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Axel Le Cesne
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Journal Articles

Abstract 2677: Multi-omics profiling identifies two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

Free
Carine Ngo, Leo Colmet-Daage, Julien Vibert, Clémence Henon, Riwan Brillet, Jia Xiang Jin, Daniel Pissaloux, Clémence Astier, Jean-Yves Blay, Axel Le Cesne, Charles Honore, Matthieu Faron, Thomas Grünewald, Franck Bourdeaut, Franck Tirode, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2677.
https://doi.org/10.1158/1538-7445.AM2025-2677
Published: 21 April 2025
View articletitled, Abstract 2677: Multi-omics profiling identifies two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics
Journal Articles

Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors

Open Access
Asuka Kawai-Kawachi, Madison M. Lenormand, Clémence Astier, Noé Herbel, Meritxell B. Cutrona, Carine Ngo, Marlène Garrido, Thomas Eychenne, Nicolas Dorvault, Laetitia Bordelet, Feifei Song, Ryme Bouyakoub, Anastasia Loktev, Antonio Romo-Morales, Clémence Henon, Léo Colmet-Daage, Julien Vibert, Marjorie Drac, Rachel Brough, Etienne Schwob, Oliviano Martella, Guillaume Pinna, Janet M. Shipley, Sibylle Mittnacht, Astrid Zimmermann, Aditi Gulati, Olivier Mir, Axel Le Cesne, Matthieu Faron, Charles Honoré, Christopher J. Lord, Roman M. Chabanon, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (1): 154–170.
https://doi.org/10.1158/0008-5472.CAN-23-3603
Published: 02 January 2025
View articletitled, Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors
Open the PDF for Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 6932: Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in desmoplastic small round cell tumors

Free
Clémence Henon, Julien Vibert, Thomas Eychenne, Nadège Gruel, Léo Colmet-Daage, Carine Ngo, Marlène Garrido, Nicolas Dorvault, Maria Eugenia Marques Da Costa, Antonin Marchais, Asuka Kawachi, Madison Lenormand, Clémence Astier, Roman Chabanon, Benjamin Verret, Rastislav Bahleda, Axel Le Cesne, Fatima Mechta-Grigoriou, Charles Honoré, Matthieu Faron, Olivier Delattre, Joshua J Waterfall, Sarah Watson, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6932.
https://doi.org/10.1158/1538-7445.AM2024-6932
Published: 22 March 2024
View articletitled, Abstract 6932: Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in desmoplastic small round cell tumors
Journal Articles

Abstract LB-190: Combination of pembrolizumab and metronomic cyclophosphamide in patients with advanced sarcomas: a french sarcoma group study

Free
Maud Toulmonde, Nicolas Penel, Julien Adam, Christine Chevreau, Jean-Yves Blay, Axel Le Cesne, Emmanuelle Bompas, Sophie Piperno-neumann, Sophie Cousin, Thierry Ryckewaert, Alban Bessede, François Ghiringhelli, Marina Pulido, ANTOINE ITALIANO
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-190.
https://doi.org/10.1158/1538-7445.AM2017-LB-190
Published: 01 July 2017
View articletitled, Abstract LB-190: Combination of pembrolizumab and metronomic cyclophosphamide in patients with advanced sarcomas: a french sarcoma group study
Journal Articles

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Free
Sylvie Rusakiewicz, Michaela Semeraro, Matthieu Sarabi, Mélanie Desbois, Clara Locher, Rosa Mendez, Nadège Vimond, Angel Concha, Federico Garrido, Nicolas Isambert, Loic Chaigneau, Valérie Le Brun-Ly, Patrice Dubreuil, Isabelle Cremer, Anne Caignard, Vichnou Poirier-Colame, Kariman Chaba, Caroline Flament, Niels Halama, Dirk Jäger, Alexander Eggermont, Sylvie Bonvalot, Frédéric Commo, Philippe Terrier, Paule Opolon, Jean-François Emile, Jean-Michel Coindre, Guido Kroemer, Nathalie Chaput, Axel Le Cesne, Jean-Yves Blay, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3499–3510.
https://doi.org/10.1158/0008-5472.CAN-13-0371
Published: 13 June 2013
View articletitled, Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Open the PDF for Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST.

Free
George D. Demetri, Michael Jeffers, Peter Reichardt, Yoon-Koo Kang, Jean-Yves Blay, Piotr Rutkowski, Hans Gelderblom, Peter Hohenberger, Michael Leahy, Margaret von Mehren, Heikki Joensuu, Giuseppe Badalamenti, Martin Blackstein, Axel Le Cesne, Patrick Schöffski, Robert G Maki, Sebastian Bauer, Binh Bui Nguyen, Jianming Xu, Toshirou Nishida, John Chung, Chetan D. Lathia, Christian Kappeler, Iris Kuss, Dirk Laurent, Paolo G Casali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-295.
https://doi.org/10.1158/1538-7445.AM2013-LB-295
Published: 15 April 2013
View articletitled, Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST.
Journal Articles

Abstract 1965: Predictive and prognostic value of miRNA expression profile in aggressive fibromatosis treated with imatinib.

Free
Armelle Dufresne, Marie Paturel, Nicolas Penel, Axel Le Cesne, Binh Bui, Daniel Pissaloux, Laurent Alberti, Jean Yves Blay
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1965.
https://doi.org/10.1158/1538-7445.AM2013-1965
Published: 15 April 2013
View articletitled, Abstract 1965: Predictive and prognostic value of miRNA expression profile in aggressive fibromatosis treated with imatinib.
Journal Articles

Abstract 1780: p53 mutation predicts limited benefit from adjuvant chemotherapy in patients with localized completely resected high grade soft tissue sarcoma: a retrospective study on 117 patients of the French Sarcoma Group

Free
Jean-Yves Blay, Hughes de The, Antoine Italiano, Binh Bui, Dominique Ranchere, Philippe Perrier, Axel Le Cesne, Agnès Leroux, Francoise Collin, Jean Michel Coindre
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1780.
https://doi.org/10.1158/1538-7445.AM10-1780
Published: 15 April 2010
View articletitled, Abstract 1780: p53 mutation predicts limited benefit from adjuvant chemotherapy in patients with localized completely resected high grade soft tissue sarcoma: a retrospective study on 117 patients of the French Sarcoma Group
Journal Articles

Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

Free
Isabelle Ray-Coquard, Claire Cropet, Martine Van Glabbeke, Catherine Sebban, Axel Le Cesne, Ian Judson, Olivier Tredan, Jaap Verweij, Pierre Biron, Inthidar Labidi, Jean-Paul Guastalla, Thomas Bachelot, David Perol, Sylvie Chabaud, Pancras C.W. Hogendoorn, Philippe Cassier, Armelle Dufresne, Jean-Yves Blay, on behalf of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5383–5391.
https://doi.org/10.1158/0008-5472.CAN-08-3845
Published: 01 July 2009
View articletitled, Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas
Open the PDF for Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas in another window
Journal Articles

Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients

Free
Cédric Ménard, Jean-Yves Blay, Christophe Borg, Stefan Michiels, François Ghiringhelli, Caroline Robert, Céline Nonn, Nathalie Chaput, Julien Taïeb, Nicolas F. Delahaye, Caroline Flament, Jean-François Emile, Axel Le Cesne, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3563–3569.
https://doi.org/10.1158/0008-5472.CAN-08-3807
Published: 15 April 2009
View articletitled, Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients
Open the PDF for Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients in another window
Journal Articles

Biological predictive factors of response to Gleevec® of 40 patients with aggressive fibromatosis

Free
Armelle Dufresne, Pierre Paul Bringuier, Dominique Ranchere, Anthony Goncalves, Nicolas Penel, Axel Le Cesne, Binh Bui, Michele Tubiana-Hulin, Jean Michel Coindre, Jean Yves Blay
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1826.
Published: 01 May 2007
View articletitled, Biological predictive factors of response to Gleevec® of 40 patients with aggressive fibromatosis
Journal Articles

KIT tyrosine kinase inhibition of dendritic cells (DC) promotes NK cell–dependent antitumor effects: Preclinical datas and clinical monitoring of imatinib mesylate treated gastro-intestinal stromal tumor patients.

Free
Julien Taieb, Christophe Borg, Magali Terme, Kouji Maruyama, Eric Angevin, Caroline Flament, Hiro Wakasugi, Axel Le Cesne, Vladimir Lazar, Jean-Yves Blay, Jean-François Emile, Mike C. Heinrich, Salah Mecheri, Thomas Tursz, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 502.
Published: 01 April 2004
View articletitled, KIT tyrosine kinase inhibition of dendritic cells (DC) promotes NK cell–dependent antitumor effects: Preclinical datas and clinical monitoring of imatinib mesylate treated gastro-intestinal stromal tumor patients.