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Anthony J. Capobianco
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Journal Articles

Abstract 2436: The multi-faceted Integrator complex in Notch-driven esophageal cancer

Elena Shersher, Annamil Alvarez-Trotta, Mohini Lahiry, Giulia Diluvio, Ramin Shiekhattar, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2436.
https://doi.org/10.1158/1538-7445.AM2023-2436
Published: 04 April 2023
View article titled, Abstract 2436: The multi-faceted Integrator complex in Notch-driven esophageal cancer
Journal Articles

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells

Annamil Alvarez-Trotta, William Guerrant, Luisana Astudillo, Mohini Lahiry, Giulia Diluvio, Elena Shersher, Hugo Kaneku, David J. Robbins, Darren Orton, Anthony J. Capobianco
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (12): 3347–3357.
https://doi.org/10.1158/0008-5472.CAN-20-3611
Published: 15 June 2021
View article titled, Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
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Includes: Supplementary data
Journal Articles

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription

Ke Jin, Wen Zhou, Xiaoqing Han, Zhiqiang Wang, Bin Li, Shawn Jeffries, Wensi Tao, David J. Robbins, Anthony J. Capobianco
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (16): 4228–4237.
https://doi.org/10.1158/0008-5472.CAN-16-3156
Published: 14 August 2017
View article titled, Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription
Open the PDF for Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription in another window
Includes: Supplementary data
Journal Articles

Abstract 4085: Notch1 signaling determines melanoma-regulating role of tumor stromal fibroblasts

Hongwei Shao, Ranran Kong, Mecker Moller, Massimiliano L. Ferrari, Leiming Zhang, Freddy Radtke, Anthony J. Capobianco, Zhao-Jun Liu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4085.
https://doi.org/10.1158/1538-7445.AM2016-4085
Published: 15 July 2016
View article titled, Abstract 4085: Notch1 signaling determines melanoma-regulating role of tumor stromal fibroblasts
Journal Articles

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

Luisana Astudillo, Thiago G. Da Silva, Zhiqiang Wang, Xiaoqing Han, Ke Jin, Jeffrey VanWye, Xiaoxia Zhu, Kelly Weaver, Taiji Oashi, Pedro E.M. Lopes, Darren Orton, Leif R. Neitzel, Ethan Lee, Ralf Landgraf, David J. Robbins, Alexander D. MacKerell, Jr, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3593–3603.
https://doi.org/10.1158/0008-5472.CAN-16-0061
Published: 14 June 2016
View article titled, The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
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Includes: Supplementary data
Journal Articles

Abstract P4-05-01: Genetic analysis of the role of Brca1 in suppression of basal-like breast cancer

Xin-Hai Pei, Feng Bai, Ho Lam Chan, Alexandria Scott, Matthew D Smith, Cheng Fan, Jason I Herschkowitz, Charles M Perou, Alan S Livingstone, David J Robbins, Anthony J Capobianco
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P4-05-01.
https://doi.org/10.1158/1538-7445.SABCS14-P4-05-01
Published: 01 May 2015
View article titled, Abstract P4-05-01: Genetic analysis of the role of Brca1 in suppression of basal-like breast cancer
Journal Articles

Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma

Zhiqiang Wang, Thiago G. Da Silva, Ke Jin, Xiaoqing Han, Prathibha Ranganathan, Xiaoxia Zhu, Avencia Sanchez-Mejias, Feng Bai, Bin Li, Dennis Liang Fei, Kelly Weaver, Rodrigo Vasquez-Del Carpio, Anna E. Moscowitz, Vadim P. Koshenkov, Lilly Sanchez, Lynne Sparling, Xin-Hai Pei, Dido Franceschi, Afonso Ribeiro, David J. Robbins, Alan S. Livingstone, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2014) 74 (21): 6364–6374.
https://doi.org/10.1158/0008-5472.CAN-14-2051
Published: 30 October 2014
View article titled, Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development

Feng Bai, Ho Lam Chan, Alexandria Scott, Matthew D. Smith, Cheng Fan, Jason I. Herschkowitz, Charles M. Perou, Alan S. Livingstone, David J. Robbins, Anthony J. Capobianco, Xin-Hai Pei
Journal: Cancer Research
Cancer Res (2014) 74 (21): 6161–6172.
https://doi.org/10.1158/0008-5472.CAN-14-1119
Published: 30 October 2014
View article titled, <em>BRCA1</em> Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development
Open the PDF for <em>BRCA1</em> Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development in another window
Includes: Supplementary data
Journal Articles

Abstract 1951: Role of embryonic signaling pathways in lung cancer

Samer Singh, Dao M. Nguyen, Anthony J. Capobianco, David J. Robbins
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1951.
https://doi.org/10.1158/1538-7445.AM2014-1951
Published: 01 October 2014
View article titled, Abstract 1951: Role of embryonic signaling pathways in lung cancer
Journal Articles

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Bin Li, Dennis Liang Fei, Colin A. Flaveny, Nadia Dahmane, Valérie Baubet, Zhiqiang Wang, Feng Bai, Xin-Hai Pei, Jezabel Rodriguez-Blanco, Brian Hang, Darren Orton, Lu Han, Baolin Wang, Anthony J. Capobianco, Ethan Lee, David J. Robbins
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4811–4821.
https://doi.org/10.1158/0008-5472.CAN-14-0317
Published: 01 September 2014
View article titled, Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
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Includes: Supplementary data
Journal Articles

NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

Kelly L. Weaver, Marie-Clotilde Alves-Guerra, Ke Jin, Zhiqiang Wang, Xiaoqing Han, Prathibha Ranganathan, Xiaoxia Zhu, Thiago DaSilva, Wei Liu, Francesca Ratti, Renee M. Demarest, Cristos Tzimas, Meghan Rice, Rodrigo Vasquez-Del Carpio, Nadia Dahmane, David J. Robbins, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4741–4751.
https://doi.org/10.1158/0008-5472.CAN-14-1547
Published: 01 September 2014
View article titled, NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis
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Includes: Supplementary data
Journal Articles

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

Silvia Licciulli, Jacqueline L. Avila, Linda Hanlon, Scott Troutman, Matteo Cesaroni, Smitha Kota, Brian Keith, M. Celeste Simon, Ellen Puré, Fred Radtke, Anthony J. Capobianco, Joseph L. Kissil
Journal: Cancer Research
Cancer Res (2013) 73 (19): 5974–5984.
https://doi.org/10.1158/0008-5472.CAN-13-1384
Published: 01 October 2013
View article titled, Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53
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Includes: Supplementary data
Journal Articles

Abstract 2645: Role of embryonic signaling pathways in lung cancer.

Samer Singh, David Robbins, Anthony J. Capobianco, Dao M. Nguyen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2645.
https://doi.org/10.1158/1538-7445.AM2013-2645
Published: 15 April 2013
View article titled, Abstract 2645: Role of embryonic signaling pathways in lung cancer.
Journal Articles

Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity

Dennis Liang Fei, Avencia Sanchez-Mejias, Zhiqiang Wang, Colin Flaveny, Jun Long, Samer Singh, Jezabel Rodriguez-Blanco, Robert Tokhunts, Camilla Giambelli, Karoline J. Briegel, Wolfgang A. Schulz, A. Jay Gandolfi, Margaret Karagas, Teresa A. Zimmers, Merce Jorda, Pablo Bejarano, Anthony J. Capobianco, David J. Robbins
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4449–4458.
https://doi.org/10.1158/0008-5472.CAN-11-4123
Published: 30 August 2012
View article titled, Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity
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Includes: Supplementary data
Journal Articles

Abstract 3336: The role of Notch signaling in esophageal adenocarcinoma

Zhiqiang Wang, Prathibha Ranganathan, Vadim Koshenkov, Feng Bai, Bin Li, Dennis Liang Fei, Alan Livingstone, Dido Franceschi, Juan Martell, David J. Robbins, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3336.
https://doi.org/10.1158/1538-7445.AM2012-3336
Published: 15 April 2012
View article titled, Abstract 3336: The role of Notch signaling in esophageal adenocarcinoma
Journal Articles

Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity

Samer Singh, Zhiqiang Wang, Dennis Liang Fei, Kendall E. Black, John A. Goetz, Robert Tokhunts, Camilla Giambelli, Jezabel Rodriguez-Blanco, Jun Long, Ethan Lee, Karoline J. Briegel, Pablo A. Bejarano, Ethan Dmitrovsky, Anthony J. Capobianco, David J. Robbins
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4454–4463.
https://doi.org/10.1158/0008-5472.CAN-10-2313
Published: 30 June 2011
View article titled, Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity
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Includes: Supplementary data
Journal Articles

Abstract LB-430: Hedgehog signaling is required for the survival and tumorigenicity of cancer cells.

Samer Singh, Zhiqiang Wang, Camilla Giambelli, Jun Long, Karoline J. Briegel, Pablo A. Bejarano, Anthony J. Capobianco, David J. Robbins
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-430.
https://doi.org/10.1158/1538-7445.AM2011-LB-430
Published: 15 April 2011
View article titled, Abstract LB-430: Hedgehog signaling is required for the survival and tumorigenicity of cancer cells.
Journal Articles

Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program

Dmitri G. Negorev, Olga V. Vladimirova, Andrew V. Kossenkov, Elena V. Nikonova, Renee M. Demarest, Anthony J. Capobianco, Michael K. Showe, Frank J. Rauscher, III, Louise C. Showe, Gerd G. Maul
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9991–10001.
https://doi.org/10.1158/0008-5472.CAN-10-1483
Published: 06 December 2010
View article titled, Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program
Open the PDF for Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program in another window
Includes: Supplementary data
Journal Articles

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

Linda Hanlon, Jacqueline L. Avila, Renée M. Demarest, Scott Troutman, Megan Allen, Francesca Ratti, Anil K. Rustgi, Ben Z. Stanger, Fred Radtke, Volkan Adsay, Fenella Long, Anthony J. Capobianco, Joseph L. Kissil
Journal: Cancer Research
Cancer Res (2010) 70 (11): 4280–4286.
https://doi.org/10.1158/0008-5472.CAN-09-4645
Published: 01 June 2010
View article titled, Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma
Open the PDF for Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes

Chelsea C. Pinnix, John T. Lee, Zhao-Jun Liu, Ronan McDaid, Klara Balint, Levi J. Beverly, Patricia A. Brafford, Min Xiao, Benjamin Himes, Susan E. Zabierowski, Yumi Yashiro-Ohtani, Katherine L. Nathanson, Ana Bengston, Pamela M. Pollock, Ashani T. Weeraratna, Brian J. Nickoloff, Warren S. Pear, Anthony J. Capobianco, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5312–5320.
https://doi.org/10.1158/0008-5472.CAN-08-3767
Published: 01 July 2009
View article titled, Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes
Open the PDF for Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes in another window
Includes: Supplementary data