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Anthony E. Pegg
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Journal Articles

Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis

Chenxu Shi, Diane E. McCloskey, Anthony E. Pegg, David J. Feith
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2483.
https://doi.org/10.1158/1538-7445.AM10-2483
Published: 15 April 2010
View article titled, Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis
Journal Articles

Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications

Subha Philip, Srividya Swaminathan, Sergey G. Kuznetsov, Sreenivas Kanugula, Kajal Biswas, Suhwan Chang, Natalia A. Loktionova, Diana C. Haines, Philipp Kaldis, Anthony E. Pegg, Shyam K. Sharan
Journal: Cancer Research
Cancer Res (2008) 68 (23): 9973–9981.
https://doi.org/10.1158/0008-5472.CAN-08-1179
Published: 01 December 2008
View article titled, Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications
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Includes: Supplementary data
Journal Articles

DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human O6-Alkylguanine-DNA Alkyltransferases

Renée S. Mijal, Sreenivas Kanugula, Choua C. Vu, Qingming Fang, Anthony E. Pegg, Lisa A. Peterson
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4968–4974.
https://doi.org/10.1158/0008-5472.CAN-05-3803
Published: 01 May 2006
View article titled, DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct <em>O</em><sup>6</sup>-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferases
Open the PDF for DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct <em>O</em><sup>6</sup>-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferases in another window
Journal Articles

Role of O6-alkylguanine-DNA alkyltransferase in protecting from chemotherapy-induced toxicity and mutations

Ryan J. Hansen, Shannon M. Delaney, Ramamoorthy Nagasubramanian, Natalia A. Loktionova, Anthony E. Pegg, M. Eileen Dolan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 128–129.
Published: 15 April 2006
View article titled, Role of <em>O</em><sup>6</sup>-alkylguanine-DNA alkyltransferase in protecting from chemotherapy-induced toxicity and mutations
Journal Articles

Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane and antitumor nitrogen mustards.

Rachel Loeber, Danae Quirk Dorr, Melissa Goggin, Anthony E. Pegg, Natalia Tretyakova
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1230.
Published: 15 April 2006
View article titled, Cross-linking of the human DNA repair protein <em>O</em><sup>6</sup>-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane and antitumor nitrogen mustards.
Journal Articles

Impact of nucleotide excision repair (NER) on the mechanism of human alkyltransferase-mediated toxicity of bis-electrophiles in Escherichia coli

Aley G. Kalapila, Sreenivas Kanugula, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 253–254.
Published: 15 April 2006
View article titled, Impact of nucleotide excision repair (NER) on the mechanism of human alkyltransferase-mediated toxicity of bis-electrophiles in <em>Escherichia coli</em>
Journal Articles

Specificity of O6-alkylguanine DNA-alkyltransferase

Qingming Fang, Sreenivas Kanugula, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 500.
Published: 01 May 2005
View article titled, Specificity of <em>O</em><sup>6</sup>-alkylguanine DNA-alkyltransferase
Journal Articles

Sequence context affects the repair of the tobacco-specific nitrosamine adduct O6-pyridyloxobutylguanine by human O6-alkylguanine-DNA alkyltransferase variants.

Renee S. Mijal, Sreenivas Kanugula, Choua C. Vu, Qingming Fang, Anthony E. Pegg, Lisa A. Peterson
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 88.
Published: 01 May 2005
View article titled, Sequence context affects the repair of the tobacco-specific nitrosamine adduct <em>O<sup>6</sup></em>-pyridyloxobutylguanine by human <em>O<sup>6</sup></em>-alkylguanine-DNA alkyltransferase variants.
Journal Articles

Antizyme inhibits N-nitrosomethylbenzylamine-induced mouse forestomach carcinogenesis in a p53-independent manner

David J. Feith, Louise Y.Y. Fong, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 915–916.
Published: 01 May 2005
View article titled, Antizyme inhibits N-nitrosomethylbenzylamine-induced mouse forestomach carcinogenesis in a p53-independent manner
Journal Articles

Methylguanine-methyltransferase expression interferes with phospholipid metabolism in melanoma tumors cells

Daniel Morvan, Pascale Rio, Anthony E. Pegg, Jean-Claude Madelmont, Aicha Demidem
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 257.
Published: 01 April 2004
View article titled, Methylguanine-methyltransferase expression interferes with phospholipid metabolism in melanoma tumors cells
Journal Articles

Modulation of mouse skin chemical carcinogenesis by altered polyamine metabolism

Xiaojing Wang, Catherine S. Coleman, David J. Feith, Thomas G. O’Brien, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1270–1271.
Published: 01 April 2004
View article titled, Modulation of mouse skin chemical carcinogenesis by altered polyamine metabolism
Journal Articles

Antizyme Overexpression in Transgenic Mice Reduces Cell Proliferation, Increases Apoptosis, and Reduces N-Nitrosomethylbenzylamine-induced Forestomach Carcinogenesis

Louise Y. Y. Fong, David J. Feith, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2003) 63 (14): 3945–3954.
Published: 21 July 2003
View article titled, Antizyme Overexpression in Transgenic Mice Reduces Cell Proliferation, Increases Apoptosis, and Reduces <em>N</em>-Nitrosomethylbenzylamine-induced Forestomach Carcinogenesis
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Journal Articles

Inactivation and Degradation of O 6-Alkylguanine-DNA Alkyltransferase after Reaction with Nitric Oxide

Liping Liu, Meng Xu-Welliver, Sreenivas Kanugula, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2002) 62 (11): 3037–3043.
Published: 01 June 2002
View article titled, Inactivation and Degradation of <em>O</em> <sup>6</sup>-Alkylguanine-DNA Alkyltransferase after Reaction with Nitric Oxide
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Journal Articles

Targeted Antizyme Expression in the Skin of Transgenic Mice Reduces Tumor Promoter Induction of Ornithine Decarboxylase and Decreases Sensitivity to Chemical Carcinogenesis

David J. Feith, Lisa M. Shantz, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (2001) 61 (16): 6073–6081.
Published: 01 August 2001
View article titled, Targeted Antizyme Expression in the Skin of Transgenic Mice Reduces Tumor Promoter Induction of Ornithine Decarboxylase and Decreases Sensitivity to Chemical Carcinogenesis
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Journal Articles

Topoisomerase I-mediated Cytotoxicity of N-Methyl-N′-nitro-N-nitrosoguanidine: Trapping of Topoisomerase I by the O6-Methylguanine

Philippe Pourquier, Jessica L. Waltman, Yoshimasa Urasaki, Natalia A. Loktionova, Anthony E. Pegg, John L. Nitiss, Yves Pommier
Journal: Cancer Research
Cancer Res (2001) 61 (1): 53–58.
Published: 01 January 2001
View article titled, Topoisomerase I-mediated Cytotoxicity of <em>N</em>-Methyl-<em>N′</em>-nitro-<em>N</em>-nitrosoguanidine: Trapping of Topoisomerase I by the <em>O</em><sup>6</sup>-Methylguanine
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Journal Articles

Effect of O6-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant O6-Alkylguanine-DNA Alkyltransferases

Yingna Cai, Michael H. Wu, Meng Xu-Welliver, Anthony E. Pegg, Susan M. Ludeman, M. Eileen Dolan
Journal: Cancer Research
Cancer Res (2000) 60 (19): 5464–5469.
Published: 01 October 2000
View article titled, Effect of <em>O</em><sup>6</sup>-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferases
Open the PDF for Effect of <em>O</em><sup>6</sup>-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferases in another window
Journal Articles

Direct Reversal of DNA Damage by Mutant Methyltransferase Protein Protects Mice against Dose-intensified Chemotherapy and Leads to in Vivo Selection of Hematopoietic Stem Cells

Susanne Ragg, Meng Xu-Welliver, Jeff Bailey, Maria D’Souza, Ryan Cooper, Saurabh Chandra, Roopa Seshadri, Anthony E. Pegg, David A. Williams
Journal: Cancer Research
Cancer Res (2000) 60 (18): 5187–5195.
Published: 01 September 2000
View article titled, Direct Reversal of DNA Damage by Mutant Methyltransferase Protein Protects Mice against Dose-intensified Chemotherapy and Leads to <em>in Vivo</em> Selection of Hematopoietic Stem Cells
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Journal Articles

Alteration of the Conserved Residue Tyrosine-158 to Histidine Renders Human O6-Alkylguanine-DNA Alkyltransferase Insensitive to the Inhibitor O6-Benzylguanine

Meng Xu-Welliver, José Leitão, Sreenivas Kanugula, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (1999) 59 (7): 1514–1519.
Published: 01 April 1999
View article titled, Alteration of the Conserved Residue Tyrosine-158 to Histidine Renders Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase Insensitive to the Inhibitor <em>O</em><sup>6</sup>-Benzylguanine
Open the PDF for Alteration of the Conserved Residue Tyrosine-158 to Histidine Renders Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase Insensitive to the Inhibitor <em>O</em><sup>6</sup>-Benzylguanine in another window
Journal Articles

α-Difluoromethylornithine Inhibits N-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Zinc-deficient Rats: Effects on Esophageal Cell Proliferation and Apoptosis

Louise Y. Y. Fong, Anthony E. Pegg, Peter N. Magee
Journal: Cancer Research
Cancer Res (1998) 58 (23): 5380–5388.
Published: 01 December 1998
View article titled, α-Difluoromethylornithine Inhibits <em>N</em>-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Zinc-deficient Rats: Effects on Esophageal Cell Proliferation and Apoptosis
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Journal Articles

Ornithine Decarboxylase Induction in Transformation by H-Ras and RhoA

Lisa M. Shantz, Anthony E. Pegg
Journal: Cancer Research
Cancer Res (1998) 58 (13): 2748–2753.
Published: 01 July 1998
View article titled, Ornithine Decarboxylase Induction in Transformation by H-Ras and RhoA
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