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Aviad Tsherniak
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Journal Articles

Abstract 1883: Large scale viability screening with PRISM underscores non-inhibitory properties of small molecules

Lucian de Waal, Kevin Larpenteur, Li Wang, Cong Zhu, Jordan Bryan, Mustafa Kocak, Corrie Aghia, Joshua Bittker, Victor Jones, Anita Vrcic, Edward McBride, Samantha Bender, Kalea Gore, Frank Li, Zhenghao Chen, Aviad Tsherniak, Aravind Subramanian, Daphne Koller, Jeffery Settleman, Chris C. Mader, David Stokoe, Ari Firestone, Jennifer A. Roth, Todd R. Golub
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1883.
https://doi.org/10.1158/1538-7445.AM2022-1883
Published: 15 June 2022
View articletitled, Abstract 1883: Large scale viability screening with PRISM underscores non-inhibitory properties of small molecules
Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Jasper E. Neggers, Brenton Paolella, Adhana Asfaw, Michael V. Rothberg, Tom A. Skipper, Radha Kalekar, Michael Burger, Neekesh Dharia, Guillaume Kugener, Jeremie Kalfon, Nancy Dumont, Yvonne Li, Liam Spurr, Annan Yang, Wenbo Wu, AndrewAdam Durbin, Brian M. Wolpin, David E. Root, Jesse Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2021-NG01
Published: 01 July 2021
View articletitled, Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
Journal Articles

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, Michael J. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Adam D. Durbin, Annan Yang, Nancy Dumont, Yvonne Y. Li, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-011.
https://doi.org/10.1158/1538-7445.PANCA20-PO-011
Published: 13 November 2020
View articletitled, Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers
Journal Articles

Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

Tsukasa Shibue, John M. Krill-Burger, Brenton R. Paolella, Benjamin Gaeta, Adhana Asfaw, Joshua M. Dempster, James M. McFarland, David E. Root, Jesse S. Boehm, Aviad Tsherniak, William C. Hahn, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-100.
https://doi.org/10.1158/1538-7445.AM2020-LB-100
Published: 15 August 2020
View articletitled, Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines
Journal Articles

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, John M. Krill-Burger, Andrew L. Hong, Guillaume Kugener, Jeremie Kalfon, Annan Yang, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Federica Piccioni, Brian M. Wolpin, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-053.
https://doi.org/10.1158/1538-7445.AM2020-LB-053
Published: 15 August 2020
View articletitled, Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4
Journal Articles

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Adam D. Durbin, Guillaume Kugener, Mark W. Zimmerman, Chuan Yan, Neekesh V. Dharia, Elizabeth S. Frank, Xiang Chen, Ken N. Ross, Brenton Paolella, Michael Krill-Burger, David E. Root, Jesse S. Boehm, Francisca Vazquez, Andrew L. Hong, Aviad Tsherniak, David M. Langenau, William C. Hahn, Todd R. Golub, Brian J. Abraham, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B10.
https://doi.org/10.1158/1538-7445.PEDCA19-B10
Published: 15 July 2020
View articletitled, Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry
Journal Articles

Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells

Steven M. Corsello, Ryan D. Spangler, Rohith T. Nagari, Mustafa Kocak, Jordan Rossen, Patrick O'Hearn, Jennifer Roth, Alfredo Gonzalez, Nancy Dumont, John Doench, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, Todd R. Golub
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2948.
https://doi.org/10.1158/1538-7445.AM2019-2948
Published: 01 July 2019
View articletitled, Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells
Journal Articles

Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2867.
https://doi.org/10.1158/1538-7445.AM2019-2867
Published: 01 July 2019
View articletitled, Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors
Journal Articles

Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing

Samantha Bender, Cong Zhu, Li Wang, Michael Rothberg, Joshua Dempster, Brenton Paolella, Mustafa Kocak, Massami Laird, Jordan Rossen, Karolina Stumbraite, Jordan Bryan, Vickie Wang, John Doench, Francisca Vazquez, Aviad Tsherniak, Todd Golub, Jennifer Roth
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2690.
https://doi.org/10.1158/1538-7445.AM2019-2690
Published: 01 July 2019
View articletitled, Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing
Journal Articles

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

Colles Price, Stanley Gill, Zandra V. Ho, Shawn M. Davidson, Erin Merkel, James M. McFarland, Lisa Leung, Andrew Tang, Maria Kost-Alimova, Aviad Tsherniak, Oliver Jonas, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2019) 79 (10): 2564–2579.
https://doi.org/10.1158/0008-5472.CAN-18-2674
Published: 15 May 2019
View articletitled, Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers
Open the PDF for Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers in another window
Includes: Supplementary data
Journal Articles

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong L. Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W.M. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2404–2414.
https://doi.org/10.1158/0008-5472.CAN-18-3066
Published: 01 May 2019
View articletitled, MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Open the PDF for MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Brian J. Abraham, Amanda Balboni-Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Todd R. Golub, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2062.
https://doi.org/10.1158/1538-7445.AM2018-2062
Published: 01 July 2018
View articletitled, Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Journal Articles

Abstract 2352: Defining a pediatric cancer dependency map

Neekesh V. Dharia, Clare Malone, Amanda Balboni Iniguez, Lillian Guenther, Liying Chen, Gabriela Alexe, Adam D. Durbin, Mark W. Zimmerman, Andrew Hong, Pratiti Bandopadhayay, Mariella G. Filbin, Thomas Howard, Brenton Paolella, Iris Fung, Josephine Lee, Phil Montgomery, John M. Krill-Burger, Brian J. Abraham, Jennifer Roth, David E. Root, Richard A. Young, A. Thomas Look, Rameen Beroukhim, Jesse S. Boehm, William C. Hahn, Todd R. Golub, Aviad Tsherniak, Francisca Vazquez, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2352.
https://doi.org/10.1158/1538-7445.AM2018-2352
Published: 01 July 2018
View articletitled, Abstract 2352: Defining a pediatric cancer dependency map
Journal Articles

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Jessie Hao-Ru Hsu, Benjamin Hubbell-Engler, Guillaume Adelmant, Jialiang Huang, Cailin E. Joyce, Francisca Vazquez, Barbara A. Weir, Philip Montgomery, Aviad Tsherniak, Andrew O. Giacomelli, Jennifer A. Perry, Jennifer Trowbridge, Yuko Fujiwara, Glenn S. Cowley, Huafeng Xie, Woojin Kim, Carl D. Novina, William C. Hahn, Jarrod A. Marto, Stuart H. Orkin
Journal: Cancer Research
Cancer Res (2017) 77 (17): 4613–4625.
https://doi.org/10.1158/0008-5472.CAN-17-0216
Published: 31 August 2017
View articletitled, PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
Open the PDF for PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1555: Pan-cancer patterns of synthetic lethality: statistical modeling of gene dependency profiles

Huwate Yeerna, Ramya Rangan, Andrew Aguirre, William Kim, Francisca Vazquez, Barbara Weir, Mahmoud Ghandi, Aviad Tsherniak, Jesse Boehm, William Hahn, Jill Mesirov, Pablo Tamayo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1555.
https://doi.org/10.1158/1538-7445.AM2017-1555
Published: 01 July 2017
View articletitled, Abstract 1555: Pan-cancer patterns of synthetic lethality: statistical modeling of gene dependency profiles
Journal Articles

Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models

Yuen-Yi Tseng, Andrew Hong, Paula Keskula, Shubhroz Gill, Jaime Cheah, Grigoriy Kryukov, Aviad Tsherniak, Francisca Vazquez, Glenn Cowley, Sahar Alkhairy, Coyin Oh, Anson Peng, Rebecca Deasy, Abeer Sayeed, Peter Ronning, Samuel Ng, Steven Corsello, Corrie Painter, David Sandak, Levi Garraway, Mark Rubin, Calvin Kuo, Sidharth Puram, David Weinstock, Adam Bass, Nikhil Wagle, Keith Ligon, Katherine Janeway, David Root, Stuart Schreiber, Paul Clemons, Aly Shamji, Aly Shamji, William Hahn, Todd Golub, Jesse Boehm
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1953.
https://doi.org/10.1158/1538-7445.AM2017-1953
Published: 01 July 2017
View articletitled, Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models
Journal Articles

Abstract 5559: Using cancer dependency data to discover tumor suppressive and oncogenic functional modules

Joshua Pan, Robin M. Meyers, Brittany C. Michel, Ann E. Sizemore, Francisca Vazquez, Barbara A. Weir, William C. Hahn, Aviad Tsherniak, Cigall Kadoch
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5559.
https://doi.org/10.1158/1538-7445.AM2017-5559
Published: 01 July 2017
View articletitled, Abstract 5559: Using cancer dependency data to discover tumor suppressive and oncogenic functional modules
Journal Articles

Abstract 4025: Accelerating drug repurposing for cancer therapy using multiplexed viability assays

Steven M. Corsello, Christopher C. Mader, Jordan Bryan, Jennifer Roth, David Peck, John Davis, Samantha Bender, Li Wang, Alice Wang, Joshua Bittker, Francisca Vazquez, Aravind Subramanian, Aviad Tsherniak, Todd R. Golub
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4025.
https://doi.org/10.1158/1538-7445.AM2017-4025
Published: 01 July 2017
View articletitled, Abstract 4025: Accelerating drug repurposing for cancer therapy using multiplexed viability assays
Journal Articles

Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer

Andrew J. Aguirre, Wei Shao, Han Xu, Barbara Weir, Francisca Vazquez, Robin Meyers, Cheng-Zhong Zhang, Mihir Doshi, Glenn S. Cowley, Theodore Ewachiw, Zeshaan Rasheed, Todd R. Golub, Kimberly Stegmaier, Charles W. Roberts, Levi A. Garraway, Matthew Meyerson, Aviad Tsherniak, David E. Root, Peter J. Espenshade, William C. Hahn
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): PR05.
https://doi.org/10.1158/1538-7445.PANCA16-PR05
Published: 14 December 2016
View articletitled, Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer
Journal Articles

Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models

Yuen-Yi Tseng, Andrew Hong, Paula Keskula, Shubhroz Gill, Jaime Cheah, Grigoriy Kryukov, Aviad Tsherniak, Francisca Vazquez, Glenn Cowley, Coyin Oh, Anson Peng, Abeer Sayeed, Rebecca Deasy, Peter Ronning, Philip Kantoff, Levi Garraway, Mark Rubin, Calvin Kuo, Sidharth Puram, Adi Gazdar, Filemon Dela Cruz, Adam Bass, Nikhil Wagle, Keith Ligon, Katherine Janeway, David Root, Stuart Schreiber, Paul Clemons, Aly Shamji, William Hahn, Todd Golub, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4367.
https://doi.org/10.1158/1538-7445.AM2016-4367
Published: 15 July 2016
View articletitled, Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models