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Journal Articles

Abstract #2706: Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, MPC-6827, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration

Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher M. Pleiman, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai

Cancer Res (2009) 69 (9_Supplement): 2706.

Published: 01 May 2009

View article titled, Abstract #2706: Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, MPC-6827, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration

Journal Articles

Abstract #5369: Identification of molecular target for small-molecule tumor inhibitor targeting Myc pathway

Gisela Claassen, Mei Vaillancourt, Nilantha Sirisoma, Han Zhong Zhang, William Kemnitzer, Chris May, Sui Xiong Cai, Ben Tseng, John Drewe

Cancer Res (2009) 69 (9_Supplement): 5369.

Published: 01 May 2009

View article titled, Abstract #5369: Identification of molecular target for small-molecule tumor inhibitor targeting Myc pathway

Journal Articles

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay, 5: SAR of the 2- and 3-positions

William Kemnitzer, Songchun Jiang, Yan Wang, Shailaja Kasibhatla, Candace Crogan-Grundy, Monica Bubenik, Denis Labrecque, Real Denis, Serge Lamothe, Giorgio Attardo, Henriette Gourdeau, Ben Tseng, John Drewe, Sui Xiong Cai

Cancer Res (2008) 68 (9_Supplement): 1266.

Published: 01 May 2008

View article titled, Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay, 5: SAR of the 2- and 3-positions

Journal Articles

2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as an inducer of apoptosis with in vivo activity

Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, Vijay Baichwal, J. Adam Willardsen, Mark Anderson, Christopher M. Pleiman, Ben Tseng, Shailaja Kasibhatla, John Drewe, Sui Xiong Cai

Cancer Res (2008) 68 (9_Supplement): 1265.

Published: 01 May 2008

View article titled, 2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as an inducer of apoptosis with in vivo activity

Journal Articles

Optimization of in vivo active small-molecule tumor inhibitor targeting Myc pathway

Gisela Claassen, Elena Brin, Mei Vaillancourt, Candace Crogan-Grundy, Chris May, Bill Kemnitzer, Nilantha Sirisoma, Han Zhong Zhang, Sui Xiong Cai, John Drewe, Ben Tseng

Cancer Res (2008) 68 (9_Supplement): 5660.

Published: 01 May 2008

View article titled, Optimization of in vivo active small-molecule tumor inhibitor targeting Myc pathway

Journal Articles

MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps

Shailaja Kasibhatla, Vijay Baichwal, Sui Xiong Cai, Bruce Roth, Ira Skvortsova, Sergej Skvortsov, Peter Lukas, Nicole M. English, Nilantha Sirisoma, John Drewe, Azra Pervin, Ben Tseng, Robert O. Carlson, Christopher M. Pleiman

Cancer Res (2007) 67 (12): 5865–5871.

https://doi.org/10.1158/0008-5472.CAN-07-0127

Published: 15 June 2007

View article titled, MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps

Journal Articles

4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Structure-activity relationships of N-substituted pyrrole fused at the 7, 8-positions

William Kemnitzer, Songchun Jiang, Hong Zhang, Real Denis, Serge Lamothe, Henriette Gourdeau, Ben Tseng, Shailaja Kasibhatla, John Drewe, Sui Xiong Cai

Cancer Res (2007) 67 (9_Supplement): 3972.

Published: 01 May 2007

View article titled, 4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Structure-activity relationships of N-substituted pyrrole fused at the 7, 8-positions

Journal Articles

4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay, structure-activity relationships of the 7, 8-positions

Sui Xiong Cai, William Kemnitzer, Shailaja Kasibhatla, Songchun Jiang, Jianghong Zhao, Ben Tseng, John Drewe, Denis Labrecque, Serge Lamothe, Henriette Gourdeau

Cancer Res (2006) 66 (8_Supplement): 266–267.

Published: 15 April 2006

View article titled, 4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay, structure-activity relationships of the 7, 8-positions

Journal Articles

Cell-based chemical genetics approach to identify small molecule inducers of selective apoptosis in tumor cell lines with deregulated Myc expression

Gisela Claassen, Candace Crogan-Grundy, Katayoun Jessen, Elena Brin, Ben Tseng, John Drewe, Shailaja Kasibhatla

Cancer Res (2006) 66 (8_Supplement): 598.

Published: 15 April 2006

View article titled, Cell-based chemical genetics approach to identify small molecule inducers of selective apoptosis in tumor cell lines with deregulated Myc expression

Journal Articles

MPC-6827: A small molecule inhibitor of microtubule formation that is not a substrate for multi-drug resistance pumps

Vijay Baichwal, Shailaja Kasibhatla, Bruce Roth, Nicki English, Nilantha Sirosoma, Sui Xiong Cai, Ben Tseng, Adrian Hobden, Christopher Pleiman

Cancer Res (2005) 65 (9_Supplement): 805.

Published: 01 May 2005

View article titled, MPC-6827: A small molecule inhibitor of microtubule formation that is not a substrate for multi-drug resistance pumps

Journal Articles

Discovery of 3-aryl-5-aryl-[1,2,4]-oxadiazole as potent apoptosis inducer

Han-Zhong Zhang, Bill Kemnitzer, Hong Zhang, Jared Kuemmerle, Kristin Mason, John Drewe, Shailaja Kasibhatla, Ben Tseng, Sui Xiong Cai

Cancer Res (2005) 65 (9_Supplement): 283.

Published: 01 May 2005

View article titled, Discovery of 3-aryl-5-aryl-[1,2,4]-oxadiazole as potent apoptosis inducer

Journal Articles

Identification of the molecular target for tumor selective apoptosis-inducing 3,5-diaryl-oxadiazole compounds

Katayoun A. Jessen, Nicki M. English, Jean Y. Wang, Sergei Maliartchouk, John Drewe, Jared Kuemmerle, Han Zhong Zhang, Ben Tseng, Sui Xiong Cai, Shailaja Kasibhatla

Cancer Res (2005) 65 (9_Supplement): 630.

Published: 01 May 2005

View article titled, Identification of the molecular target for tumor selective apoptosis-inducing 3,5-diaryl-oxadiazole compounds

Journal Articles

Antitumor activity of novel apoptosis inducers

Cancer Res (2004) 64 (7_Supplement): 1056.

Published: 01 April 2004

View article titled, Antitumor activity of novel apoptosis inducers

Journal Articles

MX90745, a new family of apoptosis inducing molecules with potent in vivo anti-cancer activities

Ben Tseng, Shailaja Kasibhatla, Azra Pervin, Nilantha Sirisoma, Jennifer Hou, Hong Zhang, Songchun Jiang, Katti Jessen, Nicki English, Ling Qui, Salam Kadhim, Chris May, Erica Wood, John Drewe, Sui Xiong Cai

Cancer Res (2004) 64 (7_Supplement): 1236.

Published: 01 April 2004

View article titled, MX90745, a new family of apoptosis inducing molecules with potent in vivo anti-cancer activities

Journal Articles

Discovery of a novel substituted chromene series as apoptosis inducers with anti-mitotic and anti-vasculature activities

Shailaja Kasibhatla, John Drewe, Ling Qiu, John Herich, Karen Meerovitch, Frederick Bergeron, David Bouffard, Quan Yang, William Kemnitzer, Songchun Jiang, Hong Zhang, Sui Xiong Cai, Henriette Gourdeau, Ben Tseng

Cancer Res (2004) 64 (7_Supplement): 950.

Published: 01 April 2004

View article titled, Discovery of a novel substituted chromene series as apoptosis inducers with anti-mitotic and anti-vasculature activities

Journal Articles

Discovery of 2-aryl-oxazole-4-carboxamide derivatives as potent apoptosis inducers.

Cancer Res (2004) 64 (7_Supplement): 576.

Published: 01 April 2004

View article titled, Discovery of 2-aryl-oxazole-4-carboxamide derivatives as potent apoptosis inducers.

Journal Articles

Discovery and structure-activity relationships of 4-Aryl-4H-chromemes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay.

Cancer Res (2004) 64 (7_Supplement): 576.

Published: 01 April 2004

View article titled, Discovery and structure-activity relationships of 4-Aryl-4H-chromemes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay.

Journal Articles

Transcriptional Up-Regulation of Paxillin Expression by Heregulin in Human Breast Cancer Cells

Ratna Vadlamudi, Liana Adam, Ben Tseng, Louis Costa, Rakesh Kumar

Cancer Res (1999) 59 (12): 2843–2846.

Published: 15 June 1999

View article titled, Transcriptional Up-Regulation of Paxillin Expression by Heregulin in Human Breast Cancer Cells

NARROW

Abstract #2706: Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, MPC-6827, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration

Abstract #5369: Identification of molecular target for small-molecule tumor inhibitor targeting Myc pathway

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay, 5: SAR of the 2- and 3-positions

2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as an inducer of apoptosis with in vivo activity

Optimization of in vivo active small-molecule tumor inhibitor targeting Myc pathway

MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps

4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Structure-activity relationships of N-substituted pyrrole fused at the 7, 8-positions

4-Aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay, structure-activity relationships of the 7, 8-positions

Cell-based chemical genetics approach to identify small molecule inducers of selective apoptosis in tumor cell lines with deregulated Myc expression

MPC-6827: A small molecule inhibitor of microtubule formation that is not a substrate for multi-drug resistance pumps

Discovery of 3-aryl-5-aryl-[1,2,4]-oxadiazole as potent apoptosis inducer

Identification of the molecular target for tumor selective apoptosis-inducing 3,5-diaryl-oxadiazole compounds

Antitumor activity of novel apoptosis inducers

MX90745, a new family of apoptosis inducing molecules with potent in vivo anti-cancer activities

Discovery of a novel substituted chromene series as apoptosis inducers with anti-mitotic and anti-vasculature activities

Discovery of 2-aryl-oxazole-4-carboxamide derivatives as potent apoptosis inducers.

Discovery and structure-activity relationships of 4-Aryl-4H-chromemes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay.

Transcriptional Up-Regulation of Paxillin Expression by Heregulin in Human Breast Cancer Cells

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