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Journal Articles

Abstract RF02-02: BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS-driven PI3Kalpha activity without affecting glucose metabolism

Pedro Beltran, Simanshu Dhirendra, Rui Xu, Ming Chen, Daniel Czyzyk, Sofia Donovan, Siyu Feng, Cindy Feng, Lijuan Fu, Felice Lightstone, Ken Lin, Anna Maciag, Dwight Nissley, Erin Riegler, Kerstin Sinkevicius, Andrew Stephen, James Stice, David Turner, Bin Wang, Keshi Wang, Yue Yang, Cathy Zhang, Frank McCormick, Eli Wallace
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): RF02-02.
https://doi.org/10.1158/1538-7445.SABCS23-RF02-02
Published: 02 May 2024
View article titled, Abstract RF02-02: BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS-driven PI3Kalpha activity without affecting glucose metabolism
Journal Articles

Abstract LB333: Improved spatially resolved single-cell transcriptomic imaging in archival tissues with MERSCOPE

Jiang He, Bin Wang, Justin He, Renchao Chen, Benjamin Patterson, Sudhir Tattikota, Timothy Wiggin, Lizi Maziashvili, Peter Reinhold, Manisha Ray, George Emanuel
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB333.
https://doi.org/10.1158/1538-7445.AM2024-LB333
Published: 05 April 2024
View article titled, Abstract LB333: Improved spatially resolved single-cell transcriptomic imaging in archival tissues with MERSCOPE
Journal Articles

Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding

Anna E. Maciag, James Stice, Bin Wang, Alok Sharma, Albert Chan, Ken Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P. Smith, Dana Rabara, Zuhui Zhang, Erik K. Larsen, Dom Esposito, John Paul Denson, Michela Ranieri, Mary Meynardie, Sadaf Mehdizadeh, Patrick Alexander, Maria Abreu Blanco, David Turner, Rui Xu, Felice C. Lightstone, Kwok Kin Wong, Dhirendra Simanshu, Keshi Wang, Andrew G. Stephen, Kerstin Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Pedro J. Beltran
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND07.
https://doi.org/10.1158/1538-7445.AM2024-ND07
Published: 05 April 2024
View article titled, Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
Journal Articles

Abstract 2802: Enterococcus faecalis-derived X facilitates pancreatic tumor by regulating immune microenvironment

Bin Wang, Chao Yang, Yongjie Xie, Tianxing Zhou, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2802.
https://doi.org/10.1158/1538-7445.AM2024-2802
Published: 22 March 2024
View article titled, Abstract 2802: <em>Enterococcus faecalis</em>-derived X facilitates pancreatic tumor by regulating immune microenvironment
Journal Articles

Abstract 6404: GRB2 stabilizes RAD51 at reversed replication forks restricting genomic instability and associated innate immune response

Zamal Ahmed, Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A. Longo, Todd Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John Tainer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6404.
https://doi.org/10.1158/1538-7445.AM2024-6404
Published: 22 March 2024
View article titled, Abstract 6404: GRB2 stabilizes RAD51 at reversed replication forks restricting genomic instability and associated innate immune response
Journal Articles

Abstract 4533: Identification of DAT-2000A, a novel potent PARG inhibitor that selectively inhibits PARPi-resistant and homologous-recombination-deficient tumors

Dan Yan, Yan Zhang, Zhangqi Yu, Yao Zhang, Jingxi Zhang, Bin Wang, Huixian Chen, Jingxue Shi, Zhiwei Bao, Xiaoling Lin, Jincong Zhuo, Kevin Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4533.
https://doi.org/10.1158/1538-7445.AM2024-4533
Published: 22 March 2024
View article titled, Abstract 4533: Identification of DAT-2000A, a novel potent PARG inhibitor that selectively inhibits PARPi-resistant and homologous-recombination-deficient tumors
Journal Articles

Abstract 4532: Discovery of DAT-1000A, a potent Polθ inhibitor that significantly enhances anti-tumor efficacy in combination with PARP inhibitor in homologous-recombination-deficient tumors

Dan Yan, Yao Zhang, Yan Zhang, Jingxi Zhang, Bin Wang, Huixian Chen, Jingxue Shi, Xiaoling Lin, Jincong Zhuo, Kevin Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4532.
https://doi.org/10.1158/1538-7445.AM2024-4532
Published: 22 March 2024
View article titled, Abstract 4532: Discovery of DAT-1000A, a potent Polθ inhibitor that significantly enhances anti-tumor efficacy in combination with PARP inhibitor in homologous-recombination-deficient tumors
Journal Articles

Abstract 2367: STING agonist ADU-S100 improves the antitumor response of CLDN18.2/CD3 BiTEs by enhancing stem-like tumor-reactive CD8+ T cells in pancreatic adenocarcinoma

Tianxing Zhou, Jingrui Yan, Bin Wang, Yongjie Xie, Chao Yang, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2367.
https://doi.org/10.1158/1538-7445.AM2024-2367
Published: 22 March 2024
View article titled, Abstract 2367: STING agonist ADU-S100 improves the antitumor response of CLDN18.2/CD3 BiTEs by enhancing stem-like tumor-reactive CD8<sup>+</sup> T cells in pancreatic adenocarcinoma
Journal Articles

Abstract A018: GRB2 acts at reversed forks in the BRCA2-RAD51-MRE11 axis: a therapeutic target and enabling predictive biomarker for PARP inhibitor-immunotherapy combination

John A. Tainer, Katharina Schlacher, Bin Wang, Guang Peng, Zamal Ahmed
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): A018.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-A018
Published: 09 January 2024
View article titled, Abstract A018: GRB2 acts at reversed forks in the BRCA2-RAD51-MRE11 axis: a therapeutic target and enabling predictive biomarker for PARP inhibitor-immunotherapy combination
Journal Articles

Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer

Ru-Hong Tu, Sheng-Ze Wu, Ze-Ning Huang, Qing Zhong, Yin-Hua Ye, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Chang-Ming Huang, Mi Lin, Jun Lu, Long-Long Cao, Ping Li
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3868–3885.
https://doi.org/10.1158/0008-5472.CAN-23-1012
Published: 01 December 2023
View article titled, Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Open the PDF for Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3312: Comparison of risk factors to molecular risk stratification in Chinese early-stage non-squamous non-small cell lung cancer patients

Naixin Liang, Jianchao Xue, Ming Zhao, Bowen Li, Yadong Wang, Zhicheng Huang, Yankai Xia, Ruirui Li, Zhongxing Bing, Zhibo Zheng, Jianpeng Zhang, Bin Wang, Zhe Feng, Xinyu Liu, Haochen Li, Xiaoqing Yu, Yang Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3312.
https://doi.org/10.1158/1538-7445.AM2023-3312
Published: 04 April 2023
View article titled, Abstract 3312: Comparison of risk factors to molecular risk stratification in Chinese early-stage non-squamous non-small cell lung cancer patients
Journal Articles

Abstract P2-03-03: The comparison of genomic alteration characteristics of young women with breast cancer between Chinese and Western population

Hong Liu, Jinpu Yu, Zanmei Xu, Fei Wang, Yang Li, Siyue Zhang, Bin Wang, Beibei Yang, Xuesong Li
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-03-03.
https://doi.org/10.1158/1538-7445.SABCS21-P2-03-03
Published: 15 February 2022
View article titled, Abstract P2-03-03: The comparison of genomic alteration characteristics of young women with breast cancer between Chinese and Western population
Journal Articles

Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)

Shun Lu, Yiping Zhang, Guojun Zhang, Jianying Zhou, Shundong Cang, Ying Cheng, Gang Wu, Peiguo Cao, Dongqing Lv, Xiangming Jin, Hong Jian, Chengshui Chen, Guanming Jiang, Panwen Tian, Kai Wang, Hui Zhao, Gongyan Chen, Qun Chen, Cuimin Ding, Junquan Yang, Renhua Guo, Guoping Sun, Bin Wang, Liyan Jiang, Wu Zhuang, Zhe Liu, Jian Fang, Yunpeng Liu, Jian Zhang, Jun Chen, Yueyin Pan, Qitao Yu, Min Zhao, Jiuwei Cui, Dianming Li, Tienan Yi, Zhuang Yu, Yan Yang, Yan Zhang, Xiuyi Zhi, Yunchao Huang, Rong Wu, Liangan Chen, Aimin Zang, Lejie Cao, Qingshan Li, Xiaoling Li, Yong Song, Donglin Wang, Shucai Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT170.
https://doi.org/10.1158/1538-7445.AM2021-CT170
Published: 01 July 2021
View article titled, Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)
Journal Articles

Abstract 2173: Genomic mutation characteristics and clinical implications of breast cancer in different age groups

Hong Liu, Jinpu Yu, Zanmei Xu, Fei Wang, Yang Li, Siyue Zhang, Bin Wang, Beibei Yang, Weifeng Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2173.
https://doi.org/10.1158/1538-7445.AM2021-2173
Published: 01 July 2021
View article titled, Abstract 2173: Genomic mutation characteristics and clinical implications of breast cancer in different age groups
Journal Articles

MAFB Promotes Cancer Stemness and Tumorigenesis in Osteosarcoma through a Sox9-Mediated Positive Feedback Loop

Yanyan Chen, Tao Wang, Mengxi Huang, Qin Liu, Chao Hu, Bin Wang, Dong Han, Cheng Chen, Junliang Zhang, Zhiping Li, Chao Liu, Wenbin Lei, Yue Chang, Meijuan Wu, Dan Xiang, Yitian Chen, Rui Wang, Weiqian Huang, Zengjie Lei, Xiaoyuan Chu
Journal: Cancer Research
Cancer Res (2020) 80 (12): 2472–2483.
https://doi.org/10.1158/0008-5472.CAN-19-1764
Published: 15 June 2020
View article titled, MAFB Promotes Cancer Stemness and Tumorigenesis in Osteosarcoma through a Sox9-Mediated Positive Feedback Loop
Open the PDF for MAFB Promotes Cancer Stemness and Tumorigenesis in Osteosarcoma through a Sox9-Mediated Positive Feedback Loop in another window
Includes: Supplementary data
Journal Articles

BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail

Zhong-yi Qin, Tao Wang, Siyuan Su, Li-ting Shen, Guang-xi Zhu, Qin Liu, Liang Zhang, Ke-wei Liu, Yue Zhang, Zhi-hua Zhou, Xiao-ning Zhang, Liang-zhi Wen, Yue-liang Yao, Wen-jing Sun, Yan Guo, Kai-jun Liu, Lei Liu, Xing-wei Wang, Yan-ling Wei, Jun Wang, Hua-liang Xiao, Pengda Liu, Xiu-wu Bian, Dong-feng Chen, Bin Wang
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4869–4881.
https://doi.org/10.1158/0008-5472.CAN-19-0442
Published: 01 October 2019
View article titled, BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail
Open the PDF for BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail in another window
Includes: Supplementary data
Journal Articles

Abstract 1911: Bi-directional cross-talk of pancreatic cancer and stellate cells, mediated through CXCR4 and hedgehog pathways, promotes chemoresistance via its effect on gemcitabine metabolism, ROS detoxification and cancer stemness

Mohammad Aslam Khan, Girijesh K. Patel, Sanjeev K. Srivastava, Sumit Arora, Haseeb Zubair, James Elliot Carter, Bin Wang, Seema Singh, Moh’d Khushman, Ajay P. Singh
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1911.
https://doi.org/10.1158/1538-7445.AM2019-1911
Published: 01 July 2019
View article titled, Abstract 1911: Bi-directional cross-talk of pancreatic cancer and stellate cells, mediated through CXCR4 and hedgehog pathways, promotes chemoresistance via its effect on gemcitabine metabolism, ROS detoxification and cancer stemness
Journal Articles

Abstract 2609: A novel MYB-AR cross-talk promoting castration-resistance in prostate cancer

Sanjeev Kumar Srivastava, Haseeb Zubair, Girijesh K. Patel, Mohammad Aslam Khan, Sachin Kumar Deshmukh, Seema Sing, Joel Andrews, Bin Wang, James E. Carter, Ajay Pratap Singh
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2609.
https://doi.org/10.1158/1538-7445.AM2019-2609
Published: 01 July 2019
View article titled, Abstract 2609: A novel MYB-AR cross-talk promoting castration-resistance in prostate cancer
Journal Articles

Precise Spatiotemporal Interruption of Regulatory T-cell–Mediated CD8+ T-cell Suppression Leads to Tumor Immunity

Xiaoyu Zhou, Shushu Zhao, Yue He, Shuang Geng, Yan Shi, Bin Wang
Journal: Cancer Research
Cancer Res (2019) 79 (3): 585–597.
https://doi.org/10.1158/0008-5472.CAN-18-1250
Published: 01 February 2019
View article titled, Precise Spatiotemporal Interruption of Regulatory T-cell–Mediated CD8<sup>+</sup> T-cell Suppression Leads to Tumor Immunity
Open the PDF for Precise Spatiotemporal Interruption of Regulatory T-cell–Mediated CD8<sup>+</sup> T-cell Suppression Leads to Tumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract A090: Targeting androgen receptor (AR) variants in castration-resistant prostate cancer (CRPC) with a cancer-specific theranostic agent

Rey-Chen Pong, Bing Guan, Bin Wang, Guiyang Hao, Xiankai Sun, Yi-Qiang Cheng, Jer-Tsong Hsieh
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A090.
https://doi.org/10.1158/1538-7445.PRCA2017-A090
Published: 14 August 2018
View article titled, Abstract A090: Targeting androgen receptor (AR) variants in castration-resistant prostate cancer (CRPC) with a cancer-specific theranostic agent