Page 1 | Search Results | Cancer Research | American Association for Cancer Research

1-13 of 13

Sort by

Sort Order Select

Journal Articles

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Vanessa T. Garrido, Zhiqun Zhou, Andrew Adams, Haleh Amirian, Edmond W. Box, Xiaodian Sun, Yuguang Ban, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant

Cancer Res (2024) 84 (8): 1320–1332.

https://doi.org/10.1158/0008-5472.CAN-23-1200

Published: 15 April 2024

View article titled, Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Includes: Supplementary data

Journal Articles

Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Vanessa Tonin Garrido, Anna Bianchi, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant

Cancer Res (2024) 84 (2_Supplement): C025.

https://doi.org/10.1158/1538-7445.PANCA2023-C025

Published: 16 January 2024

View article titled, Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Journal Articles

Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma

Samara Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin Garrido, Zhiqun Zhou, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj Nagathihalli, Nipun B. Merchant

Cancer Res (2023) 83 (7_Supplement): 3627.

https://doi.org/10.1158/1538-7445.AM2023-3627

Published: 04 April 2023

View article titled, Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma

Journal Articles

Abstract C059: Targeting tumor intrinsic p38 MAPK signaling to block IL-1α-mediated inflammatory tumor-stromal crosstalk in pancreatic cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin-Garrido, Nilesh U. Deshpande, Zhiqun Zhou, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B. Merchant

Cancer Res (2022) 82 (22_Supplement): C059.

https://doi.org/10.1158/1538-7445.PANCA22-C059

Published: 15 November 2022

View article titled, Abstract C059: Targeting tumor intrinsic p38 MAPK signaling to block IL-1α-mediated inflammatory tumor-stromal crosstalk in pancreatic cancer

Journal Articles

Abstract C040: CREB-LIF axis drives immune suppression by promoting macrophage polarization in pancreatic cancer

Siddharth Mehra, Vanessa T. Garrido, Samara Singh, Iago De Castro Silva, Anna Bianchi, Luis A. Nivelo, Nilesh U. Deshpande, Austin R. Dosch, Zhou Zhiqun, Supriya Srinivasan, Christine I. Rafie, Ifeanyichukwu C. Ogobuiro, Xi Chen, Alejandro Villarino, Jashodeep Datta, Nipun B. Merchant, Nagaraj Nagathihalli

Cancer Res (2022) 82 (22_Supplement): C040.

https://doi.org/10.1158/1538-7445.PANCA22-C040

Published: 15 November 2022

View article titled, Abstract C040: CREB-LIF axis drives immune suppression by promoting macrophage polarization in pancreatic cancer

Journal Articles

Abstract C033: KRAS-TP53 cooperativity regulates Cxcl1 to sustain tumor-permissive circuitry via granulocyte-derived CXCR2-TNF signaling in pancreatic cancer

Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Siddharth Mehra, Vanessa T. Garrido, Samara Singh, Christine I. Rafie, Zhou Zhiqun, Ifeanyichukwu C. Ogobuiro, Austin R. Dosch, Nagaraj Nagathihalli, Nipun B. Merchant, Jashodeep Datta

Cancer Res (2022) 82 (22_Supplement): C033.

https://doi.org/10.1158/1538-7445.PANCA22-C033

Published: 15 November 2022

View article titled, Abstract C033: KRAS-TP53 cooperativity regulates Cxcl1 to sustain tumor-permissive circuitry via granulocyte-derived CXCR2-TNF signaling in pancreatic cancer

Journal Articles

Abstract 2513: MDSC-derived TNF is a novel regulator of T-cell dysfunction in pancreatic cancer

Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Siddharth Mehra, Samara Singh, Austin R. Dosch, Vanessa T. Garrido, Christine I. Rafie, Nagaraj Nagathihalli, Nipun Merchant, Jashodeep Datta

Cancer Res (2022) 82 (12_Supplement): 2513.

https://doi.org/10.1158/1538-7445.AM2022-2513

Published: 15 June 2022

View article titled, Abstract 2513: MDSC-derived TNF is a novel regulator of T-cell dysfunction in pancreatic cancer

Journal Articles

Abstract 1565: Targeting stromal-specific p38 MAPK signaling to stifle inflammatory reprogramming of cancer-associated fibroblasts in pancreatic cancer

Samara Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin Garrido, Nilesh Deshpande, Zhiqun Zhou, Jashodeep Datta, Nagaraj Nagathihalli, Nipun Merchant

Cancer Res (2022) 82 (12_Supplement): 1565.

https://doi.org/10.1158/1538-7445.AM2022-1565

Published: 15 June 2022

View article titled, Abstract 1565: Targeting stromal-specific p38 MAPK signaling to stifle inflammatory reprogramming of cancer-associated fibroblasts in pancreatic cancer

Journal Articles

Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Vanessa Tonin Garrido, Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Purushottam Lamichhane, Siddharth Mehra, Samara P. Singh, Austin R. Dosch, Oliver Umland, Michael n N. VanSaun, Peter J. Hosein, Nagaraj Nagathihalli, Nipun Merchant

Cancer Res (2022) 82 (12_Supplement): 4187.

https://doi.org/10.1158/1538-7445.AM2022-4187

Published: 15 June 2022

View article titled, Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Journal Articles

Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer

Austin R. Dosch, Samara Singh, Xizi Dai, Siddharth Mehra, Anna Bianchi, Iago De Castro Silva, Supriya Srinivasan, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B. Merchant

Cancer Res (2020) 80 (22_Supplement): PO-049.

https://doi.org/10.1158/1538-7445.PANCA20-PO-049

Published: 13 November 2020

View article titled, Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer

Journal Articles

Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer

Anna Bianchi, Siddharth Mehra, Daisy Dai, Iago de Castro Silva, Prateek Sharma, Antonio Colaprico, Austin R. Dosch, Samara Singh, Nagaraj S. Nagathihalli, Nipun B. Merchant, Jashodeep Datta

Cancer Res (2020) 80 (22_Supplement): PO-046.

https://doi.org/10.1158/1538-7445.PANCA20-PO-046

Published: 13 November 2020

View article titled, Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer

Journal Articles

Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Austin R. Dosch, Xizi Dai, Michelle L. Reyzer, Deukwoo Kwon, Richard Caprioli, Nipun B. Merchant, Nagaraj S. Nagathihalli

Cancer Res (2019) 79 (24_Supplement): A11.

https://doi.org/10.1158/1538-7445.PANCA19-A11

Published: 13 December 2019

View article titled, Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Journal Articles

Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Supriya Srinivasan, Tulasigeri Totiger, Chanjuan Shi, Jason Castellanos, Purushottam Lamichhane, Austin R. Dosch, Fanuel Messaggio, Nilesh Kashikar, Kumaraswamy Honnenahally, Yuguang Ban, Nipun B. Merchant, Michael VanSaun, Nagaraj S. Nagathihalli

Cancer Res (2018) 78 (21): 6146–6158.

https://doi.org/10.1158/0008-5472.CAN-18-0579

Published: 01 November 2018

View article titled, Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Includes: Supplementary data

NARROW

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma

Abstract C059: Targeting tumor intrinsic p38 MAPK signaling to block IL-1α-mediated inflammatory tumor-stromal crosstalk in pancreatic cancer

Abstract C040: CREB-LIF axis drives immune suppression by promoting macrophage polarization in pancreatic cancer

Abstract C033: KRAS-TP53 cooperativity regulates Cxcl1 to sustain tumor-permissive circuitry via granulocyte-derived CXCR2-TNF signaling in pancreatic cancer

Abstract 2513: MDSC-derived TNF is a novel regulator of T-cell dysfunction in pancreatic cancer

Abstract 1565: Targeting stromal-specific p38 MAPK signaling to stifle inflammatory reprogramming of cancer-associated fibroblasts in pancreatic cancer

Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer

Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer

Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only