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Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
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Journal Articles

Abstract 3415: The neutrophil-to-lymphocyte ratio (NLR) reflects intratumor myeloid derived suppressor cell (MDSC) infiltration in metastatic castration-resistant prostate cancers (mCRPC)

Christina Guo, Jan Rekowski, Mateus Crespo, Bora Gurel, Wei Yuan, Adam Sharp, Rafael Grochot, Khobe Chandran, Semini Sumanasuriya, Ana Ferreira, Andrea Alimonti, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3415.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3415
Published: 15 June 2022
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Abstract 2898: HPN424, a Tri-specific T-cell Activating Construct, induces T cell-mediated cytotoxicity against human metastatic castration-resistant prostate cancers (mCRPC)

Veronica Gil, Christina Guo, George Seed, Antje Neeb, Lorenzo Buroni, Bora Gurel, Ines Figueiredo, Golzar Hemmati, Wade Aaron, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2898.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2898
Published: 15 June 2022
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Journal Articles

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigues, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1087–1100.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1807
Published: 15 February 2022
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Includes: Supplementary data
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D'Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
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Includes: Supplementary data
Journal Articles

Abstract LB035: B7-H3 as a therapeutic target in prostate cancer

Christina Guo, Ines Figueiredo, Bora Gurel, Matues Crespo, Jan Rekowski, Suzanne Carreira, Antje Neeb, Adam Sharp, Maria D. Fenor de la Maza, Pasquale Rescigno, Khobe Chandran, Ana Ferreira, Ruth Riisnaes, Susana Miranda, Rita Pereira, Veronica Gil, George Seed, Claudia Bertan, Chloe Baker, Wei Yuan, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB035.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB035
Published: 01 July 2021
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Journal Articles

Abstract CT120: Results of the glioblastoma multiforme (GBM) cohort of phase 1 trial Ice-CAP (NCT03673787): Preliminary evidence of antitumour activity of Ipatasertib (Ipa) and Atezolizumab (A) in patients (pts) with PTEN loss

Crescens Tiu, Andrea Biondo, Liam C. Welsh, Timothy L. Jones, Anna Zachariou, Toby Prout, Alison J. Turner, Robert Daly, Igor Vivanco, Christina Yap, Ben Jenkins, Mateus Crespo, Ruth Riisnaes, Suzanne Carreira, Bora Gurel, Nina Tunariu, Anna Minchom, Udai Banerji, Johann S. de Bono, Juanita S. Lopez
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT120.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT120
Published: 01 July 2021
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Journal Articles

Abstract CT161: A homologous recombination repair (HRR) functional assay to stratify patients with metastatic prostate cancer for PARP inhibitor treatment in the TOPARP-B clinical trial

Sara Arce-Gallego, Alba Llop-Guevara, Suzanne Carreira, Nuria Porta, Roberta Fasani, Diletta Bianchini, George Seed, Pasquale Rescigno, Alec Paschalis, Claudia Bertan, Chloe Baker, Jane Goodall, Susana Miranda, Ruth Riisnaes, Ines Figueiredo, Ana Ferreira, Rita Pereira, Bora Gurel, Daniel Nava Rodrigues, Wei Yuan, Jan Rekowski, Emma Hall, Violeta Serra, Johann S. de Bono, Joaquin Mateo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT161.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT161
Published: 01 July 2021
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Journal Articles

Abstract 2797: Changes in the phenotype of macrophages and CD8+ T Cells in the perivascular niche of prostate tumours following androgen deprivation

Haider Al-janabi, Xuan Pu, Munitta Muthana, Ning Wang, Mateus Crespo, Bora Gurel, Johann De Bono, Janet E. Brown, Claire E. Lewis
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2797.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2797
Published: 01 July 2021
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Journal Articles

Abstract 2362: Long non-coding RNA NORAD interaction with miR-346 impacts DNA damage response and anti-tumor immunity in prostate cancer

Claire Fletcher, Lin Deng, Folake Orafidiya, Wei Yuan, Ines Figueiredo, Bora Gurel, Damien Leach, Fadi Issa, Antje Neeb, Denisa Bogdan, Felix Dobbs, Yiannis Philippou, Emma A. Murphy, Shuang G. Zhao, Joanna Hester, Richard J. Bryant, Simon H. Reed, Karen E. Knudsen, Ian G. Mills, Johann de Bono, Charlotte L. Bevan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2362.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2362
Published: 01 July 2021
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Journal Articles

Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors

Bora Gurel, Pasquale Rescigno, Wei Yuan, Rita Pereira, Mateus Crespo, Mattia Rediti, Ines Figueiredo, Maialen Barrero, Diletta Bianchini, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Alec Paschalis, Adam Sharp, George Seed, Ruth Riisnaes, Claudia Bertan, Suzanne Carreira, Johann S. De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-075.
DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-075
Published: 15 August 2020
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Journal Articles

Abstract CT143: Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions in KRAS mutant cancers

Rajiv Shinde, Angelika Terbuch, Martin Little, Reece Caldwell, Roopa Kurup, Ruth Riisnaes, Mateus Crespo, Ruth Ruddle, Bora Gurel, Adam Stewart, Jenny King, Mona Parmar, Alison Turner, Florence Raynaud, Muneeb Mahmud, Christina Yap, Jonathan A. Pachter, Gordon B. Mills, Anna Minchom, Juanita Lopez, Susana N. Banerjee, Johann S. de Bono, Matthew Krebs, Udai Banerji
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT143.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT143
Published: 15 August 2020
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Journal Articles

Abstract CT129: HyPeR: A phase 1, dose escalation and expansion trial of guadecitabine (SGI-110), a second-generation hypomethylating agent in combination with pembrolizumab (MK3475) in patients with refractory solid tumors

Dionysis Papadatos-Pastos, Abhijit Pal, Melek Akay, Malaka Ameratunga, Sanjena Mithra, Joo-Ern Ang, Sofia Levva, Reece Caldwell, Ruth Riisnaes, Mateus Crespo, Wei Yuan, George Seed, Bora Gurel, Ines Figueiredo, Rita Pereira, Susana Miranda, Anna Ferreira, Suzanne Carreira, Claudia Bertan, Chloe Baker, Ricardo Morilla, Robert Brown, Nahal Masrour, Toby Prout, Anna Zachariou, Alison Turner, Mona Parmar, Mark Van de Velde, Ben Jenkins, Christina Yap, Nina Tunariu, Udai Banerji, Juanita Lopez, Anna Minchom, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT129.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT129
Published: 15 August 2020
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Journal Articles

Abstract CT140: Proof-of-concept evidence of immune modulation by blockade of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway in the phase I dose escalation study of Ipatasertib (Ipa) in combination with atezolizumab (A) in patients (pts) with advanced solid tumors (Ice-CAP)

Juanita S. Lopez, Andrea Biondo, Crescens Tiu, Mariana Scaranti, Malaka Ameratunga, Anna Zachariou, Alison Turner, Nina Tunariu, Toby Prout, Mona Parmar, Hannah Badham, Karen Swales, Wei Yuan, Ricardo Morilla, Mateus Crespo, Rob Daly, Ines Figueiredo, Bora Gurel, Rita Pereira, Ruth Riisnaes, Igor Vivanco, Anna Minchom, Ben Jenkins, Christina Yap, Udai Banerji, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT140.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT140
Published: 15 August 2020
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Journal Articles

Abstract 2210: Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer

Laxmi Gurunatham Pellakuru, Tsuyoshi Iwata, Bora Gurel, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2210.
DOI: https://doi.org/10.1158/1538-7445.AM2012-2210
Published: 15 April 2012
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Journal Articles

Abstract 4366: Chronic inflammation in benign prostate tissue is related to the presence of high grade prostate cancer

Bora Gurel, Marshall S. Lucia, Elizabeth A. Platz, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4366.
DOI: https://doi.org/10.1158/1538-7445.AM10-4366
Published: 15 April 2010
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Journal Articles

DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang, Bora Gurel, Toby C. Cornish, Zhijin Wu, Rafael A. Irizarry, James Morgan, Jessica Hicks, Theodore L. DeWeese, William B. Isaacs, G. Steven Bova, Angelo M. De Marzo, William G. Nelson
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8954–8967.
DOI: https://doi.org/10.1158/0008-5472.CAN-07-6088
Published: 30 October 2008
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Includes: Supplementary data