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Journal Articles

Abstract 4031: In vivo studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model

Saúl Navarro-Marchal, Carolin Temps, Iñigo Lanzagorta-Calvillo, John C. Dawson, Enrique Poradosu, Neil O. Carragher, Valerie G. Brunton, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4031.
https://doi.org/10.1158/1538-7445.AM2023-4031
Published: 04 April 2023
View article titled, Abstract 4031: <em>In vivo</em> studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model
Journal Articles

Abstract 3326: Uncovering the molecular mechanisms which predict sensitivity to a novel src kinase inhibitor NXP900 to inform personalized healthcare strategies

Neil Carragher, Rebecca Hughes, Valerie Brunton, Asier Unciti-broceta, Iñigo Lanzagorta-Calvillo, Carolin Temps, Enrique Poradosu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3326.
https://doi.org/10.1158/1538-7445.AM2022-3326
Published: 15 June 2022
View article titled, Abstract 3326: Uncovering the molecular mechanisms which predict sensitivity to a novel src kinase inhibitor NXP900 to inform personalized healthcare strategies
Journal Articles

Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Journal: Cancer Research
Cancer Res (2022) 82 (4): 632–647.
https://doi.org/10.1158/0008-5472.CAN-21-0373
Published: 15 February 2022
View article titled, Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
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Includes: Supplementary data
Journal Articles

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Carolin Temps, Daniel Lietha, Emily R. Webb, Xue-Feng Li, John C. Dawson, Morwenna Muir, Kenneth G. Macleod, Teresa Valero, Alison F. Munro, Rafael Contreras-Montoya, Juan R. Luque-Ortega, Craig Fraser, Henry Beetham, Christina Schoenherr, Maria Lopalco, Mark J. Arends, Margaret C. Frame, Bin-Zhi Qian, Valerie G. Brunton, Neil O. Carragher, Asier Unciti-Broceta
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5438–5450.
https://doi.org/10.1158/0008-5472.CAN-21-0613
Published: 01 November 2021
View article titled, A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
Open the PDF for A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability in another window
Includes: Supplementary data
Journal Articles

Abstract 3796: Targeting cancer stem cells using ALDH-dependent 5-nitrofuran prodrugs

Richard Crispin, Nathalie M. Spockeli, Val Brunton, Neil Carragher, Charlie Gourley, Douglas R. Houston, Asier Unciti-Broceta, E. Elizabeth Patton.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3796.
https://doi.org/10.1158/1538-7445.AM2016-3796
Published: 15 July 2016
View article titled, Abstract 3796: Targeting cancer stem cells using ALDH-dependent 5-nitrofuran prodrugs