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Anette Sommer
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Journal Articles

Abstract 1808: Loss of BAP1/BRCA1 counteracts spindle assembly checkpoint activation by the anti-mesothelin antibody drug-conjugate anetumab ravtansine

Anita Singh, Jin-li Luo, Sara Busacca, Alan Dawson, Krishna Kalyan Kolluri, Samuel Janes, Andrew Fry, Anette Sommer, Dean Fennell
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1808.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1808
Published: 15 August 2020
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Journal Articles

Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications

Anette Sommer, Stefanie Hammer, Sandra Berndt, Antje M. Wengner, Niels Boehnke, Markus Berger, Nils Griebenow, Andreas Steffen, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Joerissen, Anja Giese, Maria Quanz, Zhengzheng Bao, Xiuli Wu, Hilmar Weinmann, Lars Linden, Bertolt Kreft, Dominik Mumberg
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1807.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1807
Published: 15 August 2020
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Journal Articles

Abstract 2907: Identification and optimization of a novel NAMPT inhibitor-based ADC payload class for cancer therapy

Niels Böhnke, Markus Berger, Nils Griebenow, Anja Giese, Judith Günther, Anette Sommer, Stefanie Hammer, Sandra Berndt, Antje M. Wengner, Rudolf Beier, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Joerissen, Antje Rottmann, Michael Erkelenz, Naomi Barak, Ulf Bömer, Dominik Mumber, Bertolt Kreft, Lars Linden, Carl Friedrich Nising, Hilmar Weinmann
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2907.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2907
Published: 15 August 2020
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Journal Articles

Abstract 1776: Exploring anetumab ravtansine in a preclinical model of thymic carcinoma

Vincent Chen, Anette Sommer, Christoph Schatz, Sabine Zitzmann-Kolbe, In-Kyu Kim, Giuseppe Giaccone
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1776.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1776
Published: 15 August 2020
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Journal Articles

Abstract 6318: Acquired resistance in a malignant pleural mesothelioma preclinical model after treatment with Anetumab ravtansine

Christoph Schatz, Sabine Zitzmann-Kolbe, Reimo Tetzner, Marlen Keil, Jens Hoffmann, Dominik Mumberg, Anette Sommer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6318.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6318
Published: 15 August 2020
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Journal Articles

Abstract 228: KSPi-ADCs: ADCs with novel kinesin spindle protein inhibitor payloads and a tailor-made linker chemistry

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Anne-Sophie Rebstock, Sarah Johannes, Leo Marx, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Joerissen, Hilmar Weinmann
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 228.
DOI: https://doi.org/10.1158/1538-7445.AM2019-228
Published: 01 July 2019
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Journal Articles

Abstract 4829: Improved safety profile of HER2-KSPi-ADCs compared to T-DM1 in in vitro megakaryocyte assay predictive of thrombocytopenia

Anette Sommer, Pascale Buchmann, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Christian Bertling, Jenny Thoennes, Sandra Johanssen, Christoph Schatz, Dominik Mumberg
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4829.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4829
Published: 01 July 2019
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Journal Articles

Abstract 4816: Anetumab ravtansine has monotherapy efficacy in mesothelin positive patient-derived NSCLC tumor models and in a syngeneic tumor model in immunocompetent mice

Anette Sommer, Pascale Lejeune, Sabine Hoff, Annette O. Walter, Sandra Berndt, Lars Roese, Andreas Schlicker, Michael J. Wick, Cem Elbi, Dominik Mumberg, Christoph Schatz
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4816.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4816
Published: 01 July 2019
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Journal Articles

Abstract 4828: Anti-tumor activity of BAY-943, an anti-IL3RA ADC with a novel KSP inhibitor payload, in CDX and PDX AML models

Anette Sommer, Dennis Kirchhoff, Antje M. Wengner, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Anne-Sophie Rebstock, Oliver von Ahsen, Lisa Dietz, Pascale Buchmann, Sandra Johanssen, Dominik Mumberg, Bertolt Kreft
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4828.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4828
Published: 01 July 2019
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Journal Articles

Abstract 3935: Differentiation of multi-kinase inhibitors by in vivo transcript profiling: Potential implications for HCC therapy

Heidrun Ellinger-Ziegelbauer, Lukas Fiebig, Ludwig Schladt, Karl Ziegelbauer, Anette Sommer, Dieter Zopf
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3935.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3935
Published: 01 July 2018
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Journal Articles

Abstract 855: Increased in vitro potency and in vivo efficacy of FGFR2-targeted thorium-227 conjugate (FGFR2-TTC) in combination with the ATR inhibitor BAY 1895344

Katrine Wickstroem, Urs B. Hagemann, Antje M. Wengner, Anette Sommer, Alexander Kristian, Christine Ellingsen, Roger M. Bjerke, Jenny Karlsson, Olav B. Ryan, Lars Linden, Bertolt Kreft, Dominik Mumberg, Hanno Wild, Karl Ziegelbauer, Alan Cuthbertson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 855.
DOI: https://doi.org/10.1158/1538-7445.AM2018-855
Published: 01 July 2018
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Journal Articles

Abstract 46: Preclinical activity of novel antibody-drug conjugates with pyrrole-based kinesin spindle protein inhibitors targeting different tumor antigens

Anette Sommer, Sandra Berndt, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Sven Wittrock, Anne-Sophie Rebstock, Lisa Dietz, Christoph Mahlert, Simone Greven, Nils Griebenow, Yolanda Cancho-Grande, Rolf Jautelat, Heiner Apeler, Bertolt Kreft
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 46.
DOI: https://doi.org/10.1158/1538-7445.AM2017-46
Published: 01 July 2017
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Journal Articles

Abstract 5199: Preclinical activity of the FGFR2-targeted thorium-227 conjugate in preclinical models of colorectal, gastric and triple-negative breast cancer

Urs B. Hagemann, Anette Sommer, Alexander Kristian, Ellen Wang, Åsmund Larsen, Uta Wirnitzer, Heidrun Ellinger-Ziegelbauer, Steffen Sandmann, Thorsten Poethko, Jenny Karlsson, Roger M. Bjerke, Lars Linden, Bertolt Kreft, Hanno Wild, Alan S. Cuthbertson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5199.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5199
Published: 01 July 2017
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Journal Articles

Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

Hans-Georg Lerchen, Sven Wittrock, Nils Griebenow, Mario Lobell, Anne-Sophie Rebstock, Yolanda Cancho-Grande, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Anette Sommer, Sandra Berndt, Carsten Terjung, Heiner Apeler, Bertolt Kreft, Rolf Jautelat
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3234.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3234
Published: 01 July 2017
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Journal Articles

Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

Anette Sommer, Charlotte Kopitz, Christoph A. Schatz, Carl F. Nising, Christoph Mahlert, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Stefanie Hammer, Simone Greven, Joachim Schuhmacher, Manuela Braun, Ruprecht Zierz, Sabine Wittemer-Rump, Axel Harrenga, Frank Dittmer, Frank Reetz, Heiner Apeler, Rolf Jautelat, Hung Huynh, Karl Ziegelbauer, Bertolt Kreft
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (21): 6331–6339.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-0180
Published: 31 October 2016
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Includes: Supplementary data
Journal Articles

Abstract LB-117: High efficacy of BAY 1187982, an FGFR2-ADC, in overcoming drug resistance in a diffuse type gastric cancer patient-derived xenograft model with acquired resistance to pan-FGFR inhibitor AZD4547

Wen Min Lau, Eileen Teng, Kie Kyon Huang, Jin Wei Tan, Ming Teh, Wei Peng Yong, Anette Sommer, Christoph A. Schatz, Patrick Tan, Shing Leng Chan, Jimmy So
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-117.
DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-117
Published: 15 July 2016
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Journal Articles

Abstract 1684: Preclinical anti-tumor efficacy of FGFR2-ADC BAY 1187982 in patient-derived gastric, breast and ovarian cancer models

Anette Sommer, Charlotte Kopitz, Christoph Schatz, Ruprecht Zierz, Joachim Schuhmacher, Sabine Wittemer-Rump, Klaas Prins, Manuela Braun, Frank Reetz, Bertolt Kreft, Hung T. Huynh, Karl Ziegelbauer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1684.
DOI: https://doi.org/10.1158/1538-7445.AM2015-1684
Published: 01 August 2015
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Journal Articles

Abstract 1683: Pharmacokinetic/pharmacodynamic (PK/PD) and toxicokinetic/toxicodynamic (TK/TD) modeling of preclinical data of FGFR2-ADC (BAY 1187982) to guide dosing in phase 1

Sabine Wittemer-Rump, Anette Sommer, Charlotte Kopitz, Hung Huynh, Christoph Schatz, Ruprecht Zierz, Manuela Braun, Kirstin Meyer, Dirk Laurent, Jörg Lippert, Klaas Prins
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1683.
DOI: https://doi.org/10.1158/1538-7445.AM2015-1683
Published: 01 August 2015
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Journal Articles

Abstract 4491: FGFR2-ADC potently and selectively inhibits growth of gastric and breast cancer xenograft models

Anette Sommer, Carl F. Nising, Christoph Mahlert, Charlotte C. Kopitz, Hans-Georg Lerchen, Simone Greven, Beatrix Stelte-Ludwig, Joachim Schuhmacher, Ruprecht Zierz, Sabine Wittemer-Rump, Christoph Schatz, Frank Reetz, Heiner Apeler, Rolf Jautelat, Bertolt Kreft, Karl Ziegelbauer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4491.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4491
Published: 01 October 2014
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Journal Articles

Abstract DDT02-01: In vitro and in vivo characterization of a novel anti-fibroblast growth factor receptor (FGFR) 2 antibody (BAY 1179470) for the treatment of gastric cancer

Charlotte Kopitz, Anette Sommer, Stefanie Hammer, Axel Harrenga, Beatrix Stelte-Ludwig, Frank Dittmer, Frank Reetz, Ekkehard May, Ruprecht Zierz, Sabine Wittemer-Rump, Christoph Schatz, H. T. Huynh, Karl Ziegelbauer, Bertolt Kreft
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): DDT02-01.
DOI: https://doi.org/10.1158/1538-7445.AM2014-DDT02-01
Published: 01 October 2014
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