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Journal Articles

Abstract CT116: A first-in-human phase 1 study on the safety, PK, receptor occupancy, and pharmacodynamic markers of SPX-303, a first-in-class LILRB2×PD-L1 bispecific antibody

Free
Justin Moser, Hao Xie, Yujie Zhao, Yousef Zakharia, Dongdong Li, Brandon William, Dinh-Duc Nguyen, Jack Hovey, Tiffany Li, Robert Cai, Jichun Ma, Jingdong Qin, Martin Siekierzycki, Anthony Haight, Hua Jin, Weiwei Mao, Kevin Bin Li, Gui-Dong Zhu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT116.
https://doi.org/10.1158/1538-7445.AM2025-CT116
Published: 25 April 2025
View articletitled, Abstract CT116: A first-in-human phase 1 study on the safety, PK, receptor occupancy, and pharmacodynamic markers of SPX-303, a first-in-class LILRB2×PD-L1 bispecific antibody
Journal Articles

Abstract 4249: IBI3019, a first-in-class EGFR/CDH17/CD16A tri-specific antibody, demonstrated potent efficacy against CRC and an excellent safety profile in preclinical studies

Free
Tiongsun Chia, Weiwei Wu, Li Li, Shuaixiang Zhou, Jia Lu, Shuming Lin, Ming Wu, Jia Liu, Feifei Wang, Ya Liu, Chenjuan Zhu, Ying Zhang, Yayao Yan, Huisi Liu, Jian Guan, Junjie Deng, Ninghuan Li, Zhihai Wu, Bin Li, Enhong Zhong, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4249.
https://doi.org/10.1158/1538-7445.AM2025-4249
Published: 21 April 2025
View articletitled, Abstract 4249: IBI3019, a first-in-class EGFR/CDH17/CD16A tri-specific antibody, demonstrated potent efficacy against CRC and an excellent safety profile in preclinical studies
Journal Articles

Abstract 3296: IK-595, a best-in-class MEK-RAF molecular glue, drives broad and potent anti-tumor activity across RAS-MAPK pathway-altered cancers as a monotherapy and in combination

Free
Eric Haines, Rachel Catterall, Victor De Jesus, Daniel Hidalgo, Jill Cavanaugh, Marta Sanchez-Martin, Joseph D. Manna, Michael Burke, Bin Li, Sarah R. Wessel, Ao Yang, Sergio Santillana, Jeffrey Ecsedy, X. Michelle Zhang, Sabine K. Ruppel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3296.
https://doi.org/10.1158/1538-7445.AM2024-3296
Published: 22 March 2024
View articletitled, Abstract 3296: IK-595, a best-in-class MEK-RAF molecular glue, drives broad and potent anti-tumor activity across RAS-MAPK pathway-altered cancers as a monotherapy and in combination
Journal Articles

Abstract 6706: An anti-claudin 18.2/CD3 bispecific antibody for the treatment of claudin 18.2 positive gastric cancer

Free
Lili Zhao, Guimin Zhang, Zhong Liu, Jinhua Xu, Lizhi Zhao, Guangyan Li, Bin Li, Zhongsong Zhu, Wei Peng, Yuqiang Zhu, Zhaowei Chen, Zhenyu Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6706.
https://doi.org/10.1158/1538-7445.AM2024-6706
Published: 22 March 2024
View articletitled, Abstract 6706: An anti-claudin 18.2/CD3 bispecific antibody for the treatment of claudin 18.2 positive gastric cancer
Journal Articles

Abstract 5871: Unveiling mechanisms of CDK4/6 inhibitor resistance in ER+ breast cancer models with acquired resistance

Free
Bin Li, Gaoxiang Liu, Ting Ni, Wenting Shi, Qingyang Gu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5871.
https://doi.org/10.1158/1538-7445.AM2024-5871
Published: 22 March 2024
View articletitled, Abstract 5871: Unveiling mechanisms of CDK4/6 inhibitor resistance in ER+ breast cancer models with acquired resistance
Journal Articles

Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci

Available to Purchase
Bin Li, Yimin Cai, Can Chen, Gaoyuan Li, Ming Zhang, Zequn Lu, Fuwei Zhang, Jinyu Huang, Linyun Fan, Caibo Ning, Yanmin Li, Wenzhuo Wang, Hui Geng, Yizhuo Liu, Shuoni Chen, Hanting Li, Shuhui Yang, Heng Zhang, Wen Tian, Zhongchao Zhu, Bin Xu, Heng Li, Haijie Li, Meng Jin, Xiaoyang Wang, Shaokai Zhang, Jiuyang Liu, Chaoqun Huang, Xiaojun Yang, Yongchang Wei, Ying Zhu, Jianbo Tian, Xiaoping Miao
Journal: Cancer Research
Cancer Res (2023) 83 (21): 3650–3666.
https://doi.org/10.1158/0008-5472.CAN-23-0251
Published: 01 November 2023
View articletitled, Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci
Open the PDF for Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci in another window
Includes: Supplementary data
Journal Articles

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Available to Purchase
Chun-Miao Deng, Guo-Geng Zhang, Qin-Wen Liu, Jiao-Jiao Xu, Zhi-Chao Liu, Jing Yang, Tao-Yang Xu, Zhi-Gang Li, Fan Zhang, Bin Li
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1851–1865.
https://doi.org/10.1158/0008-5472.CAN-22-3490
Published: 02 June 2023
View articletitled, ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis
Open the PDF for ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers

Free
Nathan Young, George Punkosdy, Jill Cavanaugh, Collin Bantle, Alex Constan, Bin Li, James Conley, Marta Sanchez-Martin, Lan Xu, Karen McGovern, Alfredo Castro, Michelle Zhang, Jeffrey Ecsedy
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2023-1646
Published: 04 April 2023
View articletitled, Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers
Journal Articles

Abstract 257: CDX model based genome-scale CRISPR KO screens for modulators of KRAS (G12C) inhibitor sensitivity

Free
Haixin Zhao, Fangzheng Zhai, Bin Li, Qiangqiang Fan, Zhengang Peng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 257.
https://doi.org/10.1158/1538-7445.AM2023-257
Published: 04 April 2023
View articletitled, Abstract 257: CDX model based genome-scale CRISPR KO screens for modulators of KRAS (G12C) inhibitor sensitivity
Journal Articles

Abstract 6332: A humanized anti-cd40 antibody with anti-tumor pharmacological activity and cynomolgus monkey safety

Free
Zhenyu Li, Lili Zhao, Guimin Zhang, Bin Li, Zhong Liu, Guangyan Li, Zhongsong Zhu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6332.
https://doi.org/10.1158/1538-7445.AM2023-6332
Published: 04 April 2023
View articletitled, Abstract 6332: A humanized anti-cd40 antibody with anti-tumor pharmacological activity and cynomolgus monkey safety
Journal Articles

Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3

Available to Purchase
Long Liao, Yan He, Shu-Jun Li, Guo-Geng Zhang, Wei Yu, Jing Yang, Zi-Jia Huang, Can-Can Zheng, Qing-Yu He, Yan Li, Bin Li
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2444–2457.
https://doi.org/10.1158/0008-5472.CAN-21-4124
Published: 05 July 2022
View articletitled, Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Open the PDF for Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3 in another window
Includes: Supplementary data
Journal Articles

Abstract 2989: FAP facilitates ovary tumorigenesis through the NF-κB/survivin funcational axis

Free
Bin Li, Shuang Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2989.
https://doi.org/10.1158/1538-7445.AM2022-2989
Published: 15 June 2022
View articletitled, Abstract 2989: FAP facilitates ovary tumorigenesis through the NF-κB/survivin funcational axis
Journal Articles

Abstract 6241: Macc1 regulates breast cancer progression and metastasis via remodeling tumor immune microenvironment

Free
Hye-Youn Son, Woo Hang Heo, Song Bin Li, Mingji Quan, Yu Jeong Her, Kyu-Jin Lee, Ju Hee Kim, Han-Byoel Lee, Wonshik Han, Hyeong-Gon Moon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6241.
https://doi.org/10.1158/1538-7445.AM2022-6241
Published: 15 June 2022
View articletitled, Abstract 6241: Macc1 regulates breast cancer progression and metastasis via remodeling tumor immune microenvironment
Journal Articles

Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk

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Jianbo Tian, Can Chen, Meilin Rao, Ming Zhang, Zequn Lu, Yimin Cai, Pingting Ying, Bin Li, Haoxue Wang, Lu Wang, Yao Li, Jinyu Huang, Linyun Fan, Xiaomin Cai, Caibo Ning, Yanmin Li, Fuwei Zhang, Wenzhuo Wang, Yuan Jiang, Yizhuo Liu, Min Wang, Heng Li, Chaoqun Huang, Zhiyong Yang, Jiang Chang, Ying Zhu, Xiaojun Yang, Xiaoping Miao
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2084–2096.
https://doi.org/10.1158/0008-5472.CAN-21-4367
Published: 06 June 2022
View articletitled, Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk
Open the PDF for Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk in another window
Includes: Supplementary data
Journal Articles

Abstract PD6-05: Characterization of the immune landscape of primary vs metastatic breast cancer in a real-world data cohort

Free
Aparna Chhibber, Kim Van Naarden Braun, Celine Han, Han Chang, Mustimbo Roberts, Bin Li
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD6-05.
https://doi.org/10.1158/1538-7445.SABCS21-PD6-05
Published: 15 February 2022
View articletitled, Abstract PD6-05: Characterization of the immune landscape of primary vs metastatic breast cancer in a real-world data cohort
Journal Articles

Abstract LB015: Clinical evaluation of The Paris System-based artificial intelligence algorithm for reporting urinary cytopathology

Free
Wei-Lei Yang, Jen-Fan Hang, Chi-Bin Li, Ching-Ming Lee, Yi-Sheng Lin, Tang-Yi Tsao, Ming-Chen Chang, Yen-Chuan Ou, Tien-Jen Liu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB015.
https://doi.org/10.1158/1538-7445.AM2021-LB015
Published: 01 July 2021
View articletitled, Abstract LB015: Clinical evaluation of The Paris System-based artificial intelligence algorithm for reporting urinary cytopathology
Journal Articles

Abstract 1625: Distribution and prevalence of LAG-3 expression in samples of melanoma and gastric/gastroesophageal junction cancer

Free
Lloye M. Dillon, John Wojcik, Keyur Desai, Ming Lei, Lori Johnson, Bryan McCune, Krystal Johnson, Jeffrey Shuster, Steven M. Anderson, Bin Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1625.
https://doi.org/10.1158/1538-7445.AM2021-1625
Published: 01 July 2021
View articletitled, Abstract 1625: Distribution and prevalence of LAG-3 expression in samples of melanoma and gastric/gastroesophageal junction cancer
Journal Articles

Abstract CT150: Humanized CD19 CAR-T cells in the treatment of relapsed and refractory diffuse large B-cell lymphoma: A case report

Free
Tan Li, Yi Wang, Bin Li, Xueying Hu, Liu Liu, Yangyi Bao, Qiao Li, Lin Yang, Hongxia Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT150.
https://doi.org/10.1158/1538-7445.AM2021-CT150
Published: 01 July 2021
View articletitled, Abstract CT150: Humanized CD19 CAR-T cells in the treatment of relapsed and refractory diffuse large B-cell lymphoma: A case report
Journal Articles

Abstract 5477: A novel loci-selected method for microsatellite instability detection validated on a large Chinese cohort

Free
Jian Li, Zhenghang Wang, Bo Yang, Bin Li, Yunjie Song, Bei Zhang, Xiaochen Zhao, Yifan Zhou, Zhenghua Xie, Xiaofang Li, Hao Chen, Hua Dong, Yuezong Bai, Lei Xiong, Fugen Li, Jing Gao, Lin Shen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5477.
https://doi.org/10.1158/1538-7445.AM2020-5477
Published: 15 August 2020
View articletitled, Abstract 5477: A novel loci-selected method for microsatellite instability detection validated on a large Chinese cohort
Journal Articles

Abstract 1912: Study on the role of targeting ERBB and its potential resistance mechanism in biliary tract cancer

Free
Feiling Feng, Qingbao Cheng, Dadong Zhang, Chen Liu, Xiaoya Xu, Bin Li, Huizhen Wang, Yong Yu, Bin Li, Xiaobing Wu, Jun Zhou, Kaijian Chu, Zhenghua Xie, Qingxiang Gao, Lei Xiong, Fugen Li, Bin Yi, Xiaoqing Jiang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1912.
https://doi.org/10.1158/1538-7445.AM2020-1912
Published: 15 August 2020
View articletitled, Abstract 1912: Study on the role of targeting ERBB and its potential resistance mechanism in biliary tract cancer