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Barry D. Nelkin
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Journal Articles

Abstract 2171: Multi-CDK inhibition efficiently suppresses AR function and cell growth in prostate cancer

Free
Brian W. Simons, Maria Ybanez, Emmanuel S. Antonarakis, Jun Luo, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2171.
https://doi.org/10.1158/1538-7445.AM2017-2171
Published: 01 July 2017
View articletitled, Abstract 2171: Multi-CDK inhibition efficiently suppresses AR function and cell growth in prostate cancer
Journal Articles

Abstract 3093: Expression of DLL3 in metastatic melanoma, glioblastoma and high-grade extrapulmonary neuroendocrine carcinomas as potential indications for rovalpituzumab tesirine (Rova-T; SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody drug conjugate (ADC)

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Laura R. Saunders, Samuel A. Williams, Sheila Bheddah, Kumiko Isse, Sarah Fong, Marybeth A. Pysz, Himisha Beltran, Loredana Puca, Verena Sailer, Juan M. Mosquera, Yu Yin, Jiaoti Huang, Andrew J. Armstrong, Jorge Garcia, Cristina Magi-Galluzzi, Vadim Koshkin, Petros Grivas, Farhad Kosari, John Cheville, Justin C. Moser, Thomas J. Flotte, Thorvardur Halfdanarson, Aaron Mansfield, Konstantinos N. Leventakos, Julian R. Molina, Douglas W. Ball, Barry D. Nelkin, Jill E. Shea, Courtney L. Scaife, Scott J. Dylla
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3093.
https://doi.org/10.1158/1538-7445.AM2017-3093
Published: 01 July 2017
View articletitled, Abstract 3093: Expression of DLL3 in metastatic melanoma, glioblastoma and high-grade extrapulmonary neuroendocrine carcinomas as potential indications for rovalpituzumab tesirine (Rova-T; SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody drug conjugate (ADC)
Journal Articles

Abstract 2976: Small molecule screening of prostate and pancreatic cancer cell lines identifies tilorone dihydrochloride as a compound that selectively inhibits growth in cells with inhibited cyclin-dependent kinase 5

Free
Michel D. Wissing, Eunice Kim, Tikva Dadon, Joong S. Shim, Janet Mendonca, Klaus Piontek, Jun O. Liu, Michael A. Carducci, Sushant K. Kachhap, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2976.
https://doi.org/10.1158/1538-7445.AM2011-2976
Published: 15 April 2011
View articletitled, Abstract 2976: Small molecule screening of prostate and pancreatic cancer cell lines identifies tilorone dihydrochloride as a compound that selectively inhibits growth in cells with inhibited cyclin-dependent kinase 5
Journal Articles

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

Free
Georg Feldmann, Anjali Mishra, Seung-Mo Hong, Savita Bisht, Christopher J. Strock, Douglas W. Ball, Michael Goggins, Anirban Maitra, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2010) 70 (11): 4460–4469.
https://doi.org/10.1158/0008-5472.CAN-09-1107
Published: 01 June 2010
View articletitled, Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling
Open the PDF for Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling in another window
Includes: Supplementary data
Journal Articles

Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer

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Tianyun Jiang, Brendan J. Collins, Ning Jin, David N. Watkins, Malcolm V. Brock, William Matsui, Barry D. Nelkin, Douglas W. Ball
Journal: Cancer Research
Cancer Res (2009) 69 (3): 845–854.
https://doi.org/10.1158/0008-5472.CAN-08-2762
Published: 29 January 2009
View articletitled, Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells

Free
Christopher J. Strock, Jong-In Park, Eric K. Nakakura, G. Steven Bova, John T. Isaacs, Douglas W. Ball, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2006) 66 (15): 7509–7515.
https://doi.org/10.1158/0008-5472.CAN-05-3048
Published: 02 August 2006
View articletitled, Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells
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Includes: Multimedia, Supplementary data
Journal Articles

CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth

Free
Christopher J. Strock, Jong-In Park, Mark Rosen, Craig Dionne, Bruce Ruggeri, Susan Jones-Bolin, Samuel R. Denmeade, Douglas W. Ball, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5559–5563.
Published: 18 September 2003
View articletitled, CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth
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Journal Articles

Epidermal Growth Factor Receptor-independent Constitutive Activation of STAT3 in Head and Neck Squamous Cell Carcinoma Is Mediated by the Autocrine/Paracrine Stimulation of the Interleukin 6/gp130 Cytokine System

Free
Virote Sriuranpong, Jong In Park, Panomwat Amornphimoltham, Vyomesh Patel, Barry D. Nelkin, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2948–2956.
Published: 01 June 2003
View articletitled, Epidermal Growth Factor Receptor-independent Constitutive Activation of STAT3 in Head and Neck Squamous Cell Carcinoma Is Mediated by the Autocrine/Paracrine Stimulation of the Interleukin 6/gp130 Cytokine System
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Journal Articles

BARX2 Induces Cadherin 6 Expression and Is a Functional Suppressor of Ovarian Cancer Progression

Free
Grant C. Sellar, Li Li, Karen P. Watt, Barry D. Nelkin, Genevieve J. Rabiasz, Euan A. Stronach, Eric P. Miller, David J. Porteous, John F. Smyth, Hani Gabra
Journal: Cancer Research
Cancer Res (2001) 61 (19): 6977–6981.
Published: 01 October 2001
View articletitled, BARX2 Induces Cadherin 6 Expression and Is a Functional Suppressor of Ovarian Cancer Progression
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Journal Articles

Notch Signaling Induces Cell Cycle Arrest in Small Cell Lung Cancer Cells

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Virote Sriuranpong, Michael W. Borges, Rajani K. Ravi, Dagmar R. Arnold, Barry D. Nelkin, Stephen B. Baylin, Douglas W. Ball
Journal: Cancer Research
Cancer Res (2001) 61 (7): 3200–3205.
Published: 01 April 2001
View articletitled, Notch Signaling Induces Cell Cycle Arrest in Small Cell Lung Cancer Cells
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Journal Articles

Constitutive Achaete-Scute Homologue-1 Promotes Airway Dysplasia and Lung Neuroendocrine Tumors in Transgenic Mice

Free
R. Ilona Linnoila, Bihong Zhao, Janet L. DeMayo, Barry D. Nelkin, Stephen B. Baylin, Franco J. DeMayo, Douglas W. Ball
Journal: Cancer Research
Cancer Res (2000) 60 (15): 4005–4009.
Published: 01 August 2000
View articletitled, Constitutive Achaete-Scute Homologue-1 Promotes Airway Dysplasia and Lung Neuroendocrine Tumors in Transgenic Mice
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Journal Articles

Expression of Prokaryotic HhaI DNA Methyltransferase Is Transforming and Lethal to NIH 3T3 Cells

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Jianjun Wu, James G. Herman, Geoffrey Wilson, Ree Y. Lee, Ray-Whay Chiu Yen, Mack Mabry, Andrée de Bustros, Barry D. Nelkin, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1996) 56 (3): 616–622.
Published: 01 February 1996
View articletitled, Expression of Prokaryotic HhaI DNA Methyltransferase Is Transforming and Lethal to NIH 3T3 Cells
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Journal Articles

Ret Gene Silencing Is Associated with Raf-1-induced Medullary Thyroid Carcinoma Cell Differentiation

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Eleanor B. Carson, Martin McMahon, Stephen B. Baylin, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (1995) 55 (10): 2048–2052.
Published: 01 May 1995
View articletitled, Ret Gene Silencing Is Associated with Raf-1-induced Medullary Thyroid Carcinoma Cell Differentiation
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Journal Articles

Regional DNA Hypermethylation at D17S5 Precedes 17p Structural Changes in the Progression of Renal Tumors

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Michele Makos, Barry D. Nelkin, Robert E. Reiter, James R. Gnarra, James Brooks, William Isaacs, Marston Linehan, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1993) 53 (12): 2719–2722.
Published: 01 June 1993
View articletitled, Regional DNA Hypermethylation at D17S5 Precedes 17p Structural Changes in the Progression of Renal Tumors
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Journal Articles

DNA Hypermethylation Is Associated with 17p Allelic Loss in Neural Tumors

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Michele Makos, Barry D. Nelkin, Victoria R. Chazin, Webster K. Cavenee, Garrett M. Brodeur, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1993) 53 (12): 2715–2718.
Published: 01 June 1993
View articletitled, DNA Hypermethylation Is Associated with 17p Allelic Loss in Neural Tumors
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Journal Articles

c-myc Gene-induced Alterations in Protein Kinase C Expression: A Possible Mechanism Facilitating myc-ras Gene Complementation

Free
Linda F. Barr, Mack Mabry, Barry D. Nelkin, Greg Tyler, W. Stratford May, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1991) 51 (20): 5514–5519.
Published: 01 October 1991
View articletitled, c-myc Gene-induced Alterations in Protein Kinase C Expression: A Possible Mechanism Facilitating myc-ras Gene Complementation
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Journal Articles

Changes in Calcitonin Gene RNA Processing during Growth of a Human Medullary Thyroid Carcinoma Cell Line

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Barry D. Nelkin, Kurt Y. Chen, Andrée de Bustros, Bernard A. Roos, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1989) 49 (24_Part_1): 6949–6952.
Published: 15 December 1989
View articletitled, Changes in Calcitonin Gene RNA Processing during Growth of a Human Medullary Thyroid Carcinoma Cell Line
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Journal Articles

Low Incidence of Loss of Chromosome 10 in Sporadic and Hereditary Human Medullary Thyroid Carcinoma

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Barry D. Nelkin, Yusuke Nakamura, Raymond W. White, Andrée C. de Bustros, James Herman, Samuel A. Wells, Jr., Stephen B. Baylin
Journal: Cancer Research
Cancer Res (1989) 49 (15): 4114–4119.
Published: 01 August 1989
View articletitled, Low Incidence of Loss of Chromosome 10 in Sporadic and Hereditary Human Medullary Thyroid Carcinoma
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Journal Articles

Transcriptional and Posttranscriptional Modulation of Calcitonin Gene Expression by Sodium n-Butyrate in Cultured Human Medullary Thyroid Carcinoma

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Toshitaro Nakagawa, Barry D. Nelkin, Stephen B. Baylin, Andrée de Bustros
Journal: Cancer Research
Cancer Res (1988) 48 (8): 2096–2100.
Published: 01 April 1988
View articletitled, Transcriptional and Posttranscriptional Modulation of Calcitonin Gene Expression by Sodium n-Butyrate in Cultured Human Medullary Thyroid Carcinoma
Open the PDF for Transcriptional and Posttranscriptional Modulation of Calcitonin Gene Expression by Sodium n-Butyrate in Cultured Human Medullary Thyroid Carcinoma in another window
Journal Articles

DNA Methylation Patterns of the Calcitonin Gene in Human Lung Cancers and Lymphomas

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Stephen B. Baylin, Jo W. M. Höppener, André de Bustros, Paul H. Steenbergh, C. J. M. Lips, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (1986) 46 (6): 2917–2922.
Published: 01 June 1986
View articletitled, DNA Methylation Patterns of the Calcitonin Gene in Human Lung Cancers and Lymphomas
Open the PDF for DNA Methylation Patterns of the Calcitonin Gene in Human Lung Cancers and Lymphomas in another window