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Journal Articles

Abstract 659: Mechanisms of resistance to SHP2 inhibition

Wei Wei, Mitchell Geer, Xinyi Guo, Neville Sanjana, Benjamin G. Neel

Cancer Res (2022) 82 (12_Supplement): 659.

DOI: https://doi.org/10.1158/1538-7445.AM2022-659

Published: 15 June 2022

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Journal Articles

Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma

Yang Xu, Paul Taylor, Joshua Andrade, Beatrix Ueberheide, Brian Shuch, Peter M. Glazer, Ranjit S. Bindra, Michael F. Moran, W. Marston Linehan, Benjamin G. Neel

Cancer Res (2018) 78 (23): 6539–6548.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-0901

Published: 03 December 2018

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Includes: Supplementary data

Journal Articles

Abstract LB-338: SHP2 inhibition enhances sensitivity to MEK inhibitors in multiple resistant cancer models

Carmine Fedele, Kwan Ho Tang, Hao Ran, Wei Wei, Brian Diskin, George Miller, Benjamin G. Neel

Cancer Res (2018) 78 (13_Supplement): LB-338.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-338

Published: 01 July 2018

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Journal Articles

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Samantha Le Sommer, Nicola Morrice, Martina Pesaresi, Dawn Thompson, Mark A. Vickers, Graeme I. Murray, Nimesh Mody, Benjamin G. Neel, Kendra K. Bence, Heather M. Wilson, Mirela Delibegović

Cancer Res (2018) 78 (1): 75–87.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-0946

Published: 02 January 2018

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Includes: Supplementary data

Journal Articles

Abstract A2-07: Integrative functional genomics of breast cancer

Richard Marcotte, Azin Sayad, Cathy Iorio, Jason Moffat, Benjamin G. Neel

Cancer Res (2015) 75 (22_Supplement_1): A2-07.

DOI: https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-07

Published: 15 November 2015

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Journal Articles

Abstract PR14: Integrative functional genomics of breast cancer

Richard Marcotte, Azin Sayad, Cathy Iorio, Jason Moffat, Benjamin G. Neel

Cancer Res (2015) 75 (22_Supplement_2): PR14.

DOI: https://doi.org/10.1158/1538-7445.COMPSYSBIO-PR14

Published: 15 November 2015

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Journal Articles

Abstract B2-06: Computational modeling of serous ovarian carcinoma dynamics: Implications for screening and therapy

Shengqing Gu, Stephanie Lheureux, Azin Sayad, Liat Frida Hogen, Iryna Vyarvelska, Paulina Cybulska, Marcus Bernardini, Barry Rosen, Amit Oza, Benjamin G. Neel

Cancer Res (2015) 75 (22_Supplement_2): B2-06.

DOI: https://doi.org/10.1158/1538-7445.COMPSYSBIO-B2-06

Published: 15 November 2015

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Journal Articles

Abstract LB-302: PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia

Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Ankit Sinha, Toshiaki Hitomi, Toshiyuki Habu, Akio Koizumi, Sarah Wilkins, Thomas Kislinger, Christopher J. Schofield, James W. Dennis, Bradly G. Wouters, Benjamin G. Neel

Cancer Res (2015) 75 (15_Supplement): LB-302.

DOI: https://doi.org/10.1158/1538-7445.AM2015-LB-302

Published: 01 August 2015

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Journal Articles

Abstract LB-307: Computational modeling of serous ovarian carcinoma dynamics: Implications for screening and therapy

Shengqing Gu, Liat Hogen, Stephanie Lheureux, Azin Sayad, Iryna Vyarvelska, Paulina Cybulska, Marcus Bernardini, Barry Rosen, Amit Oza, Benjamin G. Neel

Cancer Res (2015) 75 (15_Supplement): LB-307.

DOI: https://doi.org/10.1158/1538-7445.AM2015-LB-307

Published: 01 August 2015

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Journal Articles

Abstract B43: Role of activated SHP2 in high-risk neuroblastoma pathogenesis

(Jane) shizhen Zhu, Benjamin G. Neel, A. Thomas Look

Cancer Res (2014) 74 (20_Supplement): B43.

DOI: https://doi.org/10.1158/1538-7445.PEDCAN-B43

Published: 09 October 2014

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Journal Articles

Abstract 80: Activated SHP2 collaborates with MYCN in neuroblastoma tumorigenesis

Xiaoling Zhang, Guang Yang, A.Thomas Look, Benjamin G. Neel, Shizhen (Jane) Zhu

Cancer Res (2014) 74 (19_Supplement): 80.

DOI: https://doi.org/10.1158/1538-7445.AM2014-80

Published: 01 October 2014

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Journal Articles

Abstract SY35-02: Phenotypic heterogeneity and instability of human serous ovarian cancer tumor-initiating cells

Benjamin G. Neel, Jocelyn M. Stewart, Bernd Bodenmiller, Laurie Ailles, Craig Gedye, Marcus Bernardini, Patricia A. Shaw, Wendy Fantl, Garry P. Nolan

Cancer Res (2012) 72 (8_Supplement): SY35-02.

DOI: https://doi.org/10.1158/1538-7445.AM2012-SY35-02

Published: 15 April 2012

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Journal Articles

Abstract LB-230: A prospective clinical trial to evaluate DNA sequencing as a diagnostic tool to guide cancer therapy: results from the initial 50 patients

Cancer Res (2012) 72 (8_Supplement): LB-230.

DOI: https://doi.org/10.1158/1538-7445.AM2012-LB-230

Published: 15 April 2012

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Journal Articles

Abstract 1232: Overcoming resistance to EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer

J Rafael Sierra, Anderson Chang, Jason Moffat, Benjamin G. Neel, Ming-Sound Tsao

Cancer Res (2012) 72 (8_Supplement): 1232.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1232

Published: 15 April 2012

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Journal Articles

Abstract 1352: Shp2 is required for CML initiation and maintenance

Shengqing Gu, Gordon Chan, Benjamin G. Neel

Cancer Res (2012) 72 (8_Supplement): 1352.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1352

Published: 15 April 2012

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Journal Articles

Abstract 3318: Phenotypic heterogeneity and instability of tumor-initiating cells in high-grade serous cancer

Jocelyn M. Stewart, Patricia A. Shaw, Marcus Q. Bernardini, Laurie E. Ailles, Benjamin G. Neel

Cancer Res (2012) 72 (8_Supplement): 3318.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3318

Published: 15 April 2012

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Journal Articles

Abstract 5084: Functional genomic classification of breast cancer using pooled lentivirus shRNA screens

Richard Marcotte, Kevin Brown, Azin Sayad, Maliha Haider, Troy Ketela, Jason Moffat, Benjamin G. Neel

Cancer Res (2012) 72 (8_Supplement): 5084.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5084

Published: 15 April 2012

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Journal Articles

Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations

Matthew J. Lazzara, Keara Lane, Richard Chan, Paul J. Jasper, Michael B. Yaffe, Peter K. Sorger, Tyler Jacks, Benjamin G. Neel, Douglas A. Lauffenburger

Cancer Res (2010) 70 (9): 3843–3850.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-3421

Published: 28 April 2010

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Includes: Supplementary data

Journal Articles

Abstract 4296A: Myeloproliferative disease induced by leukemogenic Ptpn11 (Shp-2) phosphatase arises from hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu

Cancer Res (2010) 70 (8_Supplement): 4296A.

DOI: https://doi.org/10.1158/1538-7445.AM10-4296A

Published: 15 April 2010

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Journal Articles

Abstract SSY01-03: An RNAi screen identifies a heme biosynthetic mediator as a novel radiosensitizing target for head and neck cancer

Emma Ito, Shijun Yue, Eduardo H. Moriyama, Angela B. Hui, Inki Kim, Wei Shi, Nehad M. Alajez, Nirmal Bhogal, GuoHua Li, Alessandro Datti, Aaron D. Schimmer, Brian C. Wilson, Peter P. Liu, Daniel Durocher, Benjamin G. Neel, Brian O'Sullivan, Bernard Cummings, Rob Bristow, Fei-Fei Liu

Cancer Res (2010) 70 (8_Supplement): SSY01-03.

DOI: https://doi.org/10.1158/1538-7445.AM10-SSY01-03

Published: 15 April 2010

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NARROW

Abstract 659: Mechanisms of resistance to SHP2 inhibition

Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma

Abstract LB-338: SHP2 inhibition enhances sensitivity to MEK inhibitors in multiple resistant cancer models

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Abstract A2-07: Integrative functional genomics of breast cancer

Abstract PR14: Integrative functional genomics of breast cancer

Abstract B2-06: Computational modeling of serous ovarian carcinoma dynamics: Implications for screening and therapy

Abstract LB-302: PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia

Abstract LB-307: Computational modeling of serous ovarian carcinoma dynamics: Implications for screening and therapy

Abstract B43: Role of activated SHP2 in high-risk neuroblastoma pathogenesis

Abstract 80: Activated SHP2 collaborates with MYCN in neuroblastoma tumorigenesis

Abstract SY35-02: Phenotypic heterogeneity and instability of human serous ovarian cancer tumor-initiating cells

Abstract LB-230: A prospective clinical trial to evaluate DNA sequencing as a diagnostic tool to guide cancer therapy: results from the initial 50 patients

Abstract 1232: Overcoming resistance to EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer

Abstract 1352: Shp2 is required for CML initiation and maintenance

Abstract 3318: Phenotypic heterogeneity and instability of tumor-initiating cells in high-grade serous cancer

Abstract 5084: Functional genomic classification of breast cancer using pooled lentivirus shRNA screens

Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations

Abstract 4296A: Myeloproliferative disease induced by leukemogenic Ptpn11 (Shp-2) phosphatase arises from hematopoietic stem cells

Abstract SSY01-03: An RNAi screen identifies a heme biosynthetic mediator as a novel radiosensitizing target for head and neck cancer

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