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Ann-Sofie Jemth
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Journal Articles

Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1

Ulrika Warpman Berglund, Helge Gad, Kumar Sanjiv, Ann-Sofie Jemth, Oliver Mortusewics, Lars Brautigam, Juha Rantala, Thomas Helleday
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2023-1569
Published: 04 April 2023
View article titled, Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Journal Articles

Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

Kumar Sanjiv, Helge gad, Sean G. Rudd, Oliver Mortusewicz, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, Johan Boström, José Manuel Calderon Montano1, Anna Hagenkort, Petra Groth, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Mikael Altun, Cecilia Ström, Martin Scobie, Holger Bastians, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 105.
https://doi.org/10.1158/1538-7445.AM2019-105
Published: 01 July 2019
View article titled, Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Journal Articles

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Robert Gustafsson, Ann-Sofie Jemth, Nina M.S. Gustafsson, Katarina Färnegårdh, Olga Loseva, Elisée Wiita, Nadilly Bonagas, Leif Dahllund, Sabin Llona-Minguez, Maria Häggblad, Martin Henriksson, Yasmin Andersson, Evert Homan, Thomas Helleday, Pål Stenmark
Journal: Cancer Research
Cancer Res (2017) 77 (4): 937–948.
https://doi.org/10.1158/0008-5472.CAN-16-1476
Published: 14 February 2017
View article titled, Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Open the PDF for Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor in another window
Includes: Supplementary data
Journal Articles

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Nicholas C.K. Valerie, Anna Hagenkort, Brent D.G. Page, Geoffrey Masuyer, Daniel Rehling, Megan Carter, Luka Bevc, Patrick Herr, Evert Homan, Nina G. Sheppard, Pål Stenmark, Ann-Sofie Jemth, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5501–5511.
https://doi.org/10.1158/0008-5472.CAN-16-0584
Published: 15 September 2016
View article titled, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Open the PDF for NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine in another window
Includes: Supplementary data
Journal Articles

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, Helge Gad, Mohit Narwal, Robert Gustafsson, Stella Karsten, Jordi Carreras Puigvert, Evert Homan, Carsten Berndt, Ulrika Warpman Berglund, Pål Stenmark, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2366–2375.
https://doi.org/10.1158/0008-5472.CAN-15-2380
Published: 14 April 2016
View article titled, Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Open the PDF for Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition in another window
Includes: Supplementary data