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Journal Articles

Abstract C017: Unravelling tumor-intrinsic resistance mechanisms in pancreatic cancers to T-cell mediated cytotoxicity

Judit Diaz, Pierre Levy, Jonatan Gonzalez, Asis Palazon, Sonia Guedan, Alena Gros

Cancer Res (2022) 82 (22_Supplement): C017.

DOI: https://doi.org/10.1158/1538-7445.PANCA22-C017

Published: 15 November 2022

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Journal Articles

Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors

Colin E. Evans, Asis Palazon, Jingwei Sim, Petros A. Tyrakis, Par-Ola Bendahl, Mattias Belting, Helene Rundqvist, Cristina Branco, Randall S. Johnson

Cancer Res (2016) 76 (7_Supplement): A19.

DOI: https://doi.org/10.1158/1538-7445.TUMMET15-A19

Published: 26 May 2016

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Journal Articles

Abstract 4058: Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

Sara Labiano, Asís Palazón, José I. Quetglas, Elixabet Bolaños, Arantza Azpilicueta, Aizea Morales-Kastresana, Alfonso Rodriguez, Maria Rodriguez-Ruiz, Alfonso Gurpide, M Angela Aznar, Maria Jure-Kunkel, Ignacio Melero

Cancer Res (2015) 75 (15_Supplement): 4058.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4058

Published: 01 August 2015

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Journal Articles

Abstract B12: Molecular mechanisms of HIF-1a and HIF-2a activation in nonmalignant cells at the premetastatic niche: Effects on metastatic success

Cristina Branco-Price, Asis Palazon, Jessica Xie, Randall S. Johnson

Cancer Res (2015) 75 (1_Supplement): B12.

DOI: https://doi.org/10.1158/1538-7445.CHTME14-B12

Published: 12 January 2015

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Journal Articles

Abstract B2: T cell costimulation in cancer immunotherapy with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Ivan Martinez-Forero, Arantza Azpilicueta, Elixabet Bolaños-Mateo, Estnislao Nistal-Villan, Asis Palazon, Alvaro Teijeira, Gema Perez-Chacon, Aizea Morales-Kastresana, Oihana Murillo, Maria Jure-Kunkel, Juan Manuel Zapata, Ignacio Melero

Cancer Res (2013) 73 (1_Supplement): B2.

DOI: https://doi.org/10.1158/1538-7445.TUMIMM2012-B2

Published: 02 April 2014

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Journal Articles

Abstract LB-330: Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma.

Aizea Morales-Kastresana, Miguel F. Sanmamed, Inmaculada Rodriguez, Asis Palazon, Ivan Martinez-Forero, Sara Labiano, Sandra Hervas-Stubbs, Bruno Sangro, Carmen Ochoa, Arantza Azpilikueta, Elixabet Bolaños, Ines Gütgemann, Ignacio Melero

Cancer Res (2013) 73 (8_Supplement): LB-330.

DOI: https://doi.org/10.1158/1538-7445.AM2013-LB-330

Published: 15 April 2013

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Journal Articles

Abstract 3538: The HIF-1α hypoxia response in mouse tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy

Asis Palazon, Ivan Martinez-forero, Alvaro Teijeira, Aizea Morales-Kastresana, Carlos Alfaro, Miguel Fernandez de Sanmamed, Sandra Hervas-Stubbs, Maria Jure-Kunkel, Julian Aragones, Ignacio Melero

Cancer Res (2012) 72 (8_Supplement): 3538.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3538

Published: 15 April 2012

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Journal Articles

Abstract 4567: Polyubiquitin K63-related CD137 signalsomes in T cells stimulated with agonist anti-CD137 monoclonal antibodies

Ivan Martinez Forero, Arantza Azpilicueta, Estanislao Nistal Villan, Asis Palazon, Ana Rouzaut, Tomas Aragon, Juan Dubrot, Oihana Murillo, Sandra Hervás-Stubbs, Ignacio Melero

Cancer Res (2011) 71 (8_Supplement): 4567.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4567

Published: 15 April 2011

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Journal Articles

Abstract 4740: Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment ofactivated T lymphocytes

Asis Palazon, Alvaro Teijeira, Iván Martínez-Forero, Sandra Hervás-Stubbs, Carmen Roncal, Juan Dubrot, Aizea Morales-Kastresana, Ana Rouzaut, Maria Jure-Kunkel, Ignacio Melero

Cancer Res (2011) 71 (8_Supplement): 4740.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4740

Published: 15 April 2011

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Journal Articles

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Asís Palazón, Alvaro Teijeira, Iván Martínez-Forero, Sandra Hervás-Stubbs, Carmen Roncal, Iván Peñuelas, Juan Dubrot, Aizea Morales-Kastresana, José Luis Pérez-Gracia, M. Carmen Ochoa, Laura Ochoa-Callejero, Alfredo Martínez, Alfonso Luque, Joseph Dinchuk, Ana Rouzaut, Maria Jure-Kunkel, Ignacio Melero

Cancer Res (2011) 71 (3): 801–811.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-1733

Published: 01 February 2011

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Includes: Supplementary data

Journal Articles

Abstract LB-196: Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects

Juan Dubrot, Asis Palazon, Francisca Milheiro, Ivan Martinez-Forero, Ignacio Melero

Cancer Res (2010) 70 (8_Supplement): LB-196.

DOI: https://doi.org/10.1158/1538-7445.AM10-LB-196

Published: 15 April 2010

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Journal Articles

Abstract #4134: Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-\#945;

Ana Rouzaut, Saray Garasa, Alvaro Teijeira, Ivan Martínez-Forero, Iranzo Martínez-González, Esther Larrea, Carlos Alfaro, Asís Palazón, Juan Dubrot, Sandra Hervás-Stubbs, Ignacio Melero

Cancer Res (2009) 69 (9_Supplement): 4134.

Published: 01 May 2009

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Journal Articles

Abstract #2413: Intratumoral injection of interferon-\#945; and systemic delivery of agonist anti-CD137 mAb synergize for immunotherapy in mice bearing multiple tumor lesions.

Juan Dubrot, Asis Palazon, Carmen Ochoa, Carlos Alfaro, Arantza Azpilikueta, Natalia Suarez, Ana Rouzaut, Ivan Marinez Forero, Jose L. Perez-Gracia, Aganes Le Bon, Sandra Hervas-Stubbs, Ignacio Melero

Cancer Res (2009) 69 (9_Supplement): 2413.

Published: 01 May 2009

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NARROW

Abstract C017: Unravelling tumor-intrinsic resistance mechanisms in pancreatic cancers to T-cell mediated cytotoxicity

Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors

Abstract 4058: Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

Abstract B12: Molecular mechanisms of HIF-1a and HIF-2a activation in nonmalignant cells at the premetastatic niche: Effects on metastatic success

Abstract B2: T cell costimulation in cancer immunotherapy with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

Abstract LB-330: Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma.

Abstract 3538: The HIF-1α hypoxia response in mouse tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy

Abstract 4567: Polyubiquitin K63-related CD137 signalsomes in T cells stimulated with agonist anti-CD137 monoclonal antibodies

Abstract 4740: Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment ofactivated T lymphocytes

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Abstract LB-196: Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects

Abstract #4134: Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-\#945;

Abstract #2413: Intratumoral injection of interferon-\#945; and systemic delivery of agonist anti-CD137 mAb synergize for immunotherapy in mice bearing multiple tumor lesions.

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