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Andrey Loboda
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Journal Articles

Abstract CT074: Discovery and preliminary clinical findings of MK-6598, a potent and selective inhibitor of the immune checkpoint IL4I1

Dagmar Hess, Nicolas Mach, Rahima Jamal, Anastasios Stathis, Steven F. Powell, Markus Joerger, Andrey Loboda, Yao Chen, Stuart Shumway, Erik H. Knelson, Lillian L. Siu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT074.
https://doi.org/10.1158/1538-7445.AM2025-CT074
Published: 25 April 2025
View articletitled, Abstract CT074: Discovery and preliminary clinical findings of MK-6598, a potent and selective inhibitor of the immune checkpoint IL4I1
Journal Articles

Abstract 5112: Tumor cell expression of a distinct TME gene signature defines differential drug sensitivities to EGFR/MEK/SRC targeted agents

Mingli Yang, Michael V. Nebozhyn, Lance Pflieger, Ramani Soundararajan, Michelle Maurin, Heiman Wang, Andrey Loboda, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5112.
https://doi.org/10.1158/1538-7445.AM2025-5112
Published: 21 April 2025
View articletitled, Abstract 5112: Tumor cell expression of a distinct TME gene signature defines differential drug sensitivities to EGFR/MEK/SRC targeted agents
Journal Articles

Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma

Handan Xiang, Yidan Pan, Marc A. Sze, Marta Wlodarska, Ling Li, Karyn Ann van de Mark, Haleema Qamar, Casey J. Moure, Douglas E. Linn, Josephine Hai, Ying Huo, James Clarke, Tze Guan Tan, Samantha Ho, Karen W. Teng, Muhammad N. Ramli, Michael Nebozhyn, Chunsheng Zhang, Julianne Barlow, Corinne E. Gustafson, Savanna Gornisiewicz, Thomas P. Albertson, Stephanie L. Korle, Raphael Bueno, Lily Y. Moy, Elisabeth H. Vollmann, Derek Y. Chiang, Philip E. Brandish, Andrey Loboda
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1410–1425.
https://doi.org/10.1158/0008-5472.CAN-23-1183
Published: 02 May 2024
View articletitled, Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma
Open the PDF for Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT207: Association of gene expression profiles and clinical outcomes in patients with locally advanced or recurrent/metastatic cutaneous squamous cell carcinoma treated with pembrolizumab in KEYNOTE-629

Åse Bratland, Jean-Jacques Grob, Eva Munoz Couselo, Laurent Mortier, Ralf Gutzmer, Osama Roshdy, Rene Mendoza Gonzalez, Jacob Schachter, Ana M. Arance Fernandez, Florent Grange, Nicolas Meyer, Abhishek J. Joshi, Salem Billan, Judong Shen, Razvan Cristescu, Michael Nebozhyn, Andrey Loboda, Jason Sparkowski, Burak Gumuscu, Jianda Yuan, Brett Hughes
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT207.
https://doi.org/10.1158/1538-7445.AM2024-CT207
Published: 05 April 2024
View articletitled, Abstract CT207: Association of gene expression profiles and clinical outcomes in patients with locally advanced or recurrent/metastatic cutaneous squamous cell carcinoma treated with pembrolizumab in KEYNOTE-629
Journal Articles

Abstract 6430: Gene expression signature quantifies the cellular contribution of the tumor vs. the microenvironment in determining colorectal cancer prognosis and therapeutic outcome

Mingli Yang, Timothy J. Yeatman, Michael V. Nebozhyn, Michael J. Schell, Lance Pflieger, Andrey Loboda, Warren J. Pledger, Ramani Soundararajan, Michelle Maurin, Heiman Wang, Jetsen Rodriguez Silva, Ashley Alden
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6430.
https://doi.org/10.1158/1538-7445.AM2024-6430
Published: 22 March 2024
View articletitled, Abstract 6430: Gene expression signature quantifies the cellular contribution of the tumor vs. the microenvironment in determining colorectal cancer prognosis and therapeutic outcome
Journal Articles

Abstract 2140: Association between gene expression signatures and outcomes of pembrolizumab (pembro) and paclitaxel (pac) in advanced gastric cancer (GC): Exploratory analysis from KEYNOTE-061

Kohei Shitara, Maria Di Bartolomeo, Mario Mandala, Min-Hee Ryu, Christian Caglevic, Tomasz Olesinski, Hyun C. Chung, Kei Muro, Eray Goekkurt, Raymond S. McDermott, Wasat Mansoor, Zev A. Wainberg, Chie-Schin Shih, Julie Kobie, Michael Nebozhyn, Razvan Cristescu, Z. Alexander Cao, Andrey Loboda, Mustafa Özgüroğlu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2140.
https://doi.org/10.1158/1538-7445.AM2022-2140
Published: 15 June 2022
View articletitled, Abstract 2140: Association between gene expression signatures and outcomes of pembrolizumab (pembro) and paclitaxel (pac) in advanced gastric cancer (GC): Exploratory analysis from KEYNOTE-061
Journal Articles

Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells

Mingli Yang, Thomas B. Davis B. Davis, Michael V. Nebozhyn, Andrey Loboda, Heiman Wang, Michael J. Schell, Lance Pflieger, Ramya Thota, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1083.
https://doi.org/10.1158/1538-7445.AM2021-1083
Published: 01 July 2021
View articletitled, Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells
Journal Articles

Abstract 5789: A novel role of APC-partnering mutations in the sidedness of colorectal cancer survival

Mingli Yang, Michael Schell, Andrey Loboda, Michael Nebozhyn, W. Jack Pledger, Timothy Yeatman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5789.
https://doi.org/10.1158/1538-7445.AM2020-5789
Published: 15 August 2020
View articletitled, Abstract 5789: A novel role of APC-partnering mutations in the sidedness of colorectal cancer survival
Journal Articles

Abstract LB-261: Association between tumor mutational burden (TMB) assessed by whole-exome sequencing (WES) and outcomes of pembrolizumab (pembro) monotherapy

Razvan Cristescu, Deepti Aurora-Garg, Andrew Albright, Lei Xu, Xiao Qiao Liu, Andrey Loboda, Lixin Lang, Fan Jin, Alexandra Snyder, Jared Lunceford
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-261.
https://doi.org/10.1158/1538-7445.AM2020-LB-261
Published: 15 August 2020
View articletitled, Abstract LB-261: Association between tumor mutational burden (TMB) assessed by whole-exome sequencing (WES) and outcomes of pembrolizumab (pembro) monotherapy
Journal Articles

Abstract LB-397: Pembrolizumab plus pemetrexed and platinum vs placebo plus pemetrexed and platinum as first-line therapy for metastatic nonsquamous NSCLC: analysis of KEYNOTE-189 by STK11 and KEAP1 status

Shirish M. Gadgeel, Delvys Rodriguez-Abreu, Enriqueta Felip, Emilio Esteban, Giovanna Speranza, Martin Reck, Rina Hui, Michael Boyer, Edward B. Garon, Hidehito Horinouchi, Razvan Cristescu, Deepti Aurora-Garg, Andrey Loboda, Jared Lunceford, Julie Kobie, Mark Ayers, Bilal Piperdi, M. Catherine Pietanza, Marina C. Garassino
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-397.
https://doi.org/10.1158/1538-7445.AM2020-LB-397
Published: 15 August 2020
View articletitled, Abstract LB-397: Pembrolizumab plus pemetrexed and platinum vs placebo plus pemetrexed and platinum as first-line therapy for metastatic nonsquamous NSCLC: analysis of KEYNOTE-189 by STK11 and KEAP1 status
Journal Articles

Abstract CT084: Relationship between STK11 and KEAP1 mutational status and efficacy in KEYNOTE-042: pembrolizumab monotherapy versus platinum-based chemotherapy as first-line therapy for PD-L1-positive advanced NSCLC

Byoung Chul Cho, Gilberto Lopes, Dariusz M. Kowalski, Kazuo Kasahara, Yi-Long Wu, Gilberto Castro, Hande Z. Turna, Razvan Cristescu, Deepti Aurora-Garg, Andrey Loboda, Jared Lunceford, Julie Kobie, Mark Ayers, M. Catherine Pietanza, Bilal Piperdi, Tony S. Mok
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT084.
https://doi.org/10.1158/1538-7445.AM2020-CT084
Published: 15 August 2020
View articletitled, Abstract CT084: Relationship between STK11 and KEAP1 mutational status and efficacy in KEYNOTE-042: pembrolizumab monotherapy versus platinum-based chemotherapy as first-line therapy for PD-L1-positive advanced NSCLC
Journal Articles

Abstract LB-225: RNA molecular signatures as predictive biomarkers of response to monotherapy pembrolizumab in patients with metastatic triple-negative breast cancer: KEYNOTE-086

Sherene Loi, Peter Schmid, Javier Cortés, David W. Cescon, Eric P. Winer, Deborah Toppmeyer, Hope S. Rugo, Michelino De Laurentiis, Rita Nanda, Hiroji Iwata, Ahmad Awada, Antoinette Tan, Chunsheng Zhang, Andrey Loboda, Andrew Albright, Razvan Cristescu, Maureen Lane, Anran Wang, Jared Lunceford, Gursel Aktan, Vassiliki Karantza, Sylvia Adams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-225.
https://doi.org/10.1158/1538-7445.AM2019-LB-225
Published: 01 July 2019
View articletitled, Abstract LB-225: RNA molecular signatures as predictive biomarkers of response to monotherapy pembrolizumab in patients with metastatic triple-negative breast cancer: KEYNOTE-086
Journal Articles

Abstract 2483: An integrated bioinformatics pipeline for profiling cancer-immune interaction from whole exome sequencing of pembrolizumab clinical samples

Xiaoqiao Liu, Xinwei Sher, Hongchao Lu, Jun Zhuang, Weilong Zhao, Andrew Albright, Cinthia Umemoto, Christen Wudarski, Maureen Lane, Mark Ayers, Andrea L. Webber, Sandra C. Souza, Ping Qiu, Diane Levitan, Jennifer Cho, Deepti Aurora-Garg, Matthew Marton, Alexandra Snyder, Michael Morrissey, Andrey Loboda, Ronghua Chen, Razvan Cristescu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2483.
https://doi.org/10.1158/1538-7445.AM2019-2483
Published: 01 July 2019
View articletitled, Abstract 2483: An integrated bioinformatics pipeline for profiling cancer-immune interaction from whole exome sequencing of pembrolizumab clinical samples
Journal Articles

Abstract 2571: An integral genomic/expression analysis reveals a cooperative role of APC and TP53 mutations in identifying cetuximab-sensitive colorectal cancer

Mingli Yang, Michael J. Schell, Andrey Loboda, Michael V. Nebozhyn, Jiannong Li, Jamie K. Teer, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2571.
https://doi.org/10.1158/1538-7445.AM2018-2571
Published: 01 July 2018
View articletitled, Abstract 2571: An integral genomic/expression analysis reveals a cooperative role of APC and TP53 mutations in identifying cetuximab-sensitive colorectal cancer
Journal Articles

Abstract 543: Preclinical combination strategies to enhance the efficacy of the anti-PD-1 antibody pembrolizumab

Elaine M. Pinheiro, Marlene Hinton, Ruban Mangadu, Mingmei Cai, Uyen Phan, Michael Nebozhyn, Heather Hirsch, Andrey Loboda, Sarah Javaid, Yaolin Wang, Venkataraman Sriram, Joseph H. Phillips, Terri McClanahan, Brian Long
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 543.
https://doi.org/10.1158/1538-7445.AM2016-543
Published: 15 July 2016
View articletitled, Abstract 543: Preclinical combination strategies to enhance the efficacy of the anti-PD-1 antibody pembrolizumab
Journal Articles

Abstract 3175: Identification of a unique subpopulation of mesenchymal-like colorectal cancers associated with better survival

Mingli Yang, Michael J. Schell, Michael V. Nebozhyn, Andrey Loboda, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3175.
https://doi.org/10.1158/1538-7445.AM2016-3175
Published: 15 July 2016
View articletitled, Abstract 3175: Identification of a unique subpopulation of mesenchymal-like colorectal cancers associated with better survival
Journal Articles

Abstract 1307: Assessment of gene expression in peripheral blood from patients with advanced melanoma using RNA-seq before and after treatment with anti-PD-1 therapy with pembrolizumab (MK-3475)

Mark D. Ayers, Michael Nebozhyn, Heather A. Hirsch, Razvan Cristescu, Erin E. Murphy, S. Peter Kang, Scot W. Ebbinghaus, Terrill K. McClanahan, Andrey Loboda, Jared K. Lunceford
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1307.
https://doi.org/10.1158/1538-7445.AM2015-1307
Published: 01 August 2015
View articletitled, Abstract 1307: Assessment of gene expression in peripheral blood from patients with advanced melanoma using RNA-seq before and after treatment with anti-PD-1 therapy with pembrolizumab (MK-3475)
Journal Articles

Abstract 256: Identification of additional cancers likely to respond to anti-PD-1 therapy (pembrolizumab): Evaluation of PD-L1 expression in a large molecular tumor profiling gene expression database

Mark D. Ayers, Michael Nebozhyn, Razvan Cristescu, Terrill K. McClanahan, Heather A. Hirsch, Jonathan D. Cheng, Andrey Loboda
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 256.
https://doi.org/10.1158/1538-7445.AM2015-256
Published: 01 August 2015
View articletitled, Abstract 256: Identification of additional cancers likely to respond to anti-PD-1 therapy (pembrolizumab): Evaluation of PD-L1 expression in a large molecular tumor profiling gene expression database
Journal Articles

Abstract LB-313: Integrative genomic profiling of Asian gastric cancers identifies four subgroups with distinct pathobiology and prognosis

Razvan Cristescu, Jeeyun Lee, Michael Nebozhyn, Amit Aggarwal, Jason Ting, Swee Seong Wong, Yong Yue, Christoph Reinhard, Kyoung Kim, Ingu Do, Hongyue Dai, Andrey Loboda
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-313.
https://doi.org/10.1158/1538-7445.AM2014-LB-313
Published: 01 October 2014
View articletitled, Abstract LB-313: Integrative genomic profiling of Asian gastric cancers identifies four subgroups with distinct pathobiology and prognosis
Journal Articles

Abstract 2742: The PARP inhibitor niraparib demonstrates robust activity in a subset of patient-derived triple-negative breast cancer xenograft models

Yan Wang, Stefano Cairo, Delphine Nicolle, Razvan Cristescu, Andrey Loboda, Michael Nebozhyn, Theresa Zhang, Jean-Gabriel Judde, Keith Wilcoxen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2742.
https://doi.org/10.1158/1538-7445.AM2014-2742
Published: 01 October 2014
View articletitled, Abstract 2742: The PARP inhibitor niraparib demonstrates robust activity in a subset of patient-derived triple-negative breast cancer xenograft models