Page 1 | Search Results | Cancer Research | American Association for Cancer Research

1-20 of 45

Sort by

Sort Order Select

Journal Articles

Abstract 2980: Therapeutic potential of combined targeting of casein kinase 1 alpha (CK1 alpha) and CDK7/9 with the inhibitor BTX-A51 in human liposarcomas

Cancer Res (2025) 85 (8_Supplement_1): 2980.

https://doi.org/10.1158/1538-7445.AM2025-2980

Published: 21 April 2025

View articletitled, Abstract 2980: Therapeutic potential of combined targeting of casein kinase 1 alpha (CK1 alpha) and CDK7/9 with the inhibitor BTX-A51 in human liposarcomas

Journal Articles

Abstract IA012: Panel Discussion 1: Regulatory and Non-Regulatory Challenges to the Wide Adoption of Precision Diagnostics

Anthony Letai

Cancer Res (2025) 85 (5_Supplement): IA012.

https://doi.org/10.1158/1538-7445.GENFUNC25-IA012

Published: 11 March 2025

View articletitled, Abstract IA012: Panel Discussion 1: Regulatory and Non-Regulatory Challenges to the Wide Adoption of Precision Diagnostics

Journal Articles

Abstract A040: Survival mechanisms common to immunotherapy and drug tolerant persister tumor cells

Maria Davern, Cole J Turner, Lara Bencsics, Brenda Chan, Jasmine Yun-Tong Kung, Michael Olson, Cheyanne Walker-Williams, David Barbie, Shaili Soni, Patrick Bhola, Marcela V Maus, Anthony Letai

Cancer Res (2025) 85 (5_Supplement): A040.

https://doi.org/10.1158/1538-7445.GENFUNC25-A040

Published: 11 March 2025

View articletitled, Abstract A040: Survival mechanisms common to immunotherapy and drug tolerant persister tumor cells

Journal Articles

Abstract 604: Targeting casein kinase 1 alpha (CK1 alpha) and transcriptional CDKs (CDK7/9) in human liposarcomas

Renyan Liu, Nicole L. Solimini, Patrick Bhola, Timothy B. Branigan, Jie Hao, Xin Wang, Roshen Alharthi, Michael Yorsz, Shaili Soni, Cing-siang Hu, Irit Snir-Alkalay, Prafulla Gokhale, Anthony Letai, Yinon Yinon Ben-Neriah, George D. Demetri, Geoffrey I. Shapiro

Cancer Res (2024) 84 (6_Supplement): 604.

https://doi.org/10.1158/1538-7445.AM2024-604

Published: 22 March 2024

View articletitled, Abstract 604: Targeting casein kinase 1 alpha (CK1 alpha) and transcriptional CDKs (CDK7/9) in human liposarcomas

Journal Articles

Abstract 4098: Chimeric antigen receptor (CAR) T cells overexpressing Bcl-xL increase proliferation and antitumor activity alone and in combination with BH3 mimetics

Felix Korell, Michael Olson, Diego Salas-Benito, Mark B. Leick, Rebecca C. Larson, Harrison Silva, Alessandro Gasparetto, Trisha R. Berger, Amanda Bouffard, Michael C. Kann, Markus Mergen, Tamina Kienka, Marc Wehrli, Stefanie R. Bailey, Anthony Letai, Marcela V. Maus

Cancer Res (2023) 83 (7_Supplement): 4098.

https://doi.org/10.1158/1538-7445.AM2023-4098

Published: 04 April 2023

View articletitled, Abstract 4098: Chimeric antigen receptor (CAR) T cells overexpressing Bcl-xL increase proliferation and antitumor activity alone and in combination with BH3 mimetics

Journal Articles

Abstract 4309: Early apoptotic measurements of patient-derived organoids predict patient response to therapy

Kelley E. McQueeney, Patrick Bhola, Sarah J. Hill, Anthony Letai

Cancer Res (2023) 83 (7_Supplement): 4309.

https://doi.org/10.1158/1538-7445.AM2023-4309

Published: 04 April 2023

View articletitled, Abstract 4309: Early apoptotic measurements of patient-derived organoids predict patient response to therapy

Journal Articles

Abstract 6130: Cancer sensitivity to therapy is constrained by apoptosis regulation in cells of origin

Cancer Res (2023) 83 (7_Supplement): 6130.

https://doi.org/10.1158/1538-7445.AM2023-6130

Published: 04 April 2023

View articletitled, Abstract 6130: Cancer sensitivity to therapy is constrained by apoptosis regulation in cells of origin

Journal Articles

Abstract 162: Individualizing treatment using patient derived organoids, BH3 profiling and microfluidics: A proof of concept in a patient with low-grade serous ovarian carcinoma

Brittany Meisenheimer, Ha V. Vo, Kelley E. McQueeney, Aisha L. Saldanha, Carina Feeney, Courtney H. Qi, Swati Narayan, Jennifer D. Curtis, Marisa R. Nucci, Anthony Letai, Cloud P. Paweletz, Joyce F. Liu, Ursula A. Matulonis, Elena Ivanova

Cancer Res (2023) 83 (7_Supplement): 162.

https://doi.org/10.1158/1538-7445.AM2023-162

Published: 04 April 2023

View articletitled, Abstract 162: Individualizing treatment using patient derived organoids, BH3 profiling and microfluidics: A proof of concept in a patient with low-grade serous ovarian carcinoma

Journal Articles

Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Fleur Jochems, Julie A. MacDonald, Chrysiida Baltira, Veerle Daniels, Mark de Gooijer, Olaf Van Tellingen, Anthony Letai, René Bernards

Cancer Res (2023) 83 (2_Supplement_1): PR013.

https://doi.org/10.1158/1538-7445.AGCA22-PR013

Published: 15 January 2023

View articletitled, Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Journal Articles

Abstract 4174: Augmenting NK cell based immunotherapy by targeting mitochondrial apoptosis

Rongqing Aaron Pan, Jeremy Ryan, Deng Pan, Kai Wucherpfennig, Anthony Letai

Cancer Res (2022) 82 (12_Supplement): 4174.

https://doi.org/10.1158/1538-7445.AM2022-4174

Published: 15 June 2022

View articletitled, Abstract 4174: Augmenting NK cell based immunotherapy by targeting mitochondrial apoptosis

Journal Articles

Abstract 3691: Dynamic BH3 profiling identifies novel combinations in malignant pleural mesothelioma with in vivo efficacy

Danielle S. Potter, Ruochen Du, Kin-Hoe Chow, Keith L. Ligon, Raphael Bueno, Anthony Letai

Cancer Res (2022) 82 (12_Supplement): 3691.

https://doi.org/10.1158/1538-7445.AM2022-3691

Published: 15 June 2022

View articletitled, Abstract 3691: Dynamic BH3 profiling identifies novel combinations in malignant pleural mesothelioma with in vivo efficacy

Journal Articles

Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia

Cancer Res (2021) 81 (24): 6117–6130.

https://doi.org/10.1158/0008-5472.CAN-21-1273

Published: 15 December 2021

View articletitled, Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia

Includes: Supplementary data

Journal Articles

Cell Line–Specific Network Models of ER⁺ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N. Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony Letai, Joan Montero, Réka Albert, Nikhil Wagle

Cancer Res (2021) 81 (17): 4603–4617.

https://doi.org/10.1158/0008-5472.CAN-21-1208

Published: 01 September 2021

View articletitled, Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

Includes: Supplementary data

Journal Articles

Abstract NG14: Reduction in mitochondrial priming drives resistance to targeted therapy in acute myeloid leukemia

Shruti Bhatt, Marissa S. Piosos, Elyse A. Olesinski, Binyam G. Yilma, Jeremy A. Ryan, Thelma Mashaka, Buon Leutz, Sophia Adamia, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai

Cancer Res (2021) 81 (13_Supplement): NG14.

https://doi.org/10.1158/1538-7445.AM2021-NG14

Published: 01 July 2021

View articletitled, Abstract NG14: Reduction in mitochondrial priming drives resistance to targeted therapy in acute myeloid leukemia

Journal Articles

Abstract 62: Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Joan Montero, Cecile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq

Cancer Res (2020) 80 (16_Supplement): 62.

https://doi.org/10.1158/1538-7445.AM2020-62

Published: 15 August 2020

View articletitled, Abstract 62: Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Journal Articles

Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC

Jason J Zoeller, Aleksandr Vagodny, Veerle W. Daniels, Krishan Taneja, Benjamin Y. Tan, Yoko S. DeRose, Maihi Fujita, Alana L. Welm, Anthony Letai, Joel D. Leverson, Vincent Blot, Roderick T. Bronson, Deborah A. Dillon, Joan S. Brugge

Cancer Res (2020) 80 (4_Supplement): P3-11-06.

https://doi.org/10.1158/1538-7445.SABCS19-P3-11-06

Published: 15 February 2020

View articletitled, Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC

Journal Articles

Abstract 260: Identifying cancer drug sensitivity using live cell imaging dynamic BH3 profiling of solid tumor core biopsies

Rebecca German, Elizaveta Lavrova, Timothy Hagan, Otari Chipashvili, Ewa Sicinska, James Cleary, Kimmie Ng, Anthony Letai, Patrick Bhola

Cancer Res (2019) 79 (13_Supplement): 260.

https://doi.org/10.1158/1538-7445.AM2019-260

Published: 01 July 2019

View articletitled, Abstract 260: Identifying cancer drug sensitivity using live cell imaging dynamic BH3 profiling of solid tumor core biopsies

Journal Articles

Abstract 2990: Individualized functional approach to tailoring acute myeloid leukemia therapy

Shruti Bhatt, Binyam Yilma, Elyse Olesinski, Holly Zhu, Mark Murakami, Vineeth Kumar Murali, Sophia Adamia, David M. Weinstock, Jacqueline S. Garcia, Anthony Letai

Cancer Res (2019) 79 (13_Supplement): 2990.

https://doi.org/10.1158/1538-7445.AM2019-2990

Published: 01 July 2019

View articletitled, Abstract 2990: Individualized functional approach to tailoring acute myeloid leukemia therapy

Journal Articles

Abstract 5186: Discovery of a novel histone deacetylase 6 inhibitor that kills drug-resistant breast cancer

Catríona Dowling, Eugene Dillion, Michael Hemann, Gerard Cagney, Anthony Letai, Triona Ni Chonghaile

Cancer Res (2019) 79 (13_Supplement): 5186.

https://doi.org/10.1158/1538-7445.AM2019-5186

Published: 01 July 2019

View articletitled, Abstract 5186: Discovery of a novel histone deacetylase 6 inhibitor that kills drug-resistant breast cancer

Journal Articles

Abstract 4478: High-throughput dynamic BH3 profiling identifies active cancer therapies in solid tumors

Patrick D. Bhola, Eman Ahmed, Jennifer Guerriero, Ewa Sicinska, Emily Su, Jing Ni, Elizaveta Lavrova, Otari Chipashvili, Timothy Hagan, Kimmie Ng, Andrew Aguirre, Jochen Lorch, Suzanne George, George Demetri, Jean Zhao, Anthony Letai

Cancer Res (2019) 79 (13_Supplement): 4478.

https://doi.org/10.1158/1538-7445.AM2019-4478

Published: 01 July 2019

View articletitled, Abstract 4478: High-throughput dynamic BH3 profiling identifies active cancer therapies in solid tumors

Update search

NARROW

Format

Subjects

Journal

Article Type

Issue Section

Date

Availability

Abstract 2980: Therapeutic potential of combined targeting of casein kinase 1 alpha (CK1 alpha) and CDK7/9 with the inhibitor BTX-A51 in human liposarcomas

Abstract IA012: Panel Discussion 1: Regulatory and Non-Regulatory Challenges to the Wide Adoption of Precision Diagnostics

Abstract A040: Survival mechanisms common to immunotherapy and drug tolerant persister tumor cells

Abstract 604: Targeting casein kinase 1 alpha (CK1 alpha) and transcriptional CDKs (CDK7/9) in human liposarcomas

Abstract 4098: Chimeric antigen receptor (CAR) T cells overexpressing Bcl-xL increase proliferation and antitumor activity alone and in combination with BH3 mimetics

Abstract 4309: Early apoptotic measurements of patient-derived organoids predict patient response to therapy

Abstract 6130: Cancer sensitivity to therapy is constrained by apoptosis regulation in cells of origin

Abstract 162: Individualizing treatment using patient derived organoids, BH3 profiling and microfluidics: A proof of concept in a patient with low-grade serous ovarian carcinoma

Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Abstract 4174: Augmenting NK cell based immunotherapy by targeting mitochondrial apoptosis

Abstract 3691: Dynamic BH3 profiling identifies novel combinations in malignant pleural mesothelioma with in vivo efficacy

Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia

Cell Line–Specific Network Models of ER⁺ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

Abstract NG14: Reduction in mitochondrial priming drives resistance to targeted therapy in acute myeloid leukemia

Abstract 62: Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC

Abstract 260: Identifying cancer drug sensitivity using live cell imaging dynamic BH3 profiling of solid tumor core biopsies

Abstract 2990: Individualized functional approach to tailoring acute myeloid leukemia therapy

Abstract 5186: Discovery of a novel histone deacetylase 6 inhibitor that kills drug-resistant breast cancer

Abstract 4478: High-throughput dynamic BH3 profiling identifies active cancer therapies in solid tumors

Email alerts

AACR Journals

Update search

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only