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Brendon Ladd
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Journal Articles

Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma

James A. Henderson, Scott J. Eron, Andrew Good, R Jason Kirby, Samantha Perino, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, David Cocozziello, Ashley A. Hart, Christina S. Henderson, Marta Isasa, Brendon Ladd, Matt Schnaderbeck, Michelle Mahler, Adam S. Crystal, Roy M. Pollock, Christopher G. Nasveschuk, Andrew J. Phillips, Stewart L. Fisher, David A. Proia
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): ND13.
DOI: https://doi.org/10.1158/1538-7445.AM2022-ND13
Published: 15 June 2022
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Journal Articles

Abstract LB194: Discovery and characterization of a mutant selective PI3KαH1047Xinhibitor with a best-in-class profile

Leonard Buckbinder, David J. St. Jean, Trang Tieu, Weixue Wang, Gregory Kryukov, Philip Jonsson, Jacob Alltucker, Samantha Manimala, Brendon Ladd, Angel Guzman-Perez, Darrin Stuart
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB194.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB194
Published: 15 June 2022
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Journal Articles

Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models

James A. Henderson, R. Jason Kirby, Samantha Perino, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, David Cocozziello, Scott J. Eron, Andrew Good, Ashley A. Hart, Christina Henderson, Marta Isasa, Brendon Ladd, Matt Schnaderbeck, Michelle Mahler, Roy M. Pollock, Adam S. Crystal, Christopher G. Nasveschuk, Andrew J. Phillips, Stewart L. Fisher, David A. Proia
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB007.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB007
Published: 01 July 2021
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Journal Articles

Abstract 1949: In vivo profiling of BET degraders establishes optimal pharmacological properties that showcase distinct biological differences from BET inhibitors

Brendon Ladd, David Cocozziello, Mark E. Fitzgerald, Ryan E. Michael, Ellen F. Vieux, Linda Lee, Marta Issa, Jacob D. Feala, Roman V. Agafonov, Eun Sun Park, Christopher G. Nasveschuk, David A. Proia
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1949.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1949
Published: 15 August 2020
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Journal Articles

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Hazel M. Weir, Robert H. Bradbury, Mandy Lawson, Alfred A. Rabow, David Buttar, Rowena J. Callis, Jon O. Curwen, Camila de Almeida, Peter Ballard, Michael Hulse, Craig S. Donald, Lyman J.L. Feron, Galith Karoutchi, Philip MacFaul, Thomas Moss, Richard A. Norman, Stuart E. Pearson, Michael Tonge, Gareth Davies, Graeme E. Walker, Zena Wilson, Rachel Rowlinson, Steve Powell, Claire Sadler, Graham Richmond, Brendon Ladd, Ermira Pazolli, Anne Marie Mazzola, Celina D'Cruz, Chris De Savi
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (11): 3307–3318.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2357
Published: 31 May 2016
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Includes: Supplementary data
Journal Articles

Abstract DDT01-03: Discovery and pre-clinical pharmacology of AZD9496: An oral, selective estrogen receptor down-regulator (SERD)

Hazel Weir, Mandy Lawson, Rowena Callis, Michael Hulse, Michael Tonge, Gareth Davies, Graeme Walker, Rachel Rowlinson, Jon Curwen, Zena Wilson, Steve Powell, Robert Bradbury, Alfred Rabow, Craig Donald, David Buttar, Richard Norman, Camila de Almeida, Peter Ballard, Gordon Currie, David Andrews, Graham Richmond, Anne Marie Mazzola, Ermira Pazolli, Brendon Ladd, Celina D'Cruz, Chris De Savi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): DDT01-03.
DOI: https://doi.org/10.1158/1538-7445.AM2015-DDT01-03
Published: 01 August 2015
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Journal Articles

Abstract 5374: Synergistic tumor cell killing with ganciclovir and vorinostat is due to inhibition of homologous recombination

Brendon Ladd, Donna S. Shewach
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5374.
DOI: https://doi.org/10.1158/1538-7445.AM2011-5374
Published: 15 April 2011
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Journal Articles

Abstract #4617: Homologous recombination repair promotes survival with ganciclovir

Brendon Ladd, Jessica O'Konek, Donna Shewach
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4617.
Published: 01 May 2009
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