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Journal Articles

Abstract 1103: MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC

Free
Logan C. Tyler, Anh T. Le, Hala Nijmeh, Liming Bao, Timothy R. Wilson, Brian Simmons, David Chen, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1103.
https://doi.org/10.1158/1538-7445.AM2022-1103
Published: 15 June 2022
View articletitled, Abstract 1103: MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
Journal Articles

Abstract 1102: Fyn and Src cooperate with ERBB family to drive resistance to crizotinib in ROS1+ and ALK+ NSCLC

Free
Logan C. Tyler, Nan Chen, Anh T. Le, Hala Nijmeh, Liming Bao, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1102.
https://doi.org/10.1158/1538-7445.AM2022-1102
Published: 15 June 2022
View articletitled, Abstract 1102: Fyn and Src cooperate with ERBB family to drive resistance to crizotinib in ROS1+ and ALK+ NSCLC
Journal Articles

Abstract 6387: Therapeutic targeting of lipid oxidation and apoptosis in pancreatic ductal adenocarcinoma

Free
Sarah J. Hartman, Nathalie Nadales, Stacey M. Bagby, Betelehem W. Yacob, Brian L. Gittleman, Adriana Estrada-Bernal, Anh T. Le, Christopher H. Lieu, S. Lindsey Davis, Alexis D. Leal, Jennifer R. Diamond, Wells A. Messersmith, Isabel R. Schlaepfer, Todd M. Pitts
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6387.
https://doi.org/10.1158/1538-7445.AM2020-6387
Published: 15 August 2020
View articletitled, Abstract 6387: Therapeutic targeting of lipid oxidation and apoptosis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1865: Phosphoproteomic analyses identify EGFR as a critical cooperative kinase for ALK

Free
Nan Chen, Anh T. Le, Andrea E. Doak, Guolin Zhang, Bin Fang, Eric B. Haura, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1865.
https://doi.org/10.1158/1538-7445.AM2020-1865
Published: 15 August 2020
View articletitled, Abstract 1865: Phosphoproteomic analyses identify EGFR as a critical cooperative kinase for ALK
Journal Articles

Abstract 1842: Novel KIF5B-RET+ NSCLC cell lines demonstrate differential responses to RET inhibitors

Free
Laura Schubert, Anh T. Le, Andrea E. Doak, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1842.
https://doi.org/10.1158/1538-7445.AM2018-1842
Published: 01 July 2018
View articletitled, Abstract 1842: Novel KIF5B-RET+ NSCLC cell lines demonstrate differential responses to RET inhibitors
Journal Articles

Abstract 5785: EML4-ALK variant E6a/b;A20 positive NSCLC cell lines are associated with growth upon blocking MEK-ERK pathway

Free
Bengt Hallberg, Ruth H. Palmer, Ganesh Umapathy, Dan E. Gustafsson, Joachim T. Siaw, Wasi Alam, Jikui Guan, Robert Doebele, Anh T. Le, Andrea Doak
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5785.
https://doi.org/10.1158/1538-7445.AM2018-5785
Published: 01 July 2018
View articletitled, Abstract 5785: EML4-ALK variant E6a/b;A20 positive NSCLC cell lines are associated with growth upon blocking MEK-ERK pathway
Journal Articles

Abstract B33: CRISPR/Cas9 generation of Ret and Ntrk1 fusion oncogenes and novel in vitro sgRNA screening method

Free
Laura Schubert, Anh T. Le, Stephen P. Malkoski, Raphael Nemenoff, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): B33.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-B33
Published: 14 May 2018
View articletitled, Abstract B33: CRISPR/Cas9 generation of Ret and Ntrk1 fusion oncogenes and novel in vitro sgRNA screening method
Journal Articles

EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases

Free
Aria Vaishnavi, Laura Schubert, Uwe Rix, Lindsay A. Marek, Anh T. Le, Stephen B. Keysar, Magdalena J. Glogowska, Matthew A. Smith, Severine Kako, Natalia J. Sumi, Kurtis D. Davies, Kathryn E. Ware, Marileila Varella-Garcia, Eric B. Haura, Antonio Jimeno, Lynn E. Heasley, Dara L. Aisner, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3551–3563.
https://doi.org/10.1158/0008-5472.CAN-17-0109
Published: 02 July 2017
View articletitled, EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases
Open the PDF for EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases in another window
Includes: Supplementary data
Journal Articles

Abstract LB-118: Identification of TRKA and TRKB kinase domain mutations that induce resistance to a pan-TRK inhibitor

Free
Adriana Estrada-Bernal, Anh T. Le, Brian Tuch, Tatiana G. Kutateladze, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-118.
https://doi.org/10.1158/1538-7445.AM2016-LB-118
Published: 15 July 2016
View articletitled, Abstract LB-118: Identification of TRKA and TRKB kinase domain mutations that induce resistance to a pan-TRK inhibitor
Journal Articles

Abstract 5255: EGFR is a conspiring kinase in gene fusion positive lung cancer

Free
Aria Vaishnavi, Anh T. Le, Stephen B. Keysar, Christine M. Lovly, Severine Kako, Marileila Varella-Garcia, Antonio Jimeno, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5255.
https://doi.org/10.1158/1538-7445.AM2014-5255
Published: 01 October 2014
View articletitled, Abstract 5255: EGFR is a conspiring kinase in gene fusion positive lung cancer
Journal Articles

Abstract 894: Targeting ROS1 receptor tyrosine kinase gene fusions in non-small cell lung cancer

Free
Kurtis D. Davies, Anh T. Le, Margaret C. Skokan, Mariana F. Theodoro, Marileila Varella-Garcia, D. Ross Camidge, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 894.
https://doi.org/10.1158/1538-7445.AM2012-894
Published: 15 April 2012
View articletitled, Abstract 894: Targeting ROS1 receptor tyrosine kinase gene fusions in non-small cell lung cancer
Journal Articles

Abstract 5594: ALK-driven lung cancer: Potential therapeutic strategies for treatment and prevention of drug resistance

Free
Amanda B. Pilling, Anh T. Le, Aik-Choon Tan, Jihye Kim, Katherine R. Singleton, Lynn E. Heasley, Barbara Helfrich, James DeGregori, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5594.
https://doi.org/10.1158/1538-7445.AM2012-5594
Published: 15 April 2012
View articletitled, Abstract 5594: ALK-driven lung cancer: Potential therapeutic strategies for treatment and prevention of drug resistance