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Annamaria Rapisarda
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Journal Articles

Abstract 154: Establishment and characterization of a novel clear cell sarcoma organoid model derived from a human biopsy

Petreena S. Campbell, Erik D. Harris, Nancy Moore, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, Alice Chen, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 154.
https://doi.org/10.1158/1538-7445.AM2023-154
Published: 04 April 2023
View article titled, Abstract 154: Establishment and characterization of a novel clear cell sarcoma organoid model derived from a human biopsy
Journal Articles

Abstract 5776: Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development

Annamaria Rapisarda, Eric Jones, Curtis Hose, Erik Harris, Petreena S. Campbell, Mariaestela Ortiz, John Connelly, Nanda Mahashetty, Thomas Silvers, Zahra Davoudi, Penny Sellers Brady, Tiffany Nikirk Rohrer, Julie Grams, Karen Martin, Patricia Ramsey, Lori Bowles, John R. Britt, Ralph E. Parchment, Thomas S. Dexheimer, Beverly A. Teicher, James H. Doroshow, Nathan P. Coussens
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5776.
https://doi.org/10.1158/1538-7445.AM2023-5776
Published: 04 April 2023
View article titled, Abstract 5776: Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development
Journal Articles

Abstract 3091: Patient-derived organoid drug responses corroborate known target-drug interactions for selected anticancer agents

Curtis Hose, Erik Harris, John Connelly, Petreena S. Campbell, Mariaestela Ortiz, Eric Jones, Dianne Newton, Yvonne A. Evrard, Melinda Hollingshead, Ralph Parchment, Beverly A. Teicher, Nathan P. Coussens, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3091.
https://doi.org/10.1158/1538-7445.AM2022-3091
Published: 15 June 2022
View article titled, Abstract 3091: Patient-derived organoid drug responses corroborate known target-drug interactions for selected anticancer agents
Journal Articles

Abstract 3079: Development of an automated platform for screening patient-derived organoid models

Siddhartha Paul, Curtis Hose, Eric Jones, Erik Harris, John Connelly, Petreena Campbell, Mariaestela Ortiz, Thomas S. Dexheimer, Thomas Silvers, Penny Sellers Brady, Julie Grams, Tiffany Nikirk Rohrer, Karen Martin, Patricia Ramsey, Lori Bowles, Annamaria Rapisarda, Ralph E. Parchment, Beverly A. Teicher, James H. Doroshow, Nathan P. Coussens
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3079.
https://doi.org/10.1158/1538-7445.AM2022-3079
Published: 15 June 2022
View article titled, Abstract 3079: Development of an automated platform for screening patient-derived organoid models
Journal Articles

Abstract 2915: Synergistic, cytokine mediated stimulation (IL-1α/β + IL-6) of colon cancer cells reveals a novel mechanism of DNA damage facilitated by up-regulation of NOX1 and DUOX2

Jennifer L. Meitzler, Yongzhong Wu, Agnes Juhasz, Annamaria Rapisarda, Petreena Campbell, Becky A. Diebold, Smitha Antony, Guojian Jiang, Jiamo Lu, David J. Mallick, Mariam M. Konaté, Krishnendu Roy, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2915.
https://doi.org/10.1158/1538-7445.AM2021-2915
Published: 01 July 2021
View article titled, Abstract 2915: Synergistic, cytokine mediated stimulation (IL-1α/β + IL-6) of colon cancer cells reveals a novel mechanism of DNA damage facilitated by up-regulation of NOX1 and DUOX2
Journal Articles

Abstract 3913: Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models

Petreena Campbell, Curtis Hose, Lara El Touny, Erik Harris, John Connelly, Carrie Bonomi, Kelly Dougherty, Savanna Styers, Abigail Walke, Jenna Moyer, Mariah Baldwin, Anna Wade, Michael Mullendore, Kaitlyn Arthur, Matthew Murphy, Kevin Plater, Marion Gibson, Joseph Geraghty, Michelle Gottholm-Ahalt, Tara Grinnage-Pulley, Tiffanie Chase, John Carter, Howard Stotler, Debbie Trail, Luke Stockwin, Dianne Newton, Yvonne Evrard, Melinda Hollingshead, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3913.
https://doi.org/10.1158/1538-7445.AM2020-3913
Published: 15 August 2020
View article titled, Abstract 3913: Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models
Journal Articles

Abstract 270: Temozolomide resistant MGMT negative/MMR proficient cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival

Lara El Touny, Erik Harris, Curtis Hose, John Connelly, Diana Vengsarkar, Anne Monks, Ralph E. Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 270.
https://doi.org/10.1158/1538-7445.AM2019-270
Published: 01 July 2019
View article titled, Abstract 270: Temozolomide resistant MGMT negative/MMR proficient cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival
Journal Articles

The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel

Anne Monks, Yingdong Zhao, Curtis Hose, Hossein Hamed, Julia Krushkal, Jianwen Fang, Dmitriy Sonkin, Alida Palmisano, Eric C. Polley, Laura K. Fogli, Mariam M. Konaté, Sarah B. Miller, Melanie A. Simpson, Andrea Regier Voth, Ming-Chung Li, Erik Harris, Xiaolin Wu, John W. Connelly, Annamaria Rapisarda, Beverly A. Teicher, Richard Simon, James H. Doroshow
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (24): 6807–6817.
https://doi.org/10.1158/0008-5472.CAN-18-0989
Published: 13 December 2018
View article titled, The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel
Open the PDF for The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel in another window
Includes: Supplementary data
Journal Articles

Abstract 5178: Determinants of response to temozolomide in an exceptionally sensitive patient derived model

Lara H. el Touny, John Connelly, Curtis Hose, Anne Monks, Mark W. Burkett, Erik Harris, Rene’ M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, Thomas Silvers, David Evans, Dianne Newton, Luke Stockwin, Melinda Hollingshead, Ralph Parchment, James H. Doroshow, Beverly Teicher, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5178.
https://doi.org/10.1158/1538-7445.AM2016-5178
Published: 15 July 2016
View article titled, Abstract 5178: Determinants of response to temozolomide in an exceptionally sensitive patient derived model
Journal Articles

Abstract 606: Similar 3D pharmacodynamic (3D-PD) responses of human tumor spheroids and xenografts to topoisomerase 1 inhibitor-induced DNA damage

David M. Evans, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, Silvers Thomas, Robert Kinders, Tony Navas, Scott Lawrence, Anne Monks, Annamaria Rapisarda, Ralph E. Parchment, James H. Doroshow, Beverly Teicher
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 606.
https://doi.org/10.1158/1538-7445.AM2016-606
Published: 15 July 2016
View article titled, Abstract 606: Similar 3D pharmacodynamic (3D-PD) responses of human tumor spheroids and xenografts to topoisomerase 1 inhibitor-induced DNA damage
Journal Articles

Abstract 5406: Osteosarcoma cell lines response to approved and investigational anticancer agents and statins along with gene and microRNA expression

Gurmeet Kaur, Eric Polley, Joel Morris, Thomas Silvers, Michael Selby, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Anne Monks, Annamaria Rapisarda, David Evans, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5406.
https://doi.org/10.1158/1538-7445.AM2015-5406
Published: 01 August 2015
View article titled, Abstract 5406: Osteosarcoma cell lines response to approved and investigational anticancer agents and statins along with gene and microRNA expression
Journal Articles

Abstract 3741: Development and characterization of a cell based assay for the validation of mutant IDH1 inhibitors

Nicole D. Fer, Erik Harris, Stephen Fox, Ming Zhou, Catherine Simpson, Jing Liu, Ilia Korboukh, Emily A. Hull-Ryde, William P. Janzen, Stephen V. Frye, Anne Monks, Beverly Teicher, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3741.
https://doi.org/10.1158/1538-7445.AM2014-3741
Published: 01 October 2014
View article titled, Abstract 3741: Development and characterization of a cell based assay for the validation of mutant IDH1 inhibitors
Journal Articles

Abstract 5475: Interrogation of NCI-60 patterns of growth inhibition in conjunction with investigational oncology agents kinase profiling for the elucidation of mechanistic targets

Joel Morris, Mark Kunkel, Eric Polley, Susan Holbeck, Anne Monks, David Evans, Annamaria Rapisarda, Jerry Collins, Beverly Teicher
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5475.
https://doi.org/10.1158/1538-7445.AM2014-5475
Published: 01 October 2014
View article titled, Abstract 5475: Interrogation of NCI-60 patterns of growth inhibition in conjunction with investigational oncology agents kinase profiling for the elucidation of mechanistic targets
Journal Articles

Abstract 4361: Target and drug discovery for recalcitrant, rare and neglected cancers.

Anne Monks, Annamaria Rapisarda, Kazimierz O. Wrzeszczynski, E. Michael August, Eric C. Polley, Sudhir B. Kondapaka, Gurmeet Kaur, Dianne Newton, Beverley A. Teicher
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4361.
https://doi.org/10.1158/1538-7445.AM2013-4361
Published: 15 April 2013
View article titled, Abstract 4361: Target and drug discovery for recalcitrant, rare and neglected cancers.
Journal Articles

Abstract 2416: Weekly EZN-2208 (pegylated SN-38) in combination with bevacizumab in patients with refractory solid tumors.

Woondong Jeong, Sook Ryun Park, Annamaria Rapisarda, Michelle Eugeni, Robert Kinders, Alice Chen, Giovanni Melillo, Baris Turkbey, James H. Doroshow, Shivaani Kummar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2416.
https://doi.org/10.1158/1538-7445.AM2013-2416
Published: 15 April 2013
View article titled, Abstract 2416: Weekly EZN-2208 (pegylated SN-38) in combination with bevacizumab in patients with refractory solid tumors.
Journal Articles

Abstract 890: Interleukin 11: A novel therapeutic target in IL-11Rα expressing sarcomas

Monica Mancini, Nicole Fer, Victor Perez, Beverly Teicher, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 890.
https://doi.org/10.1158/1538-7445.AM2012-890
Published: 15 April 2012
View article titled, Abstract 890: Interleukin 11: A novel therapeutic target in IL-11Rα expressing sarcomas
Journal Articles

Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion

Erika Terzuoli, Maura Puppo, Annamaria Rapisarda, Badarch Uranchimeg, Liang Cao, Angelika M. Burger, Marina Ziche, Giovanni Melillo
Journal: Cancer Research
Cancer Res (2010) 70 (17): 6837–6848.
https://doi.org/10.1158/0008-5472.CAN-10-1075
Published: 31 August 2010
View article titled, Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion
Open the PDF for Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion in another window
Includes: Supplementary data
Journal Articles

Abstract #256: Identification and characterization of a novel HIF-1 inhibitor that selectively induces DNA damage under hypoxic conditions.

Annamaria Rapisarda, Badarch Uranchimeg, Dominic Scudiero, Anna Ngo, Ng Siew Bee, Martin Everett, John Cardellina, Robert Shoemaker, Giovanni Melillo
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 256.
Published: 01 May 2009
View article titled, Abstract #256: Identification and characterization of a novel HIF-1 inhibitor that selectively induces DNA damage under hypoxic conditions.
Journal Articles

Abstract #266: Modulation of HIF-1\#945; mRNA processing by Aminoflavone: a novel mechanism of HIF-1\#945; inhibition in breast cancer cells.

Erika Terzuoli, Badarch Uranchimeg, Annamaria Rapisarda, Angelika Burger, Marina Ziche, Giovanni Melillo
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 266.
Published: 01 May 2009
View article titled, Abstract #266: Modulation of HIF-1\#945; mRNA processing by Aminoflavone: a novel mechanism of HIF-1\#945; inhibition in breast cancer cells.
Journal Articles

Abstract #250: Response of colon cancer cells to the hypoxic microenvironment: characterization of pathways involved in survival and tumorigenicity

Barbara Onnis, Badarch Uranchimeg, Annamaria Rapisarda, Robert Shoemaker, Giovanni Melillo
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 250.
Published: 01 May 2009
View article titled, Abstract #250: Response of colon cancer cells to the hypoxic microenvironment: characterization of pathways involved in survival and tumorigenicity