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Abstract 2153: ATR inhibition augments the efficacy of the lurbinectedin in small cell lung cancer

Christopher William Schultz, Yang Zhang, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Devon Atkinson, Liton Saha, Brian Elenbaas, Chien-Fei Lee, Astrid Zimmerman, Thomas Ried, Frank Zenke, Zoe Weaver, Rajaa Elmeskini, Yves Pommier, Anish Thomas

Cancer Res (2022) 82 (12_Supplement): 2153.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2153

Published: 15 June 2022

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Journal Articles

Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Ukhyun Jo, Ilya Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher Schultz, Anish Thomas, Frank Zenke, Yves Pommier

Cancer Res (2021) 81 (13_Supplement): 1055.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1055

Published: 01 July 2021

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Abstract 203: SCLC-CellMiner: An extensive cell line genomic and pharmacology resource identifies a subgroup of small cell lung cancers sensitive to targeted therapies and immunotherapies

Cancer Res (2021) 81 (13_Supplement): 203.

DOI: https://doi.org/10.1158/1538-7445.AM2021-203

Published: 01 July 2021

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Journal Articles

Abstract 5452: Neuroendocrine negative RB1 WT SCLC and LCNEC

Dmitriy Sonkin, Anish Thomas, Beverly A. Teicher

Cancer Res (2020) 80 (16_Supplement): 5452.

DOI: https://doi.org/10.1158/1538-7445.AM2020-5452

Published: 15 August 2020

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Journal Articles

Abstract CT156: Characterization of PEN-866, a Heat Shock Protein 90 (HSP90) binding conjugate of SN-38, in patient plasma and tumors from the first in human study

Anish Thomas, Kristina Kriksciukaite, Gerald Falchook, Johanna Bendel, Susanna Ulahannan, Christophe Redon, Laura Mei, Kerry Whalen, Jeffrey Bloss, Mark T. Bilodeau

Cancer Res (2020) 80 (16_Supplement): CT156.

DOI: https://doi.org/10.1158/1538-7445.AM2020-CT156

Published: 15 August 2020

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Journal Articles

Abstract PR07: Phase I/II study of mesothelin-targeted immunotoxin LMB-100 with nab-paclitaxel for patients with advanced pancreatic adenocarcinoma

Christine C. Alewine, Mehwish Ahmad, Cody J. Peer, Zishuo Hu, Min-jung Lee, Akiro Yuno, Jessica Kindrick, Anish Thomas, Seth Steinberg, Jane B. Trepel, William D. Figg, Raffit Hassan, Ira Pastan

Cancer Res (2019) 79 (24_Supplement): PR07.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-PR07

Published: 13 December 2019

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Journal Articles

Abstract 1382: Megakaryocyte potentiating factor as a predictive biomarker for therapies against malignant mesothelioma

Liang Cao, Yunkai Yu, Anish. Thomas, Jingli Zhang, Masanori Onda, Paul Meltzer, Raffit Hassan, Ira Pastan

Cancer Res (2019) 79 (13_Supplement): 1382.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1382

Published: 01 July 2019

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Journal Articles

Abstract 4932: Neuro-endocrine negative SCLC is mostly RB1 WT and may be sensitive to CDK4/6 inhibition, especially if CCND1 is amplified

Dmitriy Sonkin, Anish Thomas, Beverly A. Teicher

Cancer Res (2018) 78 (13_Supplement): 4932.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4932

Published: 01 July 2018

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Journal Articles

Abstract LB-244: Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors

Azam Ghafoor, Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse, Yves Pommier

Cancer Res (2018) 78 (13_Supplement): LB-244.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-244

Published: 01 July 2018

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Journal Articles

Temozolomide in the Era of Precision Medicine

Anish Thomas, Mamoru Tanaka, Jane Trepel, William C. Reinhold, Vinodh N. Rajapakse, Yves Pommier

Cancer Res (2017) 77 (4): 823–826.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2983

Published: 14 February 2017

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Journal Articles

Abstract 3247: Granulocytic MDSCs (CD11b+CD15+CD14-HLADR-) in peripheral blood of mesothelioma patients are elevated and suppress T cell proliferation and function via reactive oxygen species

Swati Khanna, Francis Mussai, Anish Thomas, Gary Middleton, Constance Yuan, Betsy Morrow, Jingli Zhang, Ira Pastan, Maryalice Stetler-Stevenson, Raffit Hassan

Cancer Res (2016) 76 (14_Supplement): 3247.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3247

Published: 15 July 2016

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Journal Articles

Abstract 3103: The reduced immunogenicity anti-mesothelin immunotoxin RG7787 in combination with nab-paclitaxel has significant anti-tumor efficacy against primary mesothelioma cell lines and patient derived mesothelioma tumor xenografts

Jingli Zhang, Qun Jiang, Christine Alewine, Swati Khanna, Betsy Morrow, Anish Thomas, Ira Pastan, Raffit Hassan

Cancer Res (2016) 76 (14_Supplement): 3103.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3103

Published: 15 July 2016

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Journal Articles

Abstract 4759: Whole genome sequencing of sequentially acquired lung and lymph node metastatic sites from a never smoker lung adenocarcinoma patient revealed extensive genomic heterogeneity

Shaojian Gao, Constance Cultraro, Romi BIswas, Corey A. Carter, Tapan K. Maity, Anish Thomas, Arun Rajan, Paul Meltzer, David Schrump, Giuseppe Giaccone, Javed Khan, Udayan Guha

Cancer Res (2015) 75 (15_Supplement): 4759.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4759

Published: 01 August 2015

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Journal Articles

Abstract 5466: The role of fibroblast growth factor receptor 1 (FGFR1) in small cell lung cancer (SCLC).

Anish Thomas, Jih-Hsiang Lee, Yisong Wang, Ziedulla Abdullaev, Lola Saidkhodjaeva, Svetlana D. Pack, Giuseppe Giaccone

Cancer Res (2013) 73 (8_Supplement): 5466.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5466

Published: 15 April 2013

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Journal Articles

Abstract 1999: A targeted exome sequencing platform for routine clinical molecular profiling of advanced thoracic malignancies relevant to targeted therapy.

Christopher C. Lau, Keith Killian, Yuelin J. Zhu, Yonghong Wang, Marbin Pineda, Anish Thomas, Yisong Wang, Betsy Morrow, Liqiang Xi, Mark Raffeld, Giuseppe Giaccone, Paul S. Meltzer

Cancer Res (2013) 73 (8_Supplement): 1999.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1999

Published: 15 April 2013

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NARROW

Abstract 2153: ATR inhibition augments the efficacy of the lurbinectedin in small cell lung cancer

Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Abstract 203: SCLC-CellMiner: An extensive cell line genomic and pharmacology resource identifies a subgroup of small cell lung cancers sensitive to targeted therapies and immunotherapies

Abstract 5452: Neuroendocrine negative RB1 WT SCLC and LCNEC

Abstract CT156: Characterization of PEN-866, a Heat Shock Protein 90 (HSP90) binding conjugate of SN-38, in patient plasma and tumors from the first in human study

Abstract PR07: Phase I/II study of mesothelin-targeted immunotoxin LMB-100 with nab-paclitaxel for patients with advanced pancreatic adenocarcinoma

Abstract 1382: Megakaryocyte potentiating factor as a predictive biomarker for therapies against malignant mesothelioma

Abstract 4932: Neuro-endocrine negative SCLC is mostly RB1 WT and may be sensitive to CDK4/6 inhibition, especially if CCND1 is amplified

Abstract LB-244: Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors

Temozolomide in the Era of Precision Medicine

Abstract 3247: Granulocytic MDSCs (CD11b+CD15+CD14-HLADR-) in peripheral blood of mesothelioma patients are elevated and suppress T cell proliferation and function via reactive oxygen species

Abstract 3103: The reduced immunogenicity anti-mesothelin immunotoxin RG7787 in combination with nab-paclitaxel has significant anti-tumor efficacy against primary mesothelioma cell lines and patient derived mesothelioma tumor xenografts

Abstract 4759: Whole genome sequencing of sequentially acquired lung and lymph node metastatic sites from a never smoker lung adenocarcinoma patient revealed extensive genomic heterogeneity

Abstract 5466: The role of fibroblast growth factor receptor 1 (FGFR1) in small cell lung cancer (SCLC).

Abstract 1999: A targeted exome sequencing platform for routine clinical molecular profiling of advanced thoracic malignancies relevant to targeted therapy.

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