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Ari M. Melnick
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Journal Articles

Abstract 5811: Epigenetic regulation of chromosomal instability in triple-negative breast cancer

Yang Bai, Albert Agustinus, Cem Meydan, Dylan R. McNally, Shira Yomtoubian, Liron Yoffe, Ari M. Melnick, Samuel Bakhoum, Vivek Mittal
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5811.
https://doi.org/10.1158/1538-7445.AM2023-5811
Published: 04 April 2023
View article titled, Abstract 5811: Epigenetic regulation of chromosomal instability in triple-negative breast cancer
Journal Articles

Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer

Alexey A. Soshnev, C. David Allis, Ethel Cesarman, Ari M. Melnick
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6061–6070.
https://doi.org/10.1158/0008-5472.CAN-21-2619
Published: 15 December 2021
View article titled, Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer
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Journal Articles

Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation

Jia Yi Fong, Diana Low, Luca Pignata, Kimihito Cojin Kawabata, Stanley CW Lee, Cheryl Koh, Daniele Musiani, Enrico Massignani, Cheng Mun Wun, Pierre-Alexis V. Goy, Yudao Shen, Heike Wollmann, Florence PH Gay, Genna Luciani, Dalia Barsyte, Jian Jin, Ari M. Melnick, Tiziana Bonaldi, Omar Abdel-Wahab, Ernesto Guccione
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4731.
https://doi.org/10.1158/1538-7445.AM2019-4731
Published: 01 July 2019
View article titled, Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation
Journal Articles

Abstract 1523: The mechanism of action of BCL6 in glioblastoma

Nicole M. Jones, Marie-Sophie Fabre, Dinindu Sachindra Senanayake, Katerina Hatzi, Ari M. Melnick, Melanie J. McConnell
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1523.
https://doi.org/10.1158/1538-7445.AM2017-1523
Published: 01 July 2017
View article titled, Abstract 1523: The mechanism of action of BCL6 in glioblastoma
Journal Articles

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Warren Fiskus, Veena Coothankandaswamy, Jianguang Chen, Hongwei Ma, Kyungsoo Ha, Dyana T. Saenz, Stephanie S. Krieger, Christopher P. Mill, Baohua Sun, Peng Huang, Jeffrey S. Mumm, Ari M. Melnick, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5467–5478.
https://doi.org/10.1158/0008-5472.CAN-16-0126
Published: 15 September 2016
View article titled, SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents
Open the PDF for SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents in another window
Includes: Supplementary data
Journal Articles

Abstract LB-073: Epigenome evolution in relapsed acute myeloid leukemia

Sheng Li, Francine E. Garrett-Bakelman, Stephen S. Chung, Todd Hricik, Franck Rapaport, Jay Patel, Richard Dillon, Priyanka Vijay, Anna L. Brown, Alexander E. Perl, Joy Connon, Mathijs A. Sanders, Peter J.M. Valk, Lars Bullinger, Selina Luger, Michael W. Becker, Ian D. Lewis, Luen Bik To, Richard J. D’Andrea, David Grimwade, Ruud Delwel, Bob Löwenberg, Hartmut Döhner, Konstanze Döhner, Monica L. Guzman, Duane C. Hassane, Gail J. Roboz, Martin Carroll, Christopher Y. Park, Donna S. Neuberg, Ross L. Levine, Ari M. Melnick, Christopher E. Mason
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-073.
https://doi.org/10.1158/1538-7445.AM2016-LB-073
Published: 15 July 2016
View article titled, Abstract LB-073: Epigenome evolution in relapsed acute myeloid leukemia
Journal Articles

Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma

Ana Ortega-Molina, Isaac W. Boss, Andres Canela, Heng Pan, Yanwen Jiang, Chunying Zhao, Man Jiang, Deqing Hu, Ji-Eun Lee, Hua-Tang Chen, Daisuke Ennishi, David W. Scott, Christoffer Hother, Shichong Liu, Xing-Jun Cao, Wayne Tam, Rita Shaknovich, Benjamin A. Garcia, Randy D. Gascoyne, Kai Ge, Ali Shilatifard, Olivier Elemento, Andre Nussenzweig, Ari M. Melnick, Hans-Guido Wendel
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): IA18.
https://doi.org/10.1158/1538-7445.CHROMEPI15-IA18
Published: 14 January 2016
View article titled, Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma
Journal Articles

Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma

Ana Ortega-Molina, Isaac Boss, Heng Pan, Yanwen Jiang, Deqing Hu, Xin Gao, Rita Shaknovich, Ali Shilatifard, Ari M. Melnick, Hans-Guido Wendel
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-064.
https://doi.org/10.1158/1538-7445.AM2015-LB-064
Published: 01 August 2015
View article titled, Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma
Journal Articles

Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders

Eunhee Kim, Stephen S. Chung, Jae H. Park, Young Rock Chung, Piro Lito, Julie Feldstein, Wenhuo Hu, Wendy Beguilin, Sebastien Monette, Cihangir Duy, Raajit Rampal, Leon Telis, Minal Patel, Min Kyung Kim, Ari M. Melnick, Neal Rosen, Martin S. Tallman, Christopher Y. Park, Omar Abdel-Wahab
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3140.
https://doi.org/10.1158/1538-7445.AM2014-3140
Published: 01 October 2014
View article titled, Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders
Journal Articles

Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells

Wendy Beguelin, Matt Teater, Relja Popovic, Yanwen Jiang, Leandro Cerchietti, Rita Shaknovich, Randy Gascoyne, Ross Levine, Omar Abdel-Wahab, Jonathan Licht, Olivier Elemento, Ari M. Melnick
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY09-03.
https://doi.org/10.1158/1538-7445.AM2014-SY09-03
Published: 01 October 2014
View article titled, Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells
Journal Articles

Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms

Sangeeta Nischal, Sanchari Bhattacharyya, Maximilian Christopeit, Yiting Yu, Li Zhou, Tushar D. Bhagat, Davendra Sohal, Britta Will, Yongkai Mo, Masako Suzuki, Animesh Pardanani, Michael McDevitt, Jaroslaw P. Maciejewski, Ari M. Melnick, John M. Greally, Ulrich Steidl, Alison Moliterno, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1076–1085.
https://doi.org/10.1158/0008-5472.CAN-12-0735
Published: 31 January 2013
View article titled, Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression

Pei-Chun Lin, Ya-Lin Chiu, Samprit Banerjee, Kyung Park, Juan Miguel Mosquera, Eugenia Giannopoulou, Pedro Alves, Ashutosh K. Tewari, Mark B. Gerstein, Himisha Beltran, Ari M. Melnick, Olivier Elemento, Francesca Demichelis, Mark A. Rubin
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1232–1244.
https://doi.org/10.1158/0008-5472.CAN-12-2968
Published: 31 January 2013
View article titled, Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
Open the PDF for Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 1263: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

Erica M. Gomes-DaGama, Kamalika Moulick, James H. Ahn, Hongliang Zong, Anna Rodina, Leandro Cerchietti, Maria E. Caldas Lopes-Vazquez, Kristin Beebe, Fabiana Perna, Chatzi Katerina, Ly P. Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Peter Smith-Jones, Mary Alpaugh, Steven S. Gross, Nagavarakishore Pillarsetty, Thomas Ku, Jason S. Lewis, Steven M. Larson, Levine Ross, Hediye Erdjument-Bromage, Monica L. Guzman, Stephen D. Nimer, Ari M. Melnick, Len Neckers, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1263.
https://doi.org/10.1158/1538-7445.AM2012-1263
Published: 15 April 2012
View article titled, Abstract 1263: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Journal Articles

Abstract LB-235: BCL6 enables Ph+ acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition

Cihangir Duy, Christian Hurtz, Phillip H. Koeffler, Ari M. Melnick, Markus Müschen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-235.
https://doi.org/10.1158/1538-7445.AM2011-LB-235
Published: 15 April 2011
View article titled, Abstract LB-235: BCL6 enables Ph+ acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition
Journal Articles

Derepression in the Desert: The Third Workshop on Clinical Translation of Epigenetics in Cancer Therapeutics

Arthur Zelent, Kevin Petrie, Manuel Boix-Chornet, Ari M. Melnick, Samuel Waxman, Steven D. Gore
Journal: Cancer Research
Cancer Res (2008) 68 (13): 4967–4970.
https://doi.org/10.1158/0008-5472.CAN-07-6779
Published: 01 July 2008
View article titled, Derepression in the Desert: The Third Workshop on Clinical Translation of Epigenetics in Cancer Therapeutics
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Includes: Supplementary data
Journal Articles

BCL6 attenuates DNA damage sensing in normal and malignant B-cells by directly repressing ATR.

Stella M. Ranuncolo, Jamil Dierov, Jose M. Polo, Rita Shaknovich, Martin Carroll, Ari M. Melnick
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1328.
Published: 15 April 2006
View article titled, BCL6 attenuates DNA damage sensing in normal and malignant B-cells by directly repressing ATR.