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Binghui Shen
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Journal Articles

Abstract 6996: Integrating high-throughput screening with ligand-based pharmacophore modeling and virtual screening strategies to optimize exonuclease 1 inhibitor design

Free
Jessica Hess, Li Zheng, Binghui Shen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6996.
https://doi.org/10.1158/1538-7445.AM2025-6996
Published: 21 April 2025
View articletitled, Abstract 6996: Integrating high-throughput screening with ligand-based pharmacophore modeling and virtual screening strategies to optimize exonuclease 1 inhibitor design
Journal Articles

Abstract 7199: Synergistic anticancer effects of milciclib and mirdametinib: mechanistic insights into cell cycle arrest, DNA damage, and senescence

Free
Xinyu Pei, Juifang Fan, Anh Nguyen Nguyen, Hannah Neiger, Imran A. Khan, Vladimir Bezrookove, Yu Zhou, Maureen Veilleux, Lily S. Wang, Valerie A. Gerriets, John K. Cusick, Pierre Y. Desprez, Li Zheng, Mohammed Kashani-Sabet, Binghui Shen, Yihui Shi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7199.
https://doi.org/10.1158/1538-7445.AM2025-7199
Published: 21 April 2025
View articletitled, Abstract 7199: Synergistic anticancer effects of milciclib and mirdametinib: mechanistic insights into cell cycle arrest, DNA damage, and senescence
Journal Articles

Abstract 6865: Discovery and characterization of small molecule inhibitors targeting EXO1 for BRCAness cancer therapy

Free
Yixing Wang, Jessica Hess, Li Zheng, Binghui Shen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6865.
https://doi.org/10.1158/1538-7445.AM2025-6865
Published: 21 April 2025
View articletitled, Abstract 6865: Discovery and characterization of small molecule inhibitors targeting EXO1 for BRCAness cancer therapy
Journal Articles

Abstract 5279: HSP72 expression and suppression of resistance is associated with survival in EGFR mutated NSCLC

Free
Li Zheng, Angel R. Baroz, Erminia Massarelli, Joy Huang, Ravi Salgia, Binghui Shen, Karen L. Reckamp
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5279.
https://doi.org/10.1158/1538-7445.AM2020-5279
Published: 15 August 2020
View articletitled, Abstract 5279: HSP72 expression and suppression of resistance is associated with survival in EGFR mutated NSCLC
Journal Articles

SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells

Free
Xiaoliang L. Xu, Zhengke Li, Aihong Liu, Xianqun Fan, Dan-ning Hu, Dong-Lai Qi, David W. Chitty, Renbing Jia, Jianping Qui, Justin Q. Wang, Jake Sharaf, Jun Zou, Rebecca Weiss, Hongyan Huang, Walter J. Joseph, Lily Ng, Richard Rosen, Binghui Shen, Mark W. Reid, Douglas Forrest, David H. Abramson, Samuel Singer, David Cobrinik, Suresh C. Jhanwar
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6838–6850.
https://doi.org/10.1158/0008-5472.CAN-16-3299
Published: 14 December 2017
View articletitled, SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells
Open the PDF for SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4777: Triptolide inhibits Wnt signaling due to DNA methylation alteration that is determined by dynamic histone 3 K79 lysine methylation in NSCLC

Free
Youqiang Li, Binghui Shen, Jae Kim, Dan Raz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4777.
https://doi.org/10.1158/1538-7445.AM2015-4777
Published: 01 August 2015
View articletitled, Abstract 4777: Triptolide inhibits Wnt signaling due to DNA methylation alteration that is determined by dynamic histone 3 K79 lysine methylation in NSCLC
Journal Articles

Functional Alterations of Human Exonuclease 1 Mutants Identified in Atypical Hereditary Nonpolyposis Colorectal Cancer Syndrome

Free
Xuemin Sun, Li Zheng, Binghui Shen
Journal: Cancer Research
Cancer Res (2002) 62 (21): 6026–6030.
Published: 01 November 2002
View articletitled, Functional Alterations of Human Exonuclease 1 Mutants Identified in Atypical Hereditary Nonpolyposis Colorectal Cancer Syndrome
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Journal Articles

Activation of Nuclear Factor κB in Radioresistance of TP53-inactive Human Keratinocytes

Free
Xufeng Chen, Binghui Shen, Liqun Xia, Alexander Khaletzkiy, David Chu, Jeffrey Y. C. Wong, Jian-Jian Li
Journal: Cancer Research
Cancer Res (2002) 62 (4): 1213–1221.
Published: 01 February 2002
View articletitled, Activation of Nuclear Factor κB in Radioresistance of TP53-inactive Human Keratinocytes
Open the PDF for Activation of Nuclear Factor κB in Radioresistance of TP53-inactive Human Keratinocytes in another window