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Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher

Cancer Res (2023) 83 (7_Supplement): 234.

https://doi.org/10.1158/1538-7445.AM2023-234

Published: 04 April 2023

View articletitled, Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Journal Articles

Abstract 1667: Elimusertib shows stronger antitumor activity than standard of care chemotherapy in pediatric solid tumor models

Cancer Res (2023) 83 (7_Supplement): 1667.

https://doi.org/10.1158/1538-7445.AM2023-1667

Published: 04 April 2023

View articletitled, Abstract 1667: Elimusertib shows stronger antitumor activity than standard of care chemotherapy in pediatric solid tumor models

Journal Articles

Abstract 1693: Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq

Cancer Res (2022) 82 (12_Supplement): 1693.

https://doi.org/10.1158/1538-7445.AM2022-1693

Published: 15 June 2022

View articletitled, Abstract 1693: Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq

Journal Articles

Abstract A02: Patient-derived xenograft models of neuroblastoma as improvement for the prediction of targeted therapies for childhood cancer

Dennis Gürgen, Jana Rolff, Johannes H. Schulte, Hedwig E. Deubzer, Karin Schmelz, Anton G. Henssen, Patrick Hundsdörfer, Georg Seifert, Angelika Eggert, Wolfgang Walther, Jens Hoffmann

Cancer Res (2020) 80 (11_Supplement): A02.

https://doi.org/10.1158/1538-7445.CAMODELS2020-A02

Published: 02 June 2020

View articletitled, Abstract A02: Patient-derived xenograft models of neuroblastoma as improvement for the prediction of targeted therapies for childhood cancer

Journal Articles

Abstract 1820: Circular RNAs contribute to neuroblastoma pathogenesis

Filippos Klironomos, Clara Danssmann, Julian Naderi, Annika Winkler, Uschi Luz, Patrick Hundsdoerfer, Angelika Eggert, Joern Toedling, Falk Hertwig, Johannes H. Schulte, Steffen Fuchs

Cancer Res (2019) 79 (13_Supplement): 1820.

https://doi.org/10.1158/1538-7445.AM2019-1820

Published: 01 July 2019

View articletitled, Abstract 1820: Circular RNAs contribute to neuroblastoma pathogenesis

Journal Articles

Abstract IA11: Pediatric precision oncology programs in Germany and Europe

David T. W. Jones, Barbara C. Worst, Elke Pfaff, Cornelis M. Van Tilburg, Gnana Prakash Balasubramanian, Petra Fiesel, Kristian W. Pajtler, Angelika Freitag, Ruth Witt, Andreas E. Kulozik, Felix Sahm, Andreas von Deimling, Angelika Eggert, Uta Dirksen, Peter Lichter, David Capper, Olaf Witt, Stefan M. Pfister

Cancer Res (2018) 78 (19_Supplement): IA11.

https://doi.org/10.1158/1538-7445.PEDCA17-IA11

Published: 01 October 2018

View articletitled, Abstract IA11: Pediatric precision oncology programs in Germany and Europe

Journal Articles

Abstract 2628: Synthetic lethal targeting of ATR in alternative lengthening of telomeres-dependent rhabdomyosarcoma

Heathcliff Dorado García, Jennifer von Stebut, Ian MacArthur, Koshi Imami, Natalie Timme, Kerstin Schoenbeck, Annabell Szymansky, Georg Seifert, Patrick Hundsdoerfer, Andrej Lissat, Matthias Selbach, Angelika Eggert, Johannes Schulte, Anton Henssen

Cancer Res (2018) 78 (13_Supplement): 2628.

https://doi.org/10.1158/1538-7445.AM2018-2628

Published: 01 July 2018

View articletitled, Abstract 2628: Synthetic lethal targeting of ATR in alternative lengthening of telomeres-dependent rhabdomyosarcoma

Journal Articles

Abstract 2624: Dual PLK1 and BRD4 inhibition has synergistic therapeutic effects against high-risk rhabdomyosarcoma

Natalie Timme, Shuai Liu, Hailemichael Yosief, Heathcliff Dorado García, Ian MacArthur, Annabell Szymansky, Constantin Dohna, Georg Seifert, Patrick Hundsdörfer, Andrej Lissat, Angelika Eggert, Johannes Schulte, Wei Zhang, Anton Henssen

Cancer Res (2018) 78 (13_Supplement): 2624.

https://doi.org/10.1158/1538-7445.AM2018-2624

Published: 01 July 2018

View articletitled, Abstract 2624: Dual PLK1 and BRD4 inhibition has synergistic therapeutic effects against high-risk rhabdomyosarcoma

Journal Articles

Abstract 5679: Using droplet digital PCR to analyze MYCN copy number in plasma from patients with high-risk neuroblastoma

Marco Lodrini, Annika Sprüssel, Kathy Astrahantseff, Daniela Tiburtius, Robert Konschak, Holger Lode, Matthias Fischer, Johannes H. Schulte, Angelika Eggert, Hedwig Deubzer

Cancer Res (2017) 77 (13_Supplement): 5679.

https://doi.org/10.1158/1538-7445.AM2017-5679

Published: 01 July 2017

View articletitled, Abstract 5679: Using droplet digital PCR to analyze MYCN copy number in plasma from patients with high-risk neuroblastoma

Journal Articles

Abstract LB-114: The INFORM personalized medicine study for high-risk pediatric cancer patients

Cancer Res (2015) 75 (15_Supplement): LB-114.

https://doi.org/10.1158/1538-7445.AM2015-LB-114

Published: 01 August 2015

View articletitled, Abstract LB-114: The INFORM personalized medicine study for high-risk pediatric cancer patients

Journal Articles

Abstract 4731: Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma

Anton Henssen, Kristina Althoff, Richard Koche, Andrea Odersky, Anneleen Beckers, Frank Speleman, Simon Schäfers, Katleen De Preter, Alexandra Florin, Lukas Heukamp, Annika Spruessel, Kathy Astrahanseff, Natalie Sadowski, Alexander Schramm, Angelika Eggert, Lucile Astorgues-Xerri, Eugenia Riveiro, Esteban Cvitkovic, Johannes H. Schulte

Cancer Res (2015) 75 (15_Supplement): 4731.

https://doi.org/10.1158/1538-7445.AM2015-4731

Published: 01 August 2015

View articletitled, Abstract 4731: Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma

Journal Articles

Abstract 3967: BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastoma

Johannes H. Schulte, Kristina Althoff, Emma Bell, Andrea Odersky, Anneleen Beckers, Frank Speleman, Simon Schäfers, Alexander Schramm, Angelika Eggert, Frank Westermann, Eugenia Riveiro, Esteban Cvitkovic, Anton Henssen

Cancer Res (2014) 74 (19_Supplement): 3967.

https://doi.org/10.1158/1538-7445.AM2014-3967

Published: 01 October 2014

View articletitled, Abstract 3967: BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastoma

Journal Articles

Abstract 4596: LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling.

Johannes H. Schulte, Jan Molenaar, Sven Lindner, Alexander Schramm, Pieter Mestdagh, Frank Speleman, Rogier Versteeg, Angelika Eggert

Cancer Res (2013) 73 (8_Supplement): 4596.

https://doi.org/10.1158/1538-7445.AM2013-4596

Published: 15 April 2013

View articletitled, Abstract 4596: LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling.

Journal Articles

Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis

Georg Eschenburg, Angelika Eggert, Alexander Schramm, Holger N. Lode, Patrick Hundsdoerfer

Cancer Res (2012) 72 (10): 2645–2656.

https://doi.org/10.1158/0008-5472.CAN-11-4072

Published: 14 May 2012

View articletitled, Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis

Includes: Supplementary data

Journal Articles

Abstract 1683: ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors

Riet Hilhorst, Liesbeth Hovestad, Rik de Wijn, Dirk Pijnenburg, Rob Ruijtenbeek, Alexander Schramm, Angelika Eggert, Johannes H. Schulte

Cancer Res (2012) 72 (8_Supplement): 1683.

https://doi.org/10.1158/1538-7445.AM2012-1683

Published: 15 April 2012

View articletitled, Abstract 1683: ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors

Journal Articles

Abstract #5614: The AA genotype of the regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma

Hagen Bachmann, Lukas Heukam, Klaus Schmitz, Carolin Hilburn, Philip Kahl, Reinhard Buettner, Holger Nueckel, Kurt Schmid, Winfried Sieffert, Angelika Eggert, Alexander Schramm, Johannes Schulte

Cancer Res (2009) 69 (9_Supplement): 5614.

Published: 01 May 2009

View articletitled, Abstract #5614: The AA genotype of the regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma

Journal Articles

Abstract #486: The histone demethylase LSD1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy

Johannes Schulte, So-Young Lim, Steffi Kuhfittig-Kulle, Alexander Schramm, Kristian Pajtler, Nicolaus Friedrichs, Jan Koster, Ingrid Ora, Rogier Versteeg, Roland Schuele, Reinhard Buettner, Eric Metzger, Kirfel Jutta, Angelika Eggert

Cancer Res (2009) 69 (9_Supplement): 486.

Published: 01 May 2009

View articletitled, Abstract #486: The histone demethylase LSD1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy

Journal Articles

Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

Johannes H. Schulte, Soyoung Lim, Alexander Schramm, Nicolaus Friedrichs, Jan Koster, Rogier Versteeg, Ingrid Ora, Kristian Pajtler, Ludger Klein-Hitpass, Steffi Kuhfittig-Kulle, Eric Metzger, Roland Schüle, Angelika Eggert, Reinhard Buettner, Jutta Kirfel

Cancer Res (2009) 69 (5): 2065–2071.

https://doi.org/10.1158/0008-5472.CAN-08-1735

Published: 02 March 2009

View articletitled, Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

Includes: Supplementary data

Journal Articles

Fractalkine (CX3CL1) rich neuroblastoma microenvironments favor T-cell mediated eradication of metastases following targeted IL-2 immuncytokine therapy

Holger Lode, Yan Zeng, Nicole Huebener, Stefan Fest, Ulrike Schroeder, Silke Weixler, Alexander Schramm, Angelika Eggert, Gerhard Gaedicke

Cancer Res (2007) 67 (9_Supplement): 517.

Published: 01 May 2007

View articletitled, Fractalkine (CX3CL1) rich neuroblastoma microenvironments favor T-cell mediated eradication of metastases following targeted IL-2 immuncytokine therapy

Journal Articles

N-myc Regulates Oncogenic microRNAs in neuroblastoma

Johannes Schulte, Sebastian Horn, Birgit Samans, Lukas Heukamp, Ursula-Christa Eilers, Tobias Otto, Michael Krause, Kathy Astrahantseff, Reinhard Buettner, Alexander Schramm, Holger Christiansen, Martin Eilers, Angelika Eggert, Bernd Berwanger

Cancer Res (2007) 67 (9_Supplement): 4512.

Published: 01 May 2007

View articletitled, N-myc Regulates Oncogenic microRNAs in neuroblastoma

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Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Abstract 1667: Elimusertib shows stronger antitumor activity than standard of care chemotherapy in pediatric solid tumor models

Abstract 1693: Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq

Abstract A02: Patient-derived xenograft models of neuroblastoma as improvement for the prediction of targeted therapies for childhood cancer

Abstract 1820: Circular RNAs contribute to neuroblastoma pathogenesis

Abstract IA11: Pediatric precision oncology programs in Germany and Europe

Abstract 2628: Synthetic lethal targeting of ATR in alternative lengthening of telomeres-dependent rhabdomyosarcoma

Abstract 2624: Dual PLK1 and BRD4 inhibition has synergistic therapeutic effects against high-risk rhabdomyosarcoma

Abstract 5679: Using droplet digital PCR to analyze MYCN copy number in plasma from patients with high-risk neuroblastoma

Abstract LB-114: The INFORM personalized medicine study for high-risk pediatric cancer patients

Abstract 4731: Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma

Abstract 3967: BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastoma

Abstract 4596: LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling.

Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis

Abstract 1683: ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors

Abstract #5614: The AA genotype of the regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma

Abstract #486: The histone demethylase LSD1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy

Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

Fractalkine (CX3CL1) rich neuroblastoma microenvironments favor T-cell mediated eradication of metastases following targeted IL-2 immuncytokine therapy

N-myc Regulates Oncogenic microRNAs in neuroblastoma

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