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Anil Shanker
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Journal Articles

Abstract 7111: A cross-sectional survey of genomics infrastructure at six NHGRI-funded Diversity Centers for Genome Research

Free
Xuexia Wang, Francisco A. Fernandez-Lima, Zoran Bursac, Stephen Black, Marianna Baum, Jeremy W. Pettit, Deepa Bedi, Honghe Wang, Balasubramanyam Karanam, Melissa B. Davis, Martini Rachel, Erica L. Johnson, Brian Rivers, Anderson Winkler, Jacob Galan, John Blangero, Sarah Williams-Blangero, Maarit Tiirikainen, Lang Wu, Youping Deng, Grace Pan, Olga Korolkova, Alla Ivanova, Harshana Rajakaruna, Thanigaivelan Kanagasabai, Dorin B. Borza, Rajbir Singh, Sanika Chirwa, LaMonica Stewart, Stephania T. Miller-Hughes, Aramandla Ramesh, Ebony Madden, Anil Shanker, Qingguo Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7111.
https://doi.org/10.1158/1538-7445.AM2025-7111
Published: 21 April 2025
View articletitled, Abstract 7111: A cross-sectional survey of genomics infrastructure at six NHGRI-funded Diversity Centers for Genome Research
Journal Articles

Abstract 3158: TUSC2 suppresses energy metabolism in lung cancer cells with opposite effects in normal bronchial epithelial cells

Free
Jane Tonello, Mark Berger, Anil Shanker, Alla Ivanova
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3158.
https://doi.org/10.1158/1538-7445.AM2024-3158
Published: 22 March 2024
View articletitled, Abstract 3158: TUSC2 suppresses energy metabolism in lung cancer cells with opposite effects in normal bronchial epithelial cells
Journal Articles

Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

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Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E.M. Kithsiri Wijeratne, Ashley L. Babyak, Timothy C. Back, Raj Chari, Christine N. Evans, Curtis J. Henrich, Thomas J. Meyer, Elijah F. Edmondson, Maria T. Prudente de Aquino, Thanigaivelan Kanagasabai, Anil Shanker, A.A. Leslie Gunatilaka, Thomas J. Sayers
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3374–3386.
https://doi.org/10.1158/0008-5472.CAN-20-2634
Published: 15 June 2021
View articletitled, Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins
Open the PDF for Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins in another window
Includes: Supplementary data
Journal Articles

Abstract 5665: Physical crosstalk between CD8+T and natural killer cells elicits antitumor effector response

Free
Roman V. Uzhachenko, Ashutosh Singhal, Shawn J. Goodwin, William H. Hofmeister, Anil Shanker
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5665.
https://doi.org/10.1158/1538-7445.AM2017-5665
Published: 01 July 2017
View articletitled, Abstract 5665: Physical crosstalk between CD8+T and natural killer cells elicits antitumor effector response
Journal Articles

Abstract 647: Bortezomib enhances CD8+ T Lymphocyte antitumor effector function: Potential mechanism(s) via notch regulation

Free
Ariana N. Renrick, Menaka C. Thounaojam, Portia Thomas, Samuel T. Pellom, Anil Shanker
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 647.
https://doi.org/10.1158/1538-7445.AM2017-647
Published: 01 July 2017
View articletitled, Abstract 647: Bortezomib enhances CD8+ T Lymphocyte antitumor effector function: Potential mechanism(s) via notch regulation
Journal Articles

Abstract 4161: Bortezomib enhances expression of effector molecules in antitumor CD8+ T lymphocytes by modulating Notch-NF-kB-miR-155 crosstalk

Free
Ariana N. Renrick, Menaka C. Thounaojam, Duafalia F. Dudimah, Portia Thomas, Samuel T. Pellom, Roman V. Uzhachenko, Anil Shanker
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4161.
https://doi.org/10.1158/1538-7445.AM2016-4161
Published: 15 July 2016
View articletitled, Abstract 4161: Bortezomib enhances expression of effector molecules in antitumor CD8+ T lymphocytes by modulating Notch-NF-kB-miR-155 crosstalk
Journal Articles

Abstract 934: Tributyltin-induced dysregulation of inflammatory cytokine levels in human and mouse immune cells

Free
Shanieek Lawrence, Samuel T. Pellom, Anil Shanker, Margaret Whalen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 934.
https://doi.org/10.1158/1538-7445.AM2016-934
Published: 15 July 2016
View articletitled, Abstract 934: Tributyltin-induced dysregulation of inflammatory cytokine levels in human and mouse immune cells
Journal Articles

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity

Free
Anil Shanker, Samuel T. Pellom, Jr, Duafalia F. Dudimah, Menaka C. Thounaojam, Rachel L. de Kluyver, Alan D. Brooks, Hideo Yagita, Daniel W. McVicar, William J. Murphy, Dan L. Longo, Thomas J. Sayers
Journal: Cancer Research
Cancer Res (2015) 75 (24): 5260–5272.
https://doi.org/10.1158/0008-5472.CAN-15-0794
Published: 14 December 2015
View articletitled, Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Open the PDF for Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity in another window
Includes: Supplementary data
Journal Articles

Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy

Free
Asel K. Biktasova, Duafalia F. Dudimah, Roman V. Uzhachenko, Kyungho Park, Anwari Akhter, Rajeswara R. Arasada, Jason V. Evans, Sergey V. Novitskiy, Elena E. Tchekneva, David P. Carbone, Anil Shanker, Mikhail M. Dikov
Journal: Cancer Research
Cancer Res (2015) 75 (22): 4728–4741.
https://doi.org/10.1158/0008-5472.CAN-14-1154
Published: 15 November 2015
View articletitled, Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy
Open the PDF for Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 4059: Crosstalk between CD8+ T and NK cells: fine-tuning of antitumor immune response

Free
Roman V. Uzhachenko, J Shawn Goodwin, Lino Costa, Alexander Terekhov, Menaka C. Thounaojam, William H. Hofmeister, Anil Shanker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4059.
https://doi.org/10.1158/1538-7445.AM2015-4059
Published: 01 August 2015
View articletitled, Abstract 4059: Crosstalk between CD8+ T and NK cells: fine-tuning of antitumor immune response
Journal Articles

Abstract 2735: Tributyltin alters the production and secretion of inflammatory cytokines from human and mouse immune cells

Free
Shanieek T. Lawrence, Margaret Whalen, Samuel Pellom, Anil Shanker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2735.
https://doi.org/10.1158/1538-7445.AM2015-2735
Published: 01 August 2015
View articletitled, Abstract 2735: Tributyltin alters the production and secretion of inflammatory cytokines from human and mouse immune cells
Journal Articles

Abstract 1177: Pharmacological stimulation of DLL1-Notch signaling as an effective cancer immunotherapy

Free
Asel K. Biktasova, Fred D. Dudimah, Roman Uzhachenko, Rajeswara Rao Arasada, Elena E. Tchekneva, David P. Carbone, Anil Shanker, Mikhail M. Dikov
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1177.
https://doi.org/10.1158/1538-7445.AM2014-1177
Published: 01 October 2014
View articletitled, Abstract 1177: Pharmacological stimulation of DLL1-Notch signaling as an effective cancer immunotherapy
Journal Articles

Abstract 3191: Elevation of tumor-promoting cytokines in mice exposed to the environmental contaminant tributyltin

Free
Shanieek Lawrence, Samuel Troy Pellom, Tasia Hurd-Brown, Anil Shanker, Margaret Whalen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3191.
https://doi.org/10.1158/1538-7445.AM2014-3191
Published: 01 October 2014
View articletitled, Abstract 3191: Elevation of tumor-promoting cytokines in mice exposed to the environmental contaminant tributyltin
Journal Articles

Abstract 3642: Cancer therapy by resuscitating Notch immune surveillance

Free
Duafalia F. Dudimah, Samuel T. Pellom, Jr., Roman V. Uzhachenko, David P. Carbone, Mikhail M. Dikov, Anil Shanker
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3642.
https://doi.org/10.1158/1538-7445.AM2014-3642
Published: 01 October 2014
View articletitled, Abstract 3642: Cancer therapy by resuscitating Notch immune surveillance
Journal Articles

Abstract 3983: Resuscitating immune surveillance in cancer.

Free
Duafalia F. Dudimah, Roman V. Uzhachenko, Samuel T. Pellom, Asel K. Biktasova, Mikhail M. Dikov, David P. Carbone, Anil Shanker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3983.
https://doi.org/10.1158/1538-7445.AM2013-3983
Published: 15 April 2013
View articletitled, Abstract 3983: Resuscitating immune surveillance in cancer.
Journal Articles

Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth

Free
Yuhui Huang, Luping Lin, Anil Shanker, Anshu Malhotra, Li Yang, Mikhail M. Dikov, David P. Carbone
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6122–6131.
https://doi.org/10.1158/0008-5472.CAN-10-4366
Published: 29 September 2011
View articletitled, Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth
Open the PDF for Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Abstract 1931: Impact of bortezomib-induced proteasome inhibition in vivo on antitumor T cell responses

Free
Anil Shanker, Rachel De Kluyver, Thomas J. Sayers
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1931.
https://doi.org/10.1158/1538-7445.AM10-1931
Published: 15 April 2010
View articletitled, Abstract 1931: Impact of bortezomib-induced proteasome inhibition in vivo on antitumor T cell responses
Journal Articles

Abstract 4251: Murine hepatocellular carcinoma stem cells express pluri-potency-associated transcription factors and are sensitive to immune-mediated apoptosis

Free
Rachel L. de Kluyver, Jim Stauffer, Alan Brooks, Anil Shanker, Tom Sayers
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4251.
https://doi.org/10.1158/1538-7445.AM10-4251
Published: 15 April 2010
View articletitled, Abstract 4251: Murine hepatocellular carcinoma stem cells express pluri-potency-associated transcription factors and are sensitive to immune-mediated apoptosis
Journal Articles

Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Free
Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine, Robert H. Wiltrout, Hideo Yagita, Thomas J. Sayers
Journal: Cancer Research
Cancer Res (2009) 69 (16): 6615–6623.
https://doi.org/10.1158/0008-5472.CAN-09-0685
Published: 12 August 2009
View articletitled, Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity
Open the PDF for Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity in another window
Includes: Supplementary data
Journal Articles

Abstract #5129: Bortezomib sensitizes human renal cancer cells to TRAIL-mediated apoptosis

Free
Alan Brooks, Kristen Jacobsen, Anil Shanker, Thomas Sayers
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5129.
Published: 01 May 2009
View articletitled, Abstract #5129: Bortezomib sensitizes human renal cancer cells to TRAIL-mediated apoptosis