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Journal Articles

Abstract 6790: Exploring sensitivity and resistance to proteasome inhibitors in TP53 mutated non-small cell lung carcinoma

Free
Victoria Neely, Kranthi Kumar Chougoni, Bin Hu, Jennifer E. Koblinski, Guangrong Zheng, Daohong Zhou, Swati Palit Deb, Sumitra Deb, Jorge J. Nieva, Senthil K. Radhakrishnan, Steven R. Grossman, Hisashi Harada
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6790.
https://doi.org/10.1158/1538-7445.AM2025-6790
Published: 21 April 2025
View articletitled, Abstract 6790: Exploring sensitivity and resistance to proteasome inhibitors in TP53 mutated non-small cell lung carcinoma
Journal Articles

Abstract 49: Genetic, genomic, and pharmacologic characterization of a new cohort of ancestrally diverse patient-derived xenograft models of cancer

Free
Nina M. Dashti-Gibson, Amy L. Olex, Katarzyna M. Tyc, Carson J. Walker, Oniya M. Smith, Rachel K. Myrick, Bin Hu, Praveen Bhoopathi, Madhavi Puchalapalli, Li Wang, Yue Zhang, Brydon P. Wall, Valentina Robila, Mikhail G. Dozmorov, Jinze Liu, Jennifer E. Koblinski, Jose G. Trevino, J Chuck Harrell
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 49.
https://doi.org/10.1158/1538-7445.AM2025-49
Published: 21 April 2025
View articletitled, Abstract 49: Genetic, genomic, and pharmacologic characterization of a new cohort of ancestrally diverse patient-derived xenograft models of cancer
Journal Articles

The Innate Immune System and the TRAIL–Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females

Available to Purchase
Lauren May, Bin Hu, Preksha Jerajani, Akash Jagdeesh, Ohud Alhawiti, Lillian Cai, Nina Semenova, Chunqing Guo, Madison Isbell, Xiaoyan Deng, Anthony C. Faber, Raghavendra Pillappa, Dipankar Bandyopadhyay, Xiang-Yang Wang, Alexander Neuwelt, Jennifer Koblinski, Paula D. Bos, Howard Li, Rebecca Martin, Joseph W. Landry
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4140–4155.
https://doi.org/10.1158/0008-5472.CAN-24-0585
Published: 16 December 2024
View articletitled, The Innate Immune System and the TRAIL–Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females
Open the PDF for The Innate Immune System and the TRAIL–Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females in another window
Includes: Supplementary data
Journal Articles

Abstract 1750: Decoding breast cancer: Unraveling subtype and model differences through multi-model single-cell RNA sequencing data integration

Free
Julia E. Altman, Carson J. Walker, Emily K. Zboril, Nicole S. Hairr, Rachel K. Myrick, David C. Boyd, Jennifer E. Koblenski, Madhavi Puchalapalli, Bin Hu, Mikhail G. Dozmorov, Xi Chen, Yunshun Chen, Charles M. Perou, Brian D. Lehmann, Jane E. Visvader, Amy L. Olex, J. Chuck Harrell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1750.
https://doi.org/10.1158/1538-7445.AM2024-1750
Published: 22 March 2024
View articletitled, Abstract 1750: Decoding breast cancer: Unraveling subtype and model differences through multi-model single-cell RNA sequencing data integration
Journal Articles

Abstract 7071: Pharmacological targeting of SUMOylation leads to cBAF complex stabilization and disruption of the synovial sarcoma signature

Free
Konstantinos V. Floros, Jinxiu Li, Jane L. Roberts, Richard Kurupi, Carter K. Fairchild, Bin Hu, Yanli Xing, Krista M. Dalton, Sosipatros A. Boikos, Angeliki M. Stamatouli, Mikhail G. Dozmorov, Jennifer E. Koblinski, Kevin B. Jones, Senthil K. Radhakrishnan, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7071.
https://doi.org/10.1158/1538-7445.AM2024-7071
Published: 22 March 2024
View articletitled, Abstract 7071: Pharmacological targeting of SUMOylation leads to cBAF complex stabilization and disruption of the synovial sarcoma signature
Journal Articles

Abstract 1986: Acquisition of carboplatin resistance corresponds with reduced sacituzumab govitecan efficacy in triple negative breast cancer patient derived xenografts

Free
Carson J. Walker, Julia E. Altman, Emily K. Zboril, Rachel K. Myrick, Nicole S. Hairr, David C. Boyd, Bin Hu, Mikhail G. Dozmorov, J. Chuck Harrell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1986.
https://doi.org/10.1158/1538-7445.AM2024-1986
Published: 22 March 2024
View articletitled, Abstract 1986: Acquisition of carboplatin resistance corresponds with reduced sacituzumab govitecan efficacy in triple negative breast cancer patient derived xenografts
Journal Articles

Abstract 3950: Sensitizing oncogenic mutant p53-expressing non-small cell lung cancer to proteasome inhibitors

Free
Kranthi Kumar Chougoni, Victoria L. Neely, Boxiao Ding, Eziafa Oduah, Khanh Nguyen, Bin Hu, Jennifer Koblinski, Bradford Windle, Hisashi Harada, Steven Grossman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3950.
https://doi.org/10.1158/1538-7445.AM2023-3950
Published: 04 April 2023
View articletitled, Abstract 3950: Sensitizing oncogenic mutant p53-expressing non-small cell lung cancer to proteasome inhibitors
Journal Articles

Abstract 362: MYCN-amplified neuroblastoma is addicted to iron and vulnerable to ferroptosis

Free
Konstantinos V. Floros, Mia O. Johnson-Berro, Richard Kurupi, Carter K. Fairchild, Krista Dalton, Bin Hu, Madhavi Puchalapalli, Mikhail G. Dozmorov, Jennifer E. Koblinski, James A. Olzmann, Lauren A. Cowart, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 362.
https://doi.org/10.1158/1538-7445.AM2022-362
Published: 15 June 2022
View articletitled, Abstract 362: MYCN-amplified neuroblastoma is addicted to iron and vulnerable to ferroptosis
Journal Articles

Abstract 5499: Efficacy of icotinib as adjuvant therapy for patients with stage IIA-IIIA EGFR-mutant non-small-cell lung adenocarcinoma: a multicenter, open-label, single-arm, phase II study (ICAPE)

Free
Kun Qian, Bin Hu, Ming He, Zi-Tong Wang, Yu Liu, Hua-Gang Liang, Zhi-Yong Su, Yu-Shang Cui, Li-Jun Liu, Yi Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5499.
https://doi.org/10.1158/1538-7445.AM2022-5499
Published: 15 June 2022
View articletitled, Abstract 5499: Efficacy of icotinib as adjuvant therapy for patients with stage IIA-IIIA EGFR-mutant non-small-cell lung adenocarcinoma: a multicenter, open-label, single-arm, phase II study (ICAPE)
Journal Articles

Abstract 3148: A novel mechanism of glioblastoma cell invasion regulated by a neural proteoglycan that activates Src/EGFR signaling and mediates tumor-astroglia cooperation

Free
Somanath Kundu, Hosung Sim, Bin Hu, Mohan S. Nandhu, Russell T. Matthews, Mariano S. Viapiano
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3148.
https://doi.org/10.1158/1538-7445.AM2021-3148
Published: 01 July 2021
View articletitled, Abstract 3148: A novel mechanism of glioblastoma cell invasion regulated by a neural proteoglycan that activates Src/EGFR signaling and mediates tumor-astroglia cooperation
Journal Articles

MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

Free
Konstantinos V. Floros, JinYang Cai, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, Benjamin R. Belvin, Bin Hu, Madhavi Puchalapalli, Sivapriya Ramamoorthy, Kimberly Swift, Janina P. Lewis, Mikhail G. Dozmorov, John Glod, Jennifer E. Koblinski, Sosipatros A. Boikos, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1896–1908.
https://doi.org/10.1158/0008-5472.CAN-20-1641
Published: 01 April 2021
View articletitled, MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis
Open the PDF for MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis in another window
Includes: Supplementary data
Journal Articles

Abstract PO-024: Catastrophic ATP loss underlines a metabolic combination therapy tailored for MYCN-amplified neuroblastoma

Free
Krista M. Powell, Timonthy L. Lochmann, Konstantinos V. Floros, Marissa L. Calbert, Richard Kurupi, Giovanna T. Stein, Joseph McClanaghan, Ellen Murchie, Regina K. Egan, Patricia Greninger, Mikhail Dozmorov, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Lisa Shock, Jennifer Koblisnski, John Glod, Sosipatros A. Boikos, Cyril H. Benes, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-024.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-024
Published: 02 December 2020
View articletitled, Abstract PO-024: Catastrophic ATP loss underlines a metabolic combination therapy tailored for MYCN-amplified neuroblastoma
Journal Articles

Abstract 2443: miR-146a methylation regulates proliferation and metastasis by targeted activation of VASN/TGF-beta signaling pathway in colorectal cancer

Free
Weiwei Tang, Dan Zhou, Hanxiang An, Jiapeng Kang, Mingquan Cai, Ru Zeng, Jing Song, Bin Hu, Jiabian Lian, Qin Lin, Lilin Chen, Feng Ye
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2443.
https://doi.org/10.1158/1538-7445.AM2020-2443
Published: 15 August 2020
View articletitled, Abstract 2443: miR-146a methylation regulates proliferation and metastasis by targeted activation of VASN/TGF-beta signaling pathway in colorectal cancer
Journal Articles

Abstract LB-176: Transcriptome-wide association study revealed a novel gene associated with persistent hepatitis B virus infection among Chinese

Free
Jing Han, Jing Ni, Meng Zhu, Jin Guang Fu, Zhi Bin Hu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-176.
https://doi.org/10.1158/1538-7445.AM2019-LB-176
Published: 01 July 2019
View articletitled, Abstract LB-176: Transcriptome-wide association study revealed a novel gene associated with persistent hepatitis B virus infection among Chinese
Journal Articles

Abstract 47: Brain metastatic versus non-metastatic breast cancer exosomes influence astrocyte response

Free
Megan Sayyad, Madhavi Puchalapalli, Bin Hu, Jennifer Koblinski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 47.
https://doi.org/10.1158/1538-7445.AM2018-47
Published: 01 July 2018
View articletitled, Abstract 47: Brain metastatic versus non-metastatic breast cancer exosomes influence astrocyte response
Journal Articles

A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy

Available to Purchase
Chuanzhen Yang, Weicheng Zang, Zefang Tang, Yapeng Ji, Ruidan Xu, Yongfeng Yang, Aiping Luo, Bin Hu, Zemin Zhang, Zhihua Liu, Xiaofeng Zheng
Journal: Cancer Research
Cancer Res (2018) 78 (4): 1069–1082.
https://doi.org/10.1158/0008-5472.CAN-17-2143
Published: 14 February 2018
View articletitled, A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy
Open the PDF for A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 3058: Syndecan-1 mediates breast cancer metastasis to the brain through IL-8 and PECAM-1 signaling

Free
Sierra Mosticone Wangensteen, Megan Sayyad, Madhavi Puchalapalli, Megan Sullivan, Jamie Singh, Briana Ratchford, Jayda Abrams, Majid Jahromi, Bin Hu, Michael Idowu, Jennifer Koblinski
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3058.
https://doi.org/10.1158/1538-7445.AM2017-3058
Published: 01 July 2017
View articletitled, Abstract 3058: Syndecan-1 mediates breast cancer metastasis to the brain through IL-8 and PECAM-1 signaling
Journal Articles

Abstract 3082: Deficient NOXA in HER2-amplified breast cancer drives kinase inhibitor resistance

Free
Konstantinos V. Floros, Kyung-A Song, Timothy L. Lochmann, Mark T. Hughes, Daniel A. Heisey, Hisashi Harada, Bin Hu, Jennifer Koblinski, Andrew J. Souers, Joel D. Leverson, Anthony C. Faber
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3082.
https://doi.org/10.1158/1538-7445.AM2017-3082
Published: 01 July 2017
View articletitled, Abstract 3082: Deficient NOXA in HER2-amplified breast cancer drives kinase inhibitor resistance
Journal Articles

Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis

Available to Purchase
Bin Hu, Luni Emdad, Manny D. Bacolod, Timothy P. Kegelman, Xue-Ning Shen, Mohammad A. Alzubi, Swadesh K. Das, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7321–7332.
https://doi.org/10.1158/0008-5472.CAN-13-2978
Published: 14 December 2014
View articletitled, Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis
Open the PDF for Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis in another window
Includes: Supplementary data
Journal Articles

Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas

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Mohan S. Nandhu, Bin Hu, Susan E. Cole, Anat Erdreich-Epstein, Diego J. Rodriguez-Gil, Mariano S. Viapiano
Journal: Cancer Research
Cancer Res (2014) 74 (19): 5435–5448.
https://doi.org/10.1158/0008-5472.CAN-14-0685
Published: 30 September 2014
View articletitled, Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Open the PDF for Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas in another window
Includes: Multimedia, Supplementary data