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Journal Articles

Abstract PR003: Sex-dependent changes in the aged melanoma tumor microenvironment influence metastasis and therapeutic responses

Yash Chhabra, Ashani T. Weeraratna

Cancer Res (2024) 84 (22_Supplement): PR003.

https://doi.org/10.1158/1538-7445.TUMBODY-PR003

Published: 17 November 2024

View article titled, Abstract PR003: Sex-dependent changes in the aged melanoma tumor microenvironment influence metastasis and therapeutic responses

Journal Articles

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Daniel J. Zabransky, Yash Chhabra, Mitchell E. Fane, Emma Kartalia, James M. Leatherman, Laura Hüser, Jacquelyn W. Zimmerman, Daniel Delitto, Song Han, Todd D. Armstrong, Soren Charmsaz, Samantha Guinn, Sneha Pramod, Elizabeth D. Thompson, Steven J. Hughes, Jennifer O'Connell, Josephine M. Egan, Elizabeth M. Jaffee, Ashani T. Weeraratna

Cancer Res (2024) 84 (8): 1221–1236.

https://doi.org/10.1158/0008-5472.CAN-24-0086

Published: 15 April 2024

View article titled, Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Includes: Supplementary data

Journal Articles

Abstract 358: Ferroptosis modulates melanoma progression in an age-specific manner through changes in the tumor microenvironment

Murilo R. Rocha, Yash Chhabra, Laura Huser, Elizabeth Irene Harper, Agrani Dixit, Vania Wang, Alexis E. Carey, Cheyenne Palm, Fan Huang, Ashani T. Weeraratna

Cancer Res (2024) 84 (6_Supplement): 358.

https://doi.org/10.1158/1538-7445.AM2024-358

Published: 22 March 2024

View article titled, Abstract 358: Ferroptosis modulates melanoma progression in an age-specific manner through changes in the tumor microenvironment

Journal Articles

Abstract 6631: Aging influences the pancreatic ductal adenocarcinoma tumor immune microenvironment to promote features of immunosuppression

Emma Kartalia, James M. Leatherman, Jae W. Lee, Elizabeth M. Jaffee, Ashani T. Weeraratna, Daniel J. Zabransky

Cancer Res (2024) 84 (6_Supplement): 6631.

https://doi.org/10.1158/1538-7445.AM2024-6631

Published: 22 March 2024

View article titled, Abstract 6631: Aging influences the pancreatic ductal adenocarcinoma tumor immune microenvironment to promote features of immunosuppression

Journal Articles

Abstract A005: The aged tumor microenvironment influences tolerance to targeted therapy via NR2F1 overexpression in BRAF-mutant melanoma

Manoela Tiago, Timothy J. Purwin, Mitchell E. Fane, Yash Chhabra, Jessica L. F. Teh, Rama Kadamb, Weijia Cai, Inna Chervoneva, Sheera Rosenbaum, Vivian Chua, Nir Hacohen, Michael A. Davies, Jessie Villanieva, Ashani T. Weeraratna, Claudia Capparelli, Julio A. Aguirre-Ghiso, Andrew E. Aplin

Cancer Res (2023) 83 (2_Supplement_1): A005.

https://doi.org/10.1158/1538-7445.AGCA22-A005

Published: 15 January 2023

View article titled, Abstract A005: The aged tumor microenvironment influences tolerance to targeted therapy via NR2F1 overexpression in BRAF-mutant melanoma

Journal Articles

Abstract 3638: Age-related changes in pancreatic fibroblasts promote growth and progression of pancreatic cancer

Daniel J. Zabransky, Yash Chhabra, Mitchell E. Fane, Daniel Delitto, Jacquelyn W. Zimmermann, Elizabeth M. Jaffee, Ashani T. Weeraratna

Cancer Res (2022) 82 (12_Supplement): 3638.

https://doi.org/10.1158/1538-7445.AM2022-3638

Published: 15 June 2022

View article titled, Abstract 3638: Age-related changes in pancreatic fibroblasts promote growth and progression of pancreatic cancer

Journal Articles

Abstract 3637: Age-dependent loss of HAPLN1 erodes vascular integrity via upregulation of endothelial ICAM1 in melanoma

Gloria E. Marino, Yash Chhabra, Amanpreet Kaur, Filipe Almeida, Ying Liu, Karin T. S. Eisinger-Mathason, Ashani T. Weeraratna

Cancer Res (2022) 82 (12_Supplement): 3637.

https://doi.org/10.1158/1538-7445.AM2022-3637

Published: 15 June 2022

View article titled, Abstract 3637: Age-dependent loss of HAPLN1 erodes vascular integrity via upregulation of endothelial ICAM1 in melanoma

Journal Articles

Abstract SY24-04: And by a sleep to say we end: Tumor dormancy, aging, and recurrent disease

Ashani T. Weeraratna

Cancer Res (2022) 82 (12_Supplement): SY24-04.

https://doi.org/10.1158/1538-7445.AM2022-SY24-04

Published: 15 June 2022

View article titled, Abstract SY24-04: And by a sleep to say we end: Tumor dormancy, aging, and recurrent disease

Journal Articles

Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity

Stephen M. Douglass, Mitchell E. Fane, Emilio Sanseviero, Brett L. Ecker, Curtis H. Kugel, III, Reeti Behera, Vinit Kumar, Evgenii N. Tcyganov, Xiangfan Yin, Qin Liu, Yash Chhabra, Gretchen M. Alicea, Rejji Kuruvilla, Dmitry I. Gabrilovich, Ashani T. Weeraratna

Cancer Res (2021) 81 (3): 658–670.

https://doi.org/10.1158/0008-5472.CAN-20-1238

Published: 01 February 2021

View article titled, Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity

Includes: Supplementary data

Journal Articles

Abstract 3951: Age-dependent loss of HAPLN1 affects vascular integrity and metastasis in melanoma

Gloria E. Marino, Filipe V. Almeida, Ying Liu, Gretchen M. Alicea, Mitchell E. Fane, Ashani T. Weeraratna

Cancer Res (2020) 80 (16_Supplement): 3951.

https://doi.org/10.1158/1538-7445.AM2020-3951

Published: 15 August 2020

View article titled, Abstract 3951: Age-dependent loss of HAPLN1 affects vascular integrity and metastasis in melanoma

Journal Articles

Abstract SY30-01: A wrinkle in TiME: How the aging TME drives tumor progression

Ashani T. Weeraratna

Cancer Res (2019) 79 (13_Supplement): SY30-01.

https://doi.org/10.1158/1538-7445.AM2019-SY30-01

Published: 01 July 2019

View article titled, Abstract SY30-01: A wrinkle in TiME: How the aging TME drives tumor progression

Journal Articles

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Cancer Res (2017) 77 (21): 5873–5885.

https://doi.org/10.1158/0008-5472.CAN-17-0907

Published: 31 October 2017

View article titled, ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Includes: Supplementary data

Journal Articles

Abstract 4913: Invasive melanoma cells commandeer p53 activity to promote the survival of a therapy resistant subpopulation

Marie R. Webster, Amanpreet Kaur, Abibatou Ndoye, Curtis Kugel, Subhasree Basu, Alexander Valiga, Jessica Appleton, Ying-Jie Wang, Maureen Murphy, Ashani T. Weeraratna

Cancer Res (2017) 77 (13_Supplement): 4913.

https://doi.org/10.1158/1538-7445.AM2017-4913

Published: 01 July 2017

View article titled, Abstract 4913: Invasive melanoma cells commandeer p53 activity to promote the survival of a therapy resistant subpopulation

Journal Articles

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

Cancer Res (2016) 76 (9): 2720–2730.

https://doi.org/10.1158/0008-5472.CAN-15-2137

Published: 01 May 2016

View article titled, HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

Includes: Supplementary data

Journal Articles

Abstract 3775: p53 is differentially regulated in proliferative and invasive melanoma cells

Marie R. Webster, Subhasree Basu, Amanpreet Kaur, Jessica Appleton, Maureen E. Murphy, Ashani T. Weeraratna

Cancer Res (2015) 75 (15_Supplement): 3775.

https://doi.org/10.1158/1538-7445.AM2015-3775

Published: 01 August 2015

View article titled, Abstract 3775: p53 is differentially regulated in proliferative and invasive melanoma cells

Journal Articles

Abstract 1556: Role of Klotho in age-related melanoma progression

Reeti Behera, Amanpreet Kaur, Katie Marchbank, Vanessa Dang, Marie Webster, Xiaowei Xu, Ashani T. Weeraratna

Cancer Res (2015) 75 (15_Supplement): 1556.

https://doi.org/10.1158/1538-7445.AM2015-1556

Published: 01 August 2015

View article titled, Abstract 1556: Role of Klotho in age-related melanoma progression

Journal Articles

Abstract 2906: Role of autophagy in Wnt5A-mediated melanoma invasion and metastasis

Abibatou Ndoye, Anna Budina, Marie Webster, Amanpreet Kaur, Reeti Behera, Maureen Murphy, Ashani T. Weeraratna

Cancer Res (2015) 75 (15_Supplement): 2906.

https://doi.org/10.1158/1538-7445.AM2015-2906

Published: 01 August 2015

View article titled, Abstract 2906: Role of autophagy in Wnt5A-mediated melanoma invasion and metastasis

Journal Articles

Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

Cancer Res (2015) 75 (14_Supplement): B27.

https://doi.org/10.1158/1538-7445.MEL2014-B27

Published: 16 July 2015

View article titled, Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

Journal Articles

Abstract B2: Effect of a changing microenvironment on the role of ROR receptors in melanoma progression

Michael P. O'Connell, Tura Camilli, Ashani T. Weeraratna

Cancer Res (2011) 71 (18_Supplement): B2.

https://doi.org/10.1158/1538-7445.FBCR11-B2

Published: 28 October 2014

View article titled, Abstract B2: Effect of a changing microenvironment on the role of ROR receptors in melanoma progression

Journal Articles

Abstract LB-213: Discovery and molecular modeling of a novel mutation in the vemurafenib binding site of BRAF associated with therapeutic resistance in a patient with metastatic melanoma

Aleksandar Sekulic, Ashani T. Weeraratna, Jefferey L. MacKeigan, Amanpreet Kaur, Michael O'Connell, Megan L. Goodall, Michael Barrett, Elizabeth Lenkiewitz, Tara Holley, Victoria Zismann, Michael Gordon, Gideon Bollag, Chao Zhang, Jeffrey M. Trent

Cancer Res (2014) 74 (19_Supplement): LB-213.

https://doi.org/10.1158/1538-7445.AM2014-LB-213

Published: 01 October 2014

View article titled, Abstract LB-213: Discovery and molecular modeling of a novel mutation in the vemurafenib binding site of BRAF associated with therapeutic resistance in a patient with metastatic melanoma

NARROW

Abstract PR003: Sex-dependent changes in the aged melanoma tumor microenvironment influence metastasis and therapeutic responses

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Abstract 358: Ferroptosis modulates melanoma progression in an age-specific manner through changes in the tumor microenvironment

Abstract 6631: Aging influences the pancreatic ductal adenocarcinoma tumor immune microenvironment to promote features of immunosuppression

Abstract A005: The aged tumor microenvironment influences tolerance to targeted therapy via NR2F1 overexpression in BRAF-mutant melanoma

Abstract 3638: Age-related changes in pancreatic fibroblasts promote growth and progression of pancreatic cancer

Abstract 3637: Age-dependent loss of HAPLN1 erodes vascular integrity via upregulation of endothelial ICAM1 in melanoma

Abstract SY24-04: And by a sleep to say we end: Tumor dormancy, aging, and recurrent disease

Myeloid-Derived Suppressor Cells Are a Major Source of Wnt5A in the Melanoma Microenvironment and Depend on Wnt5A for Full Suppressive Activity

Abstract 3951: Age-dependent loss of HAPLN1 affects vascular integrity and metastasis in melanoma

Abstract SY30-01: A wrinkle in TiME: How the aging TME drives tumor progression

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Abstract 4913: Invasive melanoma cells commandeer p53 activity to promote the survival of a therapy resistant subpopulation

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

Abstract 3775: p53 is differentially regulated in proliferative and invasive melanoma cells

Abstract 1556: Role of Klotho in age-related melanoma progression

Abstract 2906: Role of autophagy in Wnt5A-mediated melanoma invasion and metastasis

Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

Abstract B2: Effect of a changing microenvironment on the role of ROR receptors in melanoma progression

Abstract LB-213: Discovery and molecular modeling of a novel mutation in the vemurafenib binding site of BRAF associated with therapeutic resistance in a patient with metastatic melanoma

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