell profiling identifies key progressive disease markers

Hugh Russell, Manisha Rao, Grant Duclos, Rogelio Aguilar, Nick Barkas, Megan Callahan, Ojasvi Chaudhary, Peter Gathungu, Chris Rands, Varsha Shankarappa, Daniel Stetson, Asaf Rotem, Maurizio Scaltriti, Brian Dougherty
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4342.
https://doi.org/10.1158/1538-7445.AM2024-4342
Published: 22 March 2024
View article titled, Abstract 4342: Breast cancer multi-omic single cell profiling identifies key progressive disease markers
Journal Articles

Abstract LB293: The evolution of MRD assays: Moving beyond the tumor-Informed bespoke NGS panel

Paul Labrousse, Daniel Stetson, James Hadfield, Chris Abbosh, Ahmet Zehir, Carl Barrett, Brian Dougherty, Darren Hodgson
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB293.
https://doi.org/10.1158/1538-7445.AM2023-LB293
Published: 14 April 2023
View article titled, Abstract LB293: The evolution of MRD assays: Moving beyond the tumor-Informed bespoke NGS panel
Journal Articles

Abstract 3384: Evaluation of a tumor informed MRD assay with contrived breast cancer samples

Hugh Russell, Paul LaBrousse, Daniel Stetson, Greg Jones, Giovanni Marsico, Tim Forshew, Robert McEwen, Elza De Bruin, Christopher Abbosh, Darren Hodgson, Brian Dougherty, James Hadfield, Carl Barrett
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3384.
https://doi.org/10.1158/1538-7445.AM2023-3384
Published: 04 April 2023
View article titled, Abstract 3384: Evaluation of a tumor informed MRD assay with contrived breast cancer samples
Journal Articles

Abstract 3369: Utility of ctDNA-based targeted methylation MRD assay for hematological malignancies

Veerendra Munugalavadla, Gary de Jesus, Aleksandra Markovets, Qinwen Liu, Oliver Venn, Rafael White, Giulia Fabbri, Paul Labrousse, Dan Stetson, Brian Dougherty, Darren Hodgson, Jill Walker, Anas Younes, Daniel Auclair
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3369.
https://doi.org/10.1158/1538-7445.AM2023-3369
Published: 04 April 2023
View article titled, Abstract 3369: Utility of ctDNA-based targeted methylation MRD assay for hematological malignancies
Journal Articles

Abstract 2957: A novel circulating tumor DNA (ctDNA) assay enables monitoring of disease progression and treatment response in disseminated preclinical hematologic cancer models

Amanda L. Christie, Paul Labrousse, Courtney L. Andersen, Justine E. Roderick, Jacob Gordon, Deborah Lawson, Denise Hughes, Kimberly Maratea, Daniel Stetson, Brandon Willis, Andrew Bloecher, Corinne Reimer, Brian Dougherty
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2957.
https://doi.org/10.1158/1538-7445.AM2021-2957
Published: 01 July 2021
View article titled, Abstract 2957: A novel circulating tumor DNA (ctDNA) assay enables monitoring of disease progression and treatment response in disseminated preclinical hematologic cancer models
Journal Articles

Abstract PD1-11: Mature survival update of the double-blind placebo-controlled randomised phase II PAKT trial of first-line capivasertib plus paclitaxel for metastatic triple-negative breast cancer

Peter Schmid, Jacinta Abraham, Stephen Chan, Adrian Murray Brunt, Gia Nemsadze, Richard D Baird, Yeon Hee Park, Peter Hall, Timothy Perren, Robert C Stein, László Mangel, Jean-Marc Ferrero, Melissa Phillips, John Conibear, Javier Cortes, Andrew Foxley, Elza de Bruin, Robert McEwen, Myria Nikolaou, Daniel Stetson, Brian Dougherty, Aaron Prendergast, Max McLaughlin-Callan, Matthew Burgess, Cheryl Lawrence, Hayley Cartwright, Kelly Mousa, Nicholas Turner, Duncan Wheatley
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD1-11.
https://doi.org/10.1158/1538-7445.SABCS20-PD1-11
Published: 15 February 2021
View article titled, Abstract PD1-11: Mature survival update of the double-blind placebo-controlled randomised phase II PAKT trial of first-line capivasertib plus paclitaxel for metastatic triple-negative breast cancer
Journal Articles

Abstract CT217: POLO: Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors

Zhongwu Lai, Talia Golan, Hedy L. Kindler, Brian Dougherty, Athena Matakidou, Liqin Dong, Gershon Locker, Elizabeth A. Harrington
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT217.
https://doi.org/10.1158/1538-7445.AM2020-CT217
Published: 15 August 2020
View article titled, Abstract CT217: POLO: Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors
Journal Articles

Abstract 749: Multi-layer molecular characterization of high grade serous ovarian carcinomas

Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Patricia Roxburgh, Daniel Stetson, Athena Matakidou, Brian Dougherty, J. Carl Barrett, Ruth E. March, Colin A. Semple, C. Simon Herrington, Charlie Gourley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 749.
https://doi.org/10.1158/1538-7445.AM2019-749
Published: 01 July 2019
View article titled, Abstract 749: Multi-layer molecular characterization of high grade serous ovarian carcinomas
Journal Articles

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

Mark J. O'Connor, Cristina Cruz, Marta Castroviejo-Bermejo, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Zhongwu Lai, Josep Forment, Krishna Bulusu, Alba Llop-Guevara, Brian Dougherty, Cristina Saura, Rachel Brough, Chris J. Lord, Alejandra Bruna, Carlos Caldas, Stephen Fawell, J Carl Barrett, Susan E. Critchlow, Judith Balmaña, Elaine Cadogan, Violeta Serra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 932.
https://doi.org/10.1158/1538-7445.AM2019-932
Published: 01 July 2019
View article titled, Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response
Journal Articles

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

Violeta Serra, Cristina Cruz, Zhongwu Lai, Marta Castroviejo-Bermejo, Marta Palafox, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Filippos Michopoulos, Rachel Brough, Brian Dougherty, Elaine Cadogan, Susan Critchlow, Alejandra Bruna, J. Carl Barrett, Cristina Saura, Christopher J. Lord, Carlos Caldas, Joaquin Arribas, Judith Balmaña, Mark J. O’Connor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3503.
https://doi.org/10.1158/1538-7445.AM2019-3503
Published: 01 July 2019
View article titled, Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer
Journal Articles

Abstract 4541: MET gene copy number gains evaluated by NGS is more predictive than other methods to enrich for papillary RCC patients sensitive to savolitinib, a selective MET inhibitor

Melanie M. Frigault, Sabina Signoretti, Aleksandra Markovets, Daniel Stetson, William Howat, Martine Roudier, Vincent Haddad, Brian Dougherty, Toni K. Choueiri, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4541.
https://doi.org/10.1158/1538-7445.AM2018-4541
Published: 01 July 2018
View article titled, Abstract 4541: <em>MET</em> gene copy number gains evaluated by NGS is more predictive than other methods to enrich for papillary RCC patients sensitive to savolitinib, a selective MET inhibitor
Journal Articles

Abstract LB-223: Examination of intra-assay variability in a commercial ctDNA NGS assay with triplicate clinical plasma and pooled normal samples

Daniel Stetson, Brian Dougherty, Ambar Ahmed, Barrett Nuttall, Tristan J. Lubinski, Fakhera Afshar, Amelia Raymond, Carl Barrett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-223.
https://doi.org/10.1158/1538-7445.AM2018-LB-223
Published: 01 July 2018
View article titled, Abstract LB-223: Examination of intra-assay variability in a commercial ctDNA NGS assay with triplicate clinical plasma and pooled normal samples
Journal Articles

Abstract 5724: Homologous recombination repair gene mutations for DNA repair and immune oncology drug combinations

Jonathan R. Dry, Zhongwu Lai, Brian Dougherty, Carl Barrett, Steven Criscione
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5724.
https://doi.org/10.1158/1538-7445.AM2018-5724
Published: 01 July 2018
View article titled, Abstract 5724: Homologous recombination repair gene mutations for DNA repair and immune oncology drug combinations
Journal Articles

Abstract 4582: Capturing T cell receptor clones from circulating free DNA in cancer patients with solid malignancies

Lara McGrath, Elizabeth Maloney, Daniel Stetson, Tristan J. Lubinski, Rory Kirchner, Brian Dougherty, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4582.
https://doi.org/10.1158/1538-7445.AM2018-4582
Published: 01 July 2018
View article titled, Abstract 4582: Capturing T cell receptor clones from circulating free DNA in cancer patients with solid malignancies
Journal Articles

Abstract LB-249: Examination of analytical factors impacting concordance of plasma-tumor testing by next-generation sequencing (NGS)

Daniel Stetson, Brian Dougherty, Ambar Ahmed, Tristan Lubinski, Aleksandra Markovets, Kenneth Thress, Robert McEwen, Gaia Schiavon, David Whitston, Barrett Nuttall, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-249.
https://doi.org/10.1158/1538-7445.AM2017-LB-249
Published: 01 July 2017
View article titled, Abstract LB-249: Examination of analytical factors impacting concordance of plasma-tumor testing by next-generation sequencing (NGS)
Journal Articles

Abstract 240: Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer

Alvaro Avivar-Valderas, Robert McEwen, Amir Taheri-Ghahfarokhi, Ambar Ahmed, Daniel Stetson, Brian Dougherty, Marcello Maresca, Kevin Hudson, Francisco Cruzalegui
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 240.
https://doi.org/10.1158/1538-7445.AM2016-240
Published: 15 July 2016
View article titled, Abstract 240: Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer
Journal Articles

Abstract 641: Use of conditional reprogramming to develop and characterize cell cultures from patient-derived xenograft (PDX) models of human lung and ovarian cancer

Alexandra Borodovsky, Travis J. McQuiston, Brian Dougherty, Ambar Ahmed, David Whitston, Daniel Stetson, Gretchen K. Hubbard, Sharon S. Challberg, Brian A. Pollok, Celina M. D’Cruz
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 641.
https://doi.org/10.1158/1538-7445.AM2016-641
Published: 15 July 2016
View article titled, Abstract 641: Use of conditional reprogramming to develop and characterize cell cultures from patient-derived xenograft (PDX) models of human lung and ovarian cancer
Journal Articles

Abstract LB-123: Analysis of cell-free plasma DNA (cfDNA) identifies 3 molecular subtypes of acquired resistance to AZD9291, a novel EGFR tyrosine kinase inhibitor (TKI), in patients (pts) with advanced lung cancer

Geoffrey R. Oxnard, Kenneth S. Thress, Cloud P. Paweletz, Enriqueta Felip, Byoung Chul Cho, Daniel Stetson, Brian Dougherty, Zhongwu Lai, Aleksandra Morkovets, Ana Vivancos, Yanan Kuang, Dalia Ercan, Mireille Cantarini, J Carl Barrett, Pasi A. Janne
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-123.
https://doi.org/10.1158/1538-7445.AM2015-LB-123
Published: 01 August 2015
View article titled, Abstract LB-123: Analysis of cell-free plasma DNA (cfDNA) identifies 3 molecular subtypes of acquired resistance to AZD9291, a novel EGFR tyrosine kinase inhibitor (TKI), in patients (pts) with advanced lung cancer