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Journal Articles

The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma

Praneeth Reddy Sudalagunta, Rafael R. Canevarolo, Mark B. Meads, Maria Silva, Xiaohong Zhao, Christopher L. Cubitt, Samer S. Sansil, Gabriel DeAvila, Raghunandan Reddy Alugubelli, Ryan T. Bishop, Alexandre Tungesvik, Qi Zhang, Oliver Hampton, Jamie K. Teer, Eric A. Welsh, Sean J. Yoder, Bijal D. Shah, Lori Hazlehurst, Robert A. Gatenby, Dane R. Van Domelen, Yi Chai, Feng Wang, Andrew DeCastro, Amanda M. Bloomer, Erin M. Siegel, Conor C. Lynch, Daniel M. Sullivan, Melissa Alsina, Taiga Nishihori, Jason Brayer, John L. Cleveland, William Dalton, Christopher J. Walker, Yosef Landesman, Rachid Baz, Ariosto S. Silva, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2025) 85 (2): 378–398.
https://doi.org/10.1158/0008-5472.CAN-24-0886
Published: 15 January 2025
View article titled, The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract B019: The bone microenvironment's impact on the heterogeneity of resistance to proteasome inhibitors in multiple myeloma

David Basanta, Ryan Bishop, Anna Miller, Conor C. Lynch, Matthew Froid, Ariosto S. Silva, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_2): B019.
https://doi.org/10.1158/1538-7445.CANEVOL23-B019
Published: 01 February 2024
View article titled, Abstract B019: The bone microenvironment's impact on the heterogeneity of resistance to proteasome inhibitors in multiple myeloma
Journal Articles

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Karen L. Burger, Mario R. Fernandez, Mark B. Meads, Praneeth Sudalagunta, Paula S. Oliveira, Rafael Renatino Canevarolo, Raghunandan Reddy Alugubelli, Alexandre Tungsevik, Gabe De Avila, Maria Silva, Allison I. Graeter, Hongyue A. Dai, Nicole D. Vincelette, Antony Prabhu, Dario Magaletti, Chunying Yang, Weimin Li, Amit Kulkarni, Oliver Hampton, John M. Koomen, William R. Roush, Andrii Monastyrskyi, Anders E. Berglund, Ariosto S. Silva, John L. Cleveland, Kenneth H. Shain
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3901–3919.
https://doi.org/10.1158/0008-5472.CAN-22-2350
Published: 01 December 2023
View article titled, CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Open the PDF for CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

A Preclinical Assay for Chemosensitivity in Multiple Myeloma

Zayar P. Khin, Maria L.C. Ribeiro, Timothy Jacobson, Lori Hazlehurst, Lia Perez, Rachid Baz, Kenneth Shain, Ariosto S. Silva
Journal: Cancer Research
Cancer Res (2014) 74 (1): 56–67.
https://doi.org/10.1158/0008-5472.CAN-13-2397
Published: 05 January 2014
View article titled, A Preclinical Assay for Chemosensitivity in Multiple Myeloma
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Includes: Multimedia, Supplementary data
Journal Articles

Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer

Ariosto S. Silva, Yoonseok Kam, Zayar P. Khin, Susan E. Minton, Robert J. Gillies, Robert A. Gatenby
Journal: Cancer Research
Cancer Res (2012) 72 (24): 6362–6370.
https://doi.org/10.1158/0008-5472.CAN-12-2235
Published: 16 December 2012
View article titled, Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 3194: Reverse engineering the interplay between multiple myeloma and microenvironment

Zayar Khin, Lori Hazlehurst, Kenneth Shain, Robert Gillies, Robert Gatenby, Ariosto S. Silva
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3194.
https://doi.org/10.1158/1538-7445.AM2012-3194
Published: 15 April 2012
View article titled, Abstract 3194: Reverse engineering the interplay between multiple myeloma and microenvironment
Journal Articles

Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model

Hyung-Ok Lee, Ariosto S. Silva, Susanna Concilio, Yue-Sheng Li, Michael Slifker, Robert A. Gatenby, Jonathan D. Cheng
Journal: Cancer Research
Cancer Res (2011) 71 (20): 6327–6337.
https://doi.org/10.1158/0008-5472.CAN-11-0304
Published: 12 October 2011
View article titled, Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model
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Includes: Supplementary data
Journal Articles

Abstract 21: Understanding the progression and chemotherapy resistance of Multiple Myeloma in the bone marrow through evolutionary computational models and in vitro experiments

Ariosto S. Silva, Alexander Anderson, Robert Gillies, Robert Gatenby
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 21.
https://doi.org/10.1158/1538-7445.AM2011-21
Published: 15 April 2011
View article titled, Abstract 21: Understanding the progression and chemotherapy resistance of Multiple Myeloma in the bone marrow through evolutionary computational models and in vitro experiments
Journal Articles

Abstract 437: A putative role of hypoxia in development of de novo chemoresistance

Ariosto S. Silva, Robert A. Gatenby
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 437.
https://doi.org/10.1158/1538-7445.AM10-437
Published: 15 April 2010
View article titled, Abstract 437: A putative role of hypoxia in development of de novo chemoresistance
Journal Articles

Adaptive Therapy

Robert A. Gatenby, Ariosto S. Silva, Robert J. Gillies, B. Roy Frieden
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4894–4903.
https://doi.org/10.1158/0008-5472.CAN-08-3658
Published: 01 June 2009
View article titled, Adaptive Therapy
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Includes: Supplementary data
Journal Articles

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion

Ariosto S. Silva, Jose A. Yunes, Robert J. Gillies, Robert A. Gatenby
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2677–2684.
https://doi.org/10.1158/0008-5472.CAN-08-2394
Published: 17 March 2009
View article titled, The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
Open the PDF for The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion in another window
Includes: Supplementary data