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Journal Articles

Abstract 2885: Dihydroceramide increase precedes golgi dispersal, pro-survival autophagy, ER stress, and UPR in fenretinide + safingol treated neuroblastoma cells

Nikhil Vad, Dong Wang, Hwangeui Cho, Dattesh Verlekar, Charlie Linch, C Patrick Reynolds, Min Kang, Barry J. Maurer

Cancer Res (2018) 78 (13_Supplement): 2885.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2885

Published: 01 July 2018

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Journal Articles

Abstract 1057: Co-treatment with fenretinide and safingol induced p38 MAPK and/or FOXO3a activated pro-survival autophagy in glioblastoma multiforme cells

Nikhil Vad, Dong Wang, Charlie Linch, Barry J. Maurer

Cancer Res (2017) 77 (13_Supplement): 1057.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1057

Published: 01 July 2017

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Journal Articles

Abstract 4656: ER stress, unfolded protein response, and autophagy are pro-survival responses to fenretinide + safingol treatment in GBM cells

Nikhil M. Vad, Dong Wang, Barry J. Maurer

Cancer Res (2016) 76 (14_Supplement): 4656.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4656

Published: 15 July 2016

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Journal Articles

Abstract 2616: Comparison of the cytotoxicity and increase of reactive oxygen species and dihydroceramides of fenretinide to its major metabolites (4-oxo- and 4-methoxyphenyl fenretinide) in T-cell lymphoid malignancy, neuroblastoma, and ovarian cancer cell lines

Michael M. Song, Monish R. Makena, Ashly Hindle, Balakrishna Koneru, Thinh H. Nguyen, Hwangeui Cho, Barry J. Maurer, Min H. Kang, C. Patrick Reynolds

Cancer Res (2015) 75 (15_Supplement): 2616.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2616

Published: 01 August 2015

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Journal Articles

Abstract 1709: Molecular inhibition of autophagy enhances dihydroceramides-induced cell death in glioblastoma multiforme cell lines.

Nikhil Vad, Dong Wang, Barry J. Maurer

Cancer Res (2013) 73 (8_Supplement): 1709.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1709

Published: 15 April 2013

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Journal Articles

Abstract 4661: Levels of C22:0- and C24:0-dihydroceramide correlate with cytotoxicity in T-cell acute lymphoblastic leukemia cell lines

Michael W. Holliday, Steven B. Cox, Min H. Kang, Barry J. Maurer

Cancer Res (2012) 72 (8_Supplement): 4661.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4661

Published: 15 April 2012

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Journal Articles

Abstract 2493: Enhanced activity of fenretinide/-LYM-X-SORB^TM (4-HPR/LXS) oral powder in combination with ketoconazole and vincristine against recurrent neuroblastoma xenografts

Lluis Lopez-Barcons, Min H. Kang, Barry J. Maurer, C. Patrick Reynolds

Cancer Res (2012) 72 (8_Supplement): 2493.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2493

Published: 15 April 2012

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Journal Articles

SiRNA for the LCBII, but not the LCBI subunit of serine palmitoyl transferase can suppress fenretinide-stimulated de novo ceramide biosynthesis in neuroblastoma cell lines.

Zesheng Wan, Barry J. Maurer, C. Patric Reynolds

Cancer Res (2006) 66 (8_Supplement): 1294–1295.

Published: 15 April 2006

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Journal Articles

Fenretinide increased ceramides through progressive de novo synthesis and inhibition of sphingomyelin synthesis in a neuroblastoma cell line

Hongtao Wang, Barry J. Maurer

Cancer Res (2006) 66 (8_Supplement): 1093.

Published: 15 April 2006

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Journal Articles

Synthetic triterpenoid CDDO and its derivatives increase ceramides and are cytotoxic to pediatric acute lymphoblastic leukemia cell lines

Dong Wang, Guoying Kong, Jun Wu, Peter P. Ruvolo, Michael Andreeff, Marina Konopleva, Barry J. Maurer

Cancer Res (2006) 66 (8_Supplement): 1089–1090.

Published: 15 April 2006

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Journal Articles

Dihydroceramide desaturases are differentially expressed in Fenretinide-resistant pediatric Acute Lymphoblastic Leukemia (ALL) cell lines

Jun Wu, Barry J. Maurer

Cancer Res (2006) 66 (8_Supplement): 297.

Published: 15 April 2006

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Journal Articles

Fenretinide + D-threo-PPMP prolongs survival in human neuroblastoma murine xenograft models

Ondrej Kalous, Vanessa Maldonado, Bee-Chun Sun, C. Patrick Reynolds, Barry J. Maurer

Cancer Res (2006) 66 (8_Supplement): 1019.

Published: 15 April 2006

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Journal Articles

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against Ewing’s family tumor cell lines in hypoxia

Rita Grigoryan, Nino Keshelava, Barry J. Maurer, Sun Bee-Chun, Susan M. Ludeman, O. Michael Colvin, C. Patrick Reynolds

Cancer Res (2005) 65 (9_Supplement): 1111–1112.

Published: 01 May 2005

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Journal Articles

PPMP stereoisomers synergize fenretinide (4-HPR) cytotoxicity in human cancer cell lines in association with complex modulations of sphingolipid metabolism

Hongtao Wang, Barry J. Maurer

Cancer Res (2005) 65 (9_Supplement): 1174.

Published: 01 May 2005

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Journal Articles

Fenretinide Cytotoxicity for Ewing’s Sarcoma and Primitive Neuroectodermal Tumor Cell Lines Is Decreased by Hypoxia and Synergistically Enhanced by Ceramide Modulators

Sandeep Batra, C. Patrick Reynolds, Barry J. Maurer

Cancer Res (2004) 64 (15): 5415–5424.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-0377

Published: 02 August 2004

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Journal Articles

Metabolism of safingol in human neuroblastoma and ALL leukemia cell lines.

Hongtao Wang, Guoying Kong, Barry J. Maurer

Cancer Res (2004) 64 (7_Supplement): 465.

Published: 01 April 2004

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Journal Articles

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against neuroblastoma cell lines in hypoxia

Rita S. Grigoryan, Nino Keshelava, Barry J. Maurer, Sun Bee-Chun, Susan M. Ludeman, O. Michael Colvin, C. Patrick Reynolds

Cancer Res (2004) 64 (7_Supplement): 629.

Published: 01 April 2004

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Journal Articles

Uptake and metabolism of safingol in human neuroblastoma and leukemia cell lines

Hongtao Wang, Guo-Ying Kong, C. Patrick Reynolds, Barry J. Maurer

Cancer Res (2004) 64 (7_Supplement): 689.

Published: 01 April 2004

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Journal Articles

N -(4-Hydroxyphenyl)retinamide Elevates Ceramide in Neuroblastoma Cell Lines by Coordinate Activation of Serine Palmitoyltransferase and Ceramide Synthase

Hongtao Wang, Barry J. Maurer, C. Patrick Reynolds, Myles C. Cabot

Cancer Res (2001) 61 (13): 5102–5105.

Published: 01 July 2001

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NARROW

Abstract 2885: Dihydroceramide increase precedes golgi dispersal, pro-survival autophagy, ER stress, and UPR in fenretinide + safingol treated neuroblastoma cells

Abstract 1057: Co-treatment with fenretinide and safingol induced p38 MAPK and/or FOXO3a activated pro-survival autophagy in glioblastoma multiforme cells

Abstract 4656: ER stress, unfolded protein response, and autophagy are pro-survival responses to fenretinide + safingol treatment in GBM cells

Abstract 2616: Comparison of the cytotoxicity and increase of reactive oxygen species and dihydroceramides of fenretinide to its major metabolites (4-oxo- and 4-methoxyphenyl fenretinide) in T-cell lymphoid malignancy, neuroblastoma, and ovarian cancer cell lines

Abstract 1709: Molecular inhibition of autophagy enhances dihydroceramides-induced cell death in glioblastoma multiforme cell lines.

Abstract 4661: Levels of C22:0- and C24:0-dihydroceramide correlate with cytotoxicity in T-cell acute lymphoblastic leukemia cell lines

Abstract 2493: Enhanced activity of fenretinide/-LYM-X-SORB^TM (4-HPR/LXS) oral powder in combination with ketoconazole and vincristine against recurrent neuroblastoma xenografts

SiRNA for the LCBII, but not the LCBI subunit of serine palmitoyl transferase can suppress fenretinide-stimulated de novo ceramide biosynthesis in neuroblastoma cell lines.

Fenretinide increased ceramides through progressive de novo synthesis and inhibition of sphingomyelin synthesis in a neuroblastoma cell line

Synthetic triterpenoid CDDO and its derivatives increase ceramides and are cytotoxic to pediatric acute lymphoblastic leukemia cell lines

Dihydroceramide desaturases are differentially expressed in Fenretinide-resistant pediatric Acute Lymphoblastic Leukemia (ALL) cell lines

Fenretinide + D-threo-PPMP prolongs survival in human neuroblastoma murine xenograft models

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against Ewing’s family tumor cell lines in hypoxia

PPMP stereoisomers synergize fenretinide (4-HPR) cytotoxicity in human cancer cell lines in association with complex modulations of sphingolipid metabolism

Fenretinide Cytotoxicity for Ewing’s Sarcoma and Primitive Neuroectodermal Tumor Cell Lines Is Decreased by Hypoxia and Synergistically Enhanced by Ceramide Modulators

Metabolism of safingol in human neuroblastoma and ALL leukemia cell lines.

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against neuroblastoma cell lines in hypoxia

Uptake and metabolism of safingol in human neuroblastoma and leukemia cell lines

N -(4-Hydroxyphenyl)retinamide Elevates Ceramide in Neuroblastoma Cell Lines by Coordinate Activation of Serine Palmitoyltransferase and Ceramide Synthase

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