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Ben Z. Stanger
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Journal Articles

Abstract 6405: T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC

Margo I. Orlen, William P. Vostrejs, Rina Sor, Jayne C. McDevitt, Samantha B. Kemp, Il-Kyu Kim, Adam B. Kramer, Nataliya Tovbis Shifrin, Nune Markosyan, Cynthia Clendenin, Mallika Singh, Elsa Quintana, Marie Menard, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6405.
https://doi.org/10.1158/1538-7445.AM2025-6405
Published: 21 April 2025
View articletitled, Abstract 6405: T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC
Journal Articles

Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer

Andrew J. Aguirre, Ben Z. Stanger, Anirban Maitra
Journal: Cancer Research
Cancer Res (2024) 84 (18): 2950–2953.
https://doi.org/10.1158/0008-5472.CAN-24-1926
Published: 16 September 2024
View articletitled, Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer
Open the PDF for Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer in another window
Journal Articles

Abstract C038: Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment

Xu Han, Michelle Burrows, Laura C Kim, Jimmy Xu, Will Vostrejs, Tran Ngoc Van Le, Yanqing Jiang, Edna Cukierman, Reiss Binder Kim, Ben Z Stanger, Clementina Mesaros, Brian Keith, Celeste Simon
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C038.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C038
Published: 15 September 2024
View articletitled, Abstract C038: Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
Journal Articles

Abstract B085: The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic adenocarcinoma

Maimon E Hubbi, Catherine Wang, Erin Hollander, Yasir Suhail, Kshitiz, Alexander Muir, Ben Z Stanger, Chi V Dang
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B085.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B085
Published: 15 September 2024
View articletitled, Abstract B085: The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic adenocarcinoma
Journal Articles

Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer

Jonathan H. Sussman, Nathalia Kim, Samantha B. Kemp, Daniel Traum, Takeshi Katsuda, Benjamin M. Kahn, Jason Xu, Il-Kyu Kim, Cody Eskandarian, Devora Delman, Gregory L. Beatty, Klaus H. Kaestner, Amber L. Simpson, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2364–2376.
https://doi.org/10.1158/0008-5472.CAN-23-2352
Published: 15 July 2024
View articletitled, Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer
Open the PDF for Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

Brooke A. Brown, Paul J. Myers, Sara J. Adair, Jason R. Pitarresi, Shiv K. Sah-Teli, Logan A. Campbell, William S. Hart, Michelle C. Barbeau, Kelsey Leong, Nicholas Seyler, William Kane, Kyoung Eun Lee, Edward Stelow, Marieke Jones, M. Celeste Simon, Peppi Koivunen, Todd W. Bauer, Ben Z. Stanger, Matthew J. Lazzara
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1764–1780.
https://doi.org/10.1158/0008-5472.CAN-22-2945
Published: 04 June 2024
View articletitled, A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer
Open the PDF for A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract NG08: Dissecting and quantifying pancreatic cancer plasticity using single-cell multiomics, lineage tracing and functional genomics reveals novel mediators of therapy resistance

Arnav Mehta, Lynn Bi, Deepika Yeramosu, Michael Bogaev, Martin Jankowiak, Abigail Collins, Aziz Al'Khafaji, Milan Parikh, Mehrtash Babadi, Kyle Evans, Alex Bloemendal, Russell Kunnes, Marc Schwartz, Glen Munson, Elisa Donnard, Thouis R. Jones, Ben Z. Stanger, Jay Shendure, Jonathan Weissman, David T. Ting, Andrew Aguirre, Nir Hacohen, Dana Pe'er, Eric S. Lander
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): NG08.
https://doi.org/10.1158/1538-7445.AM2024-NG08
Published: 05 April 2024
View articletitled, Abstract NG08: Dissecting and quantifying pancreatic cancer plasticity using single-cell multiomics, lineage tracing and functional genomics reveals novel mediators of therapy resistance
Journal Articles

Abstract 6627: Boosting macrophage-specific BCAA oxidation enhances immune activation within the tumor microenvironment and diminishes tumor growth in pancreatic cancer

Gauri Mirji, Sajad Ahmad Bhat, Zachary Schug, Ben Z. Stanger, Zoltan Arany, Rahul S. Shinde
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6627.
https://doi.org/10.1158/1538-7445.AM2024-6627
Published: 22 March 2024
View articletitled, Abstract 6627: Boosting macrophage-specific BCAA oxidation enhances immune activation within the tumor microenvironment and diminishes tumor growth in pancreatic cancer
Journal Articles

Abstract 1927: Resistance to RAS-GTP inhibition in models of pancreatic ductal adenocarcinoma arises downstream of RAS effectors

Urszula N. Wasko, Jingjing Jiang, Yingyun Wang, Lorenzo Tomassoni, Lingyan Jiang, Marie Menard, Alvaro Curiel-Garcia, Tanner C. Dalton, Margo Orlen, Cole Edwards, Clint Stalnecker, Julien Dilly, Stephanie Chang, Stephen A. Sastra, Carmine F. Palermo, Timour Baslan, Sha Tian, Matthew Holderfield, Elsa Quintana, Zhengping Wang, Jacqueline A. Smith, Andrea Califano, David Wildes, Andrew J. Aguirre, Robert H. Vonderheide, Ben Z. Stanger, Scott W. Lowe, Channing J. Der, Mallika Singh, Kenneth P. Olive
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1927.
https://doi.org/10.1158/1538-7445.AM2024-1927
Published: 22 March 2024
View articletitled, Abstract 1927: Resistance to RAS-GTP inhibition in models of pancreatic ductal adenocarcinoma arises downstream of RAS effectors
Journal Articles

Abstract A098: Quantitative MRI metrics capture pancreatic cancer and stroma responses to novel KRAS inhibitor

Mamta Gupta, Hoon Choi, Emma E. Furth, Miguel Joaquim, Stephen Pickup, Cynthia Clendenin, Margo Orlen, Thomas Karasic, Hee Kwon Song, Yong Fan, Peter O’Dwyer, Robert H. Vonderheide, Mark Rosen, Ben Z. Stanger, Rong Zhou
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A098.
https://doi.org/10.1158/1538-7445.PANCA2023-A098
Published: 16 January 2024
View articletitled, Abstract A098: Quantitative MRI metrics capture pancreatic cancer and stroma responses to novel KRAS inhibitor
Journal Articles

Abstract B033: Tumor cell-intrinsic mPGES-1-PGE2-EP4 signaling is a major immunosuppressive pathway in pancreatic cancer

Nune Markosyan, Il-Kyu Kim, Charu Arora, Liz Quinones, Noah Cheng, Ben Z. Stanger, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B033.
https://doi.org/10.1158/1538-7445.PANCA2023-B033
Published: 16 January 2024
View articletitled, Abstract B033: Tumor cell-intrinsic mPGES-1-PGE2-EP4 signaling is a major immunosuppressive pathway in pancreatic cancer
Journal Articles

Abstract B101: Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma

Urszula N. Wasko, Jingjing Jiang, Lorenzo Tomassoni, Yingyun Wang, Bianca Lee, Margo Orlen, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Steven A. Sastra, Carmine F. Palermo, Stephanie Chang, Andrew J. Aguirre, Channing J. Der, Robert H. Vonderheide, Ben Z. Stanger, Andrea Califano, Mallika Singh, Kenneth P. Olive
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B101.
https://doi.org/10.1158/1538-7445.PANCA2023-B101
Published: 16 January 2024
View articletitled, Abstract B101: Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma
Journal Articles

Lineage Plasticity: The New Cancer Hallmark on the Block

Arnav Mehta, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2024) 84 (2): 184–191.
https://doi.org/10.1158/0008-5472.CAN-23-1067
Published: 16 January 2024
View articletitled, Lineage Plasticity: The New Cancer Hallmark on the Block
Open the PDF for Lineage Plasticity: The New Cancer Hallmark on the Block in another window
Journal Articles

Abstract 6394: Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma

Noah Cheng, Samantha B. Kemp, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6394.
https://doi.org/10.1158/1538-7445.AM2023-6394
Published: 04 April 2023
View articletitled, Abstract 6394: Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 6190: Polymerase theta inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in BRCA-deficient cancers

Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Anita K. Mehta, Jennifer L. Guerriero, Gerburg M. Wulf, Brian M. Wolpin, Ben Z. Stanger, Andrew J. Aguirre, James M. Cleary, Alan D. D'Andrea, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6190.
https://doi.org/10.1158/1538-7445.AM2023-6190
Published: 04 April 2023
View articletitled, Abstract 6190: Polymerase theta inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in BRCA-deficient cancers
Journal Articles

Abstract A030: Pancreas-specific circulating cell-free DNA for detection of occult metastases and prognosis in resectable pancreatic ductal adenocarcinoma

Jacob E. Till, Roni Ben-Ami, Ruth Shemer, Kristine Kim, Aseel Abdalla, Samuele Cannas, Charles M. Vollmer, Mark H. O'Hara, Ben Z. Stanger, Yuval Dor, Erica L. Carpenter
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A030.
https://doi.org/10.1158/1538-7445.PANCA22-A030
Published: 15 November 2022
View articletitled, Abstract A030: Pancreas-specific circulating cell-free DNA for detection of occult metastases and prognosis in resectable pancreatic ductal adenocarcinoma
Journal Articles

Abstract C010: Polymerase theta inhibition synergizes with anti-PD-1 immunotherapy in BRCA2-deficient pancreatic ductal adenocarcinoma

Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Jie Hao, Junning Wang, Elizabeth A. Andrews, Jennifer L. Guerriero, Brian M. Wolpin, Ben Z. Stanger, Andrew A. Aguirre, James M. Cleary, Alan A. D'Andrea, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C010.
https://doi.org/10.1158/1538-7445.PANCA22-C010
Published: 15 November 2022
View articletitled, Abstract C010: Polymerase theta inhibition synergizes with anti-PD-1 immunotherapy in BRCA2-deficient pancreatic ductal adenocarcinoma
Journal Articles

Abstract C054: Hypoxia promotes a durable epithelial-mesenchymal transition in pancreas cancer through a histone methylation-MAPK signaling axis

Brooke A. Brown, Paul J. Myers, Sara J. Adair, Jason R. Pitarresi, Shiv Sah Teli, Peppi Karppinen, Ben Z. Stanger, Todd W. Bauer, Matthew J. Lazzara
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C054.
https://doi.org/10.1158/1538-7445.PANCA22-C054
Published: 15 November 2022
View articletitled, Abstract C054: Hypoxia promotes a durable epithelial-mesenchymal transition in pancreas cancer through a histone methylation-MAPK signaling axis
Journal Articles

Abstract 5610: Targeting Rb1 in experimental pancreatic cancer remodels immune cell landscape and suppresses tumor progression

Evgenii N. Tcyganov, Taekyoung Kwak, Adi Narayana Reddy Poli, Laxminarasimha Donthireddy, Joel Cassel, Andrew Kossenkov, Rahul Shinde, Ben Z. Stanger, Joseph Salvino, Luis J. Montaner
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5610.
https://doi.org/10.1158/1538-7445.AM2022-5610
Published: 15 June 2022
View articletitled, Abstract 5610: Targeting Rb1 in experimental pancreatic cancer remodels immune cell landscape and suppresses tumor progression
Journal Articles

Abstract 3139: Disrupting prostaglandin E2 signaling to reverse treatment resistance in cancer

Nune Markosyan, Liz Quinones, Charu Aurora, Nikhil Joshi, Ilkyu Kim, Ben Z. Stanger, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3139.
https://doi.org/10.1158/1538-7445.AM2022-3139
Published: 15 June 2022
View articletitled, Abstract 3139: Disrupting prostaglandin E2 signaling to reverse treatment resistance in cancer