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Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View article titled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Open the PDF for A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract 1929: Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition and regulated by 4E-BP1

Ismail M. Meraz, Shuhong Wu, Mourad Majidi, Chenghui Ren, Yi Xu, Feng Meng, Lihui Gao, Renduo Song, Ran Zhang, Bingliang Fang, Qi Wang, Yuanxin Xi, Jing Wang, Sung Yun Jung, Jack A. Roth
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1929.
https://doi.org/10.1158/1538-7445.AM2024-1929
Published: 22 March 2024
View article titled, Abstract 1929: Acquired resistance to sotorasib in KRAS<sup>G12C</sup> mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition and regulated by 4E-BP1
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View article titled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer

Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-ll Park, Yi Zheng, Kwon-Sik Park
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4219–4233.
https://doi.org/10.1158/0008-5472.CAN-22-1170
Published: 15 November 2022
View article titled, WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Open the PDF for WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View article titled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Abstract 5354: 3-phosphoinositide-dependent kinase-1 (PDK1, PDPK1) is a driver of osimertinib acquired resistance in EGFR mutant NSCLC

Ismail M. Meraz, Mourad Majidi, Bingliang Fang, Feng Meng, Lihui Gao, RuPing Shao, Renduo Song, Feng Li, Min Jin Ha, Qi Wang, Jing Wang, Elizabeth Shpall, Sung Yun Jung, Franziska Haderk, Philippe Gui, Jonathan W. Riess, Victor Olivas, Trever G. Bivona, Jack A. Roth
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5354.
https://doi.org/10.1158/1538-7445.AM2022-5354
Published: 15 June 2022
View article titled, Abstract 5354: 3-phosphoinositide-dependent kinase-1 (PDK1, PDPK1) is a driver of osimertinib acquired resistance in EGFR mutant NSCLC
Journal Articles

Abstract 3009: A systematic review of the tumor growth metrics of patient-derived xenograft (PDX) models in the literature and in NCI PDXNet centers

Dali Li, Min Jin Ha, Yvonne A. Evrard, Huiqin Chen, Lisa M. McShane, Jeffrey Grover, Jing Wang, Bingliang Fang, Timothy DiPeri, Michael T. Lewis, Lawrence Rubinstein, Jack A. Roth, Jeffrey H. Chuang, James H. Doroshow, Jeffrey A. Moscow, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3009.
https://doi.org/10.1158/1538-7445.AM2021-3009
Published: 01 July 2021
View article titled, Abstract 3009: A systematic review of the tumor growth metrics of patient-derived xenograft (PDX) models in the literature and in NCI PDXNet centers
Journal Articles

Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan Welm, Michael T. Lewis, Bingliang Fang, Jack A. Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A. Moscow, Livio Trusolino, Annette Byrne, Jos Jonkers, Carol J. Bult, Enzo Medico, Jeffrey H. Chuang, PDXNET consortium & EurOPDX consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1673.
https://doi.org/10.1158/1538-7445.AM2020-1673
Published: 15 August 2020
View article titled, Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Journal Articles

Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts

Jessica Giordano, Xing Yi Woo, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Jeffrey A. Moscow, Carol J. Bult, Claudio Isella, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Jeffrey H. Chuang, Enzo Medico, EurOPDX consortium & PDXNET consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2020-1118
Published: 15 August 2020
View article titled, Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
Journal Articles

Abstract 557: Novel targeted combination therapies active in KRAS mutant non-small cell lung cancer (NSCLC) identified using patient-derived xenografts (PDX)

Xiaoshan Zhang, Ran Zhang, Huiqin Chen, Li Wang, Chenghui Ren, Shuhong Wu, Min Jin Ha, Jeffrey Morris, Yuanxin Xi, Jing Wang, Don L. Gibbons, John V. Heymach, Funda Meric-Bernstam, John Minna, Stephen G. Swisher, Jack A. Roth, Bingliang Fang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 557.
https://doi.org/10.1158/1538-7445.AM2020-557
Published: 15 August 2020
View article titled, Abstract 557: Novel targeted combination therapies active in KRAS mutant non-small cell lung cancer (NSCLC) identified using patient-derived xenografts (PDX)
Journal Articles

Abstract 3604: Synthetic lethality therapy for lung cancers with compromised glutathione homeostasis

Xiang Yan, Bingliang Fang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3604.
https://doi.org/10.1158/1538-7445.AM2019-3604
Published: 01 July 2019
View article titled, Abstract 3604: Synthetic lethality therapy for lung cancers with compromised glutathione homeostasis
Journal Articles

Abstract 4984: Development of an improved humanized patient-derived xenograft, Hu-PDX, mouse model for evaluation of antitumor immune response in lung cancer

Ismail M. Meraz, Mourad Majidi, Feng Meng, RuPing Shao, Min Jin Ha, Shinya Neri, Bingliang Fang, Steven H. Lin, Peggy T. Tinkey, Elizabeth J. Shpall, Jeffrey Morris, Jack A. Roth
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4984.
https://doi.org/10.1158/1538-7445.AM2019-4984
Published: 01 July 2019
View article titled, Abstract 4984: Development of an improved humanized patient-derived xenograft, Hu-PDX, mouse model for evaluation of antitumor immune response in lung cancer
Journal Articles

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis

Xiang Yan, Xiaoshan Zhang, Li Wang, Ran Zhang, Xingxiang Pu, Shuhong Wu, Lei Li, Pan Tong, Jing Wang, Qing H. Meng, Vanessa B. Jensen, Luc Girard, John D. Minna, Jack A. Roth, Stephen G. Swisher, John V. Heymach, Bingliang Fang
Journal: Cancer Research
Cancer Res (2019) 79 (1): 125–132.
https://doi.org/10.1158/0008-5472.CAN-18-1938
Published: 02 January 2019
View article titled, Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
Open the PDF for Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis in another window
Includes: Supplementary data
Journal Articles

Abstract 895: Noncanonical c-Met activation mediates de novo and acquired resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

Ratnakar Singh, Pavitra Viswanath, Shaohua Peng, Vaishnavi Sambandam, Li Shen, Lerong Li, Jing Wang, Bingliang Fang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 895.
https://doi.org/10.1158/1538-7445.AM2018-895
Published: 01 July 2018
View article titled, Abstract 895: Noncanonical c-Met activation mediates de novo and acquired resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer
Journal Articles

Abstract 5717: PKR promotes EphA2 and other proteins degradation and is predictor of survival in lung cancer

Apar Pataer, Ruping Shao, Bulent Ozpolat, Bingliang Fang, Stephen G. Swisher
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5717.
https://doi.org/10.1158/1538-7445.AM2017-5717
Published: 01 July 2017
View article titled, Abstract 5717: PKR promotes EphA2 and other proteins degradation and is predictor of survival in lung cancer
Journal Articles

Abstract 4799: Inhibition of HER2 mutant non-small cell lung cancer using 3rd generation EGFR/HER2 inhibitors

Jacqulyne P. Robichaux, Monique Nilsson, Bingliang Fang, John V. Heymach
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4799.
https://doi.org/10.1158/1538-7445.AM2016-4799
Published: 15 July 2016
View article titled, Abstract 4799: Inhibition of HER2 mutant non-small cell lung cancer using 3rd generation EGFR/HER2 inhibitors
Journal Articles

Abstract 4391: Overcoming primary ibrutinib resistance in mantle cell lymphoma

Leo Zhang, Lan Pham, Hui Zhang, Jingmeng Xie, Wenjing Tao, Taylor Bell, Zhihong Chen, Krystle Nomie, Bingliang Fang, Michael Wang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4391.
https://doi.org/10.1158/1538-7445.AM2016-4391
Published: 15 July 2016
View article titled, Abstract 4391: Overcoming primary ibrutinib resistance in mantle cell lymphoma
Journal Articles

Abstract 4739: Nutrient depletion caused by PKR induces phosphorylation of AMPK in lung cancer

Apar Pataer, Chengcheng Guo, Ruping Shao, Arlene M. Correa, Carmen Behrens, Bingliang Fang, Jack A. Roth, Ignacio I. Wistuba, Stephen G. Swisher
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4739.
https://doi.org/10.1158/1538-7445.AM2014-4739
Published: 01 October 2014
View article titled, Abstract 4739: Nutrient depletion caused by PKR induces phosphorylation of AMPK in lung cancer
Journal Articles

KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer

Bingbing Dai, Suk-Young Yoo, Geoffrey Bartholomeusz, Ryan A. Graham, Mourad Majidi, Shaoyu Yan, Jieru Meng, Lin Ji, Kevin Coombes, John D. Minna, Bingliang Fang, Jack A. Roth
Journal: Cancer Research
Cancer Res (2013) 73 (17): 5532–5543.
https://doi.org/10.1158/0008-5472.CAN-13-0712
Published: 02 September 2013
View article titled, KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer
Open the PDF for KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3444: Novel SINE CRM1 antagonists for non-small cell lung cancer (NSCLC) in vitro and in vivo.

Xiaohong Han, Shuai Wang, Yuankai Shi, Michael Wang, Liang Zhang, Bingliang Fang, Dilara McCauley, Michael Kauffman, Sharon Shacham
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3444.
https://doi.org/10.1158/1538-7445.AM2013-3444
Published: 15 April 2013
View article titled, Abstract 3444: Novel SINE CRM1 antagonists for non-small cell lung cancer (NSCLC) <em>in vitro</em> and <em>in vivo</em>.