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Antonio Di Cristofano
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Journal Articles

Abstract 1792: Synthetic lethal vulnerabilities stemming from inhibition of one carbon metabolism in anaplastic thyroid cancer

Alexander Forrest, Anil Ahsan, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1792.
https://doi.org/10.1158/1538-7445.AM2024-1792
Published: 22 March 2024
View articletitled, Abstract 1792: Synthetic lethal vulnerabilities stemming from inhibition of one carbon metabolism in anaplastic thyroid cancer
Journal Articles

Abstract LB273: An emerging paradigm of heterogeneous midkine expression in thyroid cancer

Dimitra P. Anastasiadou, Antonio Di Cristofano, George S. Karagiannis
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB273.
https://doi.org/10.1158/1538-7445.AM2023-LB273
Published: 14 April 2023
View articletitled, Abstract LB273: An emerging paradigm of heterogeneous midkine expression in thyroid cancer
Journal Articles

Abstract 4983: Anaplastic thyroid cancer cells upregulate mitochondrial one-carbon metabolism to meet purine demand, eliciting a targetable vulnerability

Adam J. Sugarman, Luong Do Huynh, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4983.
https://doi.org/10.1158/1538-7445.AM2023-4983
Published: 04 April 2023
View articletitled, Abstract 4983: Anaplastic thyroid cancer cells upregulate mitochondrial one-carbon metabolism to meet purine demand, eliciting a targetable vulnerability
Journal Articles

Abstract 806: TGFBR1*6A enhances breast cancer susceptibility and promote cell cycle transition

Kojo Agyemang, Michael Pennison, Minghui Wang, Allan Johansen, Hugo Jimenez, Carl Blackman, Ravi Singh, Ralph D'Agostino, Paul Grippo, Antonio Di Cristofano, Boris Pasche
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 806.
https://doi.org/10.1158/1538-7445.AM2021-806
Published: 01 July 2021
View articletitled, Abstract 806: TGFBR1*6A enhances breast cancer susceptibility and promote cell cycle transition
Journal Articles

Abstract 1801: Sequential inhibition of BCL-XL and MCL1 elicits massive apoptosis in anaplastic thyroid cancer cells

Xhesika Shanja-Grabarz, Justin Cidado, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1801.
https://doi.org/10.1158/1538-7445.AM2020-1801
Published: 15 August 2020
View articletitled, Abstract 1801: Sequential inhibition of BCL-XL and MCL1 elicits massive apoptosis in anaplastic thyroid cancer cells
Journal Articles

Abstract LB-089: Direct BAX activation effectively induces apoptosis in anaplastic thyroid cancer cells

Xhesika Shanja-Grabarz, Francesca Di Cristofano, Evripidis Gavathiotis, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-089.
https://doi.org/10.1158/1538-7445.AM2019-LB-089
Published: 01 July 2019
View articletitled, Abstract LB-089: Direct BAX activation effectively induces apoptosis in anaplastic thyroid cancer cells
Journal Articles

Abstract 5779: CDK4/6 inhibitors and anaplastic thyroid cancer: An investigation into the retinoblastoma cancer pathway and potential therapeutic targets

Kristen A. Wong, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5779.
https://doi.org/10.1158/1538-7445.AM2018-5779
Published: 01 July 2018
View articletitled, Abstract 5779: CDK4/6 inhibitors and anaplastic thyroid cancer: An investigation into the retinoblastoma cancer pathway and potential therapeutic targets
Journal Articles

SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance

Arturo Orlacchio, Michela Ranieri, Martina Brave, Valeria Antico Arciuch, Toni Forde, Daniela De Martino, Karen E. Anderson, Phillip Hawkins, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6914–6926.
https://doi.org/10.1158/0008-5472.CAN-17-2105
Published: 14 December 2017
View articletitled, SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance
Open the PDF for SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance in another window
Includes: Supplementary data
Journal Articles

Abstract 1068: Driver pathway blockage synergizes with PLK1 inhibition in anaplastic thyroid cancer

Daniela De Martino, Emrullah Yilmaz, Arturo Orlacchio, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1068.
https://doi.org/10.1158/1538-7445.AM2017-1068
Published: 01 July 2017
View articletitled, Abstract 1068: Driver pathway blockage synergizes with PLK1 inhibition in anaplastic thyroid cancer
Journal Articles

Abstract 2368: Differential role of Pik3caH1047R and Pten-/- mutations in thyroid cancer development

Michela Ranieri, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2368.
https://doi.org/10.1158/1538-7445.AM2017-2368
Published: 01 July 2017
View articletitled, Abstract 2368: Differential role of Pik3caH1047R and Pten-/- mutations in thyroid cancer development
Journal Articles

Abstract 330: SGK1 activation is essential for PI3K-dependent tumor development

Arturo Orlacchio, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 330.
https://doi.org/10.1158/1538-7445.AM2017-330
Published: 01 July 2017
View articletitled, Abstract 330: SGK1 activation is essential for PI3K-dependent tumor development
Journal Articles

Abstract 188: Isoform-specific AKT functions in thyroid carcinoma development

Michela Ranieri, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 188.
https://doi.org/10.1158/1538-7445.AM2016-188
Published: 15 July 2016
View articletitled, Abstract 188: Isoform-specific AKT functions in thyroid carcinoma development
Journal Articles

Abstract 4376: Beyond AKT: Critical pathways for PI3K-dependent transformation

Arturo Orlacchio, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4376.
https://doi.org/10.1158/1538-7445.AM2016-4376
Published: 15 July 2016
View articletitled, Abstract 4376: Beyond AKT: Critical pathways for PI3K-dependent transformation
Journal Articles

Abstract 54: PI3K-directed metabolic reprogramming in thyroid cancer

Daniela De Martino, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 54.
https://doi.org/10.1158/1538-7445.AM2016-54
Published: 15 July 2016
View articletitled, Abstract 54: PI3K-directed metabolic reprogramming in thyroid cancer
Journal Articles

Abstract 2713: Combination of PLK1 and PI3K inhibitors shows strong synergy in anaplastic thyroid cancer

Emrullah Yilmaz, Arturo Orlacchio, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2713.
https://doi.org/10.1158/1538-7445.AM2016-2713
Published: 15 July 2016
View articletitled, Abstract 2713: Combination of PLK1 and PI3K inhibitors shows strong synergy in anaplastic thyroid cancer
Journal Articles

Abstract 5412: Lysosome disruption rapidly and effectively induces necrosis in aggressive thyroid carcinomas

Devora Champa, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5412.
https://doi.org/10.1158/1538-7445.AM2015-5412
Published: 01 August 2015
View articletitled, Abstract 5412: Lysosome disruption rapidly and effectively induces necrosis in aggressive thyroid carcinomas
Journal Articles

Abstract 2158: PDK1-dependent activation of RSK is an absolute requirement for PI3K oncogenic activity in the thyroid gland

Arturo Orlacchio, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2158.
https://doi.org/10.1158/1538-7445.AM2015-2158
Published: 01 August 2015
View articletitled, Abstract 2158: PDK1-dependent activation of RSK is an absolute requirement for PI3K oncogenic activity in the thyroid gland
Journal Articles

Abstract 2023: MYC amplification and overexpression in metastatic anaplastic thyroid cancer dictates response to therapy

Emrullah Yilmaz, Marika A. Russo, Arturo Orlacchio, Toni Forde, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2023.
https://doi.org/10.1158/1538-7445.AM2015-2023
Published: 01 August 2015
View articletitled, Abstract 2023: MYC amplification and overexpression in metastatic anaplastic thyroid cancer dictates response to therapy
Journal Articles

Abstract 4776: PDK1-dependent activation of AGC kinases is an absolute requirement for AKT oncogenic activity

Arturo Orlacchio, Valeria Antico Arciuch, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4776.
https://doi.org/10.1158/1538-7445.AM2014-4776
Published: 01 October 2014
View articletitled, Abstract 4776: PDK1-dependent activation of AGC kinases is an absolute requirement for AKT oncogenic activity
Journal Articles

Inhibition of AMPK and Krebs Cycle Gene Expression Drives Metabolic Remodeling of Pten-Deficient Preneoplastic Thyroid Cells

Valeria G. Antico Arciuch, Marika A. Russo, Kristy S. Kang, Antonio Di Cristofano
Journal: Cancer Research
Cancer Res (2013) 73 (17): 5459–5472.
https://doi.org/10.1158/0008-5472.CAN-13-1429
Published: 02 September 2013
View articletitled, Inhibition of AMPK and Krebs Cycle Gene Expression Drives Metabolic Remodeling of Pten-Deficient Preneoplastic Thyroid Cells
Open the PDF for Inhibition of AMPK and Krebs Cycle Gene Expression Drives Metabolic Remodeling of Pten-Deficient Preneoplastic Thyroid Cells in another window
Includes: Supplementary data