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Abstract 3161: High throughput drug screening to uncover molecular vulnerabilities in pancreatic ductal adenocarcinoma

Nikta Feizi, Eugenia Flores-Figueroa, Karen Ng, Zhen-Mei Liu, Farnoosh Abbas Aghababazadeh, Gun Ho Jang, Daniela Bevacqua, Stephanie Ramotar, Shawn Hutchinson, Anna Dodd, Julie Wilson, Robert Grant, Ronan Mclaughlin, Erica Tsang, Jennifer Knox, Steven Gallinger, Benjamin Haibe-Kains, Faiyaz Notta

Cancer Res (2025) 85 (8_Supplement_1): 3161.

https://doi.org/10.1158/1538-7445.AM2025-3161

Published: 21 April 2025

View articletitled, Abstract 3161: High throughput drug screening to uncover molecular vulnerabilities in pancreatic ductal adenocarcinoma

Journal Articles

Abstract 2060: Independent validation of endogenous retrotransposable elements as predictive biomarkers of immune checkpoint blockade response

Cancer Res (2025) 85 (8_Supplement_1): 2060.

https://doi.org/10.1158/1538-7445.AM2025-2060

Published: 21 April 2025

View articletitled, Abstract 2060: Independent validation of endogenous retrotransposable elements as predictive biomarkers of immune checkpoint blockade response

Journal Articles

Abstract 3896: Multi-omic and multi-region profiling of uterine leiomyoma reveals intra- and inter-tumor heterogeneity

Chelsea De Bellis, Sujay Vennam, Christopher Eeles, Philippe Jolivet, Deirdre Lum, Benjamin Haibe-Kains, Matt van de Rijn, Joanna Przybyl

Cancer Res (2025) 85 (8_Supplement_1): 3896.

https://doi.org/10.1158/1538-7445.AM2025-3896

Published: 21 April 2025

View articletitled, Abstract 3896: Multi-omic and multi-region profiling of uterine leiomyoma reveals intra- and inter-tumor heterogeneity

Journal Articles

Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T-cell Pyrimidine Synthesis

David Allard, Jeanne Cormery, Salma Bricha, Camille Fuselier, Farnoosh Abbas Aghababazadeh, Lucie Giraud, Emma Skora, Benjamin Haibe-Kains, John Stagg

Cancer Res (2025) 85 (4): 692–703.

https://doi.org/10.1158/0008-5472.CAN-24-1875

Published: 17 February 2025

View articletitled, Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T-cell Pyrimidine Synthesis

Includes: Supplementary data

Journal Articles

Abstract C059: Hub gene analysis identifies CAD as a potential mediator for drug resistance in pancreatic cancer

Foram Vyas, Barbara Grünwald, Kazeera Aliar, Gun Ho Jang, Grainne O'Kane, Thomas Kislinger, Steven Gallinger, Benjamin Haibe-Kains, Rama Khokha

Cancer Res (2024) 84 (2_Supplement): C059.

https://doi.org/10.1158/1538-7445.PANCA2023-C059

Published: 16 January 2024

View articletitled, Abstract C059: Hub gene analysis identifies CAD as a potential mediator for drug resistance in pancreatic cancer

Journal Articles

Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity

Wail Ba-Alawi, Sisira Kadambat Nair, Bo Li, Anthony Mammoliti, Petr Smirnov, Arvind Singh Mer, Linda Z. Penn, Benjamin Haibe-Kains

Cancer Res (2022) 82 (13): 2378–2387.

https://doi.org/10.1158/0008-5472.CAN-21-2395

Published: 05 July 2022

View articletitled, Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity

Includes: Supplementary data

Journal Articles

Abstract LB519: Bimodality of gene expression in cancer patients as interpretable biomarkers for drug sensitivity

Benjamin Haibe-Kains, Wail Ba-alawi

Cancer Res (2022) 82 (12_Supplement): LB519.

https://doi.org/10.1158/1538-7445.AM2022-LB519

Published: 15 June 2022

View articletitled, Abstract LB519: Bimodality of gene expression in cancer patients as interpretable biomarkers for drug sensitivity

Journal Articles

Abstract 1356: Meta-analysis and lack of independence assumption: Application in biomarker discovery

Farnoosh Abbas-Aghababazadeh, Benjamin Haibe-Kains

Cancer Res (2021) 81 (13_Supplement): 1356.

https://doi.org/10.1158/1538-7445.AM2021-1356

Published: 01 July 2021

View articletitled, Abstract 1356: Meta-analysis and lack of independence assumption: Application in biomarker discovery

Journal Articles

Abstract 3401: Targeting lysosomal homeostasis in ovarian cancer through drug repurposing

Stefano Marastoni, Aleksandra Pesic, Sree Narayanan Nair, Zhu Juan Li, Ali Madani, Benjamin Haibe-Kains, Bradly G. Wouters, Anthony Joshua

Cancer Res (2020) 80 (16_Supplement): 3401.

https://doi.org/10.1158/1538-7445.AM2020-3401

Published: 15 August 2020

View articletitled, Abstract 3401: Targeting lysosomal homeostasis in ovarian cancer through drug repurposing

Journal Articles

Modeling Cellular Response in Large-Scale Radiogenomic Databases to Advance Precision Radiotherapy

Venkata SK. Manem, Meghan Lambie, Ian Smith, Petr Smirnov, Victor Kofia, Mark Freeman, Marianne Koritzinsky, Mohamed E. Abazeed, Benjamin Haibe-Kains, Scott V. Bratman

Cancer Res (2019) 79 (24): 6227–6237.

https://doi.org/10.1158/0008-5472.CAN-19-0179

Published: 13 December 2019

View articletitled, Modeling Cellular Response in Large-Scale Radiogenomic Databases to Advance Precision Radiotherapy

Includes: Supplementary data

Journal Articles

Abstract B46: Targeting pancreatic cancer organoids with dual BET and CBP/P300 inhibitor NEO2734

Nikolina Radulovich, Laura Tamblyn, Heewon Seo, Benjamin Haibe-Kains, Mathieu Lupien, Francis Gilles, Ming S. Tsao

Cancer Res (2019) 79 (24_Supplement): B46.

https://doi.org/10.1158/1538-7445.PANCA19-B46

Published: 13 December 2019

View articletitled, Abstract B46: Targeting pancreatic cancer organoids with dual BET and CBP/P300 inhibitor NEO2734

Journal Articles

Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts

Arvind S. Mer, Wail Ba-Alawi, Petr Smirnov, Yi X. Wang, Ben Brew, Janosch Ortmann, Ming-Sound Tsao, David W. Cescon, Anna Goldenberg, Benjamin Haibe-Kains

Cancer Res (2019) 79 (17): 4539–4550.

https://doi.org/10.1158/0008-5472.CAN-19-0349

Published: 03 September 2019

View articletitled, Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts

Includes: Supplementary data

Journal Articles

Abstract 967: Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells

Laura M. Richards, Owen Whitley, Florence M. Cavalli, Zhaleh Safikhani, Fiona Coutinho, H. Artee Luchman, Benjamin Haibe-Kains, Samuel Weiss, Peter Dirks, Gary Bader, Trevor J. Pugh

Cancer Res (2019) 79 (13_Supplement): 967.

https://doi.org/10.1158/1538-7445.AM2019-967

Published: 01 July 2019

View articletitled, Abstract 967: Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells

Journal Articles

Abstract 3378: Systematic pharmacogenomic analysis of large patient derived xenografts data

Arvind Singh Mer, Wail Ba-alawi, Petr Smirnov, Yi Xiao Wang, Ben Brew, Ming-Sound Tsao, David Cescon, Anna Goldenberg, Benjamin Haibe-Kains

Cancer Res (2019) 79 (13_Supplement): 3378.

https://doi.org/10.1158/1538-7445.AM2019-3378

Published: 01 July 2019

View articletitled, Abstract 3378: Systematic pharmacogenomic analysis of large patient derived xenografts data

Journal Articles

Abstract 3211: Therapeutic effects of radiotherapy on cancer cell lines using RadioGx computational platform

Venkata S. Manem, Meghan Lambie, Petr Smirnov, Mark Freeman, Victor Kofia, Mohamed E. Abazeed, Scott V. Bratman, Benjamin Haibe-Kains

Cancer Res (2018) 78 (13_Supplement): 3211.

https://doi.org/10.1158/1538-7445.AM2018-3211

Published: 01 July 2018

View articletitled, Abstract 3211: Therapeutic effects of radiotherapy on cancer cell lines using RadioGx computational platform

Journal Articles

Abstract 4623: Meta-analysis of transcriptomic profiles identifies prognostic model for pancreatic ductal adenocarcinoma patients

Vandana Sandhu, Knut Jorgen Labori, Ayelet Borgida, Ilinca Lungu, John Bartlett, Sara Hafezi-Bakhtiari, Rob Denroche, Gun Ho Jang, Danielle Pasternack, Faridah Mbaabali, Matthew Watson, Julie Wilson, Elin H. Kure, Steven Gallinger, Benjamin Haibe-Kains

Cancer Res (2018) 78 (13_Supplement): 4623.

https://doi.org/10.1158/1538-7445.AM2018-4623

Published: 01 July 2018

View articletitled, Abstract 4623: Meta-analysis of transcriptomic profiles identifies prognostic model for pancreatic ductal adenocarcinoma patients

Journal Articles

Abstract 854: Validation of a viability assay for assessing radiation response and investigating drug/radiation combinations

Meghan Lambie, Venkata S. Manem, Benjamin Haibe-Kains, Scott V. Bratman

Cancer Res (2018) 78 (13_Supplement): 854.

https://doi.org/10.1158/1538-7445.AM2018-854

Published: 01 July 2018

View articletitled, Abstract 854: Validation of a viability assay for assessing radiation response and investigating drug/radiation combinations

Journal Articles

CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities

Venkata Manem, George Alexandru Adam, Tina Gruosso, Mathieu Gigoux, Nicholas Bertos, Morag Park, Benjamin Haibe-Kains

Cancer Res (2018) 78 (8): 2140–2143.

https://doi.org/10.1158/0008-5472.CAN-17-1383

Published: 15 April 2018

View articletitled, CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities

Includes: Multimedia, Supplementary data

Journal Articles

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Peter J. Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains, Linda Z. Penn

Cancer Res (2018) 78 (5): 1347–1357.

https://doi.org/10.1158/0008-5472.CAN-17-1231

Published: 28 February 2018

View articletitled, Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Includes: Supplementary data

Journal Articles

Software for the Integration of Multiomics Experiments in Bioconductor

Cancer Res (2017) 77 (21): e39–e42.

https://doi.org/10.1158/0008-5472.CAN-17-0344

Published: 01 November 2017

View articletitled, Software for the Integration of Multiomics Experiments in Bioconductor

Includes: Multimedia, Supplementary data

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Abstract 3161: High throughput drug screening to uncover molecular vulnerabilities in pancreatic ductal adenocarcinoma

Abstract 2060: Independent validation of endogenous retrotransposable elements as predictive biomarkers of immune checkpoint blockade response

Abstract 3896: Multi-omic and multi-region profiling of uterine leiomyoma reveals intra- and inter-tumor heterogeneity

Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T-cell Pyrimidine Synthesis

Abstract C059: Hub gene analysis identifies CAD as a potential mediator for drug resistance in pancreatic cancer

Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity

Abstract LB519: Bimodality of gene expression in cancer patients as interpretable biomarkers for drug sensitivity

Abstract 1356: Meta-analysis and lack of independence assumption: Application in biomarker discovery

Abstract 3401: Targeting lysosomal homeostasis in ovarian cancer through drug repurposing

Modeling Cellular Response in Large-Scale Radiogenomic Databases to Advance Precision Radiotherapy

Abstract B46: Targeting pancreatic cancer organoids with dual BET and CBP/P300 inhibitor NEO2734

Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts

Abstract 967: Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells

Abstract 3378: Systematic pharmacogenomic analysis of large patient derived xenografts data

Abstract 3211: Therapeutic effects of radiotherapy on cancer cell lines using RadioGx computational platform

Abstract 4623: Meta-analysis of transcriptomic profiles identifies prognostic model for pancreatic ductal adenocarcinoma patients

Abstract 854: Validation of a viability assay for assessing radiation response and investigating drug/radiation combinations

CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Software for the Integration of Multiomics Experiments in Bioconductor

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